ライフサイエンスコーパス: concept

1 tes the rationale behind the "water-in-salt" concept.

2 m Cav-1(-/-) mice were used to test proof of concept.

3 d these heterolayered dendrimers as proof-of-concept.

4 , provide evidence in support of the general concept.

5 a modification of existing compound space ML-concepts.

6 ve been employed to capture the semantics of concepts.

7 le in semantic processing for abstraction of concepts.

8 hips, and the refinement of existing species concepts.

9 s and edges represent the similarity between concepts.

10 As a proof of concept, a rapid assay consisting of a cell-based biosen

11 ut-Carneiro and Fitzgerald discuss the basic concepts about inflammasome composition, assembly and ac

12 cal workshops were useful for learning basic concepts about ultrasound imaging, allowing students to

13 cladding is being considered as an advanced concept/accident tolerant fuel for light water reactors

14 baum 2019) and functions to protect the self-concept against evidence of incompetence, immorality, an

15 To address this, we propose a new concept: allowing nonprofessional scientists to be credi

16 The concept allows partitioning of soil pore space according

17 As a proof-of-concept, an X-ray phase contrast under bending condition

18 view generated a total of 37 papers for this concept analysis.

19 pose a new analog content-addressable memory concept and circuit to overcome these limitations by uti

20 To demonstrate proof of concept and estimate effect size, we performed the first

21 ibility of the intentionally nonlocal design concept and its ability to achieve a fully passive and b

22 Our data provide an important proof-of-concept and model system for the potential use of allele

23 erate the development of new carbon material concepts and carbon-derived battery technologies towards

24 Innovative, emerging material concepts and development of low-PGM and PGM-free catalys

25 Here we review emerging concepts and discuss the therapeutic implications of man

26 e networks in which nodes represent distinct concepts and edges represent the similarity between conc

27 tle is known about how it connects different concepts and infers semantic relations.

28 are purposely selected for emphasizing basic concepts and mechanistic understanding.

29 ometabolism in atherosclerosis, new exciting concepts and potential targets for intervention are emer

30 ages; it requires a profound revision of the concepts and technologies on which industrial chemical p

31 onse based on the light-use efficiency (LUE) concept, and uses a comprehensive dataset of soil and mi

32 h item in the guidelines, (2) to clarify key concepts, and (3) to provide illustrative examples.

33 h item in the guidelines, (2) to clarify key concepts, and (3) to provide illustrative examples.

34 In a proof-of-concept application, we isolated bacteria from whole blo

35 In a proof-of-concept approach, we explored a clinically translatable

36 Yet, these concepts are often contradictory and apply at different

37 These concepts are placed within the context of both normal ph

38 ld; thus establishing CPA beyond its initial concept as the time-reversal of a laser cavity, while of

39 ndependently assessed each study to identify concepts associated with the systems thinking and comple

40 In this Tutorial review the concept behind this olefination reaction and its applica

41 The proof-of-concept bioelectronic devices include electrophysiologic

42 bination DNA repair is not an all-or-nothing concept, but a spectrum, and that where a tumor stands o

43 We demonstrated this concept by showing that IL-4 receptor signaling in mouse

44 Notably, a new concept called the minimum mean voltage is proposed as a

45 Since the holobiont concept came into the limelight ten years ago, we have b

46 roof-of-concept that the plant-soil feedback concept can be applied to steer soil microbiomes with th

47 pace exploration missions, novel measurement concepts, capable of detecting low concentrations of bio

48 Single neurons, the so-called concept cells (CCs), may be responsible for complex task

49 is now leading to the initiation of proof-of-concept clinical trials using senolytics for several end

50 This review summarizes key concepts, clinical limitations, and important opportunit

51 work stresses the need to revisit classical concepts concerning viral and tumour immunity, which wil

52 s of compounds, using structure-based design concepts, coupled with optimization of cellular potency,

53 ly a small cohort, these meaningful proof-of-concept data now warrant further investigation in a larg

54 This study provides proof-of-concept data supporting the use of complex coacervates f

55 We provide a proof-of-concept demonstration in the GEDmatch database, and we s

56 ss(5), which-although versatile for proof-of-concept demonstrations(6-16) and fundamental studies(17-

57 This work describes the concept, design, and realization of the first multisite

58 ties across the group, which are driven from concepts discovered in studies of the individual members

59 tion in various types of solid-state battery concepts (e.g., Li-ion, Li-S, and Li-air), and we will s

60 ools for concept recognition and trained our concept embeddings, BioConceptVec, via four different ma

61 Concept embeddings-which involve the learning of vector

62 Prenatal maternal distress-an umbrella concept encompassing multiple negative psychological sta

63 Concepts enumerated herein afford opportunities for repl

64 The results show that the concepts exhibit high correlations, albeit these are som

65 As a proof-of-concept experiment, we demonstrate a functioning complex

66 To demonstrate the sensor concept experimentally, we fabricated a microfluidic dev

67 Proof-of-concept experiments showed that the presence of BCG-spec

68 This study demonstrates the proof of concept for 1D and 2D NMR methods in the targeted and un

69 and colleagues provide preclinical proof of concept for a new therapeutic strategy and address an un

70 Our results provide proof-of-concept for a paradigm of microbially-derived biosensors

71 nucleoside analogues and provided a proof of concept for application as inhibitors for the protein me

72 This work provides a proof of concept for fundamental catalytic action of the hollow n

73 294X mutation in vivo and provide a proof of concept for future preclinical studies of nonsense suppr

74 thod presented showcase a promising proof-of-concept for granting an exclusively light-triggered resi

75 Our results offer a proof-of-concept for modifying synthetic nanogels with a combinat

76 We present a new concept for on-chip separation that leverages bidirectio

77 Proof of concept for OSPW source identification using diagnostic

78 As a proof of concept for super-resolution applications, we use nanogr

79 eomyelitis, and then we validated a proof of concept for the lateral flow assay (LFA).

80 Here, we establish a proof-of-concept for the molecular sieving separation of species

81 here reported constitutes the first proof of concept for the potential application of the peptide mar

82 Our initiative offers a proof of concept for the repurposing of existing approaches to en

83 These results provide a proof of concept for understanding age-related vascular changes a

84 important focus in the development of novel concepts for improved management of tuberculosis (TB).

85 through the understanding of rational design concepts for more efficient polarizing agents (PAs).

86 er, there are limited demonstrations of such concepts for photons.

87 Concepts from dynamical systems theory, including multi-

88 and a Ru catalyst via the borrowing hydrogen concept has been described.

89 Recently, this concept has been translated to two-dimensional photonic

90 A concept has emerged that cellular metabolic programs reg

91 However, the concept has not been evaluated with data.

92 and social normalization), discuss how these concepts have been addressed in other fields and examine

93 The proof of concept herein points to a mechanistic basis for possibl

94 Inspired by this concept, herein we transform yeast peroxisomes into micr

95 In a proof-of-concept human study on the therapeutic, we found that am

96 Application of the proof-of-concept illustrated here, using a feedback loop to coupl

97 ar iron(II) system that captures this design concept in a homogeneous setting through the use of a re

98 armaceuticals this research represents a new concept in achieving targeted delivery of radiopharmaceu

99 We suggest applying a well-known concept in computer science-committee machines-in the co

100 and identifies size-mismatch as an important concept in control of electronic couplings.

101 rms of attitude change that protect the self-concept in dissonance reduction are useful primarily for

102 Network controllability is a recent concept in network neuroscience that purports to predict

103 here to track "dynamic doping", an important concept in organic electronics and in polythiophene-base

104 d.SIGNIFICANCE STATEMENT Agency is a central concept in philosophy and psychology.

105 We tested this concept in two pathogenic Cryptococcus yeast species by

106 Herein, we report proof-of-concept in vivo efficacy in an streptozotocin-induced va

107 d by the preliminary results from a proof-of-concept in-vivo experiment of tracking an individual's B

108 Here, we discuss and update key concepts in animal domestication in light of recent cont

109 Stemming from the foundational concepts in chemistry and biology, these methodologies e

110 and population scales is fundamental to many concepts in ecology [1], including migration [2, 3].

111 nt of metasurfaces has revolutionized design concepts in nanophotonics, enabling a new family of opti

112 reported some utilization of complex systems concepts in the analysis of qualitative data.

113 sensus argues that the emergence of abstract concepts in the human brain, such as a "table", requires

114 achieved and subsequently harnessed for new concepts in therapy.

115 As a proof of concept, in situ separation and imaging of lipid isomers

116 ical water activity (based on water activity concepts) indicate that pomaces and extrudates retain cr

117 Two proof-of-concept inorganic probes that exploit a novel mechanism

118 ellular homeostasis and that this biosensing concept is able to discriminate analytes with different

119 The LLPS concept is also likely useful in designing new therapeut

120 The proof of concept is demonstrated by detecting different concentra

121 This concept is demonstrated for a holey-structured acoustic

122 The validity of this new catalyst-design concept is further demonstrated with the regioselective

123 A proof of concept is shown using a ketone mixture introduced to th

124 As a proof-of-concept, it is demonstrated that these materials can be

125 specific gene flow, are called syngameons, a concept largely inspired from work focusing on Quercus.

126 ented transformation, albeit at the proof of concept level, offers a new approach toward a cleaner ro

127 Thus, there is no need for a concept like "metabolic memory" to explain these observa

128 This concept linking texture feature estimates and task based

129 s reported, using Mg(2) TiO(4) as a proof-of-concept material.

130 The concept may be applicable to other self-healing mechanis

131 We present a proof-of-concept method to infer the total tumour pressure, that

132 computational approach to propose a proof of concept model showing that a single, simple network effe

133 model supporting different DNA nanostructure concepts (multilayer DNA origami, wireframe DNA origami,

134 , we provide examples of where this emerging concept needs to be tested.

135 Concurrently, the concept of "memory of chirality" has been proven as a po

136 ervoirs is introduced to demonstrate the new concept of "structronics" (a neologism derived from "str

137 In this study, we demonstrate the concept of "topology-matching design" for virus inhibito

138 Here we introduce the concept of "trapped air" metamaterial, fabricated via va

139 Capitalising on the concept of "wisdom of crowds", which states that a group

140 The concept of 'idiopathic' Parkinson's disease (PD) as a si

141 ecedents, attributes and consequences of the concept of 'living in the moment'.

142 servation is rationalized by introducing the concept of a dynamic, "effective" adhesive force, a sing

143 Herein we report the novel concept of a microalgae living biosensor by enhancing ph

144 In this work, we propose a concept of a microfabricated analysis cell based on an I

145 lele across different cells, introducing the concept of a mutational "transcriptotype" that differs f

146 The results represent a proof-of-concept of a new algorithm of personalized anti-tumor th

147 subjects in a German cohort, supporting the concept of a role for inflammation in PRKN/PINK1-linked

148 bioconjugation are essential to realise the concept of all-polymer-based biosensors that do not depe

149 Development of the concept of aurophilicity and its use in designing novel

150 enetics have all contributed to changing the concept of axSpA from one of erosions in the sacroiliac

151 Generalizing the concept of Bell nonlocality to networks leads to novel f

152 Studies of both the concept of chiral symmetry breaking as well as the subse

153 from wastes by EDUF fits perfectly with the concept of circular economy.

154 t atrial appendage closure) are based on the concept of combining several interventions to improve an

155 -state photoluminescence, contributes to the concept of conformational isomerism in nanoclusters, and

156 The core concept of continuous variation being due to multiple Me

157 Herein, we report a concept of creating shape selectivity in MNPs/porous nan

158 We introduce the concept of demographic competence to describe the abilit

159 The concept of dormancy has been validated in C. neoformans

160 standing of these properties is based on the concept of electronic charge transfer.

161 beyond meme-centered or an organism-centered concept of fitness based on free-energy minimization, to

162 GB) structure has a long history(1) and the concept of GBs undergoing phase transformations was prop

163 This novel concept of infant formula composition has given rise to

164 ative explanations of influence, notably the concept of injunctive norms and the relation to moral co

165 As a proof of concept of its manufacturability, biocompatibility, and

166 We review the published evidence for the concept of LC as a prothrombotic state, discuss discorda

167 Since LINbase leverages the concept of Life Identification Numbers (LINs), which are

168 In summary, the concept of miniaturized microcage designs with such stra

169 It focuses on the concept of monoclonal gammopathy of clinical significanc

170 studied in simple systems by leveraging the concept of multiple simultaneous synthetic dimensions.

171 Tomasello proposes that the concept of obligation develops "from the inside-out": em

172 Thus, we developed the concept of peptide matrix structure, which is constructe

173 of this analysis therefore was to define the concept of post-intensive care syndrome.

174 Recently, the concept of preventive antiepileptic treatment to modify

175 Here, we briefly review the general concept of redundancy and focus on the evolutionary impo

176 the primary prevention of CVD introduced the concept of risk-enhancing factors that are specific to w

177 will help a structural engineer to adapt the concept of spider web, its properties, and damage patter

178 Scalability is based on an intuitive concept of stacking modules, like conventional toy inter

179 This article introduces the concept of synthetic datasets, which is an emerging meth

180 development and adoption of a systems-based concept of systemic autoinflammatory diseases is anticip

181 Thus, this study established the proof of concept of targeting TF as a new target in CAR-NK immuno

182 propose an integrative approach based on the concept of the 'nidobiome', a new unit of microbiome-hos

183 The concept of the clinical utility of a negative MBI result

184 -field approach to wave imaging based on the concept of the distortion matrix.

185 A broader concept of the vulnerable patient, not just the vulnerab

186 We introduce a concept of using analogous methods to manipulate biomass

187 The novel concept of Well-Associated Proteins (WAPs) introduced he

188 hey were originally developed to measure the concepts of interest or developed in non-mealtime activi

189 eveloped, tested, and/or used to measure the concepts of interest, including mealtime caregiving know

190 ties and later used or tested to measure the concepts of interest.

191 anisms at a systems level by integrating the concepts of neural population coding with distributed pr

192 This paper aims to define the concepts of primary pseudotumor cerebri, in which the ca

193 Using concepts of probability theory and inferential statistic

194 In this article, we explain the main concepts of such analyses and provide a detailed workflo

195 Our concept offers a practical, all-optical, fully three-dim

196 The impact of this concept on "breathing" MOFs is discussed. I(2) sorption,

197 yploidization strategies that expand current concepts on the evolution of flowering plants.

198 Exemplarily, as proof of concept, one nontarget pollutant was identified as N-met

199 The concept presented shows considerable promise and paves t

200 Both concepts produced almost identical risk estimates.

201 The DCI concept provides basic knowledge of the magnitude of fac

202 The numerous discoveries and innovative concepts realized in motile micro- and nanostructures ha

203 ormance machine learning-based NER tools for concept recognition and trained our concept embeddings,

204 ccess a comprehensive summary of fundamental concepts regarding lipid peroxidation, experimental tool

205 We also discuss concepts related to the development of fluid dynamics in

206 In line with current concepts relating the microbiome and the immune system,

207 ied by United Network for Organ Sharing, the concept remains controversial due to presumed lack of pu

208 The most effective concept reported so far is based on a pool of randomly o

209 Scaling up such concepts requires controlling individual nuclei, which c

210 As proof of concept, results showed that INSeq screens successfully

211 % for the monotonicity, intersection and sub-concept rules, respectively.

212 The proof-of-concept scheme consists of a spinning core made of uncur

213 rmaceuticals developed under the radiohybrid concept show equal or better targeting characteristics t

214 decades, the field has grown from a proof of concept stage to a broad range of methods for accessing

215 The "exposome" concept strives to capture the diversity and range of ex

216 materials, application of scalable proof-of-concept studies, and acknowledgment of all treatment out

217 This work represents a novel proof-of-concept study demonstrating the feasibility of computer

218 d with liver tissue, we conducted a proof-of-concept study evaluating the efficacy of 3'-deoxy-3'-(18

219 Overall, this proof-of-concept study has supported the development of DHA-based

220 This proof-of-concept study holds promise as a novel immunotherapy com

221 This proof-of-concept study presents Raman hyperspectroscopic analysis

222 Our proof-of-concept study provides a powerful new methodology for st

223 This positive proof-of-concept study supports the continued development of GSK2

224 This proof of concept study targets the translational rigor of such bi

225 Here, we present a proof-of-concept study to noninvasively derive the thermodynamic

226 digestion x reduction-HILIC/MS), a proof of concept study using two mAbs is described here.

227 Based on this first proof-of-concept study, we propose multi-scale phase contrast x-r

228 bility and developmental biology and to test concepts such as phase separation of chromatin.

229 Current explanatory concepts suggest seizures emerge from ongoing dynamics o

230 Our findings resolve existing controversial concepts surrounding A-genome origins and provide valuab

231 Therefore, this proof-of-concept technique shows significant potential for highly

232 ymatic modifications, led us to a verifiable concept termed "superchanneling." In superchanneling, th

233 The concept that a minority of group A streptococcus (GAS) e

234 rnatively spliced exons, consistent with the concept that altered splicing might be a common mechanis

235 The proof of concept that an enantioselective version of this reactio

236 The concept that dietary changes could improve the response

237 The concept that exposure in utero to maternal anti-brain an

238 Transcriptomic data support the concept that functional, rather than compositional, prop

239 l oligosaccharide synthesis is an attractive concept that has been successfully applied to a large nu

240 This work is not only a proof-of-concept that HDX-MS can be used to get structural insigh

241 This study explores the concept that homologous recombination DNA repair is not

242 -specific CD8+ T cells has provided proof-of-concept that immunotherapy can be highly effective, but

243 Collectively, these results support the concept that inositol-1,4,5-trisphosphate type 3 recepto

244 absence of this epitope, substantiating the concept that other antigens can be sufficient for parasi

245 We also provide proof-of-concept that polarized HLCs can be used for pharmacokine

246 sult of poor stromal ecology, supporting the concept that purely tumour epithelium-centric metrics of

247 arrhythmia susceptibility and reinforces the concept that RA plays a critical role in the pathophysio

248 These findings challenge the whole lp...pai concept that refers to elusive orbital interactions that

249 This study provides the first proof-of-concept that stable, hydrophobic oxidovanadium complexes

250 ies have provided increasing support for the concept that the nucleolus represents a multilayered bio

251 This study provides a proof-of-concept that the plant-soil feedback concept can be appl

252 The evidence to date supports the concept that the thrombotic manifestations of severe COV

253 The concept that there is a single "cochlear amplification r

254 f species between times approaching zero), a concept that we describe as destructive creation.

255 and synapses and brain-computer interfacing concepts that interlink brain and brain-inspired devices

256 sotropic kernel functions, which are the two concepts that we tackle in this paper.

257 tal data and DFT calculations, as a proof of concept, the capacity to utilize the Mn-MOF for electroc

258 As proofs-of-concept, the rGO-PLA electrode was applied for serotonin

259 A proof-of-concept therapy study with a single administration of (2

260 As a proof-of-concept, this technique was then applied to hairpin mono

261 With the presentations of new concepts, this review opens for new research questions a

262 framework and explain underlying fundamental concepts through experimental examples with the RNA-bind

263 whether monkeys would generalize the middle concept to a 7 dot series.

264 Here, we generalize this concept to a G protein-coupled receptor, somatostatin re

265 eral challenges have to be overcome for this concept to become a practical way to encode and manipula

266 terials which limit the applicability of the concept to metamaterials such as microfabricated metal-a

267 mEos expressed as intrabodies, as a proof-of-concept to perform single-particle tracking on a range o

268 We provide a proof-of-concept to show how Raman spectroscopy can be used to id

269 mmentary extends the target article's useful concepts to consider collective instances of representat

270 The identified studies used systems concepts to depict and describe a system at one point in

271 caffold hopping and bioisosteric replacement concepts to eliminate unwanted structural motifs and to

272 In this study, we extend these concepts to interrogate the interdependence of cell type

273 the cholangiocyte channel, allowing proof-of-concept toxicity studies with the biliary toxin, biliatr

274 in this concise review, which recaps current concepts underlying the biology and therapeutic rational

275 ve the learning of vector representations of concepts using machine learning models-have been employe

276 that bridges experimental and bioinformatics concepts using the Oxford Nanopore Technologies (ONT) se

277 As a proof of concept, various Int derivatives have demonstrated succe

278 As a proof of concept, we characterized the function of the histone re

279 As a proof-of-concept, we demonstrate a design of a sensor for EGFR ty

280 echnical challenges for this REBCO shim coil concept, we demonstrate its feasibility for the next gen

281 As a proof of concept, we developed a 5-plex assay measuring interleuk

282 As proof-of-concept, we employed net-clipping to form three new MOFs

283 Through this concept, we establish, synthesize, and thoroughly study

284 As a proof-of-concept, we first investigate the utility of COMBAT with

285 As a proof of concept, we investigate the Ras-Raf system, a well-chara

286 As a proof-of-concept, we manufactured and characterized the propertie

287 As a proof of concept, we performed digital LAMP on a sp-SlipChip to q

288 lying our framework to Germany as a proof of concept, we show significant losses in functional plant

289 As a proof-of-concept, we show that an OCS pipeline focused on genes c

290 As a proof-of-concept, we show that joint DA of multiple independent s

291 For proof of concept, we tested PNAs targeting miRNA-155 and employed

292 As a proof-of-concept, we used this technique to measure the single-pe

293 After a discussion of the aims and concepts, we describe equipment and representative examp

294 Via a range of concepts, we related bio-physicochemical constituents of

295 Corals exemplify this concept, where shifts in the algal symbiont community ca

296 Greater understanding of these important concepts will improve the diagnosis and management of pa

297 We demonstrate the detection concept with cysteine modifying S-nitrosylation and ADP-

298 round and recent findings underpinning these concepts with a focus on two major pathological proteins

299 Here, we combine concepts with empirical support to design optimal landsc

300 fish (bony fish) support the unbranched axon concept, with 94% of axons terminating in single glomeru