ライフサイエンスコーパス: complex

1 s the beta subunit of VGCC and the p11/Anxa2 complex.

2 e Wnt/beta-catenin-dependent transcriptional complex.

3 ion of a Tat substrate with the Tat receptor complex.

4 individually as well as in the cross-linked complex.

5 y-initiating TBK1 kinase and the ULK1 kinase complex.

6 sential role in tensioning the hair cell MET complex.

7 tress-activated FOXO1 through formation of a complex.

8 nfluence, but the eukaryote response is more complex.

9 ing a megadalton-scale tRNA multi-synthetase complex.

10 charge-transfer character of these inclusion complexes.

11 acts as a quencher for the light-harvesting complexes.

12 egulated accumulation in these foci of BRCA1 complexes.

13 e level of eIF2-GTP-Met-tRNA(i)(Met) ternary complexes.

14 assembly-disassembly cycle of neuronal SNARE complexes.

15 the phospholipid requirements of ion channel complexes.

16 ation of novel gene products and subcellular complexes.

17 ild integrative structural models of protein complexes.

18 n fluxes from photosynthetic and respiratory complexes.

19 Polycomb repressive complex 2 (PRC2) silences expression of developmental tr

20 of the immune system and polycomb repressive complex 2 in pathological AD.

21 g site by recruiting the polycomb repressive complex 2 to induce bivalent chromatin at the Wapl promo

22 that encode subunits of the adaptor protein complex 4 (AP-4) lead to prototypical yet poorly underst

23 nit of the pentameric cytoskeletal SCAR/WAVE complex, a major downstream target of RAC1, in a mouse m

24 tem involves two distinct receptor-G protein complexes, a conventional ternary complex that activates

25 ssembly be it in proteins or in coordination complexes affords us a better understanding of the assem

26 des represent entities of the protein-ligand complex (amino acids and ligands) and the edges represen

27 stand causes of sex-biased mortalities, more complex analyses are needed that incorporate various eco

28 des a range of ready-to-use workflows to run complex analyses requiring minimal intervention by users

29 f kinematic loops (e.g., cycling models) and complex anatomy (e.g., patellar motion).

30 vision, eukaryotic cells undergo a dramatic, complex and coordinated remodelling of their cytoskeleto

31 The extracellular matrix (ECM) is a complex and dynamic meshwork of cross-linked proteins th

32 er resolution, facilitating the discovery of complex and dynamic protein networks.

33 This complex and highly dynamical chemical process involves a

34 The pathophysiology is complex and involves a strong genetic predisposition, ep

35 The control of NK cell responses is complex and only partially understood.

36 ce for this transformation involving a sigma complex and oxidative cleavage transition state.

37 n at these GC-rich microsatellites: the DSIF complex and PAF1C.

38 UNX1 is a component of the HDAC3 corepressor complex and that HDAC3 preferentially binds to RUNX1 rat

39 the origins of cell-to-cell variability are complex and the individual contributions of different fa

40 stability of state trajectories which may be complex and time-varying.

41 y ligands to stabilize late transition metal complexes and are conventionally considered to have litt

42 many new high-resolution structures of large complexes and membrane proteins are determined regularly

43 erences between the UBE2K-Ub and UBE2K-Ub(2) complexes and show how the UBA domain can alter the posi

44 DNA prior to integration (the target capture complex) and two forms of the RAG strand transfer comple

45 phorylated PPIn species within the PM, Golgi complex, and endosomal compartments.

46 Ion mobility spectra of citric acid (CA) are complex, and several peaks are observed for CA and its f

47 ameters that define the stability of p53/DNA complexes, and provide insight into the pathways by whic

48 This effect on ETC complexes appears to be independent of protein lipoylati

49 hetic electron transport, large multiprotein complexes are connected by small diffusible electron car

50 Eluted proteins and protein complexes are detected by the mass spectrometer after el

51 t that silicate-bridging [AlO(2)(OH)(4)](5-) complexes are favored, stabilized by hydroxyl ligands an

52 Both complexes are necessary for transcriptional regulation b

53 rtained that five coordinate amide iodine(V) complexes are unreactive toward redox reactions due to t

54 impairs the integrity of the gamma-secretase complex as well as its catalytic activity toward its sub

55 perspectives and significance of using metal complexes as ER stress-inducing agents for the treatment

56 e(III) complexes cannot compete with Gd(III) complexes as T(1) MRI contrast agents.

57 ide insight into the pathways by which those complexes assemble.

58 Successful preservation of the nickel complex at polymer chain ends is evidenced by nuclear ma

59 Together with the location of this landslide complex at the head of the major knickzone defining the

60 MIS5-4 Still Bay and Howiesons Poort techno-complexes at Diepkloof Rock Shelter, South Africa.

61 an essential but homeostatic contributor to complex bacterial behaviors.

62 arget- and species-specific integration in a complex bacterial community.

63 ow proper quantification of microplastics in complex beverage matrices.

64 ile modification of NCys-bearing proteins in complex biological milieu.

65 onized our understanding of gene function in complex biological settings, including T cell immunology

66 roteomics and phosphorproteomics analysis in complex biosamples.

67 est that the two carbon atoms of the L->C(2) complex both have carbene character.

68 ned the crystal structure of the LSD1/CoREST complex bound to a 191-bp nucleosome.

69 regulated by the nuclear receptor NR4A1/Sp1 complex bound to the proximal germinal center (GC)-rich

70 However, current protocols yield either complex but highly heterogeneous aggregates ('organoids'

71 ticulum (ER) are assembled into multiprotein complexes, but little is known about the mechanisms requ

72 method that is applicable for any multimeric complex by investigating the stoichiometry of Kv2.1/Kv6.

73 lts in distinct modes of derepression of the complex by PopP2 and AvrRps4.

74 We purified SMALP-lipid-protein complexes by chromatography and quantitatively analyzed

75 radiobiologic dose metrics that involve more complex calculations.

76 The classical 2-oxoglutaric dehydrogenase complex can exist as a previously undiscovered hybrid co

77 Early studies suggested that Fe(III) complexes cannot compete with Gd(III) complexes as T(1)

78 rovided by the palliative care team for more complex cases-is unique from palliative care in adults g

79 r membrane for the recovery of lysozyme from complex CEW solution.

80 biology, the simple circuits, combined into complex circuits, form systems-level functions.

81 Surprisingly, Ndc80 complex clustering is independent of the organization an

82 rs of a songbird family-corvids-also evolved complex cognitive skills but a detailed understanding of

83 itro after activation with zymosan or immune complexes, compared with wild-type (WT) neutrophils.

84 Hydrophilic host-guest complexes, consisting of water-soluble azobenzene and al

85 Language is a complex construct involving linguistic as well as visual

86 Macroautophagy is initiated primarily by a complex containing ULK1 or ULK2 (two paralogs of the yea

87 Thus, cationic complexes containing strongly basic NHC ligands and nonc

88 or of mortality at 10 years in patients with complex coronary artery disease.

89 The major issue is modeling the complex crosstalk among transcription factors (TFs) and

90 ose is synthesized by the cellulose synthase complex (CSC) containing CELLULOSE SYNTHASE1 (CESA1), CE

91 rosette-structured cellulose synthase (CESA) complexes (CSCs).

92 Ctf4 and the heterotrimeric fork protection complex (Csm3/Tof1 and Mrc1), which has important roles

93 Anaphase promoting complex/cyclosome (APC/C) is reported to play an importa

94 ty has long been a hurdle in the analysis of complex data in areas such as computational biology, eco

95 ducibly resolving hidden cell populations in complex datasets.

96 The Galphas-GPCR complex detected with Nb37 displayed higher mobility wit

97 can identify key network modules related to complex diseases like COPD.

98 ngstrom crystal structure of the CypA/PreNAC complex displays a contact between alanine 53 of alpha-s

99 n the transcription factor HY5 controlling a complex downstream growth program.

100 d by the oncogenic SOX2-GLI1 transcriptional complex driving melanoma invasion through the induction

101 nto phosphorus as well as other structurally complex, e.g., layered solids that are relevant in diver

102 riants in the gene encoding a member of this complex, EMC1.

103 ics of paramagnetic transition metal hydride complexes, especially of the abundant 3d metals, is impo

104 Finally, IL-2/alphaIL-2 complex-expanded Treg cells could be recalled upon aller

105 Each bimetallic complex features a relatively short Ni-M bond length, ra

106 ts due to the difficulty of interpreting the complex features they learn.

107 onal active flow control strategies in other complex fluid mechanics applications.

108 d that the regulatory subunits of these AHAS complexes form a core to which the catalytic subunit dim

109 (F4TCNQ), is of interest for charge transfer complex formation and as a p-dopant in organic electroni

110 f eIF2gamma impairs CDC123 promotion of eIF2 complex formation and decreases the level of eIF2-GTP-Me

111 y reveal the nature of SARAH domain-mediated complex formation and provide mechanistic insights into

112 (MS) for the biophysical characterization of complex formation of a BsAb with two target antigens, cl

113 ard inhibition of MHC class I:beta2M:peptide complex formation.

114 Large bottlebrush complexes formed from the polysaccharide hyaluronan (HA)

115 pplications of advanced methods for sampling complex free-energy landscapes at near nonergodicity con

116 stimuli-responsive materials that mimic the complex functions of living systems.

117 While the MT nucleator, gamma-tubulin ring complex (gamma-TuRC) has been identified, precisely how

118 leiotropy and offer further insight into the complex genetic architecture of cross-cancer susceptibil

119 g gapless telomere-to-telomere assemblies of complex genomes is one of the ultimate challenges in gen

120 structured DNA is sufficient to predict the complex genomic behaviour of STRs, including abundance a

121 capture (Hi-C)(1,2) analysis has revealed a complex genomic landscape of internal chromosomal struct

122 te this devastation, the biomedical research complex has allocated billions of dollars and scientists

123 steps leading to the final grafted molecular complex have been identified by DFT.

124 The complexes have been obtained by kneading method.

125 orly understood forms of childhood-onset and complex hereditary spastic paraplegia: SPG47 (AP4B1), SP

126 et but rather from the multilevel control of complex homeostatic processes.

127 on genome-wide association studies (GWAS) of complex human traits in the UK Biobank has not been inve

128 factor 2 (Nrf2) enables idebenone to bypass Complex I in cells with poor NQO1 expression.

129 ivator 1-alpha and oxidative phosphorylation complex II and III were significantly lower in IMB than

130 Despite the decreased mitochondrial area, complex III and V expression increased in debanding comp

131 t to a high-affinity heterotrimeric receptor complex (IL-2Ralpha/IL-2Rbeta/gamma(c)).

132 to obtain atomic models of multiple protein complexes implicated in intraerythrocytic survival of th

133 man body, but this interaction is especially complex in the primary gateway to the body: the oral cav

134 rase (PAP) are recruited by the CPSF30-hFip1 complex in vitro, and both hFip1 binding sites in CPSF30

135 was used to delineate a Vif/CBF-beta/PPP2R5 complex in which Vif is predicted to bind the same PPP2R

136 trinsic flexibility of LHCII pigment-protein complexes in a membrane environment, revealing putative

137 ion crystal structure of the BRAF(KD)-14-3-3 complex, in which dimeric 14-3-3 enforces a dimeric BRAF

138 novel strategies that may shed light on this complex infection and provide insights into the future o

139 Atopic dermatitis (AD) is a complex inflammatory disorder with multiple interactions

140 d "search-and-capture." Inhibition of Arp2/3 complex inhibits TMT assembly by both mechanisms.

141 mber of test chimeras and example oligomeric complexes inside living cells.

142 Complex interaction between genetics, epigenetics, envir

143 DENV infection and provide insights into the complex interaction between the virus and innate recepto

144 thalamus and brainstem nuclei, which mediate complex interactions with the brain's cortical processin

145 W156A and L160E, which become buried at the complex interface, disrupt binding of hIL-23p19 to hIL-2

146 A complex interrelationship may exist between gut dysbiosi

147 anges which terminate with an opening of the complex into two separate domains, one of which acts as

148 ase and an essential component of the Smc5/6 complex, involved in sister chromatid cohesion, chromoso

149 have seen an impressive development of iron complexes involving organophosphorus ligands applied in

150 tanding of the putative PC-1/PC-2 polycystin complex is lacking due to technical hurdles in reliably

151 onstrating that the AHR-ARNT transcriptional complex is necessary for expression of MMP1 in OFs.

152 ther, these results demonstrate that the CTK complex is negative regulator of cat-3 expression by aff

153 The resulting single-component Co(-I) complex is proposed as the direct pre-catalyst.

154 However, the study of SIM-SUMO complexes is complicated by their typically low affinity

155 ure that is cleaved at its base by an enzyme complex known as the Microprocessor (Drosha/DGCR8).

156 t cell metabolism is an integral part of the complex landscape of regulatory mechanisms underlying ce

157 the first time) N(2) respiration limits for complex life.

158 Integrin-based focal adhesion complexes link the glial membrane to the extracellular m

159 A decrease in the total levels of complex lipids such as phosphatidylethanolamines (PE), l

160 lung transplantation, with more numerous and complex lymphatic sprouting developing thereafter.

161 subunit of the major m(6)A methyltransferase complex), m(6)A demethylases (ALKBH5 and FTO), or m(6)A

162 ally dispersed rhodium in rhodium diethylene complexes, made by the reaction of Rh(eta(2)-C(2)H(4))(2

163 ens to uncover regulatory mechanisms driving complex mammalian signaling networks.

164 de products, in cell culture media, or other complex matrices.

165 ailability, and weather, we investigated the complex mechanisms affecting reproductive success in an

166 n-electronic, physical unclonable, optically complex media sensitive to neutrons for use in a high-se

167 ukocytoclastic vasculitis (LCV) is an immune-complex mediated vasculitis characterized by neutrophili

168 Importantly, Dg-Dys complex-mediated cell-autonomous control of F-actin fibe

169 alized with VPS35, a subunit of the retromer complex mediating recycling from endosomes, in a subset

170 in binds to class I major histocompatibility complex (MHC) molecules in the endoplasmic reticulum (ER

171 all united by the need to precisely control complex microbial dynamics in spatially extended environ

172 A complex microbiota inhabits various microenvironments of

173 res instead characterize them as "unresolved complex mixtures", with quantification limited to a smal

174 he protein's functionality and a view of its complex molecular mechanisms.

175 ngs establish that evolution can produce new complex molecular structures and functions via simple ge

176 heterogeneous collection of disorders with a complex molecular underpinning.

177 that select the outcomes of the reactions of complex molecules.

178 proportion of the surviving colonies display complex morphologies that contain cells with multiple sp

179 mosome occupancy of the Escherichia coli SMC complex, MukBEF, the chromosome is organized as a series

180 identification and quantitation of cells in complex multilayered tissues.

181 tion flow across senses to interact with our complex multisensory world.

182 Our system does not require complex nanofabrication.

183 may be suitable for the synthesis of various complex natural and unnatural cyclopentanoid targets.

184 onstructed a robust framework to predict how complex network behavior in DCvNs emerges from the chemi

185 Link prediction in a complex network is a problem of fundamental interest in

186 lectrical conductivity-and the presence of a complex network of passive components that acts as a hig

187 nlinear model of cascade failure in weighted complex networks considering overloaded edges to describ

188 The Nuclear Pore Complex (NPC) has emerged as an important hub for proces

189 Nuclear pore complexes (NPCs) are important for cellular functions be

190 ne bodies, as well as in polycomb repressive complex occupancy and CTCF binding sites are associated

191 Cigarette smoke is the first complex odor whose in vivo receptor response pattern has

192 ented here can be applied to any peptide-MHC complex of interest with a structural model as input, re

193 y molecular redox) in memristors based on Ru-complexes of azo-aromatic ligands.

194 vel of single molecules or small interacting complexes of molecules.

195 ss A penicillin-binding proteins (aPBPs) and complexes of SEDS proteins and class B PBPs (bPBPs).

196 U2-type or the U12-type spliceosomes, large complexes of small nuclear ribonucleoprotein particles a

197 ectrum, a new spectral clustering method for complex omic data.

198 ion search by highly motile ATL and ATL-UvrA complexes on DNA at the molecular level.

199 The dimeric complexes on Psi RNA require an intact dimer interface w

200 Recently, tying isolated vortex knots in the complex optical field has been realized.

201 The six-subunit origin recognition complex (ORC), a DNA replication initiator, defines the

202 Moreover, key physical properties of complex-oxide thin films, such as piezoelectricity and m

203 tial responses to regulatory inputs generate complex patterns of binary and graded cell fates.

204 We hypothesized that a premature His complex (PHC) will always perturb AVRT because the His b

205 In view of the complex photoreactivity previously observed for dyads co

206 These complexes preferentially assemble on different classes o

207 VSG in humans is a complex procedure and includes peri-operative antibiotic

208 er, the intrinsic mechanisms regulating this complex process are not well defined and their understan

209 h key mRNA and microRNAs are regulating this complex process in pathological and healthy conditions.

210 F binding site or depletion of RAD21 cohesin complex protein can recover distal polyadenylation site

211 ion, and built classification models for the complex protein spatial distribution in normal and cance

212 Within this complex proteomics background, BSA spiked at 1:5:10 rati

213 Realistic description of competing phases in complex quantum materials has proven extremely challengi

214 The more complex reality is that a given disorder may be influenc

215 ture of an agonist-bound activated DRD2-G(i) complex reconstituted into a phospholipid membrane.

216 Cell surface Cnx-ERp57 complexes reduce these extracellular disulfide bonds and

217 protein contamination, and it is chemically complex-reflecting a wide range of physiological states

218 The LIN28:pre-let-7:TUTase ternary complex regulates pluripotency and oncogenesis by contro

219 ect a comprehensive understanding of SWI/SNF complex regulation.

220 enhancer boundaries enables deconvolution of complex regulatory loci into modular units.

221 nt genomic studies have partly clarified the complex relationship between European UP "cultures" and

222 The endosomal sorting complex required for transport-III (ESCRT-III) catalyzes

223 The endosomal sorting complexes required for transport (ESCRTs) mediate divers

224 heterogeneity in phenotype trends indicates complex responses to spatiotemporal environmental gradie

225 In order to better elucidate the complex role played by CYP2J2 in cardiac cells, we perfo

226 including key components of the nuclear pore complex scaffold and the transmembrane nucleoporin POM12

227 The well-defined Ru(II)-NHC-diamine complexes show unique structure and coordination chemist

228 Mutations in NHE6 cause complex, slowly progressive neurodegeneration.

229 This complex spanned most of central Europe and exhibits demo

230 water incorporated in the supramolecular DES complex stabilizes the transition states and favors the

231 the presence of UV-induced DNA lesions these complexes stall.

232 us, our results support that SHR-SCR protein complex stoichiometry and regulation of SHR transcriptio

233 neered epitope-focused immunogens displaying complex structural motifs.

234 oalescence of liquid droplets and ignore the complex structural properties of spheroids.

235 challenging issue for scientists due to the complex structure and various barrier mechanisms surroun

236 ing approach to transform flat films into 3D complex structures that are difficult to achieve by conv

237 it is always challenging to design platinum complexes suitable for such research.

238 s nanoparticle binding, without the need for complex surface chemistries acting as blocking agents.

239 ns, and may help to explain some of the more complex symptoms associated with parietal damage, such a

240 conclude that dysregulation of the retromer complex system is an early event in the development of t

241 We conducted a systematic search to identify complex system process evaluations that involve qualitat

242 es that are characteristic of nonequilibrium complex systems.

243 In complex tasks such as foraging, the internal state is dy

244 ns, which are organized into morphologically complex terminal trees.

245 ed with deep tetanuran divergences were more complex than currently recognized, with implications for

246 s proposed in 2017, being different and more complex than other oxyluciferins.

247 required metabolic changes are also no less complex than those observed for multiple other of the 56

248 -G protein complexes, a conventional ternary complex that activates G proteins and an inverse-coupled

249 ly reported Hsc70-Hsp105-SGTA-Bag2 cytosolic complex that also mediates SV40 ER-to-cytosol transport.

250 ify members of a membrane-tethered ubiquitin complex that attenuates Hedgehog signaling strength and

251 Indeed, TMG-SYNPHOS forms a copper complex that catalyzes hydroboration of 1,1-disubtituted

252 cium uniporter is a Ca(2+)-gated ion channel complex that controls mitochondrial Ca(2+) entry and reg

253 ex) and two forms of the RAG strand transfer complex that differ based on whether target site DNA is

254 ining TCP-1 (CCT or TRiC) is a multi-subunit complex that folds many of the proteins essential for ca

255 ing system (MICOS) is a multisubunit protein complex that is essential for the proper architecture of

256 tes G proteins and an inverse-coupled binary complex that maintains the inactive state when agonist i

257 bit cyclin and cyclin-dependent kinase (CDK) complex that promotes fibrosis and hypertrophy.

258 via formation of an intense charge transfer complex that subsequently decays to eliminate thiocyanat

259 cription have identified specific, canonical complexes that may promote RNAPII-transcription at these

260 ltaneously: the equilibrium stability of the complex, the association and dissociation kinetics, and

261 r path to the next generation of two-step VT complexes through incorporation of mixed-valence class I

262 hatase activity of a Ppp2r2c-containing Pp2a complex to reduce Erk1/2 activity.

263 ectron microscopy (cryoEM) structure of PDE6 complexed to GTP-bound Galpha(T).

264 ncluding stabilized topoisomerase-1 cleavage complexes (Top1ccs).

265 plications to summary-level GWASs data of 33 complex traits.

266 at poly(ADP-ribose) polymerase 1 (PARP1)-DNA complexes trapped by PARP inhibitors, thereby promoting

267 opy (FSRS) to a multichromophoric biological complex, trimers of LHCII.

268 of structures remains unclear, as networks' complex underlying formation dynamics are usually unobse

269 tivariable analyses that also adjust for the complex variance structure of the oral environment.

270 demonstrating long-term genomic stability of complex VSV recombinants carrying large transgenes.IMPOR

271 ngus, from the Cryptococcus humicola species complex, was more abundant from bronchoscopy samples tha

272 g wildlife habitats and wildlife behavior in complex ways.

273 Using a benchmark of other LRR protein complexes, we further demonstrated that the present appr

274 8]) hosts in water; resulting supramolecular complexes were characterized by NMR, ESI-MS, UV-vis, ITC

275 The complexes were crystallized, and their structures were d

276 rved subunit of the chromatin remodeling BAF complex, which has known contributions to developmental

277 te of catalysis, a protein-bound Mn(4)CaO(x) complex, which passes through >=5 intermediate states in

278 ns were carried out on the substrate-Fe(III) complexes, which shed light on diastereoselective reduct

279 ared by oxidation of a zero-valent beryllium complex with 2,2,6,6-tetramethylpiperidin-1-oxyl (TEMPO)

280 omain of a model ASO-binding protein PC4, in complex with a full PS 2'-OMe DNA gapmer ASO.

281 structure of Bacillus subtilis LS (SacB) in complex with a levan-type fructooligosaccharide and util

282 rystal structure of the HCV E2 ectodomain in complex with AR3X, a bNAb with an unusually long CDRH2 t

283 ic structures of the BBSome by itself and in complex with ARL6(GTP), and we describe the changes in B

284 e for Brd4 association and that inability to complex with Brd4 does not support episomal replication.

285 cryo-EM structures of apo-CA hexamers and in complex with cyclophilin A (CypA) at near-atomic resolut

286 roteins can exist either as monomers or in a complex with Gbetagamma, and the details of combinatoria

287 X-ray structures in complex with HIV-1 RT/dsDNA showed binding of the conjug

288 Mechanistically, TALP-3 and ANKR-26 form a complex with key gating component DYF-19, the homolog of

289 We show that CSB forms a stable complex with Pol II and acts as an ATP-dependent process

290 enable computational modeling of the docked complex with RT.

291 In eukaryotes, Spt5 forms a complex with Spt4 and regulates processive transcription

292 o-hybrid analysis suggest that ZC3H5 forms a complex with three other proteins, encoded by genes Tb92

293 Surprisingly, RSV G complexed with 3G12 adopts a distinct conformation not o

294 ing the EC1 and EC1+2 domains of human CDHR3 complexed with viral isolate C15a.

295 We also observed plant analogs of animal complexes with distinct molecular assemblies, including

296 MRP are highly conserved, multi-protein/RNA complexes with essential roles in processing ribosomal a

297 at it efficiently crosslinks noncovalent RNA complexes with mimimal sequence bias and establish that

298 The overall context of the camps was complex, with more than 100 organizations devoted to pro

299 RNA virus IBs are important immunomodulatory complexes within infected cells.IMPORTANCE Many viruses

300 Single molecule imaging of p44/p62 complexes without XPD reveals they bind to and randomly