ライフサイエンスコーパス: concerted

1 eps: C-H bond activation; C-C coupling via a concerted 1,2-aryl transfer; proto-demetalation; nucleop

2 of DFT calculations, a mechanism involving a concerted 1,4-hydride shift/electrocyclization process a

3 isomer, perhaps hinting at the potential for concerted 2 e(-) /2 H(+) transfers.

4 for concerted (Cope-type) hydroamination and concerted [3 + 2] aminocarbonylation reaction pathways.

5 ubsequently rearrange via stepwise [1,3]- or concerted [3,3]-sigmatropic shifts, ultimately convergin

6 e superstructures emerges as a result of the concerted 3D co-assembly of the organic and inorganic co

7 ability within planetary boundaries requires concerted action by individuals, governments, civil soci

8 Concerted action by local and indigenous communities, en

9 rst module, [Ca2+]i-spike trains require the concerted action of a classical CaV-like channel and a p

10 nvasive pathogens often requires coordinated concerted action of a large group of stakeholders.

11 In addition, a concerted action of alkaline phosphatase and adenylate k

12 n response to abiotic stress, which requires concerted action of both cis- and trans-regulatory featu

13 The concerted action of both genetic mechanisms, in combinat

14 ss recent evidence revealing the complex and concerted action of both SPN populations on drug-induced

15 on is an intricate process that requires the concerted action of both viral and host cell components.

16 on is an intricate process that requires the concerted action of both viral and host cell components.

17 Taken together, we propose that the concerted action of DDK, Polo-like kinase, and CDK1 prom

18 nstrate that qE is entirely dependent on the concerted action of diatoxanthin and Lhcx proteins, with

19 s essential intestinal functions through the concerted action of diverse enteric neurons (ENs).

20 yotic DNA replication fidelity relies on the concerted action of DNA polymerase nucleotide selectivit

21 They mature from proplastids through the concerted action of genes in both the organellar and the

22 are positioned in space and time through the concerted action of key mitotic entry biochemical regula

23 ption, and RNA processing each depend on the concerted action of many different protein and RNA molec

24 etic precursors is needed, necessitating the concerted action of metabolism and protein synthesis dur

25 ter's activity is regulated by Ca(2+) due to concerted action of MICU1 and MICU2, two paralogous, but

26 ral entry is a complex process requiring the concerted action of multiple cellular elements.

27 somes migrate and are positioned through the concerted action of PP2A-B55/SUR-6-regulated nuclear env

28 yotic genome is rigorously controlled by the concerted action of protein factors and RNAs.

29 ing the viral and cellular membranes via the concerted action of the attachment (G) and fusion (F) gl

30 ce toward the derepressed state, revealing a concerted action of the two boundaries at a distance.

31 his is established during development by the concerted action of tissue-level, intercellular planar c

32 Here we show that the concerted action of two enzymes commonly involved in nat

33 the trans-Golgi network (TGN) depends on the concerted action of two types of tethering factors: long

34 major birth defect according to the European Concerted Action on Congenital Anomalies and Twins (EURO

35 Even with immediate and concerted action, 710 million metric tons of plastic was

36 aR-mediated phagocytosis is regulated by the concerted actions of activating FcgammaR and inhibitory

37 such as antitumoral immunity, occur through concerted actions of cells and spatial domains.

38 ede tumor development by years, requires the concerted actions of nearly a dozen EBV proteins and num

39 , water, and urea are reabsorbed through the concerted actions of solute carrier channels and aquapor

40 Piloerection (goosebumps) requires concerted actions of the hair follicle, the arrector pil

41 alternative polyadenylation, and it is their concerted actions that define a gene's expression outcom

42 e good progress, China must take a series of concerted actions, including more investments in public

43 Thus, the concerted activation of both Toll-like receptors and C-t

44 Infection is restrained by the concerted activation of tissue-resident and circulating

45 drug-induced cross-link repair requires the concerted activities of translesion synthesis (TLS), Fan

46 which likely discharge in response to either concerted activity among a large proportion of inputs or

47 This metabolic shift was driven by the concerted activity of 3 transcriptional regulators (PdhR

48 Memories are a product of the concerted activity of many brain areas.

49 en has been attributed to differences in the concerted activity of neural networks.

50 One shift depended on the concerted activity of seven Grs.

51 We found that TBT elicited concerted alterations in the expression of "chromatin or

52 ot support a frequently invoked mechanism of concerted amine/thiol proton transfer and C-S bond forma

53 acquisition in zebrafish and illustrate how concerted analyses across hierarchical levels can provid

54 ng of ion channels and receptors occurs in a concerted and cell-specific manner, resulting in the app

55 a C-C bond through concomitant heterolytic, concerted and homolytic pathways.

56 odeling elucidates the existence of both the concerted and stepwise mechanisms and uncovers the root

57 100 and 300 K there is a competition between concerted and stepwise pathways when nuclear quantum eff

58 T calculations, which suggests that separate concerted and stepwise reaction mechanisms are operating

59 ed the full potential energy surface for the concerted and stepwise reactions of tetrafluoroethylene

60 ocarbonyl compounds produces ketenes by both concerted and stepwise Wolff rearrangements.

61 the PCET mechanism could be switched between concerted and the two stepwise PCET mechanisms (electron

62 ng of the place of the IFN system within the concerted antiviral response.

63 We conclude that a concerted approach involving medical, veterinary, parasi

64 nd the major transition structure suggests a concerted asynchronous mechanism for the formal annulati

65 Fragmentation takes place in a concerted asynchronous reaction.

66 Recognized 170 years ago, concerted attempts to understand these cells began only

67 s of the kinetic isotope effects establish a concerted but asynchronous pericyclic pathway.

68 system, homolytic C-H bond cleavage involves concerted but asynchronous transfer of the H(+) and e(-)

69 mental and computational studies establish a concerted but highly asynchronous mechanism.

70 nergy of favorable band energy alignment and concerted cascade interfacial carrier extraction, render

71 A regioselective, path-breaking concerted cascade route allows the placement of six-memb

72 Owing to the concerted catalysis, the ZnFe(0.4) Co(1.6) O(4) oxide de

73 xample of a one-electron redox event causing concerted change in multiple iron centers.

74 Finally, concerted changes in coordination of care, payment struc

75 tory system of female An. coluzzii undergoes concerted changes that correlate with the onset of host

76 bound singlet substrate via a three-electron concerted charge-transfer mechanism.

77 These findings highlight how concerted chemical changes on a conserved structural sca

78 iotic process of depolyploidization known as concerted chromosome loss (CCL).

79 These concerted cis/trans interactions, which allow the plant

80 ytic domains (HNH and RuvC), responsible for concerted cleavage of the two DNA strands.

81 Concerted clinical and policy interventions are needed t

82 This can only be achieved through a concerted collaborative approach from physicians, indust

83 l to end tuberculosis within a generation, a concerted, collective, and collaborative effort is requi

84 A concerted, community-wide effort will be needed to devel

85 These results support the hypothesis that concerted conformational changes open the lateral portal

86 Comparison of these structures reveals concerted conformational rearrangements through which th

87 trinsic tryptophan fluorescence, reveals the concerted conformational transitions that occur during s

88 show that nonadditivity arises not only from concerted conformational transitions, but also from conf

89 Brazil's food supply but - if combined with concerted conservation and restoration policies - provid

90 on of cell division and metabolism, but also concerted control of the structure and function of organ

91 f their stereochemistry provided support for concerted (Cope-type) hydroamination and concerted [3 +

92 hilic aromatic substitutions that proceed by concerted (cS(N) Ar) rather than classical, two-step, S(

93 he reaction is believed to be a spontaneous, concerted cycloaddition.

94 tanton simulations show that below 100 K the concerted DHT tunneling pathway dominates but between 10

95 ) particle corners leads to an activated and concerted displacement of neighboring edge S.

96 This type of concerted divergence is a previously unreported fate of

97 Here, we provide an example of concerted divergence of simultaneously duplicated genes

98 Ni(0)-[1.1.1]propellane complex followed by concerted double C-C bond activation to give the key 3-m

99 rmal selectivity pattern in which a formally concerted double migration gives rise to predominant but

100 midine dimers are removed from the genome by concerted dual incisions bracketing the lesion, followed

101 ssing on high-level cell functions and their concerted effect on cellular migration patterns.

102 d very large depolarization depending on the concerted effects of extreme lifetime enhancement and re

103 We further address the concerted effects of such regulation on vascular functio

104 combine to define a stem cell domain through concerted effects on FSC differentiation to ECs and FCs

105 Our findings demonstrate that Sox9 exerts concerted effects on transcription, BP proliferation, ne

106 A coordinated and concerted effort across patients, families, researchers,

107 oundation of academic science will require a concerted effort between funding agencies, universities,

108 Only a concerted effort from all stakeholders will achieve equi

109 roval, there may be justification for a more concerted effort from the molecular imaging community in

110 of disciplines and approaches, and how this concerted effort has been driven by the development of n

111 A concerted effort has been made in the field to determine

112 ts indicates that carbapenem hydrolysis is a concerted effort involving multiple residues.

113 A concerted effort is needed to ensure that all patients w

114 Thus, a concerted effort is required to investigate how immune d

115 regulation by GEFs and GAPs will require the concerted effort of many laboratories working together,

116 We argue that concerted effort should be made globally in germline pre

117 In this Perspective, we propose a national concerted effort to create a Precancer Atlas (PCA), inte

118 at build these individual databases demand a concerted effort to ensure interoperability among resour

119 As a result, there has been a concerted effort to model human stress in mice.

120 and local government authorities directed a concerted effort to remove wild pigs from the county unt

121 An important element of the concerted effort to respond to spills includes the abili

122 the research community, in the absence of a concerted effort to study genes in an unbiased way, many

123 oblems will benefit from a more explicit and concerted effort to work together.

124 vil society, need to tackle this aspect in a concerted effort.

125 ct deaths on death certificates will require concerted efforts and consensus across medical instituti

126 Concerted efforts are also needed to reduce persistent r

127 Concerted efforts are needed to ensure that participatio

128 Concerted efforts are needed to improve the execution an

129 We contend that more concerted efforts are needed to integrate these fields s

130 Concerted efforts are needed to reduce health inequaliti

131 racterization, despite more than 60 years of concerted efforts by investigators.

132 Achieving this goal will require concerted efforts by social, academic, professional and

133 sion-making regarding their use will require concerted efforts from multiple actors.

134 of Pt-alloy nanocatalysts during ORR demands concerted efforts in precision synthesis, advanced atomi

135 new edited crop varieties, we advocate: (i) concerted efforts in the advancement of 'omics' technolo

136 process previously suggested to require the concerted efforts of a YcaO enzyme (PurCD) and an amidoh

137 Concerted efforts should be made to collect robust data

138 ginning to be recognized and managed(11,12), concerted efforts to develop effective electrochemical n

139 Concerted efforts to overcome limitations in the general

140 result is physically plausible will require concerted efforts to reduce significant uncertainties in

141 ic drops in cost, advances in technology and concerted efforts to translate sequencing data into acti

142 rode eliminates stepwise pathways and forces concerted electron transfer and proton binding.

143 a locally excited state (LES) is followed by concerted electron transfer from the phenol to the anthr

144 (3) H(4) O, while the latter resulted in the concerted elimination of CO+C(2) H(4) products.

145 o-hydroxybenzaldehyde and amine) undergoes a concerted Eschweiler-Clarke type decarboxylation with al

146 This novel cascade features many concerted events, including the formation of two azometh

147 Still, support for this idea of concerted evolution of the morphology of the lizard sens

148 Here, we describe a closely concerted experimental and computational study, includin

149 lmark of bacterial genomes, where they allow concerted expression of functionally related genes as si

150 sma and Plasmodium scRNA-seq results reveals concerted expression of gene sets, despite fundamental d

151 be part of a regulatory system that enables concerted expression of the necessary genes from both nu

152 Pericyclic reactions-which proceed in a concerted fashion through a cyclic transition state-are

153 g inflammation, proteins and lipids act in a concerted fashion, calling for combined analyses.

154 ts confirm that these activations occur in a concerted fashion, wherein the proton and electron are t

155 ydrogen bonding proceeded in an asynchronous concerted fashion.

156 either in distinct elementary steps or in a concerted fashion.

157 of glycan-based receptor usage, entailing a concerted, fine-tuned activity of two envelope protein s

158 the oxygen abstracts the leaving H-atom in a concerted, four-center (H3C...*...H...O*)() transition s

159 e have debunked an erroneous assumption of a concerted fragmentation process for (OCP)(-) , rather th

160 Despite concerted functional genomic efforts to understand the c

161 dering that root performance is based on the concerted functions of its different cell types, we unde

162 overexpressed in kidney tumors as part of a concerted gene coexpression program that can support hig

163 l organization of chromosomes contributes to concerted gene expression.

164 ty and map FFRs, we provide a foundation for concerted global and national strategies to maintain or

165 iated alkyl halide activation proceeds via a concerted halogen-atom abstraction mechanism.

166 ransfer, inner-sphere electron transfer, and concerted halogen-atom abstraction.

167 ICH exhibits a concerted helical displacement upon active-site cysteine

168 These concerted high-latitude expansion events contrast with r

169 Remarkably, replication restart requires the concerted histone H3 chaperone activities of ATRX/DAXX a

170 We find that the reaction takes place by concerted hydrogen atom (H(*)) transfer that couples to

171 Concerted in vivo validation experiments in mouse and ze

172 Concerted increases in abundance were seen within variou

173 inus of IN results in maximal stimulation of concerted integration activity and greatly improves the

174 Concerted integration of both viral DNA ends into a targ

175 s high-affinity membrane binding arises from concerted interaction at multiple sites on the C2A domai

176 ription of a chromatin template involves the concerted interaction of many different proteins and pro

177 related adhesion molecule, ELFN1, and their concerted interplay during development specifies selecti

178 ty in neuronal networks is associated with a concerted interplay of alpha2delta1 and alpha2delta3 sub

179 ity owing to laundry detergent exposure; and concerted intervention is needed in this age group.

180 Collective, concerted intervention is required to effectively discou

181 the studied cycloadditions were found to be concerted involving small free activation energies and a

182 cal minima) for Li(+) diffusion and activate concerted ion migration, leading to a low activation ene

183 atomic detail of the replisome that performs concerted leading- and lagging-DNA strand synthesis at a

184 s secretion by SNARE interactions as well as concerted lipid interplay.

185 mains of all filovirus GPs tested suffered a concerted loss of prefusion conformation at elevated tem

186 ) causes CO to dissociate from Cu(B)(+) in a concerted manner through steric and/or electronic effect

187 Our work unveils how NMDAR domains move in a concerted manner to transduce long-range conformational

188 ne insertion into the B-H bond occurred in a concerted manner.

189 couples with dsDNA-dependent activation in a concerted manner.

190 plication and stability in both distinct and concerted manners.

191 ad re-routed their folding pathway to enable concerted maturation of other structural motifs spanning

192 haKG)-dependent nonheme iron enzymes, both a concerted mechanism (both cofactor and substrate binding

193 nd an exonucleolytic decay assay we define a concerted mechanism for triplex formation and uncover a

194 ction proceeds via a stepwise and when via a concerted mechanism has not yet been established.

195 Diels-Alder reaction occurs via a concerted mechanism if the diene termini are held in clo

196 ng a mixture of (18)O(2)/(16)O(2) suggests a concerted mechanism in O(2) addition.

197 found that MAPK4 activated AKT via a novel, concerted mechanism independent of PI3K.

198 These results demonstrate that the concerted mechanism is operative in DAOCS and by extensi

199 The concerted mechanism of oxidative addition proceeds throu

200 adical revealed that LCuF proceeds through a concerted mechanism, while LCuCl and LCuBr follow a step

201 iously measured KIE ~ 2.5, which best fits a concerted mechanism.

202 ribosome from SecA to the translocase via a concerted mechanism.

203 e Fe(IV) -oxo and release of water through a concerted mechanism.

204 x proceeds by a p K(a)-driven "asynchronous" concerted mechanism.

205 as well as enhanced proton tunneling for the concerted mechanism.

206 ion of (4 + 2) products by both stepwise and concerted mechanisms involving regioselective addition t

207 rest recently is the finding of a variety of concerted mechanisms that do not involve the formation o

208 ansformation proceeds in a single step via a concerted Meisenheimer-type transition state.

209 the ambiphilic M(2)[DBA] activate H(2) in a concerted, metal-like fashion.

210 ivalent methylenic C(sp(3))-H bonds prior to concerted metalation deprotonation activation.

211 inated alkyne, which suggests operation of a concerted metalation-deprotonation (CMD) mechanism.

212 ing the cleavage of the meta-C-H bond in the concerted metalation-deprotonation (CMD) process.

213 The reversibility of the concerted metalation-deprotonation exchange of eight par

214 rate-limiting C-H activation process via the concerted metalation-deprotonation pathway, which is sli

215 l calculations, where a trigonal bipyramidal concerted metalation-deprotonation transition state is p

216 We previously discovered concerted molecular changes among interacting members of

217 Concerted molecular changes that occur in specific cell

218 gration occurs via a mechanism that combines concerted motion of lithium ions with large, quasi-perma

219 inding drives a contraction of the cavity by concerted motion of the ATPase domains, which could push

220 pecifically, low-frequency motions involving concerted motions of the crown scaffold and the H3O(+) i

221 Currently, either a concerted movement involving all four subunits of the te

222 cess of electron transfer often involves the concerted movement of a proton.

223 s through the cores of NPC1/NPC1L1 proteins; concerted movement of various domains is needed for tran

224 closing of the MacB periplasmic domains via concerted movements of the second transmembrane segment

225 Concerted multidisciplinary efforts have led to the deve

226 ver 1000 generations, by acquiring multiple, concerted mutations.

227 We show that infra-slow periodic patterns of concerted neural activity, indeed, reflect the idle stat

228 dissociation and DFT calculations indicate a concerted nucleophilic attack mechanism.

229 reactions usually proceed through a radical, concerted or ionic mechanism; transformations in which a

230 er, whether their catalytic cycles involve a concerted or stepwise cyclization mechanism has not been

231 her a given aryl fluoride substrate favors a concerted or stepwise mechanism.

232 ores have also been designed that react in a concerted or, more rarely, a heterolytic manner.

233 Concerted over-representation of network factors in cont

234 dies suggest that rather than occurring by a concerted oxidative addition, these reactions involve st

235 uctive elimination that occurred either by a concerted pathway or a radical rebound sequence that is

236 h activating groups are not mandatory in the concerted pathways.

237 The experiments implicated a concerted PCET mechanism involving intramolecular electr

238 difying the nature of the proton acceptor in concerted PCET processes.

239 work shows how enzymes are able to catalyse concerted pericyclic reactions involving ambimodal trans

240 The oxidation appears to proceed by a concerted process involving a manganese hydroperoxide sp

241 This method allowed us to dissect the concerted process of E1-E2-catalyzed Ub conjugation in o

242 nate immune response to infection requires a concerted process of gene expression that is regulated a

243 candidate reaction paths point to a one-step concerted process, with the nucleophile playing a critic

244 ionic pair Cys105(-)/His224(+) rather than a concerted process.

245 onses against invading pathogens require the concerted production of three key cytokines: TNF-alpha,

246 that trains on large ensemble comparisons of concerted protein motions in opposing functional states

247 n of the activated haloalkyne, assisted by a concerted proton abstraction by the triflate, and that t

248 ng was used to support an initial, slow, and concerted proton transfer with release of isobutylene, f

249 s either a hydrogen-atom transfer (HAT) or a concerted proton-coupled electron transfer (cPCET).

250 One uses concerted proton-coupled electron transfer (PCET) from a

251 This mechanism is based on multi-site concerted proton-coupled electron transfer (PCET) involv

252 Inverted region behavior for concerted proton-coupled electron transfer (PCET) was re

253 tion of unsaturated substrates via reductive concerted proton-electron transfer (CPET) must overcome

254 l chemical oxidants to achieve multiple-site concerted proton-electron transfer (MS-CPET) activation

255 Multiple-site concerted proton-electron transfer (MS-CPET) reactions w

256 port details C-H oxidation via multiple-site concerted proton-electron transfer (MS-CPET), where the

257 combination of photoredox-mediated multisite concerted proton-electron transfer (MS-PCET) and nickel

258 inetic and thermodynamic analyses evidence a concerted proton-electron transfer pathway for these pro

259 These concerted proton-electron-transfer (CPET) reactions are

260 lectron transfer for X = NO(2), CF(3), Cl to concerted-proton/electron transfer (or hydrogen-atom tra

261 condensation of acetaldehyde but, rather, by concerted reaction of coadsorbed acetaldehyde and ethano

262 The rate of the concerted reaction should depend symmetrically on change

263 Development and homeostasis rely upon concerted regulatory pathways to establish the specializ

264 A systematic and concerted research effort is required to address the def

265 acteria detection techniques there have been concerted research efforts towards developing new biosen

266 r findings suggest lipid binding initiates a concerted rotation of the cytoplasmic domain subunits, w

267 ely transform into monodentate NO(3)(-) by a concerted rotation with simultaneous O(2) adsorption ont

268 ble iminium intermediate, and a lower energy concerted S(N)2 mechanism.

269 But so far only isolated examples of concerted S(N)Ar reactions have been described and a coh

270 n energy minimum, leading to a switch from a concerted sigmatropic shift to its aborted or interrupte

271 the reaction mechanism reveal an unexpected, concerted SNAr mechanism, with the organocatalyst playin

272 ion, wherein a conjugated triene undergoes a concerted stereospecific cycloisomerization to a cyclohe

273 ell, and the complex formed then undergoes a concerted structural transition that results in the crea

274 DFT calculations indicate a partially concerted substitution mechanism.

275 that RNA or DNA base pairs are broken by the concerted symmetric movement of complementary nucleobase

276 globally and highlight the broader need for concerted, targeted and timely conservation of freshwate

277 we observed a mechanistic crossover from the concerted to a dissociative CS(N)Ar type of reactivity f

278 groups at C2, a range of possibilities from concerted to aborted pathways is accessible, including t

279 e reactant to follow a post-transition-state concerted trajectory on the bifurcated force-modified po

280 ether, our study reveals novel principles of concerted transcriptional regulation by multiple TRs at

281 onses to surrounding cues require temporally concerted transcriptional regulation of multiple genes.

282 We infer that the concerted transition model can be used to link radioliga

283 ons of receptor activity using the coagonist concerted transition model demonstrate that the response

284 Here, we employed the Monod-Wyman-Changeux concerted transition model to analyze muscimol binding i

285 The coagonist concerted transition model was used to determine overlap

286 mbination, in the framework of the coagonist concerted transition model.

287 tivated conformations, we demonstrate that a concerted transition of all four subunits after voltage

288 nanoparticles proceeds via an unsymmetrical concerted transition state in which there is partial pos

289 arbon-fluorine bond formation proceeds via a concerted transition state rather than a discrete Meisen

290 to TRAK motor protein adaptors to ensure the concerted transport of the two mitochondrial membranes a

291 orst invasive species-and that one decade of concerted trophic rewilding restored this invasion to pr

292 Shewanella oneidensis ccNiR is reduced in a concerted two-electron step to generate an {FeNO}(7) moi

293 therapeutic resistance can be caused by the concerted upregulation of interdependent pathways.

294 Only recently the alternative, concerted version of this mechanism has gained acceptanc

295 ce points to the fact that H addition occurs concerted with C-O bond scission.

296 tion to the ipso position of the phenyl ring concerted with C-O scission.

297 have band structures that promote facile PT concerted with electron transfer (ET), known as the Volm

298 ucleophilic 3'-OH, and this deprotonation is concerted with the phosphoryl transfer.

299 In addition, DFT calculations reveal a concerted yet highly asynchronous [4 + 2]-cycloaddition

300 at tubulins recruited by TOG1 and TOG2 serve concerted, yet distinct, roles in MT plus-end tracking a