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2 model to receptor behavior was tested using concatemeric alpha1beta2gamma2 GABA(A) receptors express
3 We have investigated the activation of the concatemeric alpha1beta2gamma2L GABA(A) receptor by comb
5 amplification to enrich HBV DNA, generating concatemeric amplicons containing multiple successive co
6 sed lentiviral vectors and developed a novel concatemeric array transfection technique for the introd
10 ed template jumping on the ncRNA generates a concatemeric cDNA, which becomes double-stranded upon vi
15 he ONT MinION by using the rolling circle to concatemeric consensus (R2C2) method to circularize and
17 s, we developed Smart-Seq2 Rolling Circle to Concatemeric Consensus (Smar2C2), which identifies and q
18 ta2gamma2L channels, selectively into either concatemeric construct altered the mode of activity elic
19 activated voltage sensor conformations, but concatemeric constructs containing up to three E140R sub
20 amma2L-beta2-alpha1 and beta2-alpha1 subunit concatemeric constructs expressed in human embryonic kid
21 iation by neurosteroids, into one of the two concatemeric constructs had a relatively small effect on
22 We used beta2alpha1gamma2L and beta2alpha1 concatemeric constructs to determine the functional effe
23 question using alpha4 and beta2 subunits in concatemeric constructs with the alpha5 subunit, express
24 2delta receptors employing free subunits and concatemeric constructs, expressed in Xenopus oocytes, H
25 rolled by a synthetic promoter consisting of concatemeric copies of the cis-acting site recognized by
26 nslocation and a nuclease activity that cuts concatemeric DNA and generates the termini of viral geno
28 in which BDCRB permits limited packaging of concatemeric DNA but induces skipping of cleavage sites.
29 on that give rise to persistent circular and concatemeric DNA episomes through intramolecular and int
30 nitiation of phage T4 packaging on "endless" concatemeric DNA in vivo by terminase depends upon inter
34 results from an ATP-driven translocation of concatemeric DNA into the prohead by the phage terminase
35 s a double-stranded DNA virus that processes concatemeric DNA into virion chromosomes by cutting at s
37 y tailed bacteriophages and herpesviruses, a concatemeric DNA is cut and inserted into an empty proca
38 n attractive drug target because cleavage of concatemeric DNA is not required in mammalian cell DNA r
39 onment within an Escherichia coli cell, (ii) concatemeric DNA is required for the successful completi
40 ome maturation is a complex process in which concatemeric DNA molecules are translocated into capsids
41 luorescence microscopy is used to observe T7 concatemeric DNA packaging at the level of a single (mic
42 lex that excises a unit length genome from a concatemeric DNA precursor (genome maturation) and conco
43 da is the excision of a single genome from a concatemeric DNA precursor and insertion of genomic DNA
45 ase II alpha also is required for untangling concatemeric DNA progeny for optimal transcription of la
47 viruses that package monomeric genomes from concatemeric DNA substrates and the nucleotide switch me
48 licate on noncomplementing cells but cleaved concatemeric DNA to ca. 35 to 98% of wild-type levels.
49 lease domain (amino acids 361-610) that cuts concatemeric DNA to generate a headful-size viral genome
50 with this complex process is the cutting of concatemeric DNA to initiate and terminate DNA packaging
53 10% wild-type efficiency, 55am33am defective concatemeric DNA was packaged at least 100-fold less eff
54 ow the accumulation of human cytomegalovirus concatemeric DNA while the formation of new genomes was
55 ication results in the production of complex concatemeric DNA, which is cleaved into unit length vira
60 rtal vertex to recognize, package and cleave concatemeric dsDNA, ultimately giving rise to a pressuri
61 thesized viral DNA remained in a branched or concatemeric form that caused it to be trapped at the ap
62 identify and localize AAV genomes and their concatemeric forms in cultured cells and in tissue, and
63 ocation and an endonuclease that cleaves the concatemeric genome at both initiation and completion of
64 an cytomegalovirus terminase complex cleaves concatemeric genomic DNA into unit lengths during genome
66 for the cleavage and packaging of replicated concatemeric herpes simplex virus type 1 (HSV-1) DNA cor
67 s the dimer interface and the behaviour of a concatemeric human homologue argue that the transport cy
68 ain portions of the HDR clones contained the concatemeric IDLV genomic structure at the target site,
69 report that this system can lead to frequent concatemeric insertions of the viral vector genome at th
70 We then describe strategies to prevent the concatemeric inserts by cutting the vector genome after
72 of loci 3, 4, 6, and 8 produced head-to-tail concatemeric intermediates; loci 1, 2, and 5 produced he
73 n lambda virions are generated by nicking of concatemeric intracellular DNA by terminase, the lambda
80 predict equimolar populations of h-t linear concatemeric molecules differing only in the relative or
81 on of cre must have contributed to resolving concatemeric molecules either prior to or after DNA inte
84 ch enzyme was incubated with double-stranded concatemeric polynucleotides containing a site-specific
85 The enzymes excise a single genome from a concatemeric precursor (genome maturation) and then pack
87 von Willebrand factor (VWF) is an ultralong concatemeric protein important in hemostasis and thrombo
89 her GABA concentrations, suggesting that the concatemeric receptors have a lower affinity to GABA.
90 Pharmacological tests demonstrated that the concatemeric receptors were potentiated by pentobarbital
92 proteases Kex1p and Kex2p in processing the concatemeric repeats in RiPP precursor peptides are also
93 verse phage satellites that were packaged as concatemeric repeats within naturally occurring bacterio
94 ydroxylation of an asparagine residue in the concatemeric repeats, followed by a C(sp(2))-O aryl coup
96 Herpesvirus DNA replication proceeds via concatemeric replicative intermediates that are comprise
97 Herpesvirus DNA replication proceeds via concatemeric replicative intermediates that are comprise
100 ation of vector sequences, including complex concatemeric structures, were detected in 1 out of 100 c
101 ith currents from receptors composed of five concatemeric subunits in which the subunit stoichiometry
102 lication (RDR) is needed to produce the long concatemeric T4 DNA molecules that serve as substrates f
103 ransmitter GABA and basal activity employing concatemeric ternary GABAA receptors expressed in Xenopu
105 ral terminase are required for processing of concatemeric viral DNA and packaging of individual viral
106 ns a large subunit that is thought to cleave concatemeric viral DNA during the packaging initiation a
107 uses use powerful molecular motors to cleave concatemeric viral DNA into genome-length units and pack
108 e 1 U(L)28 gene is essential for cleavage of concatemeric viral DNA into genome-length units and pack
111 required to release individual genomes from concatemeric viral DNA.IMPORTANCE This paper shows a rol
113 es to detect and thoroughly characterize the concatemeric viral vector insertions, and we highlight a