ライフサイエンスコーパス: concussion

1 l Modification diagnosis codes indicative of concussion.

2 the direct result of, or be exacerbated by, concussion.

3 urn to school and activities gradually after concussion.

4 urenine metabolites following sports-related concussion.

5 tom exacerbations (spikes) in children after concussion.

6 ate using both in vitro and murine models of concussion.

7 enefits of early physical activity following concussion.

8 n suspected traumatic brain injury (TBI) and concussion.

9 ct, in the absence of a clinically diagnosed concussion.

10 return to play less than 24 hours after the concussion.

11 st enduring physiological deficits following concussion.

12 ld validity for predicting outcome following concussion.

13 ppears greater among those with a history of concussion.

14 and 6 control participants with MCI without concussion.

15 Mechanism and sport-specific activity of concussion.

16 nd related health care utilization rates for concussion.

17 sociated with duration of symptoms following concussion.

18 f symptoms in student athletes who sustain a concussion.

19 ng about return to play after sports-related concussion.

20 ily structure and history of brain injury or concussion.

21 cussion symptoms (PCS) in children following concussion.

22 elationship is not explained by a history of concussion.

23 None of the players experienced a concussion.

24 growing demand for objective evaluations of concussion.

25 f mild traumatic brain injury, also known as concussion.

26 whether or not symptoms were associated with concussion.

27 ge, 1-21 years) since the last self-reported concussion.

28 f multiple abnormal menstrual patterns after concussion.

29 ury currently arouses stronger interest than concussion.

30 aging in the absence of clinically diagnosed concussions.

31 efforts to effectively reduce soccer-related concussions.

32 Test scores, and the number of grade 3 (G3) concussions.

33 .6% of boys' concussions and 25.3% of girls' concussions.

34 symptoms for both sexes was history of prior concussions.

35 Heading the ball accounted for 30.5% of concussions.

36 ental health of athletes who suffer multiple concussions.

37 heading in the prior 12 months and lifetime concussions.

38 ith retired athletes without a history of G3 concussion (1 of 5) older than 63 years (P = .01).

39 Of the 68 patients who had a concussion, 16 (23.5%) experienced 2 or more abnormal me

40 athletes, 8 of whom had MCI and a history of concussion, 21 cognitively healthy control participants,

41 Concussion, a form of mild TBI, might be associated with

42 nts were aged 11 to 18 years and sustained a concussion (according to the Centers for Disease Control

43 our knowledge, little research has examined concussion across the youth/adolescent spectrum and even

44 Ten recently concussion adolescents and young adults completed 20 day

45 injury (mTBI), also commonly referred to as concussion, affects millions of Americans annually.

46 Twelve sustained concussions after baseline testing then completed post-i

47 n in 81 youth athletes (18 with a history of concussion, ages 13-18) during the tests of the Nike Sen

48 Patients who recovered from concussion also had lower HRQoL than norms at 4 weeks (m

49 However, concussions also occur in several other settings, such a

50 lear whether mild traumatic brain injury, or concussion, also confers risk.

51 in US high schools and is a leading cause of concussion among adolescents.

52 ommon mechanism of injury in heading-related concussions among boys (78.1%) and girls (61.9%).

53 s concussions, little research has evaluated concussions among middle-school athletes.

54 33 (1.35-4.04, p = 0.002) for 1 diagnosis of concussion and >1 diagnosis of concussion, respectively,

55 Among the athletes, 17 had a G3 concussion and 11 did not.

56 ed return to play at least 30 days after the concussion and 3.1% resulted in return to play less than

57 tion between HRQoL and PPCS at 4 weeks after concussion and assess the degree of impairment of HRQoL

58 sociation between sustaining a sport-related concussion and cognitive impairment later in life.

59 Diagnoses of concussion and control diagnoses of broken limb bones we

60 es in serum proteins following sport-related concussion and determine whether candidate biomarkers di

61 presenting to the emergency department with concussion and head injury within the previous 48 hours

62 ry is a primary neuropathological feature of concussion and is thought to greatly contribute to the c

63 e neurocognitive sequelae of a sport-related concussion and its management are poorly defined.

64 but no objective test reliably identifies a concussion and its severity.

65 Concussion and mild traumatic brain injury (TBI) are int

66 linked to conversations about sport-related concussion and mild traumatic brain injury.

67 calable biological marker for sports-related concussion and other types of mild traumatic brain injur

68 sociation between sustaining a sport-related concussion and poorer cognitive function later in life i

69 Concussion and subconcussive impacts have been associate

70 prospective evidence of reduced CBF in human concussion and subsequent recovery.

71 lationship between long-term consequences of concussion and the function of the hypothalamic-pituitar

72 d patient populations (ie, those affected by concussion and those affected by various degrees of trau

73 History of clinician-diagnosed concussion and years of football experience.

74 re was a significant inverse relationship of concussion and years of football played with hippocampal

75 fic activity, responsible for 30.6% of boys' concussions and 25.3% of girls' concussions.

76 nts included sprains and strains, fractures, concussions and bleeding.

77 compared with less severe injuries, such as concussions and cranial fractures, more severe injuries,

78 GROUND AND The relationship between repeated concussions and neurodegenerative disease has received s

79 o significant associations between number of concussions and performance on cognitive tests.

80 Until now, the interacting effects of concussions and the normal ageing process on white matte

81 ed by sex, age at death, severity (including concussion), and different follow-up times after diagnos

82 use of a recovery position, recognition of a concussion, and 6 other first aid topics.

83 tive diagnostic biomarkers for sport-related concussion, and inflammatory markers may provide prognos

84 protein B were measured immediately after a concussion, and they decreased during rehabilitation.

85 l injuries regardless of severity, including concussions, and athlete exposure information were docum

86 The effects of TBI and concussion are not restricted to cognition and balance.

87 While concussions are recognized etiological factors for a spe

88 ld likely be a more effective way to prevent concussions as well as other injuries.

89 l neurocognitive testing with Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT).

90 urocognitive testing with the Immediate Post-Concussion Assessment and Cognitive Testing evaluation w

91 on symptom scale), cognition (Immediate Post-Concussion Assessment and Cognitive Testing), and balanc

92 s has a potential clinical utility of proper concussion assessment and management.

93 linical preseason baseline testing regarding concussion assessment measures.

94 The Child Sport Concussion Assessment Tool (SCAT3) is a postconcussion s

95 Football practices were a major source of concussion at all 3 levels of competition.

96 l volume compared with athletes without a G3 concussion at the 40th percentile (P = .03), 60th percen

97 d injury models are important tools to study concussion biomechanics but are impractical for real-wor

98 tic brain injury (mTBI), also referred to as concussion, can result in chronic post-concussive syndro

99 with more Medicaid patients using the ED for concussion care (478/1290 Medicaid patients [37%] used t

100 he importance of the primary care setting in concussion care management, and demonstrate the potentia

101 Concussions carry devastating potential for cognitive, n

102 cessing of sound correctly identifies 90% of concussion cases and clears 95% of control cases, sugges

103 I; eg, sports concussions), whether repeated concussions cause long-term cognitive deficits remains c

104 tic brain injury (mTBI, often referred to as concussion) causes differential mitochondrial responses

105 erity, cognition (Standardized Assessment of Concussion-child version [SAC-C]), and balance (modified

106 ts (5-17 years) presenting to three tertiary concussion clinics between April 2018 and March 2019.

107 d to patient populations presenting to sport concussion clinics or to emergency departments (EDs) and

108 e first study to show an association between concussion, cognition, and anatomical structural brain c

109 Concussions comprised 9.6%, 4.0%, and 8.0% of all injuri

110 All eligible patients had concussions consistent with the Zurich consensus diagnos

111 Concussion cumulative incidence, incidence rate, and des

112 opathological evaluation of a swine model of concussion demonstrated a notably similar pattern of axo

113 In current usage 'concussion' describes a clinical presentation, but does

114 such as facilitating head impact sensors in concussion detection via a mobile device.

115 Specifically, we hypothesize that concussions disrupt the processing of the fundamental fr

116 We hypothesize that concussions disrupt these auditory processes, and that t

117 Twenty-three were not diagnosed with a concussion during the season and completed both baseline

118 Concussions during practice might be mitigated and shoul

119 n Symptoms Questionnaire scores and lifetime concussion events (rho = 0.58, P = .02 and rho = 0.52, P

120 Here we show that children who sustained a concussion exhibit a signature neural profile.

121 es without concussions, former athletes with concussions exhibited widespread white matter anomalies

122 ely one-third of children experiencing acute concussion experience ongoing somatic, cognitive, and ps

123 and psychosocial functioning in relation to concussion exposure and apolipoprotein epsilon4 status.

124 rmance on these measures was associated with concussion exposure.

125 biomechanics at the micro- and mesoscale of concussion, few have addressed the multiscale transmissi

126 Even in the absence of concussion, football players may experience repeated BBB

127 control group of 15 retired athletes without concussions, former athletes with concussions exhibited

128 age in 15 retired athletes with a history of concussions, free of comorbid medical conditions.

129 adolescents aged 5.00-17.99 years with acute concussion from 9 Pediatric Emergency Research Canada ne

130 Thirty-five players had a concussion from September 13, 2012, to January 31, 2013;

131 Clearly differentiating concussion from traumatic brain injury is essential to a

132 Importance: Recovery from concussion generally follows a trajectory of gradual imp

133 Older retired athletes with at least 1 G3 concussion had significantly smaller bilateral hippocamp

134 Players with and without a history of concussion had smaller hippocampal volumes relative to h

135 Players with a history of concussion had smaller hippocampal volumes than players

136 former college players with more than three concussions had lower FA in a broadly distributed area o

137 erved: Nonspeed players with more than three concussions had lower FA in frontal white matter compare

138 Over the past decade, concussion has become the most widely discussed injury i

139 Previous epidemiologic research on concussions has primarily been limited to patient popula

140 rial changes in regional CBF following human concussion have yet to be performed.

141 Sports-related concussions have been shown to lead to persistent subcli

142 Lifetime concussion history and demographic features were not sig

143 .5 [8] vs 60.24 [7]; P = .002); those with a concussion history and MCI performed worse (mean [SD], 3

144 D PSC revealed a similar interaction between concussion history and position (all adjusted P < .004).

145 A separate interaction between concussion history and position was observed: Nonspeed p

146 Retired athletes with concussion history but without cognitive impairment had

147 ive PSD ratio was significantly lower in the concussion history group on the tests of target capture,

148 ferences between athletes with and without a concussion history on 5 cognitive measures but did show

149 aying position seem to modify the effects of concussion history on white matter structure and neural

150 cant interaction between career duration and concussion history was observed; former college players

151 ross three crossed factors: career duration, concussion history, and primary playing position.

152 hanges in those with a history of mTBI (i.e. concussion), however, have not been consistently reporte

153 edical care of children and adolescents with concussion (ie, the Lystedt Law), with all other states

154 ectral density (PSD) ratio to the history of concussion in 81 youth athletes (18 with a history of co

155 Concussion in adolescence was associated with a raised r

156 There is continuing concern about effects of concussion in athletes, including risk of the neurodegen

157 Child SCAT3 scores for young athletes with a concussion in athletic and clinical settings.

158 To assess whether concussion in childhood or adolescence is associated wit

159 notable association with MS was observed for concussion in childhood, or broken limb bones in childho

160 re symptomology and prolonged recovery after concussion in children and adolescents.

161 and at 24 to 48 hours (late acute) following concussion in football players (n = 106), matched uninju

162 Sports-related concussion in professional ice hockey players is associa

163 Understanding whether concussion in sport is associated with worsening cogniti

164 differences across states, rates of treated concussion in states without legislation were 7% higher

165 had 1 or more in-person clinical visits for concussion in the CHOP unified electronic health record

166 958 high school athletes from Maine with no concussion in the past 6 months who completed a preseaso

167 h care utilization rates among children with concussion in the United States are both directly and in

168 The estimated number of concussions in RIRP averaged 14 (median=7; IQR 5-40).

169 Despite a high number of concussions in RIRP, differences in mental health, socia

170 ify network activity changes after simulated concussions in vitro and therewith develop a platform fo

171 The findings suggest estimates of concussion incidence based solely on ED visits underesti

172 Medicine called for comprehensive nationwide concussion incidence data across the spectrum of athlete

173 Cumulative concussion incidence was 13.0% per season, and the incid

174 Concussion is frequently undiagnosed as a cause of psych

175 s on traumatic brain injury and assumes that concussion is merely a mild form of traumatic brain inju

176 jor impediment to improving the treatment of concussion is our current inability to identify patients

177 sulted in a lack of understanding about what concussion is, and how to diagnose, monitor, and treat i

178 presenting with a history of sports-related concussions is linked to diffuse white matter abnormalit

179 Mild traumatic brain injury (mTBI, cerebral concussion) is a risk factor for the development of psyc

180 Mild traumatic brain injury, or concussion, is associated with a range of neural changes

181 During the same period, states with concussion laws demonstrated a 10% higher concussion-rel

182 ion legislation, and (3) the effect of state concussion laws on trends in states with concussion legi

183 from the Veterans Affairs-Boston University-Concussion Legacy Foundation and Framingham Heart Study

184 Concussion legislation has had a seemingly positive effe

185 ate concussion laws on trends in states with concussion legislation in effect by means of negative bi

186 (2) postlegislation trends in states without concussion legislation, and (3) the effect of state conc

187 are both directly and indirectly related to concussion legislation.

188 pite recent increased awareness about sports concussions, little research has evaluated concussions a

189 tes has passed legislation for sport-related concussion, making this health issue important for physi

190 cations, monitoring menstrual patterns after concussion may be warranted in this population.

191 tact with another player was the most common concussion mechanism.

192 lso increased in players with sports-related concussion(median, 0.075 mug/L; range, 0.037-0.24 mug/L)

193 ential confounders including age, sex, prior concussions, migraine, anxiety, learning disability, dep

194 kynurenine levels would correlate with post-concussion mood symptoms.

195 egiate football players without a history of concussion (n = 25), and non-football-playing, age-, sex

196 layers with a history of clinician-diagnosed concussion (n = 25), collegiate football players without

197 lescent and young women with a sport-related concussion (n = 68) or a nonhead sport-related orthopedi

198 at 1-week (N=14; 9.29 days) and 1-month post-concussion (N=14, 30.93 days).

199 t the frequency-following response indicates concussion occurrence and severity.

200 ntional research should target the effect of concussion on HRQoL.

201 Sport-related concussion or nonhead sport-related orthopedic injury.

202 in 30 days after a sport-related injury to a concussion or sports medicine clinic at a single academi

203 There was no evidence that concussion or vision symptom trajectories varied over ti

204 Multiple concussions or even a single moderate to severe TBI can

205 e development of AD pathology after repeated concussions or TBI.

206 rovided an independent measure of real-world concussion outcome (ie, number of days withheld from com

207 Finally, concussed athletes with worse concussion outcome, defined as number of days until retu

208 were more common if reporting more than nine concussions (p=0.028), although these symptoms were not

209 Among 637 eligible concussion patients, 155 (24%) reported pre-existing anx

210 53 athlete exposures (AEs) among girls (4.50 concussions per 10,000 AEs), and 442 concussions were su

211 tained during 1,592,238 AEs among boys (2.78 concussions per 10,000 AEs).

212 g participants aged 5 to 18 years with acute concussion, physical activity within 7 days of acute inj

213 likely have immediate repercussion on sports concussion prevention and management policy and sporting

214 main outcome measure was the Rivermead Post-Concussion Questionnaire-16 (RPQ-16) collected before co

215 concussion rate was higher than the practice concussion rate across all 3 competitive levels.

216 The game concussion rate for college athletes (3.74 per 1000 athl

217 The practice concussion rate in college (0.53 per 1000 athlete exposu

218 The game concussion rate was higher than the practice concussion

219 Concussion rates in young female soccer players are grea

220 air with his or her head) given the rise in concussion rates, with some calling for a ban on heading

221 better understand individual differences in concussion recovery.

222 er NFL players with and without a history of concussion recruited from the North Texas region and age

223 from youth soccer would likely prevent some concussions, reducing athlete-athlete contact across all

224 Baseline scores on a computerized concussion-related cognitive battery were used for cogni

225 ut legislation had a 75% overall increase in concussion-related health care utilization during the sa

226 the following: (1) prelegislation trends in concussion-related health care utilization from January

227 th concussion laws demonstrated a 10% higher concussion-related health care utilization rate compared

228 th legislation experienced a 92% increase in concussion-related health care utilization, while states

229 The study evaluated whether concussion-related neurophysiological impairments were d

230 olescent spectrum and even less has examined concussion-related outcomes (ie, symptoms and return to

231 Differences in concussion-related outcomes existed by level of competit

232 differences or level-specific variations in concussion-related policies and protocols, athlete train

233 r of impacts to the head or neck followed by concussion-related symptoms, exhibited greater dual task

234 o were > 28 days postconcussion, had chronic concussion-related symptoms, had normal visual acuity, a

235 The initial concussion-related visit was selected and variation in t

236 Safely returning athletes to sport after concussion relies on accurately determining when their s

237 rkers are more efficient at deciphering post-concussion residual neurocognitive deficits and thus has

238 diagnosis of concussion and >1 diagnosis of concussion, respectively, compared with none.

239 Concussion resulted in significantly increased amplitude

240 The 1-season concussion risk was highest in high school (9.98%) and c

241 Youth football had the lowest 1-season concussion risks in 2012 (3.53%) and 2013 (3.13%).

242 nsitive approach for sideline or post-injury concussion screening.

243 conflicts, mTBI patients with even a single concussion showed a significant slow-down in all respons

244 rise the evidence on the association between concussion sustained by professional/elite athletes and

245 Concussions sustained during high school-sanctioned socc

246 Primary outcomes were mean concussion symptom and vision symptom severity scores me

247 r conceptualizing, collecting, and analyzing concussion symptom data.

248 re persistent symptoms on the validated Post-Concussion Symptom Inventory at 4 weeks.

249 (>/=3 new or worsening symptoms on the Post-Concussion Symptom Inventory) was assessed at 28 days po

250 There were few differences in concussion symptom patterns by injury mechanism.

251 Secondary outcomes, time to concussion symptom recovery and time to return to academ

252 Total concussion symptom scores varied from 2 to 97 (mean +/-

253 In the absence of a recent concussion, symptom reporting is related to sex and pree

254 Better characterization of acute concussion symptomatology is needed in order to advance

255 d a number of idiosyncratic features of post-concussion symptomatology.

256 To identify predictors of persistent concussion symptoms (PCS) in children following concussi

257 uency partially recover to control levels as concussion symptoms abate, suggesting a gain in biologic

258 ted an additional 2.64 (95% CI 1.84 to 3.44) concussion symptoms and 7.45 (95% CI 5.22 to 9.68) highe

259 We inquired weekly about concussion symptoms and, if present, the symptom type an

260 he temporal and structural dynamics of acute concussion symptoms at the individual-patient level.

261 ayers were also assessed with Rivermead Post Concussion Symptoms Questionnaire and magnetic resonance

262 oncentrations correlated with Rivermead Post Concussion Symptoms Questionnaire scores and lifetime co

263 Compared with youth, a higher number of concussion symptoms were reported in high school athlete

264 ury, general and mental health, life stress, concussion symptoms, cognitive function, disability and

265 cological momentary assessment (EMA) of post-concussion symptoms.

266 d function that occur independently of overt concussion symptoms.

267 l and scientific understanding of persistent concussion symptoms.

268 useful therapeutically in acute TBI and post-concussion syndrome.

269 matter compared with those with zero to one concussion (t25 = 3.861; adjusted P = .002).

270 matter compared with those with zero to one concussion (t29 = 2.774; adjusted P = .037), and the opp

271 ler hippocampal volumes than players without concussion (t48 = 3.15; P < .001; mean difference, 761 m

272 ce, 1788 muL; 95% CI, 1317-2258 muL; without concussion: t48 = 4.35; P < .001, mean difference, 1027

273 lative to healthy control participants (with concussion: t48 = 7.58; P < .001; mean difference, 1788

274 was significantly higher among patients with concussion than among those with an orthopedic injury (o

275 or ability in the athletes with a history of concussion that may have implications for diagnosis, reh

276 Prior concussion that results in loss of consciousness is a ri

277 symptom, and the proportion of patients with concussions that had long return-to-play time (ie, requi

278 is the most common activity associated with concussions, the most frequent mechanism was athlete-ath

279 njury as a likely pathological substrate for concussion, thereby providing a framework to develop tru

280 e of traumatic brain injury (TBI), from mild concussion to severe, penetrating injury.

281 Importance: Although concussion treatment guidelines advocate rest in the imm

282 By examining concussion visits across an entire pediatric health care

283 Frequency of initial concussion visits at each type of health care location.

284 Concussion visits in the EHR were defined based on Inter

285 y prognosticators of PCS following pediatric concussion was conducted.

286 mpal volume in retired athletes with MCI and concussion was significantly smaller compared with contr

287 injury and were considered to have an acute concussion were enrolled across 9 pediatric emergency de

288 In RIRP, persisting symptoms attributed to concussion were more common if reporting more than nine

289 Athletes with a history of G3 concussion were more likely to have MCI (7 of 7) compare

290 Overall, 1429 sports-related concussions were reported among youth, high school, and

291 Overall, 627 concussions were sustained during 1,393,753 athlete expo

292 s (4.50 concussions per 10,000 AEs), and 442 concussions were sustained during 1,592,238 AEs among bo

293 hological patterns consistent with models of concussion wherein brainstem white matter tracts undergo

294 ld traumatic brain injury (rmTBI; eg, sports concussions), whether repeated concussions cause long-te

295 tors have yet to evaluate the association of concussion with menstrual patterns in young women.

296 physician-diagnosed migraine history, prior concussion with symptoms lasting longer than 1 week, hea

297 escent and young women after a sport-related concussion with those after sport-related orthopedic inj

298 Among the 351 soccer players, there were 59 concussions with 43 742 athletic exposure hours.

299 wer leg injury within the past 2 months or a concussion within the past month.

300 compared with those who have recovered from concussion, yet deficits in HRQoL are pervasive across a