ライフサイエンスコーパス: compound

1 ding to a higher than expected TMFs for this compound.

2 ovides an attractive probe molecule and lead compound.

3 ing food processing and are important flavor compounds.

4 he solution during the detection of phenolic compounds.

5 lution of processes that involve blending of compounds.

6 -activity relationships within this class of compounds.

7 herapy, but are less well studied with novel compounds.

8 ns of organomagnesium reagents with carbonyl compounds.

9 re an important class of biologically active compounds.

10 g blocks on the way to biologically-relevant compounds.

11 eteroaromatic systems, including biorelevant compounds.

12 , agrochemicals, and pharmaceutically active compounds.

13 t drug sensitivity for 265 common anticancer compounds.

14 regardless of the chemical structure of the compounds.

15 towards the selective recovery of bioactive compounds.

16 inolenic acid-rich oils and minor functional compounds.

17 gels with the catalytically active hexameric compounds.

18 (WLS), confirming heteroscedasticity for all compounds.

19 % of the volatile composition, were the main compounds.

20 that one of them does while using unexpected compounds.

21 The resulting compounds (1 and 2) display a bowl-to-bowl inversion at

22 he somatostatin receptor was also blocked by compound 101 in slices from naive but not morphine-treat

23 type series exemplified by the trans racemic compound 11i.

24 The title compounds, (-)-2 and (+)-2, representing potentially val

25 sub-micromolar potency at MT receptors, with compound 21 reaching EC(50) of 0.36 nM.

26 med antiviral activity screening to identify compounds 29 and 30 with EC(50) values of 110 and 120 nM

27 h in PC3 cells even after the removal of the compound; 3) binds to tubulin [dissociation constant (K(

28 This resulted in identification of compound 4 with desired FXIa inhibitory potency and good

29 The lead compound 48c, induced necrosis in several mutant and FLT

30 Compound 5 represents a new class of selective ligands w

31 o developed two structurally similar control compounds, 5 (MS167) and 7 (MS168).

32 We found one compound, 7I, that is more active than the parent compou

33 How such compounds act in concert remains to be elucidated.

34 spase 7, and PARP-1 analyses show that these compounds activate apoptosis.

35 ences were observed in the contents of aroma compounds after roasting.

36 parallel screening of commercially available compounds against a panel of clinically relevant BLs: cl

37 e antiviral activity of the eight identified compounds against BIRFLU was further confirmed with seas

38 lly that the antibacterial activities of the compounds against efflux-deficient Escherichia coli are

39 e examined the antiviral activity of natural compounds against the following influenza virus strains:

40 ese are excellent reservoirs to host organic compounds against the harsh surface conditions of Mars.

41 of secondary metabolites (terpenes, phenolic compounds, alcohol).

42 IR spectra with those of suitable reference compounds allows us to identify their specific isomeric

43 To understand how these compounds alter T cell function, we assessed their thera

44 ation of vinylarenes with alpha-halocarbonyl compounds and arylzinc reagents.

45 We report the design and synthesis of the compounds and binding results for the JH1, JH2, and JH2

46 relationship between exposure to TTR-binding compounds and circulating T4 levels in humans has been r

47 The compounds and corresponding ganglio-oligosaccharides wer

48 Detection of urinary volatile organic compounds and ELISA assays showed that the loading-condi

49 gh-throughput screening of selected targeted compounds and identified high-value targets, including p

50 ution mode in order to eliminate interfering compounds and improve separation and peak shape.

51 rmed the sensory relevance of the identified compounds and indicated lipid oxidation and the Maillard

52 catalogue of qubit materials to Ni(2+)-based compounds and offers a future pathway for optical readou

53 an remember a previous contact with pathogen compounds and respond nonspecifically to reinfection, a

54 tability of the enriched extract in phenolic compounds and the main bioactivities described for these

55 udy, it was aimed to determine the bioactive compounds and volatile aroma compounds of the sour cherr

56 e nuclei, using both user-selected reference compounds and/or linear regression methods.

57 et size, viscosity, peroxide value, volatile compounds, and sensory properties.

58 studies in healthy rats confirmed that both compounds are BBB permeable and that bladder accumulatio

59 Theranostic compounds are likely to impact many cancers in the near

60 terization and theoretical analysis of these compounds are presented.

61 -fibroblast growth factor receptor 3 (FGFR3) compounds are showing promising results in the treatment

62 The compounds are shown to directly target tau pre-mRNA in c

63 These compounds are thought to act by cysteine modification to

64 oxides, rare-earth-based, and intermetallic compounds) are key components of modern technological ap

65 ptor neurons to sense a plant-derived bitter compound, aristolochic acid (ARI).

66 irected mutagenesis analyses confirmed these compounds as active site-directed reversible inhibitors

67 of trimethylamine N-oxide, a proinflammatory compound associated with cardiovascular and neurological

68 investigate the adsorption of surface-active compounds at the water-oil interface subjected to an ele

69 mic profiles accurately ranked the reference compounds (AUC-ROC >= 0.9).

70 h-throughput techniques to isolate effective compounds based on screening of entire compound librarie

71 We identified a compound, BCH070, that inhibits asexual growth of multip

72 de and tetrazole-based derivatives, NDM-1 by compounds bearing a thiol, a thiosemicarbazide or thiose

73 The latter compounds, better known as plasmalogens, harbor a vinyl

74 bstitutions in the PDE3A active site abolish compound binding.

75 MSO/saline (0.4 and 8 mg/kg) and a reference compound, BTZ043, DMSO/saline (0.4 and 8 mg/kg).

76 ASH Benefits) in rural Bangladeshi household compounds by assessing prevalence ratios, differences, a

77 termine solubility limits of various organic compounds by exploiting their pH-active carboxylic acid

78 Analysis of volatile oxidation compounds can be an alternative method for p-anisidine v

79 The majority of volatile compounds characterizing the aroma profile of palinca we

80 o specially designed representatives of this compound class.

81 ributions and to follow homologous series or compound classes, instead of individual components, as a

82 icable to the functionalization of important compound classes, such as ligand derivatives and polyaro

83 hese are still too complex to examine beyond compound classes.

84 this work was to classify the major phenolic compounds, compare the effectiveness of the different ex

85 rients, and other health-promoting bioactive compounds contained in nuts and dried fruits may synergi

86 r or triangular geometry, discrete molecular compounds containing a linear array of more than three m

87 Natural isotopic abundances of mixtures of compounds containing chlorine, bromine, and sulfur heter

88 The designed compounds containing such a salt bridge reached high ora

89 ucts obtained by MHG presented high phenolic compound content and antioxidant capacity.

90 idant capacity, exopolysaccharides, phenolic compound content and in vitro starch digestion.

91 Thus, the digestion affects the compounds content in both encapsulated and unencapsulate

92 We find that oxidation of phenolic compounds contributes the majority of BBSOA from emitted

93 The layered structure of this compound coupled with uniquely easy migration of water m

94 C) oxaphosphetanes (Channel A), whereas MoBA compounds decomposed faster via the isomer (C(6)H(4), O)

95 Bioactive compounds demonstrating antioxidant activity were analyz

96 odified A, B, and C rings, as well as hybrid compounds derived from colchicinoids including prodrugs,

97 promising solutions for property prediction, compound design, and retrosynthetic planning, which are

98 ition that was optimized by structure-guided compound design.

99 magnitude from 0.28 to 13 500 ng/L, with 38 compounds detected in >50% of samples.

100 based biosensor has been tested for phenolic compound detection, with catechol as target analyte, in

101 o the target protein, in early steps of lead compound development, and this process makes it less tim

102 Concerning Ca(V)3.1, the compound did not alter the shape of the instantaneous cu

103 In this work we demonstrate that aromatic compounds, dissolved in the hydrocarbon phase, can have

104 These results suggest that methyl-compounds driven methane production drives a cryptic met

105 These compounds emerge as interesting brain-permeable multitar

106 The direct alpha-arylation of carbonyl compounds emerged over the last two decades as a straigh

107 Isoprene is the dominant non-methane organic compound emitted to the atmosphere(1-3).

108 HEDGES also converts unresolved or compound errors into substitutions, restoring synchroniz

109 Furthermore, of the higher-affinity compounds examined, none showed any agonist activity.

110 to conjugated polydiazenediyl chains, these compounds exhibit metallic properties.

111 These MBA(2)SnI(4) compounds exhibit the largest level of octahedral bond d

112 le-particle wavefunctions, three of the five compounds exhibited thermally activated delayed fluoresc

113 ly production, the use of natural antifungal compounds extracted by emerging technologies led to a su

114 and other animals may reveal additional new compound families and signaling paradigms.

115 relationship, the well-known spin crossover compound [Fe(Htrz)(3)](n)[ClO(4)](2n) (1) was re-evaluat

116 Nitrogen compounds, fermentable sugars, total phenolic content an

117 ne oxide-dimer acid (HFPO-DA), a replacement compound for perfluorooctanoic acid (PFOA), was detected

118 We identified DBeQ as a promising lead compound for structural optimization aimed at selective

119 um antiviral drug target and identifies lead compounds for further development.

120 in assigning reactive positions in the probe compounds for the monodentate attack leading to an ozone

121 CANOPUS explicitly targets compounds for which neither spectral nor structural refe

122 vely) and protected the oil against volatile compound formation (heptanal, (E,E)-2,4-heptadienal, (Z)

123 were found responsible for alpha-dicarbonyl compound formation.

124 le, biocompatible isolation of the bioactive compound from its surroundings with minimal interactions

125 rt the isolation and identification of three compounds from 430D-F5 that reduce virulence and abate d

126 and/or convenient an orientation of phenolic compounds from algae towards an industrial application.

127 agriculture and medicine, using mixtures of compounds from different classes is widely accepted as o

128 l approach for in situ extraction of organic compounds from hydrothermal vent fluids through a unique

129 ubbles rapidly extract and liberate volatile compounds from the sample.

130 In addition, some compounds from this family are able to undergo click-and

131 This compound has a good thermal-neutron-capture cross-sectio

132 udy and biological evaluation of synthesized compounds has highlighted new SAR, and low toxicity prof

133 Although such compounds have an important biological and chemical rele

134 od regulators around the world because these compounds have been associated to acute and chronic toxi

135 w detectable activity; beyond this, 10 of 23 compounds have IC(50) better than 50 muM.

136 s between sensory attributes and native beer compounds have not been evaluated within the concentrati

137 The results indicated that the analyzed compounds have the potential to migrate from the polypro

138 ave been explored including heterobimetallic compounds, heterotrimetallic compounds of either linear

139 CA1 activities can be genetically separated, compound heterozygosity for functional complementary mut

140 ere, we report a cause of NKD resulting from compound heterozygous mutations in minichromosomal maint

141 study WD variants in both the homozygous and compound-heterozygous states to better understand the ge

142 nse factors are obtained for a wide range of compounds, highlighting good efficiency of HF formation

143 different selectivity enhances the power of compound identification without increasing the analysis

144 The major compounds identified in the fruit flesh included soluble

145 nd inactive enantiomers of other TQS-related compounds identify the orientation of the cyclopentenyl

146 empferol-3-O-galactoside was the predominant compound in almond skin and whole kernel but it was not

147 ivated by heat and by capsaicin, the pungent compound in chili peppers.

148 the metabolic pathway of benzopyrene, a main compound in cigarettes.

149 dance response) to assess the effects of the compound in dysregulated behaviors within the transgenic

150 A lead compound in the series, JMS-053 (7-imino-2-phenylthieno[

151 SO-d(6) solution (DFT prediction for a model compound in the vacuum: 90-100 kJ mol(-1) ).

152 a), pH(max), and K(sp) values of three model compounds in a fast and low sample consumption (<1 mg) m

153 rmation of lipid hydroperoxides and carbonyl compounds in a stripped sunflower oil.

154 The low stability of the organozinc compounds in an acidic environment was exploited to acco

155 Due to the wide distribution of these compounds in both the ambient and built environments, fu

156 LC(+mcra) can generate bioactive compounds in larger quantity including conjugated linole

157 The concentration of these compounds in migration exceeded the maximum level establ

158 was not related to the abundance of platinum compounds in the cochlea, rather cisplatin had a dose-de

159 es as a permeability barrier against noxious compounds in the external environment.

160 biological activities were proposed for this compound including anticancer, antimicrobial, anti-infla

161 he binding between hPXR and a number of PFAS compounds, including alternatives whose activity on hPXR

162 est method detection limits to-date for many compounds, including highly toxic iodinated, brominated,

163 multaneously quantifying multiple endogenous compounds, including IBC, thiamine, N(1)-methylnicotinam

164 These compounds, including one proposed to disrupt the dimer,

165 Molecular glue compounds induce protein-protein interactions that, in t

166 n situ formed C-N network, yielding a stable compound insensitive to O(2) and H(2)O.

167 design cycles needed to optimize hit or lead compounds into high-quality chemical probes or drug cand

168 The final compound is significantly smaller than others reported i

169 onent analysis (PCA) projection of the input compounds is also provided, Hence the user can interacti

170 and the ecological function of the produced compounds is of importance to reveal functional interact

171 75)]O(2), present in almost all oxygen-redox compounds, is lost on charging, driven in part by format

172 tive modulator activity was with ginsenoside-compound K (CK), containing a monosaccharide (glucose) a

173 Compounds known to induce MT release like progesterone,

174 High doses of the initial lead compound led to tumor stasis in an activated B-cell-like

175 ctive compounds based on screening of entire compound libraries based on desired phenotypes.

176 n flow to generate pharmaceutically relevant compound libraries.

177 nd fragment-based drug discovery to identify compounds likely to bind PRLR and interfere with its sig

178 le-cell sequence such populations because of compounding losses.

179 und, 7I, that is more active than the parent compound, LQZ-7, and when given orally effectively inhib

180 These compound mice displayed accelerated prostate tumor forma

181 uO)(3)Mo=Mo(OtBu)(3)] and a new paramagnetic compound, [Mo(OtBu)(5)].

182 , 2'-hydroxy-3-phenylpropionate, and two new compounds, namely (Z)-1,6-bis(2-hydroxyphenyl)-3,4-diphe

183 lier studies with N-(hydroxymethyl)benzamide compounds, no evidence for mechanistic variation based u

184 Compound NS5806 has been shown to potentate I(to) in can

185 -does not account for the loss of the parent compound observed during the initial phase of the proces

186 ere used to expand our chemical knowledge of compounds observed in superfood samples.

187 eterobimetallic compounds, heterotrimetallic compounds of either linear or triangular geometry, discr

188 ndary metabolism is a reservoir of bioactive compounds of immense biotechnological and biomedical pot

189 t communities that are closer to traditional compounds of Indigenous Masai people express weaker rela

190 the periodic table makes catenated nitrogen compounds of interest for development of high-energy-den

191 eading to a stereoselective synthesis of the compounds of interest.

192 e the bioactive compounds and volatile aroma compounds of the sour cherry vinegar, and to investigate

193 he periodic table to form kinetically stable compounds often with chemically stable N-N bonds but whi

194 Among cutin compounds, omega-hydroxy fatty acids and polyhydroxy-fat

195 e networks, the fast and portable sensing of compounds, on-demand biomanufacturing, building cells fr

196 the user can interactively observe the same compound or a group of selected compounds which is proje

197 s in the content of flavonoids, organosulfur compounds, organic acids, water soluble sugars and amino

198 omparative analysis of model bioactive/toxic compounds (ouabain and CdCl(2)) demonstrates that cellul

199 sess the importance of pathways for aromatic compound oxidation that do not result in ring hydroxylat

200 Among the RTO compounds, p-cymene and thymol were the most abundant in

201 and medicinal properties related to multiple compounds, particularly Delta-9-tetrahydrocannabinol and

202 l (FGbeta(3) cells) was used to test a novel compound (PAWI-2) to eradicate CSCs.

203 vity of legacy scales and how disequilibrium compounds persist long after treatment changes have been

204 acetic and butyric acid as well as aldehydes compounds, phenol and 1-octanol were detected by sniffer

205 ts bring new insights for studies with venom compounds, PIs, and drug design.

206 tion growth which, in tandem, could strongly compound population heat exposure.

207 kyl groups are important motifs in bioactive compounds, positively influencing pharmacokinetics, pote

208 The phenolic compounds present as soluble forms were completely relea

209 Some compounds present in chicory, such as polyphenols, inuli

210 When we compared Binner annotations of 75 compounds previously identified in human plasma samples

211 mutant model of retinitis pigmentosa, a lead compound, Q525, afforded sustained RET activation and pr

212 tions of alkyl ureas with amide and aromatic compounds, relative to interactions with water.

213 In this Article, two standard compounds, representative of mono- and disulfated peptid

214 Subsequent SAR study of AS4583 gave compound RJ-LC-07-48 which exhibited greater potency in

215 An oral compound, SEP-363856, that does not act on dopamine D2 r

216 l properties of a pyrazolopyrimidine-derived compound series.

217 sfer (MLCT) excited states of Ru polypyridyl compounds serve as the dye sensitizers.

218 wn graphite patterns (or combined with other compounds) serve as conductive traces and sensing electr

219 All compounds show normal (10-fold higher) molar CO(2) versu

220 ttracted workers, the combination of all six compounds showed greater arrestant activity than 2-pheny

221 cavenger (beta-methylcyclodextrin) or statin compound (simvastatin) blocked ATP and IL-33 release by

222 ucture, interatomic potentials, and chemical compound space in chronological order.

223 ogical contexts in Kenya and Tanzania, using compound-specific delta(13)C and Delta(13)C values of th

224 nt is a useful source of essential bioactive compounds such as steroids, flavonoids and phenylpropano

225 allosteric modulators, including endogenous compounds, such as cholesterol and neurosteroid pregneno

226 re distributions along with heath beneficial compounds, such as total phenolic content (TPC) and asco

227 l lymphoma (DLBCL) xenograft model, but this compound suffered from a short in vivo half-life and sub

228 used to investigate how semivolatile organic compounds (SVOCs) partition among indoor reservoirs in (

229 eural effects have been puzzling because the compounds target distinct molecular receptors in the bra

230 ing fibrosis and to screen for anti-fibrotic compounds targeting glycogen synthase kinase 3, which ha

231 ated, less oxygenated, and more N-containing compounds than ESI.

232 ra with more aliphatic-like and N-containing compounds than toluene-doping.

233 e have identified trifluoperazine (TFP) as a compound that interferes with this phenotype conversion.

234 PFBS, a short-chain PFAS compound that would presumably exhibit lesser TMFs, had

235 esent study, we report the identification of compounds that act specifically to prevent fungal infect

236 ainable alternative for preparing N,O-biaryl compounds that are widely used as ligands and catalysts.

237 Our efforts yielded low-molecular weight compounds that bind TAR with low micromolar affinity (K(

238 n be protracted, thus limiting the number of compounds that can be advanced into clinical studies.

239 an alternative sequence for the synthesis of compounds that contain the pyrrolodiketopiperazine struc

240 discovery of alpha-chloroacetamide (alphaCA) compounds that covalently modify cysteine-54 (C54) of th

241 tal monitoring programs target predetermined compounds that do not reflect the complete exposure of c

242 The screen identified several compounds that interfere with transcription, DNA damage

243 ously reported, we identified small-molecule compounds that modulate the skeletal muscle channel isof

244 is the first report of a promising class of compounds that not only targets the DNA damage cancer re

245 These include compounds that pups cannot synthesise themselves, such a

246 Given the paucity of compounds that reduce hyperexcitability and neuron loss,

247 We identified 21 novel compounds that selectively inhibit this enzyme.

248 Development of small molecule compounds that target several cancer drivers has shown g

249 The objective was to identify the chemical compounds that would typify each category.

250 In the case of diazo ketone compounds, this shift occurred spontaneously on prolonge

251 tratingly complicated and difficult class of compounds to analyze, manipulate, and use.

252 itoring often requires a priori selection of compounds to be measured, and so, it may not detect rele

253 e a strategy to tune RNA structure-targeting compounds to the cellular localization of the target.

254 These compounds, together with a number of previously prepared

255 e for the advanced sensing of pharmaceutical compounds toward safeguarding human health and ecosystem

256 The mesityl imido compound [U(NMes)(NP(pip)(3))(4)], 2-U(PN)NMes, exhibits

257 ues, demonstrating the importance of testing compounds under physiologically relevant conditions.

258 for possible new drug candidates and natural compounds upon bioinformatics drug repurposing analyses,

259 ioavailability of a broad spectrum of active compounds upon mucosal administration, mucus-penetrating

260 e E90K GnRHR mutant vs. a library of 645,000 compounds using a cell-based calcium detection system.

261 We study these compounds using transient spectroscopy and modelling to

262 mpaign focused on a pyrazole-based series of compounds, using structure-based design concepts, couple

263 Many organic and main-group compounds, usually acids or bases, can accelerate chemic

264 Distribution of individual phenolic compounds varied, their total content in berries was con

265 We have further modified this compound via a structure-based approach and performed an

266 both tritium and carbon-11 into the desired compounds via methylation of pharmaceutical precursors b

267 The fugacity, relative to the pure compound, was measured using solid-phase micro extractio

268 Li(x)Ni(0.8)Co(0.15)Al(0.05)O(2) as a model compound, we use operando synchrotron X-ray diffraction

269 ic and hexanic peel extracts, while 7 and 10 compounds were detected in the ethanolic and hexanic pul

270 Newly synthesized compounds were examined in vitro, and their mechanism of

271 Several trimeric compounds were found to be capable of forming co-gels wi

272 milar groups and even benzene rings of spicy compounds were fund to be critical in the spicy sensing

273 Consequently, 19 and 14 compounds were identified in the ethanolic and hexanic p

274 ransport assays confirmed that some of these compounds were in vitro substrates of the transporter an

275 Some of the obtained compounds were proven to be active as inhibitors of PDE1

276 originated 34 phenolic acids, and flavonoid compounds were screened against acetylcholinesterase, bu

277 The synthesized compounds were tested for their antiproliferative activi

278 Several compounds were transformed during ozone pretreatment tha

279 Concentration distributions of indicator compounds were used to isolate sustained air pollution "

280 rve the same compound or a group of selected compounds which is projected by both PCA and embedded by

281 here where it is oxidized to reactive Hg(II) compounds, which efficiently deposit to surface ecosyste

282 el was employed to virtually screen ~138,000 compounds, which increased the identification of active

283 which increased the identification of active compounds, while decreasing screening time and resources

284 ues confirmed the redox behaviour of the new compound with concentration and scan rate dependant irre

285 ore from which emerged nidufexor (LMB763), a compound with partial FXR agonistic activity in vitro an

286 dation of solid-state structures of all five compounds with <1.1 angstrom resolution.

287 ain an overview of all features, focusing on compounds with anti-inflammatory, antioxidant or antimic

288 d and deuterium-labeled dimeric lignin model compounds with beta-O-4 linkages were evaporated and ion

289 It yielded water-soluble compounds with carbon number and aromaticity up to 2-fol

290 t the intriguing possibility of synthesizing compounds with electron-precise M=B triple bonds analogo

291 tomba fruit as a promising source of natural compounds with high antioxidant activities.

292 r limits of thiol reactivity but less so for compounds with intermediate reactivity.

293 endly procedure were revealed as a source of compounds with relevant antioxidant and anticancer activ

294 s ability to identify and characterize novel compounds with specific cellular potency for either WT o

295 data and specific rotation of the synthetic compounds with that of the reported data.

296 e as interesting brain-permeable multitarget compounds, with a potential as anti-Alzheimer agents bey

297 hemistry approaches to generate libraries of compounds, with some ending as promising drug candidates

298 both enzymatic and nonenzymatic antioxidant compounds within the body, represents an important bioan

299 iori selection of parameters for any desired compound without additional optimization.

300 Detection of potentially harmful compounds without expensive instrumentation, entrapment