ライフサイエンスコーパス: complementarity-determining region 3

1 ed clones (as confirmed by sequencing of the complementarity-determining region 3).

2 dominant germ line genes as well as dominant complementarity determining region 3.

3 d substantial sequence homology within their complementarity-determining region 3.

4 acids, such as arginine, in the heavy chain complementarity-determining region 3.

5 use of a restricted set of sequences in the complementarity-determining region 3.

6 ral mimicry of C-terminal domain peptides by complementarity-determining region 3.

7 but they all had very different sequences in complementarity-determining region 3.

8 hybridomas, with mutations concentrating in complementarity-determining region 3.

9 tirely determined by junctional diversity in complementarity-determining region-3.

10 maturation-associated changes in heavy-chain complementarity determining region 3, a key antigen-bind

11 mmunoglobulin light chains with 5-amino acid complementarity determining region 3s, a key feature of

12 t use, and in the length and features of the complementarity-determining region 3, a major determinan

13 a single clonotypic expansion of the encoded complementarity-determining region 3 amino acid sequence

14 re, increased palindromic nucleotides in the complementarity determining regions 3 and long stretches

15 y a single, conservative substitution in the complementarity-determining region 3 and the other conta

16 bnAbs, including a short CDRL3 (light-chain complementarity-determining region 3) and mutations that

17 ional protein antigens since the heavy chain complementarity-determining region 3 appears to play onl

18 ggests that cationic residues in the H chain complementarity-determining region 3 are important for t

19 Complementarity-determining region 3 averaged 10 amino a

20 Using high-throughput and single-cell TCR-complementarity-determining region 3 beta (TCR-CDR3beta)

21 Vgamma2Vdelta2 TCR has a basic region in the complementarity-determining region 3 binding groove that

22 rsity, somatic hypermutation, or heavy chain complementarity determining region 3 biochemical feature

23 nced to date possess a 10-amino acid L chain complementarity-determining region-3 (CDR-3) having an i

24 In the productive repertoire, the H chain complementarity determining region 3 (CDR3(H)) was signi

25 We found sequence identity for complementarity determining region 3 (CDR3) among a majo

26 5 shows that the tip of the CH65 heavy-chain complementarity determining region 3 (CDR3) inserts into

27 The complementarity determining region 3 (CDR3) length adjus

28 thin this population were documented by both complementarity determining region 3 (CDR3) length polym

29 vo quantitative TCR beta chain V segment and complementarity determining region 3 (CDR3) length reper

30 technique that displays the distribution of complementarity determining region 3 (CDR3) lengths for

31 served tryptophan residue in the heavy chain complementarity determining region 3 (CDR3) of mAbs A an

32 ifiers was a biophysicochemical motif in the complementarity determining region 3 (CDR3) of TCRbeta c

33 conserved arginine-serine-serine sequence in complementarity determining region 3 (CDR3) of the V(bet

34 Also, the Vbeta complementarity determining region 3 (CDR3) regions from

35 h very similar and unusually long beta-chain complementarity determining region 3 (CDR3) regions in C

36 es of amino acids within the antigen binding complementarity determining region 3 (CDR3) repertoire o

37 These TCRs encoded a range of V, J, and complementarity determining region 3 (CDR3) sequences on

38 or a histidine in their alpha- or beta-chain complementarity determining region 3 (CDR3) were highly

39 ined by the presence of a short motif in the complementarity determining region 3 (CDR3), disregardin

40 V5E1, by virtue of complementarity determining region 3 (CDR3), may also en

41 les on TCR composition at the highly diverse complementarity determining region 3 (CDR3), which confe

42 ough each of these Fabs contained a distinct complementarity determining region 3 (CDR3)-H sequence.

43 mon overrepresentation of a histidine in the complementarity determining region 3 (CDR3; 15% of alpha

44 n dominated the interaction and, whereas the complementarity determining region-3 (CDR3) loops exclus

45 e distinct ccRCC patient tumor cohorts using complementarity determining region-3 (CDR3) sequence rec

46 ent selection acting on three regions of the complementarity-determining region 3 (CDR3) antigen-bind

47 d that the somatically generated light chain complementarity-determining region 3 (CDR3) contributes

48 l in mice and humans, we wondered whether 1) complementarity-determining region 3 (CDR3) diversity wa

49 Crystal structure analysis revealed that the complementarity-determining region 3 (CDR3) elements of

50 We measured the size distribution of the complementarity-determining region 3 (CDR3) for expanded

51 hape complementarity, and the TCR beta chain complementarity-determining region 3 (CDR3) has minimal

52 Complementarity-determining region 3 (CDR3) is the most

53 JH4 rather than JH1 and exhibit more diverse complementarity-determining region 3 (CDR3) junctions wi

54 We used complementarity-determining region 3 (CDR3) length analy

55 In 51p1-encoded immunoglobulin M (IgM), complementarity-determining region 3 (CDR3) length and f

56 Analysis of TRBJ gene usage and complementarity-determining region 3 (CDR3) length distr

57 study the diversity of Vbeta usage and beta complementarity-determining region 3 (CDR3) length of TC

58 Vbeta8.1 TCR repertoire directly ex vivo by complementarity-determining region 3 (CDR3) length spect

59 CR-based assay that permits determination of complementarity-determining region 3 (CDR3) length varia

60 tudy the diversities of Vbeta usage and beta complementarity-determining region 3 (CDR3) lengths of T

61 s were enriched for clones utilizing uniform complementarity-determining region 3 (CDR3) lengths.

62 Moreover, the sequences of the complementarity-determining region 3 (CDR3) loop from to

63 ue regions" of VpreB and lambda5 replace the complementarity-determining region 3 (CDR3) loop of an a

64 d always be identified at position 98 of the complementarity-determining region 3 (CDR3) loop of TCR

65 germline-encoded residues of its delta chain complementarity-determining region 3 (CDR3) loop to bind

66 result of a conformational change in the TCR complementarity-determining region 3 (CDR3) loop.

67 de centric, dominated by two residues of the complementarity-determining region 3 (CDR3) loops that a

68 essed TCR beta-chains with highly homologous complementarity-determining region 3 (CDR3) loops.

69 ongly with a somatically recombined TCRdelta complementarity-determining region 3 (CDR3) motif derive

70 dentical between patients but share a common complementarity-determining region 3 (CDR3) motif.

71 d several phylogenetically conserved Vgamma2 complementarity-determining region 3 (CDR3) motifs betwe

72 ients with skewed repertoires, cDNA from the complementarity-determining region 3 (CDR3) of 4 TCR-Vbe

73 structure and key amino acid residues on the complementarity-determining region 3 (CDR3) of FLCs are

74 We used complementarity-determining region 3 (CDR3) of the immun

75 Complementarity-determining region 3 (CDR3) of the TCR i

76 fected macaques by assessing T-cell receptor complementarity-determining region 3 (CDR3) profiles and

77 Analysis of complementarity-determining region 3 (CDR3) regions cont

78 We performed deep sequencing of TCRbeta complementarity-determining region 3 (CDR3) regions in s

79 ng of rearranged T-cell receptor (TCR) Vbeta complementarity-determining region 3 (CDR3) regions, a p

80 ha11(+)Vbeta3(+) Th (70%) express a critical complementarity-determining region 3 (CDR3) residue (glu

81 ed selected usage of TCR V beta families and complementarity-determining region 3 (CDR3) segments.

82 s such as clonality that do not leverage the complementarity-determining region 3 (CDR3) sequence.

83 eveloped a computational method to infer the complementarity-determining region 3 (CDR3) sequences of

84 information and ensures recovery of complete complementarity-determining region 3 (CDR3) sequences, a

85 TCR transcripts, including complementarity-determining region 3 (CDR3) sequences, w

86 ing anchored RT-PCR of all the TCRbeta locus complementarity-determining region 3 (CDR3) sequences.

87 th conserved motifs and global similarity of complementarity-determining region 3 (CDR3) sequences.

88 peripheral blood lymphocytes was assessed by complementarity-determining region 3 (CDR3) size distrib

89 We have used complementarity-determining region 3 (CDR3) size distrib

90 as been studied by examining the profiles of complementarity-determining region 3 (CDR3) sizes expres

91 We examined the heterogeneity of complementarity-determining region 3 (CDR3) sizes of Ig

92 atients, multiple monoclonal and oligoclonal complementarity-determining region 3 (CDR3) spectratype

93 receptor (TCR), the variable beta (VB)-chain complementarity-determining region 3 (CDR3), can serve a

94 ns of V(D)J gene segments that contribute to complementarity-determining region 3 (CDR3), the region

95 oding an even number of Cys (two or four) in complementarity-determining region 3 (CDR3), which is an

96 as made it challenging to search through the Complementarity-determining region 3 (CDR3), which is re

97 re including antibodies with quasi-identical complementarity-determining region 3 (CDR3), which sugge

98 variable major antigen-binding determinant, complementarity-determining region 3 (CDR3), with specif

99 ing a high-resolution analysis of the TCR VB complementarity-determining region 3 (CDR3).

100 major components of junctional diversity in complementarity-determining region 3 (CDR3).

101 ymocytes that express shorter TCR beta-chain complementarity-determining region 3 (CDR3).

102 o acid residue in the second position of the complementarity-determining region 3 (CDR3).

103 ements and display considerable diversity in complementarity-determining region 3 (CDR3).

104 hitecture, including V, D, J regions and the complementarity-determining region 3 (CDR3).

105 lthy donors, that patients have shorter TCRB complementarity-determining region 3s (CDR3), in all cel

106 low number of N nucleotide insertions in the complementarity-determining region-3 (CDR3) of their TCR

107 hips between the amino acid sequences of the complementarity-determining region-3 (CDR3) represented

108 pparent bias for histidine at position 95 of complementarity-determining region-3 (CDR3).

109 ere, we show that exome reads mapping to the complementarity-determining-region 3 (CDR3) of mature T-

110 V(D)J junctional regions encode complementarity-determining-region 3 (CDR3), an antigen-

111 global changes in T cell receptor beta chain complementarity determining region 3 (CDR3beta) sequence

112 The ultralong heavy chain complementarity determining region 3 (CDR3H) of bovine a

113 nique structure in its ultralong heavy chain complementarity determining region 3 (CDR3H) that folds

114 igh-affinity antibodies with long human-like complementarity-determining region 3 (CDR3H), broad epit

115 and sequenced to identify utilized V genes, complementarity-determining regions 3 (CDR3s), and joini

116 he relative roles of VH FR1, heavy (H) chain complementarity determining region 3 (CDRH 3) and the li

117 r unusual traits, such as a long heavy chain complementarity determining region 3 (CDRH3) and autorea

118 (BLV1H12) which has an ultralong heavy chain complementarity determining region 3 (CDRH3) provides a

119 that a four-residue insertion in heavy chain complementarity-determining region 3 (CDRH3) contributed

120 The lineage Abs bore an anionic heavy chain complementarity-determining region 3 (CDRH3) of 25 amino

121 it does not require a rare short light chain complementarity-determining region 3 (CDRL3).

122 s CD8 independent but correlated with longer complementarity-determining regions 3 characteristic of

123 ve N-region additions, Vh usage, and charged complementarity-determining region 3 consistent with aut

124 MRL/lpr mice still revealed the presence of complementarity-determining region 3 containing apparent

125 ealed an extended VH binding interface, with complementarity-determining region 3 deeply penetrating

126 alphabeta TCR after grafting of a G8 or KN6 complementarity-determining region 3-delta (CDR3delta) l

127 ent lineages converge to the same responding Complementarity Determining Region 3, demonstrating conv

128 e characterized by a substantial decrease in complementarity determining region 3 diversity.

129 clones reveals a marked heterogeneity in the complementarity-determining region 3 domain and differen

130 ct human scFv from a library with randomized complementarity-determining region 3 domains.

131 mAbs against both Valpha24 and the invariant complementarity-determining region 3 epitope of the huma

132 er, neutralizing antibodies possessed longer complementarity-determining region 3 for both heavy and

133 mmunoglobulin heavy-chain gene coding in the complementarity-determining region 3 for three repeats o

134 However, the heavy chain complementarity-determining region 3 (H-CDR3) of most pa

135 ese, the PG9 antibody has a long heavy chain complementarity determining region 3 (HCDR3) and possess

136 tein E2 epitope using an unusual heavy chain complementarity determining region 3 (HCDR3) containing

137 nition is typically dominated by heavy chain complementarity determining region 3 (HCDR3) interaction

138 Eight Ab heavy-chain complementarity determining region 3 (HCDR3) loops from

139 nt anti-ssDNA Fab, DNA-1, and 16 heavy chain complementarity determining region 3 (HCDR3) mutant vari

140 encoded and immunoglobulin (Ig) heavy-chain complementarity determining region 3 (HCDR3) residues, w

141 10E8-class bnAbs possess a long heavy chain complementarity determining region 3 (HCDR3) with a spec

142 ult of stabilization of the long heavy chain complementarity determining region 3 (HCDR3).

143 idues (H97-H100A) in the apex of heavy chain complementarity-determining region 3 (HCDR3) are disorde

144 egion and how variability within heavy-chain complementarity-determining region 3 (HCDR3) can be acco

145 a strong dependence on antibody heavy chain complementarity-determining region 3 (HCDR3) is a major

146 ults from a short and inflexible heavy chain complementarity-determining region 3 (HCDR3) loop and a

147 h unusual features, such as long heavy-chain complementarity-determining region 3 (HCDR3) loops.

148 The heavy chain complementarity-determining region 3 (HCDR3) of the anti

149 unusual traits, including a long heavy chain complementarity-determining region 3 (HCDR3), polyreacti

150 gage Env with an uncommonly long heavy-chain complementarity-determining region 3 (HCDR3), suggesting

151 r) guided affinity maturation by heavy-chain complementarity-determining region 3 (HCDR3)-focused mut

152 racterized by long, hydrophobic, heavy chain complementarity-determining region 3s (HCDR3s) that inte

153 .03 except for amino acid differences in the complementarity-determining region 3 in both heavy and l

154 a higher than average frequency of atypical complementarity-determining regions 3, including those m

155 ells were expressing identical TCR Vbeta13.6/complementarity-determining region 3/J region sequences.

156 llowed the characteristic public clone using complementarity determining region 3 length T cell reper

157 nt of junctional diversity, and mean H chain complementarity determining region 3 length.

158 nvestigated the CD8 TCR V beta repertoire by complementarity-determining region 3 length analysis usi

159 Complementarity-determining region 3 length and amino ac

160 Complementarity-determining region 3 length displays sug

161 D8+ T cells by TCRV beta surface expression, complementarity-determining region 3 length distribution

162 little evidence for changes in Vss usage or complementarity-determining region 3 length distribution

163 mers and a panel of anti-Vss Abs, as well as complementarity-determining region 3 length distribution

164 r an absolute deletion of a single preferred complementarity-determining region 3 length polymorphism

165 V (IGHV), D (IGHD), and J (IGHJ) gene usage, complementarity-determining region 3 length, and somatic

166 Analysis of complementarity determining region 3 lengths of 24 TCR-b

167 ntly evolved clones, and a narrower range of complementarity-determining region 3 lengths at day 15.

168 a recurrent amino acid sequence motif in the complementarity-determining region 3 loop and a prevalen

169 containing an Asn-Pro-Phe peptide within the complementarity-determining region 3 loop is a function-

170 ng site is dominated by a single heavy-chain complementarity-determining region 3 loop, with minor co

171 These results demonstrate that the complementarity-determining region 3 loops contribute to

172 Our results highlight the role of the TCR complementarity-determining region 3 loops for controlli

173 the V beta elements and the sequences of the complementarity-determining region 3 loops of their TCRs

174 teraction was dominated by the hypervariable complementarity-determining region 3 loops, indicating t

175 in the T-cell receptor Vbeta gene usage and complementarity-determining region 3 loops.

176 y body demonstrated the presence of the same complementarity determining region 3 motifs found in MBP

177 unique and thus far not reported heavy-chain complementarity determining region 3 motifs, of which 4

178 Those responses are mostly mediated by complementarity-determining region 3 motifs created by q

179 demonstrated sets of related, but different, complementarity-determining region 3 nucleotide sequence

180 use the biochemical features encoded by the complementarity determining region 3 of each B cell rece

181 Tyrosine and glycine constitute 40% of complementarity determining region 3 of the immunoglobul

182 Mutagenesis of M88 showed that the complementarity determining regions 3 of both gammadelta

183 ere used to replace the extended heavy chain complementarity-determining region 3 of an IgG antibody

184 h-throughput sequencing of the TCRbeta chain complementarity-determining region 3 of liver-infiltrati

185 re, we observed a shift in the properties of complementarity-determining region 3 of the BCR heavy ch

186 we altered single amino acid residues of the complementarity-determining region 3 of the beta-chain o

187 through interactions with the unusually long complementarity-determining region 3 of the HC33.1 heavy

188 and identified an A to S substitution in the complementarity-determining region 3 of the variable reg

189 ponse was the generation of arginines in the complementarity-determining region-3 of DNA-binding hybr

190 n with sequencing of the highly variable TCR complementarity-determining region 3, permitting a quant

191 evels of unproductive sequences and distinct complementarity determining region 3 properties.

192 e and carrying an unusually long heavy-chain complementarity-determining region 3, recognized the Por

193 Spectratyping of the complementarity-determining region 3 regions reveals tha

194 We found that T-cell receptor beta (TCRbeta) complementarity-determining region 3 repertoire sequenci

195 exhibited the dominant responses of TCR-beta complementarity-determining region 3-restricted T cell s

196 it has always been tempting to assume that a complementarity-determining region 3 sequence has been a

197 a 20-mer TCR peptide incorporating a common complementarity-determining region 3 sequence of the imm

198 novial compartment; (3) some T-cell receptor complementarity-determining region 3 sequence similariti

199 In six of seven specimens, the same complementarity-determining region 3 sequence was repeat

200 variable region beta) gene usage and a CDR3 (complementarity-determining region 3) sequence to assess

201 d CD154(-) fractions revealed more than 6000 complementarity determining region 3 sequences and motif

202 nd a greater frequency of unique heavy chain complementarity determining region 3 sequences compared

203 Some complementarity determining region 3 sequences were comm

204 opologies are possible because of the unique complementarity-determining region 3 sequences created d

205 In addition, complementarity-determining region 3 sequences formed in

206 TRUST assembled more than 30 million complementarity-determining region 3 sequences of the B

207 However, the complementarity-determining region 3 sequences of the V

208 Analysis of expressed TCRB complementarity-determining region 3 sequences showed th

209 dentical T-cell receptor variable beta-chain complementarity-determining region 3 sequences were iden

210 e whether these differences in V beta usage, complementarity-determining region 3 sequences, and the

211 cell responses that preferentially recognize complementarity-determining region 3 sequences, contribu

212 with nearly identical heavy and light chain complementarity-determining region 3 sequences.

213 etermining region 3 length distribution, and complementarity-determining region 3 sequencing analysis

214 ow cytometry, Vbeta repertoire analysis, and complementarity-determining region 3 sequencing) were us

215 ated expression of T cell clones with intact complementarity determining region 3 signals.

216 However, PCR-based complementarity-determining region 3 size spectratyping

217 ells in Jak3(-/-) and CTLA-4(-/-) mice using complementarity-determining region 3 spectratype analysi

218 The complementarity-determining region 3 spectratypes of thy

219 IV disease, using a sensitive beta-variable complementarity-determining region 3 spectratyping appro

220 We identified targeting motifs based on the complementarity-determining region 3 structure of dAbs f

221 igh-throughput T cell receptor sequencing of complementarity determining region 3 T cell receptor bet

222 ten had a Y-x-R motif within the heavy-chain complementarity determining region 3 to make key contact

223 of T cell receptor (TCR) alpha or beta chain complementarity-determining region 3 transcripts by real

224 sequenced and the amino acid sequence of the complementarity-determining region 3 was deduced.

225 , characterized by their uniquely rearranged complementarity-determining region 3, were detected in d