ライフサイエンスコーパス: condensate

1 rated membraneless organelles ("biomolecular condensates").

2 oid matrix is a phase-separated, liquid-like condensate.

3 ible for the spatial stability of the magnon condensate.

4 citation spectrum of a thermalised polariton condensate.

5 s and nucleic acids into a single functional condensate.

6 strate, K-Ras, into the LAT:Grb2:SOS protein condensate.

7 ith a definite direction with respect to the condensate.

8 ion into dynamic three-dimensional molecular condensates.

9 ts1/Smaug drives self-assembly into gel-like condensates.

10 led atomic(28) and solid-state polariton(29) condensates.

11 S) are among the most prominent biomolecular condensates.

12 romote the formation of various biomolecular condensates.

13 quid-like properties, they remained distinct condensates.

14 here specific identities are established for condensates.

15 ch and P:H-rich foci inside the droplet-like condensates.

16 d composition of multicomponent biomolecular condensates.

17 n formation of concentrated, phase-separated condensates.

18 hat have been observed for many biomolecular condensates.

19 ty of and are enriched within multicomponent condensates.

20 RNA granules are protein/RNA condensates.

21 ons with RNA, giving rise to small and fluid condensates.

22 gth and time scales relevant to biomolecular condensates.

23 h properties of membraneless phase-separated condensates.

24 es an inner ring barrier with two vestibular condensates.

25 to predict the composition of multicomponent condensates.

26 trol the pathological gelation of functional condensates.

27 which are now understood as phase-separated condensates.

28 nhibits LLPS of TFEB and also dissolves TFEB condensates.

29 ents of euchromatic transcriptionally active condensates.

30 also represent phase-separated biomolecular condensates.

31 ely high levels promote dissolution of these condensates.

32 and is stimulated by DNA to form liquid-like condensates.

33 Mx1 nuclear bodies comprised phase-separated condensates.

34 ins and through the assembly of biomolecular condensates.

35 g macromolecular structures that behave like condensates.

36 reby driving immiscibility between different condensates.

37 together with viral RNA, forms biomolecular condensates.

38 n the formation, regulation, and function of condensates.

39 contribute to the formation of biomolecular condensates.

40 ontrolling polynucleotide incorporation into condensates.

41 ght into the physics of magnon Bose-Einstein condensates.

42 ctivity that is characteristic of endogenous condensates.

43 emixing and the formation of phase-separated condensates.

44 se II and its cofactors, within biomolecular condensates.

45 bind Atg8 and mediate phase separation into condensates.

46 yndrome disrupt the ability of MeCP2 to form condensates.

47 odynamics, superconductors and Bose-Einstein condensates.

48 ves RNA molecules into networked RNA/protein condensates.

49 essing (P) bodies-membraneless, biomolecular condensates.

50 ping membranes, recently termed biomolecular condensates.

51 rotypic protein-protein interactions, form a condensate(1) in the Xi.

52 are likely important to functional cellular condensates: (1) the ability to generate condensates wit

53 -dimensional semiconductors, such as exciton condensates(21) and Bose-Hubbard models(22), and optoele

54 smaller assemblies known as transcriptional condensates(8-11).

55 the NF-kappaB subunit p65 to a biomolecular condensate-a mechanism conserved across the Orthopneumov

56 uid-liquid phase separation (LLPS), known as condensates, also facilitate compartmentalization of cel

57 s linked to its organization as a multiphase condensate and how dysregulation of this organization co

58 ear, we generated fibres from single-protein condensates and characterized their structural and mater

59 ituent that defines the identity of cellular condensates and controls the temporal and spatial distri

60 d Frankfurter sausages using different smoke condensates and cooking temperatures.

61 d N protein forms partially ordered gel-like condensates and discrete 15-nm particles based on multiv

62 ssess if (and how) membraneless biomolecular condensates and IDPs/IDRs are functionally involved in k

63 nt findings that implicate specific types of condensates and IDPs/IDRs in important cellular level pr

64 cryptochrome 2 promotes formation of PFK-1.1 condensates and recruitment of aldolase/ALDO-1.

65 a DNA-dependent phase transition to gel-like condensates and SRPK1-mediated phosphorylation likely he

66 emerging evidence regarding the link between condensates and the initiation and progression of cancer

67 The macromolecular features that enable condensates and the regulatory pathways that control the

68 rly work in the field focused on identifying condensates and understanding how their physical propert

69 morphology, including IL-13, cigarette smoke condensate, and retinoic acid deficiency, at concentrati

70 domains that contribute to the formation of condensates, and mutations in MECP2 that lead to Rett sy

71 tion, significantly impaired by hardening of condensates, and regained by substituting its condensati

72 e of aberrant phase transitions, demixing of condensates, and time evolution of material properties,

73 Biomolecular condensates are emerging as an important organizational

74 Biomolecular condensates are found throughout eukaryotic cells, inclu

75 These PAR-mediated condensates are linked to cancer, viral infection, and n

76 In vivo, functional protein-based condensates are often referred to as membraneless organe

77 Many nuclear and cytoplasmic condensates are rich in RNA and RNA-binding proteins (RB

78 We show that these vesicular condensates are stable at specific mixture compositions

79 The mechanisms that recruit transcripts to condensates are under intense study; however, how mRNAs

80 These "bound condensates" are expected to assemble well below the sat

81 a indicate that P bodies, and probably other condensates, are compositionally simpler than suggested

82 hite-opaque TFs can co-assemble into complex condensates as observed on single DNA molecules.

83 modulate the formation and dynamics of these condensates as well as the trafficking of their componen

84 ring relies only on liquid properties of the condensate, as an alternative condensation chemistry als

85 This article discusses the possibility that condensates assemble on multivalent surfaces such as DNA

86 We summarize the conceptual underpinnings of condensate assembly and leverage these concepts by conne

87 wever, especially of phenylalanine's role in condensate assembly because experiments on FtoA and tyro

88 rly in situations where it is important that condensate assembly is spatially constrained, such as ge

89 ncer-related mutations to aberrantly altered condensate assembly, suggesting that condensates play a

90 defined assembly and disassembly of the CPC condensate at the inner centromere can reveal general pr

91 PrLDs support the assembly of multifactorial condensates at a synthetic locus within live eukaryotic

92 Cryo-electron tomography of Ede1-containing condensates, at the plasma membrane and in autophagic bo

93 mersing atomic impurities in a Bose-Einstein condensate (BEC) with near-resonant interactions.

94 report production of rubidium Bose-Einstein condensates (BECs) in an Earth-orbiting research laborat

95 Expansion of the photon component of the condensate boosts the leaky field beyond the boundary of

96 epletion of a high-density exciton-polariton condensate by detecting the spectral branch of elementar

97 e biogenesis and dynamics of phase-separated condensates by serving as assembly platforms or by formi

98 that quantum depletion of exciton-polariton condensates can closely follow or strongly deviate from

99 vidual residues on molecules in biomolecular condensates can provide specificity that gives rise to d

100 Ph SAM-dependent condensates can recruit PRC1 from extracts and enhance P

101 ly been discovered that several such protein condensates can undergo a further irreversible phase tra

102 Phase locking of the two condensates causes formation of a standing wave of the c

103 onally, we show that, during the motion, the condensate cloud harvests non-condensed magnons, which r

104 ed with this approach include exhaled breath condensate collected from cystic fibrosis patients as we

105 The resulting condensates comprise a core of Lge1 encapsulated by an o

106 Here, we investigated whether condensates concentrate small-molecule cancer therapeuti

107 regulates Pol II partitioning into distinct condensates connected with transcription initiation or s

108 al RNP-bodies (BR-bodies) are a biomolecular condensate containing the RNA degradosome mRNA decay mac

109 , transport, and interaction of biomolecular condensates containing distinct sets of nucleoporins.

110 Condensates containing RNA polymerase II (Pol II) materi

111 and concentration of small molecules within condensates contributes to drug pharmacodynamics and tha

112 in which the richly multicomponent nature of condensates could complicate this simple picture.

113 s causes formation of a standing wave of the condensate density and quantized vortices.

114 , which results in a partial compensation of condensate depletion.

115 ensation while other genomic regions promote condensate dissolution, potentially preventing aggregati

116 of RNAs produced during elongation stimulate condensate dissolution.

117 PFK-1.1 condensates do not correspond to stress granules and mig

118 In agreement with a model of condensate-driven transcription initiation, large cluste

119 tole) and the potential application of smoke condensates (e.g., Rudinsmoke C for sausages and Smokez

120 , the components that produce locus-specific condensates, elements of specificity, and the emerging u

121 roperties of HSF1 foci changed; small, fluid condensates enlarged into indissoluble gel-like arrangem

122 ction of cAMP signaling to form biomolecular condensates enriched in cAMP and PKA activity, critical

123 rect experimental evidence that magnons in a condensate exhibit repulsive interaction resulting in th

124 PFK-1.1 condensates exhibit liquid-like properties, including sp

125 studies of enzymatic reactions in biological condensates focusing on basic concepts in enzymology and

126 ole of PARylation in regulating biomolecular condensates, followed by discussion of current knowledge

127 ion (LLPS) compartmentalizes transcriptional condensates for gene expression, but little is known abo

128 Liquid-like N-protein condensates form in mammalian cells in a concentration-d

129 Membraneless organelles or condensates form through liquid-liquid phase separation(

130 ses, the precise sequence features governing condensate formation and identity remain unclear.

131 ity to the reversible and dynamic process of condensate formation is proposed to enable the robust an

132 steps in transcription initiation stimulate condensate formation, whereas the burst of RNAs produced

133 ase transitions exhibit timing jitter in the condensate formation.

134 protein, RNA, and DNA that enable reversible condensate formation; and how these processes are utiliz

135 ol mechanism where low levels of RNA promote condensates formed by electrostatic interactions whereas

136 rt a selective autophagy pathway for protein condensates formed by endocytic proteins in yeast.

137 Condensates formed by MeCP2 selectively incorporate and

138 In recent years, condensates formed by phase separation have emerged as a

139 Vts1 condensates formed from purified protein can transform n

140 AfrLEA6 condensates formed in vitro selectively incorporate targ

141 In vivo, the condensate-forming region of Lge1 is required to ubiquit

142 mical and cellular functions of biomolecular condensates from the recent literature and organize thes

143 years have brought a focus on understanding condensate functions.

144 Excitonic condensate has been long-sought within bulk indirect-gap

145 Whereas the role of RBPs in condensates has been well studied, less attention has be

146 suggest that protein-lncRNA phase-separated condensates have a broader role as regulators of transcr

147 Transcriptional condensates have been hypothesized to phase separate at

148 Phase-separated condensates have been recently discovered at many struct

149 These condensates have common features and emergent properties

150 increase the connectivity of multicomponent condensates have higher critical points as pure systems

151 The exhaled breath condensate hydrogen peroxide concentrations trended towa

152 using this system to measure exhaled breath condensate hydrogen peroxide for monitoring oxidative st

153 We evaluated exhaled breath condensate hydrogen peroxide in 60 patients (ages 20-83;

154 d assay and device to measure exhaled breath condensate hydrogen peroxide in asthma patients and heal

155 Our findings suggest that condensate immiscibility may be a very general feature i

156 We show that G3BP condensates impede RNA entanglement and recruit addition

157 lly, we explore the self-localization of the condensate in a gap-state, driven by the interplay of ef

158 monstrate controlled loading of the coherent condensate in distinct orbital lattice modes of differen

159 tion of the two components of the degenerate condensate in the real space by applying a local pulsed

160 single-molecule tracking as tools to assess condensates in bacteria.

161 our understanding of the widespread roles of condensates in cell biology.

162 the formation of RNA-dependent biomolecular condensates in cells and in vitro.

163 P2 is a dynamic component of heterochromatin condensates in cells, and is stimulated by DNA to form l

164 nin destruction complex to form biomolecular condensates in cells, which concentrate key components t

165 shed light on the formation of biomolecular condensates in cells.

166 protein forms liquid-liquid phase-separated condensates in cellular-like conditions through multifac

167 We also discuss the role of RNA-protein condensates in development, disease and homeostasis, emp

168 st commonly observed topology of RNA-protein condensates in experiments and simulations.

169 In this review, we will discuss the role of condensates in gene activation; the multivalent features

170 ppropriate biophysical properties of protein condensates in gene regulation and cancer.

171 , and modulate the dynamics of intracellular condensates in live cells.

172 characterization of polariton Bose-Einstein condensates in micro-cavities of high quality are at the

173 tissue-specific splicing can influence FXR1 condensates in muscle development and how mis-splicing p

174 dynamic behavior of complex, multicomponent condensates in neurodegeneration.

175 ata suggests a role for multiple perinuclear condensates in organizing the piRNA pathway and promotin

176 bserved in non-equilibrium exciton-polariton condensates in planar semiconductor microcavities.

177 MEG-3 traps mRNAs into non-dynamic condensates in vitro and binds to ~500 mRNAs in vivo in

178 AKAP95 forms phase-separated and liquid-like condensates in vitro and in nucleus.

179 perturb the composition of HOXD13-containing condensates in vitro and in vivo and alter the transcrip

180 rugs become concentrated in specific protein condensates in vitro and that this occurs through physic

181 , which we demonstrate forms phase-separated condensates in vitro, and truncation mutations in the in

182 vely recruited to the surfaces of RNA or RNP condensates in vitro.

183 orm intertwining clusters to build elongated condensates in vivo which are dependent on the Piwi-inte

184 ed droplets in vitro and liquid-like nuclear condensates in vivo, and this ability is negatively regu

185 colytic protein PFK-1.1 can dynamically form condensates in vivo.

186 solution conditions produces supramolecular condensates in which the chromatin is physically constra

187 dense phase to form a liquid droplet (i.e., condensate) in aqueous solution.

188 tifaceted cellular functions of biomolecular condensates, including cell compartmentalization through

189 modulate the biophysical features of native condensates, including their size, shape, viscosity, liq

190 s stabilize various archetypal intracellular condensates-including the nucleolus, Cajal bodies, stres

191 wide range of proteins have been reported to condensate into a dense liquid phase, forming a reversib

192 of the quantum liquid is excited out of the condensate into higher momentum states via interaction-i

193 to create a non-degenerate, single-component condensate is decisive for understanding of underlying p

194 This condensate is required for gene silencing and for the an

195 teraction, it is generally expected that the condensate is unstable with respect to the real-space co

196 The ground state of a fermionic condensate is well protected against perturbations in th

197 One class of such condensates is composed of two polymer species, where ea

198 e find that the fluidity of SYD-2 and ELKS-1 condensates is essential for efficient mixing and incorp

199 nd P-bodies-implying that the composition of condensates is finely tuned by the thermodynamics of the

200 re the liquid-to-solid transition of protein condensates is functional, however, is that of silk spin

201 While the irreversible gelation of protein condensates is generally related to malfunction and dise

202 Transition of NPR1 into condensates is required for formation of the NPR1-Cullin

203 The stable excited nature of the condensate lattice with strong interactions between site

204 in the dynamics and function of RNA-protein condensates like stress granules.

205 ucleoprotein (RNP) granules are biomolecular condensates-liquid-liquid phase-separated droplets that

206 which fusion occurs is a direct indicator of condensate liquidity, which is key to both cellular func

207 g recognition that membraneless biomolecular condensates, many of which are organized or regulated by

208 titioning properties, and that disruption of condensates may be a common consequence of mutations in

209 Surface-bound condensates may find multiple biological uses, particula

210 s suggest that unblending of transcriptional condensates may underlie human pathologies.

211 e observations of the H(2)O(2) production in condensate microdroplets showed that H(2)O(2) was genera

212 In neurons, PFK-1.1 forms phase-separated condensates near synapses in response to energy stress f

213 components through formation of biomolecular condensates-non-stoichiometric assemblies of protein and

214 generates a periodic modulation of the edge condensate observable as a "fast-mode" oscillation of th

215 ring hydrogen peroxide in the exhaled breath condensate of asthma patients and healthy participants.

216 Spin-triplet superconductors are condensates of electron pairs with spin 1 and an odd-par

217 Our data suggest that layered condensates of histone-modifying enzymes generate chroma

218 The relevance of our results to condensates of IDPs is discussed.

219 Stress granules (SGs) are condensates of mRNPs that form in response to stress.

220 Stress granules are condensates of non-translating mRNAs and proteins involv

221 granules (SGs) are evolutionarily conserved condensates of ribonucleoproteins that assemble in respo

222 (2020) investigate stress-induced nuclear condensates of the RNA-binding protein TDP-43, uncoverin

223 BRD3 forms phase-separated condensates of which the formation is promoted by DIGIT,

224 ts indicate that the assembly of the protein condensate on the membrane surface can drive lipid phase

225 ncy to self-associate will form multilayered condensates on binding surfaces.

226 n and storage, and transport of membraneless condensates on membrane-bound organelles.

227 ss diverse contexts, e.g., within biological condensates or alongside existing filaments.

228 RNA-binding proteins and proteins that form condensates or fibrils.

229 chanistically, TiPARP forms distinct nuclear condensates or nuclear bodies in an ADP ribosylation-dep

230 heterochromatin and euchromatin through its condensate partitioning properties, and that disruption

231 haled nitric oxide (FeNO) and exhaled breath condensate pH and nitrogen oxides (NOx).

232 ompositions, we report a hollow vesicle-like condensate phase of nucleoprotein assemblies that is dis

233 Macromolecule condensates, phase separation, and membraneless compartm

234 re setting up a tug of war between different condensate phases within the S:P:H:L quaternary.

235 The system contains a Bose-Einstein condensate placed in an optical potential with the depth

236 Biomolecular condensates play a key role in organizing RNAs and prote

237 altered condensate assembly, suggesting that condensates play a key role in tumorigenesis.

238 Here, we review how these condensates play roles in regulating microtubule density

239 Understanding the regulation of condensates promises to provide novel insights into how

240 esting a general framework for how chromatin condensates promote cellular functions.

241 ts two components have significant impact on condensate properties.

242 mRNAs enriched in membraneless condensates provide functional compartmentalization with

243 microscopy, this work investigates chromatin condensates, providing new insights into the physical or

244 concentrated within phase-separated nuclear condensates, providing new insights to drug efficacy and

245 n and highlight considerations for designing condensate reconstitution experiments.

246 sical or material properties of biomolecular condensates regulate cancer.

247 hese sequence perturbations, the RGG-derived condensates remain liquid-like.

248 and aromatic content, which exhibit variable condensate saturation concentrations and temperature clo

249 ndependent XCI phase(8), indicating that the condensate seeded by the E-repeat underlies the developm

250 igenetic repression, because cigarette smoke condensate selectively increased SMAD3 promoter methylat

251 rsible liquid-to-solid transition of protein condensates, shed light on the role of physical factors

252 tatic binding to RNA, and formation of large condensates, signifying the role of arginine in driving

253 re magnon BEC differs essentially from other condensates, since it takes place simultaneously at +/-

254 ging in driven-dissipative exciton-polariton condensates, since their non-equilibrium nature is predi

255 ugh formation of salicylic acid-induced NPR1 condensates (SINCs).

256 our of quantum fluctuations in a Cooper pair condensate: single-charge tunnelling (charge qubit(6,7))

257 hibit repulsive interaction resulting in the condensate stabilization and propose a mechanism, which

258 In the context of RNA-processing condensates such as the nucleolus, this manifests in the

259 on (LLPS) mediates formation of membraneless condensates such as those associated with RNA processing

260 the Xi compartment by seeding a heteromeric condensate that consists of ubiquitous RNA-binding prote

261 anules and Mutator foci, two phase-separated condensates that are the sites of piRNA-dependent mRNA r

262 conclude that RNAP clusters are biomolecular condensates that assemble through LLPS.

263 ermodynamic driving forces for LLPS, forming condensates that can facilitate the assembly and process

264 The nucleus contains diverse phase-separated condensates that compartmentalize and concentrate biomol

265 own that many nuclear processes occur within condensates that compartmentalize and concentrate the pr

266 us LLPS, and give rise to nucleoli and other condensates that do not exhibit a fixed saturation conce

267 es (SGs) are membrane-less ribonucleoprotein condensates that form in response to various stress stim

268 cell integrity during drying and by forming condensates that may act as protective compartments for

269 self-assembling into centrosome-independent condensates that serve as ectopic microtubule-organizing

270 mblies represent membraneless organelles, or condensates, that form via liquid-liquid phase separatio

271 describe here the shared features of nuclear condensates, the components that produce locus-specific

272 he formation and dissolution of biomolecular condensates through liquid-liquid phase separation (LLPS

273 Here we demonstrate that TAZ forms nuclear condensates through liquid-liquid phase separation to co

274 nd that over time hBEX3 transits from liquid condensates to aggregates that are reversible upon tempe

275 teins of other viruses can form biomolecular condensates to spatiotemporally regulate N protein local

276 rained explicit-chain model for biomolecular condensates underlain by liquid-liquid phase separation

277 Readily observable, PRD-derived cytoplasmic condensates underwent fusion and fluorescence recovery a

278 processes, including formation of biological condensates via liquid-liquid phase separation.

279 LINP1 self-assembles into phase-separated condensates via RNA-RNA interactions that reorganize to

280 Altering the properties of the condensate was found to affect the concentration and act

281 t the nucleation and the growth processes of condensate water microdroplets govern H(2)O(2) generatio

282 In the presence of tRFs, biomolecular condensates were smaller and in higher number, showing a

283 e, pH, salt concentration) of multicomponent condensates, where stability is positively correlated wi

284 molecules are highly concentrated within the condensates, whereas phase separation is overall regulat

285 observe formation of structured or patterned condensates which suggests the possible roles of polynuc

286 in the rapidly evolving field of biological condensates, which are spontaneously formed by macromole

287 he energetic barrier for nucleation of TAF15 condensates, which in turn further recruit RNA polymeras

288 nent of the destruction complex biomolecular condensate, while other E3 proteins are not.

289 rise to compositionally specific and tunable condensates, while relative linkage between nodes underl

290 topologies, and (2) the ability to generate condensates whose composition and duration are self-limi

291 eolus represents a multilayered biomolecular condensate, whose formation by liquid-liquid phase separ

292 ved to be important for stabilization of the condensate with respect to a real-space collapse.

293 we show that TPX2 phase separates into a co-condensate with tubulin, which mediates microtubule nucl

294 Tau PRD formed heterotypic condensates with EB1, a regulator of plus-end microtubul

295 lar condensates: (1) the ability to generate condensates with layered functional topologies, and (2)

296 porting tumorigenesis require AKAP95 to form condensates with proper liquidity and dynamicity.

297 are consistent with multi-component protein condensates with roles to promote cell survival.

298 This advance hints that distinct condensates with specialized functional compositions mig

299 FUS, whereas arginine (R) mutants form mixed condensates with WT FUS.

300 0(8) atoms, similar to current Bose-Einstein condensates, with the density of a solid object.