ライフサイエンスコーパス: complex formation

1 ed distinct intermediates during NS5 and SLA complex formation.

2 tion is tightly coupled to progressive SNARE complex formation.

3 of hydrophobic interactions that led to the complex formation.

4 alled to the specific sites to form a stable complex formation.

5 estigated the thermodynamics and kinetics of complex formation.

6 f any other tyrosine residue, is crucial for complex formation.

7 g a hierarchical binding mechanism of PSD-95 complex formation.

8 re and ionic strength on the kinetics of TTR complex formation.

9 ins and DNA sequences contribute to specific complex formation.

10 replication, but not in the pre-replication complex formation.

11 uncovered that IPRib assembly precedes CPRib complex formation.

12 S chains and promotes Sdc2-VEGFA(165)-VEGFR2 complex formation.

13 ere found to be independent of the extent of complex formation.

14 ocyte Binding Proteins showed no evidence of complex formation.

15 of Staufen and HuR mediates 3'-UTR-dependent complex formation.

16 nd MCU processing regulates higher order MCU-complex formation.

17 fluence subsequent homotypic and heterotypic complex formation.

18 bly through promoting prefusion SNARE binary complex formation.

19 ecular mechanism-the promotion of Mad2-Cdc20 complex formation.

20 he importance of ribose 2'-OH groups for the complex formation.

21 rinsic requirement of the CRISPR integration complex formation.

22 t roles in catalysis and in enzyme-substrate complex formation.

23 chain crosslinking and amylose-stearic acid complex formation.

24 onship between shapes, main-chain folds, and complex formation.

25 tr) but is unable to complete stereospecific complex formation.

26 orphan nuclear receptor-gammat (ROR-gammat) complex formation.

27 copper in the presence of ammonia to promote complex formation.

28 g to the RecA homology search before ternary complex formation.

29 sociations, subcellular localization, and co-complex formation.

30 atin modifications to promote pre-initiation complex formation.

31 ll permeability, and inhibition of RAB25:FIP complex formation.

32 -bisphosphate (PIP2) and is related to SNARE complex formation.

33 heir fusion competency with respect to SNARE complex formation.

34 ore efficient in promoting membrane-mediated complex formation.

35 the regions in PBP A1 and PgdA required for complex formation.

36 ug delivery, antibody production and protein complex formation.

37 ffect on SG formation is independent of HOPS complex formation.

38 binding at the 5' SS by promoting long-lived complex formation.

39 further show compaction of the protein upon complex formation.

40 s positive and greater than Keq for divalent complex formation.

41 investigation of influenza virus polymerase complex formation.

42 anism that is mediated by ternary AcrAB-TolC complex formation.

43 interactions with XRCC4 that enable synaptic complex formation.

44 ins and are thought to instead promote SNARE complex formation.

45 he function of weakly active enzymes through complex formation.

46 omponents of the U2 snRNP and required for A complex formation.

47 lly diverse IRESs, impacts both steps of the complex formation.

48 on TRPV1 responsible for TRPA1-TRPV1 (A1-V1) complex formation.

49 ard inhibition of MHC class I:beta2M:peptide complex formation.

50 mportance in initiating tight IC-p150(Glued) complex formation.

51 in suppression of inhibitory protease-serpin complex formation.

52 to covary, suggesting importance for protein complex formation.

53 teracting with the C-tail and engaging it in complex formation.

54 re the LUBAC-A20 axis regulates TAK1 and IKK complex formation.

55 steps of transcription after promoter closed complex formation.

56 he topological framework responsible for UAF complex formation.

57 adhesions by acting as a nucleator of focal complex formation.

58 ay branchpoint enzyme chorismate mutase upon complex formation.

59 Exon 17b peptides also promote fodrin-actin complex formation.

60 y O(2) and by stabilizing Mn(II) via ternary complex formation.

61 F4-glycosaminoglycan interactions leading to complex formation.

62 changes associated with nickel-activated DNA complex formation.

63 he function of weakly active enzymes through complex formation.

64 ptive R-SNARE binding site to allow template complex formation.

65 d that AIP is also required for PDE3A-SLFN12 complex formation.

66 n and transcriptional activity on initiation complex formation.

67 ion of the proximal heme-binding motifs upon complex formation, a finding that may be of functional r

68 stitution of interface residues critical for complex formation abrogated allosteric activation of Leg

69 And, the critical pHs associated with complex formation (accessed by turbidity) was found to s

70 hat coordinate eIF4F regulation with ternary complex formation after treatment with genotoxic therape

71 ound the interface destabilized higher-order complex formation and altered the cooperative DNA-bindin

72 that fibronectin interferes with PF4/heparin complex formation and anti-PF4/heparin antibody-induced

73 (F4TCNQ), is of interest for charge transfer complex formation and as a p-dopant in organic electroni

74 Thus, physiological RAP80-BRCA1 complex formation and BRCA1 PARsylation contribute to th

75 3 and 76, which are required for SPZ1-TWIST1 complex formation and cancer cell migration in vitro and

76 C-terminus affects multiple aspects of NHE3 complex formation and changes the NHE3 lipid raft distri

77 n their ability to increase the rate of open complex formation and decrease the rate of promoter esca

78 f eIF2gamma impairs CDC123 promotion of eIF2 complex formation and decreases the level of eIF2-GTP-Me

79 und, define the biochemical requirements for complex formation and describe the protein-protein inter

80 on these results, we propose mechanisms for complex formation and drug efflux.

81 Interchange of complex formation and electron-transfer reactions betwee

82 ribed control mechanism for sigma-anti-sigma complex formation and establish c-di-GMP as the central

83 tulated in vitro, impair STAT3-ERBIN-SMAD2/3 complex formation and fail to constrain nuclear pSMAD2/3

84 omplexes provided critical insights into tip complex formation and function.

85 thin nsp1beta and PCBP2 that are involved in complex formation and function.

86 suggests how FRDA clinical mutations affect complex formation and FXN activation.

87 try techniques to investigate GPCR-G protein complex formation and G-protein activation.

88 and cell-based methods to assess Galpha-RGS complex formation and Galpha enzymatic activity, we foun

89 Rad54 is crucial for Rad51-mediated synaptic complex formation and homology search.

90 rtner both in stereospecific protein-protein complex formation and in reversible phosphotransfer.

91 -3 rescued endothelial p53 and PPARgamma-p53 complex formation and induced target genes, such as APLN

92 ed in relation to its participation in SNARE complex formation and its interaction with phosphoinosit

93 appears to affect intermediates in the open complex formation and its N-terminal tail is required fo

94 dings advance the understanding of Nem1-Spo7 complex formation and its role in the phosphatase cascad

95 nst aggregated misfolded protein with immune complex formation and kidney fibrosis.

96 ligase RNF146, which blocks LKB1/STRAD/MO25 complex formation and LKB1 activation.

97 pproach based on cyclodextrin/drug inclusion complex formation and loading into liposomes was applied

98 corresponding decrease in platelet-leukocyte complex formation and markedly reduced generation of fac

99 ECs rescued eNOS function by increasing eNOS complex formation and NO production.

100 We validate Cascade expression, complex formation and nuclear localization in human cell

101 rmore, we confirm the residues essential for complex formation and observed a movement of the drug en

102 this reaction is two-fold: it enables "ate" complex formation and overcomes catalytic inhibition by

103 between GAPDH and sGCbeta in cells and their complex formation and potential heme transfer using puri

104 y reveal the nature of SARAH domain-mediated complex formation and provide mechanistic insights into

105 plied to the isolated DHO subunit mimics the complex formation and reversibly activates the isolated

106 he protein domains crucial for the Nxf2/Panx complex formation and show that the amino-terminal porti

107 NSs interacted with ABIN2 and promoted TPL2 complex formation and signalling activity, resulting in

108 This effect is strictly dependent on complex formation and sorting determinants that regulate

109 ng from MeOH is critical for the hyponitrite complex formation and stabilization.

110 TraK also promotes stable TraJ-TraB complex formation and stimulates binding of TraI with Tr

111 enable elevated cytosolic cRel:IkappaBalpha complex formation and subsequent 4-1BB-induced IkappaBal

112 osome completion but dispensable for ESCRT-I complex formation and the degradation of epidermal growt

113 role of these proteins during transcription complex formation and the importance of protein-protein

114 NBS1 from TRF2, promoting TRF2-Apollo/SNM1B complex formation and the protection of leading-strand t

115 IFN-gamma-mediated perturbation of TPO:c-MPL complex formation and the resulting inhibition of a crit

116 tween Drosophila E2F1 and Sd disrupts Yki/Sd complex formation and thereby suppresses Yki target gene

117 located near critical residues for TLR4-MD-2 complex formation and TLR4-MD-2-LPS dimerization.

118 xhibited positive cooperativities of ternary complex formation and were more potent degraders than te

119 sion-limited binding, (ii) transient ternary complex formation, and (iii) fast exchange of monomers b

120 situ generation of allenamide, pai-allyl-Pd complex formation, and decarboxylative allylic alkynylat

121 U2 snRNP recruitment, enhances spliceosome A complex formation, and facilitates exon definition throu

122 ains regulate protein scaffolding, signaling complex formation, and kinase activation, and play essen

123 ata suggest that asymmetry promotes synaptic complex formation, and modifying ends with additional tr

124 l PRC2 core proteins, the disruption of PRC2 complex formation, and the degradation of its subunits.

125 indicator of defective eIF2-GTP-Met-tRNAiMet complex formation, and, likewise, overexpression of huma

126 xin-1-SNAP-25 heterodimers, precluding SNARE complex formation; and binding to trans-SNARE complexes,

127 eckpoint activation, whereas the PALB2-BRCA2 complex formation appears to be more critical for checkp

128 tations in SHOC2, MRAS, and PP1 that promote complex formation are found in Noonan syndrome.

129 Details of the molecular mechanism of complex formation are not well established, despite nume

130 show that the C-edge is critical for stable complex formation, betaarr1 recruitment, receptor intern

131 Immunoprecipitation analysis demonstrated complex formation between ADAM15 and ZO1/ZO2.

132 Here, we find that increased complex formation between angiotensin II AT1 and bradyki

133 Complex formation between apoE and Abeta was confirmed b

134 ecognition was evaluated with the well-known complex formation between avidin and biotin as a model s

135 s found to be static suggesting ground-state complex formation between betaLG and vitamin B12, which

136 e thermodynamic and structural mechanisms of complex formation between IL-11 and IL-11Ralpha differ s

137 This is the first study to show a complex formation between iron-progoitrin and iron-sinal

138 In human end-stage HF, the complex formation between NDPK-C and Galphai2 was increa

139 binding site and actually enhances specific complex formation between NPr and EI(Ntr).

140 DNMDP induces complex formation between phosphodiesterase 3A (PDE3A) a

141 Complex formation between PLEKHA7, PDZ domain-containing

142 ion was indicative of lectin recognition and complex formation between PNA and glycoproteins containi

143 were used to investigate binary and ternary complex formation between ProRS, YbaK, and tRNAPro.

144 Fusion involves complex formation between SNARE proteins anchored to adj

145 This extension of interfacial complex formation beyond metal elements opens promising

146 and found that OA-NO(2) inhibits RAD51-ABL1 complex formation both in vitro and in cell-based immuno

147 ly the key residues for the receptor-peptide complex formation but also which positions should be avo

148 does not alter MutSbeta subunit abundance or complex formation but does partially control its subcell

149 n, thermodynamic properties indicated stable complex formation but higher propensity of protein aggre

150 These results validate concurrent multiple complex formation by bimodal PNAs with additional nucleo

151 s transcription at the early stage of closed complex formation by blocking interaction of RNA polymer

152 ruthenium center, but instead with precursor complex formation by hydrogen bonding.

153 gatekeeper for both binary and ternary SNARE complex formation by locking the syntaxin-1 in a cleft o

154 tion fluorescence microscopy, we demonstrate complex formation by showing that bait and prey molecule

155 tigate the mechanism of specific EI(Ntr):NPr complex formation by the study of transient encounter co

156 , and downstream signaling, and GPCR-betaarr complex formation can be used as a generic readout of GP

157 ns suggest that additional rounds of ternary complex formation can occur on the ribosome during proof

158 correlation with the metal-ligand (citrate) complex formation constant (Kf).

159 electivities may be observed if the stepwise complex formation constant, K(ILn), is not sufficiently

160 The calculation of the complex formation constants in the polymeric membrane wi

161 itro and in mammalian cells; (ii) such HSP90 complex formation directly correlates with the extent of

162 uctural studies disclosed defective ribosome complex formation due to a conformational change of rRNA

163 antly in Muller cells, governs deep vascular complex formation during development and in ischemic ret

164 of heparin, suggesting a role for heparin in complex formation during proteolysis.

165 nteractors are important regulators of SNARE complex formation during vesicle fusion.

166 esistant form of GNU, which promotes PNG-GNU complex formation, elevation of Cyclin B, and meiotic de

167 rgely disordered in the transition state for complex formation, except for two helices, one from each

168 KCNQ-SMIT complex formation facilitates ion channel-solute transpo

169 Nevertheless, the intermediate complex formation from the dissociation of the stable co

170 ubule antigen-specific antibodies and immune complex formation has not been well characterized in hum

171 Fixation in solution and complex formation have been characterized by crystallogr

172 de progress in understanding protein-protein complex formation; however, the molecular mechanisms for

173 , EMRE could paradoxically inhibit uniporter complex formation if expressed in excess.

174 on fork showed that RPA promotes DNA-(H3-H4) complex formation immediately adjacent to double-strande

175 be rescued by increasing SYP41-SYP61 t-SNARE complex formation, implicating TNO1 as a tethering facto

176 mpairing Beclin 1-Bcl-2 autophagy-regulatory complex formation in a ROS-dependent fashion.

177 or SYP61 significantly increases SYP41-SYP61 complex formation in a tno1 mutant, and rescues the salt

178 We characterize the role of ternary complex formation in driving selectivity, showing that i

179 the binding of trypsin and BPTI and protein complex formation in general.

180 d junctional tension to inhibit premature TJ complex formation in lower layers while promoting increa

181 e the importance of studying protein-protein complex formation in membrane mimetic systems.

182 sc155 protein levels and prevented paranodal complex formation in neonatal animals.

183 terface residues and found that they disrupt complex formation in pull-down assays and cellular co-lo

184 e resonance energy transfer to measure SNARE complex formation in real time.

185 SI-MS to investigate the factors that govern complex formation in solution and gas phases by comparin

186 demonstrate the importance of heterogeneous complex formation in tau function.

187 platelet activation, and platelet-leukocyte complex formation in the bronchoalveolar space.

188 g liposomes to evaluate the role of cyt c-CL complex formation in the induction and stimulation of cy

189 dispensability of the HX motif for trimeric complex formation in the large majority of HOX proteins.

190 induced by Munc13-1 initiates ternary SNARE complex formation in the neuronal system.

191 Here we show that trans-SNARE complex formation in the presence of NSF-alphaSNAP requi

192 e hydrophobic core of the interface disrupts complex formation in vitro and impairs recombination in

193 A" shape is necessary for efficient Rev-RcRE complex formation in vitro and nuclear export activity i

194 tions in the CI:MOR binding interface impair complex formation in vitro, and when introduced in vivo,

195 s and the individual CDs confirmed inclusion complex formation in water.

196 ws the calculation of the kinetics of immune complexes' formation in a continuous-flow system using c

197 y FH and did not inhibit terminal complement complex formation induced by zymosan.

198 Analysis of the data indicates that complex formation is a diffusion-controlled process with

199 on, it is best that ethylene and methylidene complex formation is avoided altogether.

200 also found that beta-Arr2-mediated GIT1/eNOS complex formation is dependent on Erk1/2 and Src, two ki

201 ITC showed that the complex formation is primarily entropy driven and DC sug

202 y and secretion, suggesting that the ternary complex formation is required for PRAP1 to facilitate MT

203 o be crucially and nonlinearly correlated to complex formation, leading to ultrasensitive responses.

204 Complex formation leads to a significant reduction in lo

205 d further analysis demonstrated that high MW complex formation leads to aggregation of CIAPIN1 in int

206 Disruption of PF4-VWF complex formation may provide a new therapeutic approach

207 s-1, a close structural homolog of PU.1, 2:1 complex formation may represent an alternative autoinhib

208 inding component likely occurs via a ternary complex formation mechanism.

209 uctural changes of the aptamer and PSMA upon complex formation, mechanistic explanation for inhibitio

210 ide of syntaxin 1a, thereby inhibiting SNARE complex formation, Munc18b and -c, which have a more wid

211 ated kinase 1 (TAK1) mediates LMP1 signaling complex formation, NEMO ubiquitination and subsequent IK

212 nto the surrounding micelle in solution, and complex formation occurs independently of the ESI proces

213 (MS) for the biophysical characterization of complex formation of a BsAb with two target antigens, cl

214 Complex formation of DENV and ZIKV with Fab C10 stabiliz

215 Inclusion complex formation of essential oils (EOs) and RAMEB were

216 The complex formation of monocytes and T cells was also elev

217 Moreover, complex formation of PLDgamma1 and BIR2 was further prom

218 ainly in the presence of glucose may lead to complex formation of SA, SB, PS and BP with HSA and acce

219 his article, we provide evidence that immune complex formation of serum IgA plays an important role i

220 ich otherwise facilitates the ligand-induced complex formation of the immune receptor kinases EF-TU R

221 of the initial steps of H(2)O adsorption and complex formation on a Ag(111) surface, based on couplin

222 to bacteria, which enhances membrane attack complex formation on M. catarrhalis and thus leads to in

223 isrupted, we note loss of stable dimer-dimer complex formation on the DNA, compromised oriP-containin

224 structural reorganization likely accompanies complex formation on the head-to-tail array of binding s

225 tion to goethite at pH 3, suggesting ternary complex formation or, in the case of humic acid, incorpo

226 IGR IRES activity either decreased 40S-IRES complex formation, or increased the rate of the conforma

227 Functionally, disrupting DISC1/Ndel1 complex formation prolongs mitotic length and interferes

228 that exhibit significant signal changes with complex formation-properties that may be readily encount

229 impact of gRNA structural alterations on RNP complex formation, R-loop dynamics, and endonuclease act

230 The complex formation reduced or eliminated the affinity of

231 Complex formation requires functional interactions betwe

232 ses VEGF receptor 2 (VEGFR2)-Src-VE-cadherin complex formation, resulting in increased cell surface V

233 The V-complex formation significantly increased resistant star

234 Short charged motifs are steering complex formation, still allowing the bound state to ret

235 s also depend on the kinetics following open complex formation such as initial nucleotide incorporati

236 ompounds that block mTOR signaling and eIF4F complex formation, such as rapamycin and its analogs, ha

237 reveals longer lasting states preceding open complex formation, suggesting enhanced supercoiling buil

238 hese studies revealed a dynamic mechanism of complex formation that involves large conformational cha

239 the establishment of infection, replication complex formation, the synthesis of nonstructural protei

240 insights into how DNMDP induces PDE3A-SLFN12 complex formation, thereby killing cancer cells with hig

241 iles, and ubiquitination, as well as ternary complex formation thermodynamics.

242 ulates necroptosis by inhibiting RIPK1-RIPK3 complex formation; this regulation may serve as an impor

243 nsulin stimulation, where it regulates focal complex formation through an interaction with paxillin.

244 TFF1 blocks IL6Ralpha-GP130 complex formation through interfering with binding of IL

245 o CyRPA blocks binding of CyRPA to PfRh5 and complex formation thus illuminating the molecular mechan

246 ion during early steps of Cas9/guide RNA-DNA complex formation, thus additionally destabilizing the p

247 es binding to Mis18alpha:Mis18beta, limiting complex formation to the G1 phase of the cell cycle.

248 Us such as glibenclamide promote Barr1/Epac2 complex formation, triggering enhanced Rap1 signaling an

249 and this UFMylation is required for the MRN complex formation under unperturbed conditions and DSB-i

250 ion, FLS2 accumulation, or inhibit FLS2-BAK1 complex formation upon flagellin perception.

251 stically, IRAK2 suppressed respiratory super-complex formation via interaction with PHB1 and OPA1 upo

252 entate-mononuclear/bidentate-binuclear As-Fe complex formation via legend exchange.

253 Complex formation was analyzed through monitoring of the

254 fliximab contained infliximab-TNF complexes; complex formation was associated with ADA formation with

255 We found that complex formation was cluster dependent and that a react

256 This complex formation was driven by increasing entropy.

257 The BSA/lutein complex formation was entropically driven and lutein was

258 At pH 7.4, CA-BSA complex formation was entropically driven.

259 In planta, NatB complex formation was essential for enzymatic activity.

260 TAZ/TEA domain transcription factor1 (TEAD1) complex formation was essential to initiate downstream t

261 Complex formation was found to be optimal for biopolymer

262 Although SNARE complex formation was unaffected, we found that C8-PI(3,

263 plasma membrane, indicating increased SNARE complex formation, whereas FRET with other tested SNAREs

264 cts as an acceptor center in charge transfer complex formation which is supported by ESP and contour

265 They facilitate cotranslational protein complex formation, which establishes a role for 3'-UTRs

266 he digestibility of starch and amylose-lipid complex formation while having no substantial differenti

267 nscription factor 4 (TCF4) and disrupt their complex formation, while not affecting beta-catenin nucl

268 iciency of a typical natural CM and requires complex formation with 3-deoxy-d-arabino-heptulosonate 7

269 rous hydrophobic contacts account for stable complex formation with a buried surface area of 3094 A(2

270 xtended this analysis to demonstrate altered complex formation with and loss of function of TDP-43 (T

271 nding the [4Fe-4S] cluster and promotes BchL-complex formation with BchNB.

272 examers, further stabilized by electrostatic complex formation with chitosan polymer.

273 Calcium signaling leads to a promotion of complex formation with Cobl-like's cofactor Abp1.

274 nces Hippo kinase activity in cells, whereas complex formation with dRassF inhibits it.

275 ssive dynein movements that are activated by complex formation with dynactin and a cargo adaptor.

276 and utilizes the same precursor reagents for complex formation with each of the explosives which can

277 heir pathogenicity by assaying the impact on complex formation with Ggamma and resultant mutant Gbeta

278 gL mutant was not a result of alterations in complex formation with gH or alterations in cellular loc

279 enced the thermodynamics and kinetics of the complex formation with HSA.

280 ns of NLRC4, but not its CARD, can engage in complex formation with HSC70.

281 GCbeta predicted by the model mediate direct complex formation with HSP90 both in vitro and in mammal

282 hobically modified using oleic acid prior to complex formation with insulin to enable distribution of

283 t show that its polymerase activity requires complex formation with its partner class B PBP.

284 Upon complex formation with KRAS, two distinct states were ob

285 extension (NTE) of MOB1A not only regulated complex formation with LegK7 but also served as a dockin

286 ted innate immune activation requires immune complex formation with naturally occurring IgG anti-beta

287 urther investigation into E66S CCL5-Evasin-4 complex formation with NMR spectroscopy showed that resi

288 ter being responsible for most of Scribble's complex formation with other proteins.

289 It is known that complex formation with proteins can mask this undesirabl

290 effects on stress-induced depression by the complex formation with Regulator of G protein Signaling

291 Amylose-lipid complex formation with suitable fatty acids/lipids seems

292 blood as well as their PD-L1 expression and complex formation with T cells.

293 cattering was used to demonstrate that, upon complex formation with target RNA or DNA, TIA-1 RRM23 ad

294 homodimerization, membrane recruitment, and complex formation with the effector protein SAV1, each i

295 ta, indicate a sequential set of events: the complex formation with the inhibitor Lys(32) in the tryp

296 ecific roles depending on the ligand and the complex formation with the type 2 receptor.

297 phosphorylation of 53BP1 at S380 accelerates complex formation with USP7 and CENPF to regulate their

298 ity of PARP1 is not required for the initial complex formation with XPC in the nucleoplasm but it enh

299 d via protein painting effectively disrupted complex formation, with the most potent inhibitor having

300 molecules and the first evidence of boronate complex formation within the binding pocket.