ライフサイエンスコーパス: concerted action of

1 replication depend on the direct linkage and concerted action of 1a's self-interacting capping and he

2 ng multiple overlapping DNA molecules by the concerted action of a 5' exonuclease, a DNA polymerase a

3 rst module, [Ca2+]i-spike trains require the concerted action of a classical CaV-like channel and a p

4 Therefore, we propose that only the concerted action of a combination of inhibitory receptor

5 ted ATPase activity and gating depend on the concerted action of a full complement of Rpt subunits co

6 Selenocysteine incorporation requires the concerted action of a kink-turn structural RNA (SECIS) e

7 ion repair (NER) in yeast is effected by the concerted action of a large complex of proteins.

8 nvasive pathogens often requires coordinated concerted action of a large group of stakeholders.

9 This event requires the concerted action of a large number of fusion-competent s

10 The concerted action of a large number of individual molecul

11 borate biochemical process that requires the concerted action of a large set of transcription factors

12 highly coordinated process that requires the concerted action of a large, dynamic, ribonucleoprotein

13 ration in vitro, which is carried out by the concerted action of a novel Sec incorporation domain and

14 targeted for proteasomal degradation by the concerted action of a SUMO-targeted ubiquitin ligase (ST

15 st paramyxoviruses infect host cells via the concerted action of a tetrameric attachment protein (var

16 lization of these alpha-glucans requires the concerted action of a variety of enzymes, including glyc

17 and exocytosis, whereas cytokinesis requires concerted actions of a contractile actomyosin ring and t

18 rimarily at the transcriptional level by the concerted actions of a limited number of hepatocyte-enri

19 port is a finely tuned process requiring the concerted actions of a number of accessory factors.

20 interactions are mediated by elaboration and concerted actions of a variety of growth and differentia

21 aR-mediated phagocytosis is regulated by the concerted actions of activating FcgammaR and inhibitory

22 In addition, a concerted action of alkaline phosphatase and adenylate k

23 rameters are maintained and regulated by the concerted action of all components under a diverse range

24 ntly can control a single gate formed by the concerted action of all four Kir6.2 subunit inner helice

25 actic cell migration on Ln-5 is regulated by concerted action of alpha 3beta 1 and alpha 6 beta 4 int

26 These studies suggest a mechanism for the concerted action of alpha-toxin and PFO during C. perfri

27 We demonstrate that a concerted action of an anionic cholesterol derivative, c

28 ll division in Escherichia coli requires the concerted action of at least 10 essential proteins.

29 rephosphorylated and inactivated through the concerted action of at least 3 different kinases: CK1, G

30 The herpesvirus entry machinery requires the concerted action of at least four glycoproteins; however

31 phosphosulfate (PAPS), is synthesized by the concerted action of ATP sulfurylase and adenosine 5'-pho

32 in a complex environment and are guided by a concerted action of attractive and repulsive factors to

33 This behavior resulted from the concerted actions of axo-somatic sodium channels that in

34 eta-amyloid precursor proteins (APP), by the concerted action of beta- and gamma-secretase(s).

35 gram during early tooth development requires concerted actions of Bmp, Fgf and Wnt signaling from the

36 n response to abiotic stress, which requires concerted action of both cis- and trans-regulatory featu

37 The concerted action of both genetic mechanisms, in combinat

38 plete recovery of DNA synthesis requires the concerted action of both pol II and pol III.

39 actor receptor (EGFR) signaling requires the concerted action of both positive and negative factors.

40 The concerted action of both positive feedback loops resulte

41 Furthermore, stimulation is dependent on the concerted action of both Rad51 protein and RPA, implying

42 Concerted action of both regions sustains responses to d

43 ss recent evidence revealing the complex and concerted action of both SPN populations on drug-induced

44 on is an intricate process that requires the concerted action of both viral and host cell components.

45 on is an intricate process that requires the concerted action of both viral and host cell components.

46 tringent aerobic repression results from the concerted action of both.

47 NIK cleavage requires the concerted actions of both fusion partners and generates

48 represents a gain of function requiring the concerted actions of both the API2 and MALT1 moieties of

49 3' alpha E (hs1,2) is down-regulated by the concerted actions of BSAP, octamer, and G-rich DNA-bindi

50 Exocytotic secretion is promoted by the concerted action of calcium, guanine nucleotide, and pro

51 Thus, the concerted action of calcium- and voltage-activated potas

52 Apoptosis is orchestrated by the concerted action of caspases, activated in a minimal two

53 We propose that the concerted action of Cdc28/Cdk1 and Cdc5/Polo on their co

54 such as antitumoral immunity, occur through concerted actions of cells and spatial domains.

55 onal program regulated by the sequential and concerted action of cellular transcription factors and T

56 l lineage specification is accomplished by a concerted action of chromatin remodeling and tissue-spec

57 e mammary-specific casein genes requires the concerted action of chromatin remodeling enzymes and tra

58 per se but is most likely the result of the concerted action of coactivator proteins recruited by th

59 ow that cueP expression is controlled by the concerted action of CueR, which detects the presence of

60 The concerted action of CVF and CPA significantly increases

61 y cyanophycin synthetase and degraded by the concerted action of cyanophycinase (that releases beta-a

62 ent that growth cone guidance depends on the concerted actions of cytoskeletal proteins, molecular mo

63 Activation of BAX through the concerted action of cytosolic p53 and Pin1 may integrate

64 Taken together, we propose that the concerted action of DDK, Polo-like kinase, and CDK1 prom

65 nstrate that qE is entirely dependent on the concerted action of diatoxanthin and Lhcx proteins, with

66 NCRs are targeted to the endosymbionts, and concerted action of different sets of peptides governs d

67 transcriptional induction is mediated by the concerted action of different transcription factor famil

68 s essential intestinal functions through the concerted action of diverse enteric neurons (ENs).

69 yotic DNA replication fidelity relies on the concerted action of DNA polymerase nucleotide selectivit

70 intenance of genomic stability relies on the concerted action of DNA repair and DNA damage signaling

71 We show the concerted actions of DNMT enzymes in the establishment a

72 occurs in sequential steps and requires the concerted action of E2 conjugating proteins and E3 ligas

73 hanism of colonization that results from the concerted action of effector proteins translocated into

74 y converge during beta-selection through the concerted action of Egr1 and NF-ATc1, respectively.

75 otein coding genes in metazoans involves the concerted action of enhancer binding proteins and the RN

76 Chromosomal transcription involves the concerted action of enormous, multisubunit chromatin rem

77 at PMS2 defective lymphomas may arise by the concerted action of environmental and perhaps endogenous

78 Concerted actions of estrogen and progesterone via their

79 abolished T cell recognition; for others, a concerted action of evasins was required to abrogate rec

80 A model is presented to explain how the concerted action of EXO and GEN activities may contribut

81 ross-links on DNA, most likely employing its concerted action of exonuclease and gap-dependent endonu

82 e present study, we test the hypothesis that concerted action of exonuclease and gap-dependent endonu

83 Stem cell self-renewal is controlled by concerted actions of extrinsic niche signals and intrins

84 ion implies that synergy can result from the concerted action of factors stimulating two different st

85 We have studied the concerted action of factors that influence the balance b

86 Thus, our data show how the concerted actions of FGF13 and FGF14 regulate the polari

87 ement of the Beet yellows virus requires the concerted action of five viral proteins including a homo

88 g embryonic morphogenesis is mediated by the concerted action of four proteins that delay the formati

89 Thus, the concerted actions of GABAergic inhibition from three Apl

90 ctivity of which seems to be mediated by the concerted action of GATA and IRF proteins.

91 They mature from proplastids through the concerted action of genes in both the organellar and the

92 /220 for initial attachment, followed by the concerted action of gH, gL, gB, and gp42 for membrane fu

93 an a week after exposure to stress, required concerted action of glucocorticoids and catecholamines a

94 ane fusion and secretion are promoted by the concerted action of GTP and Ca2+, although the precise s

95 cient duplication of the genome requires the concerted action of helicase and DNA polymerases at repl

96 e milieu to an inflamed landscape, where the concerted action of highly functional CD8(+) T cells and

97 rthermore, they identify a strategy by which concerted actions of histone deacetylases and other co-r

98 PG sacculus is a dynamic event requiring the concerted action of hydrolases that cleave the cross-lin

99 ndings provide mechanistic insights into the concerted actions of IFT and adaptor proteins in ODA tra

100 cat ventrobasal thalamus is mediated by the concerted action of Ih and a Ba(2+)-sensitive current wi

101 anical hyperalgesia that is generated by the concerted action of inflammatory mediators present in in

102 The concerted action of inositol 1,4,5-trisphosphate (IP3) a

103 nce of adaptive immune responses through the concerted action of interferon-stimulated genes (ISGs).

104 roteolysis is equally complex, involving the concerted action of internal proteases of prokaryotic or

105 Our results highlight that the concerted action of Isw1 and the nuclear exosome ensures

106 pUL83 disrupts IFI16 by concerted action of its N- and C-terminal domains, in wh

107 is, cell migration, and ERK signaling by the concerted action of its proline-rich region (PRR), RhoGA

108 retained at the sites of DSB damage via the concerted action of its three highly conserved PBZ, PIP

109 This fusion results from the concerted action of its two envelope glycoproteins, the

110 The concerted action of JAK kinases, members of the Src-kina

111 are positioned in space and time through the concerted action of key mitotic entry biochemical regula

112 During homeostasis, the concerted action of local niche signals and epigenetic r

113 l model of spore inhalation and clearance by concerted actions of macrophages and neutrophils, and us

114 Good additivity was found for the concerted action of magainin 2, the fungicidal lipopepti

115 ial developmental response that involves the concerted action of many different cell types, is highly

116 ption, and RNA processing each depend on the concerted action of many different protein and RNA molec

117 etic and environmental cues and requires the concerted action of many genes.

118 ochore and SAC signaling proteins due to the concerted action of many kinases and phosphatases is a s

119 Based on the concerted action of MAPK4-AKT and MAPK4-PDK1 axis in pro

120 mitment and differentiation is driven by the concerted action of master transcriptional regulators at

121 iated fear-memory enhancement results from a concerted action of mechanisms that strengthen memory th

122 results are important for understanding the concerted action of membrane-permeabilizing compounds in

123 etic precursors is needed, necessitating the concerted action of metabolism and protein synthesis dur

124 ter's activity is regulated by Ca(2+) due to concerted action of MICU1 and MICU2, two paralogous, but

125 creening methods are essential to define the concerted actions of miRNAs in cardiovascular disease.

126 mmalian mitochondrial promoters requires the concerted action of mitochondrial RNA polymerase (mtRNAP

127 se entry in metazoans with open mitosis, the concerted action of mitotic kinases disassembles nuclei

128 proteins across cellular membranes with the concerted action of mostly three membrane proteins: TatA

129 We suggest that the concerted action of MtuMutT1 and Rv1700 plays a crucial

130 The mechanism may involve the concerted action of multiple antiretroviral effectors co

131 Muscle regeneration is the result of the concerted action of multiple cell types driven by the te

132 ral entry is a complex process requiring the concerted action of multiple cellular elements.

133 te that dynein recruitment to cargo requires concerted action of multiple dynein cofactors.

134 ession of HCV replication is mediated by the concerted action of multiple effectors.

135 While concerted action of multiple elements of the immune syst

136 icrobial phenotypes are typically due to the concerted action of multiple gene functions, yet the pre

137 The concerted action of multiple hydrogen bonds keeps the te

138 y powerful host immune responses through the concerted action of multiple immune-evasins.

139 Tumorigenesis requires the concerted action of multiple pathways, including pathway

140 gulation is a complex process, involving the concerted action of multiple physiologically relevant ef

141 membrane curvature induction depends on the concerted action of multiple proteins, controlling the l

142 ar matrix (ECM) remodeling, which requires a concerted action of multiple proteolytic enzymes and the

143 x polarizes diverse animal cells through the concerted action of multiple regulators.

144 king during synaptic plasticity requires the concerted action of multiple signaling pathways and the

145 hemokine signals may be mediated through the concerted action of multiple suppressive pathways that p

146 Our results therefore demonstrate the concerted action of multiple synaptic mechanisms for rob

147 The regulation of transcription involves the concerted action of multiple transcription factors (TFs)

148 Cellular identity requires the concerted action of multiple transcription factors (TFs)

149 cles to transcription may be overcome by the concerted actions of multiple accessory factors.

150 l protein S6 kinase is regulated through the concerted actions of multiple phosphatases and kinases.

151 velopment of the nervous system requires the concerted actions of multiple transcription factors, yet

152 minant pathways are defined that require the concerted action of multivalent membrane Ig cross-linkin

153 acellular membrane fusion is mediated by the concerted action of N-ethylmaleimide-sensitive factor at

154 urs relatively slowly and is mediated by the concerted actions of natural IgM and complement.

155 ede tumor development by years, requires the concerted actions of nearly a dozen EBV proteins and num

156 Stem cell self-renewal is controlled by concerted actions of niche signals and intrinsic factors

157 uration of the second P-cluster requires the concerted action of NifZ, Fe protein, and MgATP and that

158 se results reveal a fundamental role for the concerted action of NO and O2 in physiological regulatio

159 adrenergic activation, are regulated through concerted actions of NO synthase/GSNOR and that aberrant

160 rosine nitration and loss of activity by the concerted action of NOS-3 and XO were also confirmed in

161 ellular repair capacity by orchestrating the concerted actions of nucleotide excision repair (NER) an

162 is a dynamic process that is governed by the concerted action of numerous cell cycle regulatory prote

163 cellular function, and is maintained by the concerted action of numerous nuclear proteins, including

164 f breast cancer cells was achieved through a concerted action of OM on cell cycle components.

165 e-RC), which is loaded onto chromatin by the concerted action of origin recognition complex, Cdc6, an

166 Osteoclast formation depends on the concerted action of osteoblast-derived receptor activato

167 Strikingly, the concerted action of p53 and POLiota decelerates nascent

168 y controlling the expression of Pax3 and the concerted action of Pax3 and Sox10 on their target genes

169 This can be achieved by a concerted action of peptidoglycan (PG) hydrolases and PG

170 rly coded proteins Pet309p, Pet111p, and the concerted action of Pet54p, Pet122p, and Pet494p, respec

171 ar matrix (ECM) organization and require the concerted action of planar cell polarity (PCP) proteins

172 )K27 H3 histone modifications created by the concerted action of Polycomb (PcG) and Trithorax histone

173 or single S5-6 region was replaced suggest a concerted action of pore-lining regions in the control o

174 somes migrate and are positioned through the concerted action of PP2A-B55/SUR-6-regulated nuclear env

175 Concerted action of priming and activating amino acids i

176 yotic genome is rigorously controlled by the concerted action of protein factors and RNAs.

177 malian cells through G1 is controlled by the concerted action of protein kinases, the activities of w

178 -infected and tumor cell targets through the concerted action of proteins contained in cytolytic gran

179 The concerted actions of PRR signaling, specific viral-restr

180 ecQ but not with UvrD helicase, suggesting a concerted action of RecQ helicases and pol delta.

181 ating is a cooperative process involving the concerted action of residues from more than a single pro

182 ised, receptors are polyubiquitylated by the concerted action of RF10 and RF12 and degraded.

183 Our data showed that the concerted action of Rho and Rac modulate the establishme

184 precursors is regulated by actin and by the concerted action of Rho- and p21-activated kinases.

185 associated siRNAs involves the noncanonical, concerted action of RNA POLYMERASE IV, RNA-DEPENDENT RNA

186 umulation during inflammation depends on the concerted action of selectin and integrin adhesion molec

187 Through the concerted action of selective Watson-Crick base-pairing

188 n iron homeostasis is maintained through the concerted action of sensory and regulatory networks that

189 e expression during development requires the concerted action of sequence-specific transcriptional re

190 Drosophila compound eye is specified by the concerted action of seven nuclear factors that include E

191 cell homing to the bone marrow requires the concerted action of several adhesion molecules.

192 The concerted action of several cytokines is necessary for r

193 that transgene locus formation involves the concerted action of several DNA break-repair mechanisms.

194 c(2) N-glycan structures is catalyzed by the concerted action of several exoglycosidases, including a

195 lum-Golgi complex-trans-Golgi network by the concerted action of several glycosyltransferases, an epi

196 Although many genes are regulated by the concerted action of several hormones, hormonal signaling

197 in (Blimp)-1-dependent program involving the concerted action of several proplasma transcriptional re

198 Eukaryotic DNA mismatch repair requires the concerted action of several proteins, including prolifer

199 ular inflammation and thrombosis require the concerted actions of several different agonists, many of

200 The concerted actions of Shh and Bmp7 can direct mouse embry

201 and self-renewal--whose balance requires the concerted action of signal transduction pathways, transc

202 Mammalian organogenesis results from the concerted actions of signaling pathways in progenitor ce

203 educes their expression levels, suggesting a concerted action of Smad2 and -4 in regulating TGF-beta

204 eaction in regulated exocytosis requires the concerted action of soluble N-ethylmaleimide-sensitive f

205 , water, and urea are reabsorbed through the concerted actions of solute carrier channels and aquapor

206 Through the concerted action of specialized stress sensors, the prot

207 lesions during genomic replication requires concerted actions of specialized DNA polymerases in a po

208 and conformational remodeling fueled by the concerted action of specific RNA-dependent ATPases/helic

209 that transcriptional activation through the concerted action of SREBP and Sp1 can occur by at least

210 cholesterol synthesis are stimulated by the concerted action of SREBPs along with coregulators that

211 ll self-renewal is tightly controlled by the concerted action of stem cell-intrinsic factors and sign

212 li, PI-1 and PI-2, both of which require the concerted action of structural proteins and sortases for

213 dence for molecular mechanisms involving the concerted actions of SUD-M and SUD-C, which result in sp

214 nance of female sexual identity requires the concerted actions of Sxl and bam.

215 Our results highlight the concerted actions of synaptic excitation and inhibition

216 us type 1 (HTLV-1) expression depends on the concerted action of Tax, which drives transcription of t

217 Expression of the virus depends on the concerted action of Tax, which drives transcription of t

218 FPR-blocked and active thrombin indicated a concerted action of the active site and exosite I during

219 is in Saccharomyces cerevisiae occurs by the concerted action of the actomyosin system and septum for

220 ar dopamine levels and is metabolized by the concerted action of the aromatic amino acid decarboxylas

221 ing the viral and cellular membranes via the concerted action of the attachment (G) and fusion (F) gl

222 Plant root development is mediated by the concerted action of the auxin and cytokinin phytohormone

223 atterning of vertebrate embryos requires the concerted action of the Bone Morphogenetic Protein (BMP)

224 s from Saccharomyces cerevisiae involves the concerted action of the cap-binding protein eIF4E and th

225 Our results allow us to propose a concerted action of the four conserved cysteines of VKOR

226 nvelope with the plasma membrane through the concerted action of the fusion (F) protein and the recep

227 Carbamoyl phosphate synthesis requires the concerted action of the glutaminase (GLN) and carbamoyl-

228 on, and will be useful for understanding the concerted action of the mechanisms that drive self-assem

229 scade reactions, less is known about how the concerted action of the microvilli population encodes li

230 ibosylnicotinamide to NAD which involves the concerted action of the PnuC transporter and NRK, follow

231 lyl conformers that can be interconverted by concerted action of the RBD4 and CY domains of RanBP2.

232 Here, we show that the concerted action of the RecFOR complex directs the loadi

233 SRP1/pY is recycled from the ribosome by the concerted action of the ribosome-recycling factor (RRF)

234 , and a deacylated tRNA, is processed by the concerted action of the ribosome-recycling factor (RRF),

235 proteasome-dependent degradation due to the concerted action of the scaffolding protein Axin and its

236 class of effector molecules dependent on the concerted action of the SH3, SH2, and catalytic domains

237 the endoplasmic reticulum is mediated by the concerted action of the signal recognition particle (SRP

238 holesterol homeostasis is maintained through concerted action of the SREBPs and LXRs.

239 Paramyxoviruses initiate entry through the concerted action of the tetrameric attachment glycoprote

240 e cytokinetic Z ring at midcell requires the concerted action of the three Min proteins.

241 These results indicated that the concerted action of the three mutated residues (D86A, E8

242 Depending on the oxygen tension, a concerted action of the three transcription factors regu

243 We have studied the concerted action of the three underlying mechanisms, nam

244 an early progenitor stage, indicating that a concerted action of the transcription factor Runx1, toge

245 engage gene expression programs through the concerted action of the transcription factors ATF4, ATF6

246 ynthesis of carbamoyl phosphate requires the concerted action of the two active sites within the homo

247 ce toward the derepressed state, revealing a concerted action of the two boundaries at a distance.

248 The concerted actions of the CNS and the immune system are e

249 hesis and cell shape maintenance require the concerted actions of the CrgA, Rv0008c, FtsI, and Wag31

250 t takes several hours and is mediated by the concerted actions of the group IV cytosolic phospholipas

251 Piloerection (goosebumps) requires concerted actions of the hair follicle, the arrector pil

252 g nicking and powered by ATP hydrolysis, the concerted actions of the helicase and nuclease domains o

253 osphatidylinositol at its site of use by the concerted actions of the phosphoinositide kinases and PL

254 on epigenetic regulation carried out by the concerted actions of the Polycomb and Trithorax group of

255 cytoskeletal structures by orchestrating the concerted actions of the triumvirate of SphK1, FLNa, and

256 The concerted actions of the ZRR complex increase pools of e

257 rent substrate specificities and require the concerted action of their transmembrane domains (TMDs) a

258 sing the viral and target cell membranes via concerted action of their two envelope glycoproteins: th

259 formation is most likely orchestrated by the concerted action of these different parts of the protein

260 ensity of docked vesicles, suggesting that a concerted action of these mechanisms underlies the funct

261 of events in wild-type cells, demonstrate a concerted action of these proteins prior to, and indepen

262 ontaneous STIM1 activation, showing that the concerted action of these relatively weak restraints ser

263 The concerted actions of these enzymes largely determine the

264 The individual and/or concerted actions of these pathways could be leveraged t

265 majority of proteins in mammalian cells by a concerted action of three distinct pairs of active sites

266 s, this process is tightly controlled by the concerted action of three G proteins, the 54-kD subunit

267 of herpes simplex virus is regulated by the concerted action of three immediate-early (alpha) protei

268 his is established during development by the concerted action of tissue-level, intercellular planar c

269 The repression of transcription, through the concerted actions of tissue specific DNA binding protein

270 olycistronic mRNAs that are dissected by the concerted action of trans-splicing and polyadenylation.

271 different patterns can be maintained by the concerted action of transcription factors (TFs), it was

272 development and stress response requires the concerted action of transcription factors and chromatin-

273 activation in higher eukaryotes requires the concerted action of transcription factors and coactivato

274 pecification and commitment is driven by the concerted action of transcription factors and IL-7 signa

275 The concerted action of transcriptional repressors, chromati

276 This reaction is a result of the concerted action of two catalytic domains of FDH, the am

277 for selective histone exchange that uses the concerted action of two distinct chromatin-remodeling en

278 of the Paramyxovirinae subfamily rely on the concerted action of two envelope glycoprotein complexes,

279 Here we show that the concerted action of two enzymes commonly involved in nat

280 es its direct interaction with Bim1p and the concerted action of two MT motors-Kip3p and dynein.

281 rrelations can be explained as a result of a concerted action of two mutation mechanisms, which we na

282 ontrol the timing of output pathways via the concerted action of two oppositely acting enzymes.

283 are segregated at cell division involves the concerted action of two plasmid-encoded proteins that as

284 Fusion is orchestrated via the concerted action of two surface glycoproteins: an attach

285 is B cell fate decision is determined by the concerted action of two surface proteins on activated T

286 d a complex polyferredoxin, each require the concerted action of two translocases for their assembly.

287 the trans-Golgi network (TGN) depends on the concerted action of two types of tethering factors: long

288 f enveloped viruses enters cells through the concerted action of two viral glycoproteins.

289 c cycling, which is tightly regulated by the concerted actions of two highly conserved enzymes, serve

290 Vs mediate entry into host cells through the concerted actions of two surface glycoproteins: a recept

291 our knowledge, a possible mechanism for the concerted action of tyrosine kinases, GIT1/betaPIX prote

292 Ubiquitination is mediated by the concerted action of ubiquitin-conjugating enzymes (Ubcs

293 extricated from the clathrin lattice by the concerted action of up to six Hsc70 molecules, which int

294 This process requires the concerted action of various proteins, including Apg5p.

295 e size of which can be remodeled through the concerted actions of various cues.

296 Reovirus infection requires the concerted action of viral and host factors to promote ce

297 nscribed in infected plant cells through the concerted action of viral and host factors.

298 action potential (AP) is transmitted by the concerted action of voltage-gated ion channels.

299 uning of persistent activity arises from the concerted action of widespread inhibition mediated by pe

300 while viral genome replication requires the concerted action of Zta and six other viral proteins at