ライフサイエンスコーパス: conditional

1 ate recommendations formulation as strong or conditional.

2 cts of EP2 antagonism that are reproduced by conditional ablation of EP2 receptors in immune myeloid

3 Conditional ablation of IGF1 in alveolar fibroblasts or

4 for insulin signaling in folliculogenesis as conditional ablation of Igf1r in primary follicles elici

5 erial infection and of tumor growth that the conditional ablation of Irf4 in CD11c(+) DCs results in

6 1, reduces intracellular replication, whilst conditional ablation of the substrate AMA1 produces host

7 Here, we show that conditional activation of Notch in squamous cells activa

8 Here, we propose that netrin is involved in conditional adhesion, a reversible and localized process

9 sis, we used the ACTB-Cre gene to activate a conditional Akt1 p.(E17K) allele in the mouse.

10 g that was heterozygous for both Cre and the conditional allele (betaA-Akt1WT/flx) was viable.

11 In addition to the conditional alleles, constitutive knockout alleles were

12 Functional neuroimaging reveals that conditional alpha2-Na/K ATPase knockout triggers spontan

13 Conditional analysis and functional annotation prioritiz

14 esent a simple and general approach based on conditional analysis of a locus on multiple traits, over

15 Conditional analysis revealed a second signal indexed by

16 Conditional analysis reveals that distinct neuropsychiat

17 with height associations, confirmed through conditional analysis.

18 are among the first to acheive AAV-mediated, conditional and inducible DAergic knockdown in vivo.

19 We used multi-trait conditional and joint analysis (mtCOJO) to adjust GWAS s

20 promises; countries are left to choose their conditional and unconditional emissions reductions accor

21 the identified associations: colocalization, conditional, and fine-mapping analyses together with TWA

22 all, our findings demonstrate the utility of conditional associations for improving the performance o

23 Conditional autophagy deficiency in adult mice causes li

24 The model employs a conditional autoregressive prior to integrate a function

25 r for this pathogenic process in the hepatic conditional beta-catenin knockout mouse model.

26 Therefore, we examined single Akt isoform, conditional brain-specific Akt1, and double Akt1/3 mutan

27 Fifty years ago, the first isolation of conditional budding yeast mutants that were defective in

28 d within a generalizable framework to design conditional cancer diagnostics and therapeutics and show

29 This study explored how conditional cell-type-specific ablation of GSK-3beta in

30 ork distinguish between 'for' loops and 'if' conditional code functions.

31 CZ (N = 77,096) and PD (N = 417,508) using a conditional/conjunctional false discovery rate (FDR) app

32 d general intelligence (N = 269,867) using a conditional/conjunctional false discovery rate (FDR) sta

33 ticity properties of PV-INs, we investigated conditional/conventional double KO mice of BMP-receptor

34 We thus show a potential 'dark side' to conditional cooperation ('lone wolf effect') and draw im

35 Thus, we examine the dynamic emergence of conditional cooperation under different default settings

36 We show that conditional CRISPR mutagenesis is robust across many tar

37 ted lineage tracing with Cxcr4 inhibition or conditional Cxcr4 ablation in photothrombotic stroke, we

38 Consequently, conditional D2R knockout mice displayed a significant re

39 Maf and Mafb conditional deletion (cDKO) decreases the survival of MG

40 Conditional deletion of activation-induced cytidine deam

41 Neural crest specific conditional deletion of Adar1 in mice leads to global de

42 Conditional deletion of Arp3 in primary melanocytes caus

43 Conditional deletion of Bcl6 from thymocytes reduced pre

44 y cilia, in a mouse model of SCLC induced by conditional deletion of both Trp53 and Rb1 in the adult

45 Conditional deletion of EGFR in hematopoietic stem and p

46 Conditional deletion of fatty acid synthase (Fasn) in SG

47 t in a metabolic syndrome-like phenotype and conditional deletion of Gprc6a in pancreatic beta-cell a

48 Conditional deletion of Hdac3 within myeloid progenitors

49 ion mode dependence is phenocopied following conditional deletion of HR gene Brca2.

50 Conditional deletion of LATS1/2 kinases abolished the in

51 e is essential for optimal thermogenesis, as conditional deletion of Mpc1 in brown adipocytes leads t

52 Accordingly, despite mice with conditional deletion of Nf1 in mature osteoblasts (Nf1(f

53 Conditional deletion of NKG2D in T cells impairs the abi

54 an activated form of NOTCH2 (pL2.Lgr5.N2IC), conditional deletion of NOTCH2 (pL2.Lgr5.N2fl/fl), or lo

55 nic acid (KA) and pilocarpine in mice with a conditional deletion of Orai1 (or its activator STIM1) i

56 Here, we showed that conditional deletion of synaptotagmin-2, the fastest Ca2

57 Conditional deletion of the gene cluster encoding the ga

58 fects of activation of nutrient signaling by conditional deletion of the mTORC1 inhibitor, TSC2, in a

59 Conditional deletion of Tph1 in lymphocytes resulted in

60 Here, we report that tamoxifen-induced conditional deletion of TSPO in resident microglia using

61 Both global and conditional deletion of Vegfc in endothelial or leptin r

62 Conditional deletion of VMAT2 in astrocytes postnatally

63 Conditional deletion of Wntless or porcupine, both of wh

64 Conditional deletion of YAP or TAZ resulted in more seve

65 ll mutant mouse that allows for cre-mediated conditional deletion, combined with a PSNL pain model.

66 Using conditional deletions in mice as well as CRISPR/Cas9 app

67 ariate Hurdle model to infer a sparse set of conditional dependencies which reflect not only relation

68 This conditional depletion also led to a reduction of mature

69 SQSTM1-neutralizing monoclonal antibodies or conditional depletion of Insr in myeloid cells using the

70 Conditional depletion of PICH using the auxin-inducible

71 erformed safely in patients who have non-MRI-conditional devices, in pacemaker-dependent patients wit

72 in cancer and accelerate the development of conditional diagnostics and therapeutics for multiple ca

73 egulation in cancer and guides the design of conditional diagnostics and therapeutics.

74 ng strategy for directly estimating the full conditional distribution of y at each x under no assumpt

75 eters and derive the Gibbs sampler using the conditional distributions of them.

76 rved in such mice, even in the presence of a conditional dominant negative p53 protein and chronic hy

77 red for embryo development, we carried out a conditional Dot1l knockout in growing oocytes using the

78 genome-wide significant variants had larger conditional effect sizes consistent with disorder-specif

79 nge each other's incentives by committing to conditional emissions reductions, before countries decid

80 Conditional endothelial-specific disruption of Piezo1 in

81 ntation of the Epigenetic Pacemaker (EPM), a conditional expectation maximization algorithm that esti

82 Likewise, the conditional expression (doxycycline-controlled) of HNF4a

83 his end, we generated knock-in mice with Cre-conditional expression of a cytidine base editor and tes

84 We analyzed the effects of conditional expression of an activated form of NOTCH2 (p

85 DENT PROTEIN KINASE1 (CPK1), we analyzed the conditional expression of constitutively active CPK1 in

86 autochthonous transgenic mouse model whereby conditional expression of MYC and Twist1 enables hepatoc

87 over time and cell type specificity through conditional expression of the TF-enzyme fusion.

88 The conditional expression strategy bypassed the impediment

89 quilibrium-independent ADHD-associated loci (conditional FDR < 0.01), of which 30 were shared between

90 initialization and single-shot readout with conditional fidelity greater than 95 per cent.

91 ssion along with proliferative capacity in a conditional FIH-1 transgenic mouse.

92 ccoli RNA aptamer that binds and activates a conditional fluorophore for live cell imaging of RNA.

93 RNA aptamers that bind and activate conditional fluorophores provide a tool for RNA visualiz

94 atient-derived pluripotent stem cells (PSCs) conditional for the FA pathway were differentiated into

95 Moreover, mice with a conditional forebrain deletion of EphA4, display forelim

96 Conditional gene deletion studies revealed that T-bet ex

97 Techniques of protein regulation, such as conditional gene expression, RNA interference, knock-in

98 accurate manner, we propose a deep learning conditional generative adversarial network (GAN) capable

99 Conditional genetic deletion of PTEN results in robust C

100 the developing cerebral cortex by combining conditional genetic deletion with the mosaic analysis wi

101 alysis of the Daam2-VHL complex coupled with conditional genetic knockout mouse models, we further di

102 llenges, thus limiting wider applications of conditional genetics.

103 etically tractable organisms for multiplexed conditional genome engineering.

104 n a genetically engineered mouse harboring a conditional Halo-Ago2 allele expressed from the endogeno

105 Using conditional inactivation in the embryonic mouse eye, our

106 In vivo conditional inactivation of an essential m(6)A writer co

107 unders and any other covariates required for conditional independence of missingness and outcome.

108 Using conditional-inducible H2A.Z knockout (cKO) mice, we show

109 Conditional inference tree analysis revealed that ventra

110 ormation for complex disease, and that their conditional informativeness for disease cannot be inferr

111 To examine this, we generated conditional Insr,Igf1r, and double receptor knockout mic

112 are B cell intrinsic, we generated mice with conditional IRF-1 deficiency.

113 ted with these prodrugs resemble those after conditional IspH knockdown.

114 Conditional kidney tubule-specific ENaC gamma-subunit kn

115 We also used conditional kidney tubule-specific knockout mice lacking

116 ture, we used Cre/lox technology to generate conditional Kiss1r knockout exclusively in BAT (BAT-Kiss

117 Finally, we crossed EP3R conditional knock-out mice with either VGluT2-IRES-cre o

118 rocyte activation, we generated an inducible conditional knock-out mouse in which the Cav1.2 alpha su

119 Through time-dependent conditional knock-out of Unc-4, we found that its functi

120 Here we show that mice with inducible conditional knockdown (KD) of Dsc2 in IEC (Villin-Cre(ER

121 We used a mouse model with Tbx5 conditional knockdown in Hh-receiving cells (marked by G

122 Moreover, conditional knockdown of ARID1 in the generative cell ca

123 Finally, quantitative imaging, conditional knockdown, and optical highlighting indicate

124 ate a gene in a given tissue by generating a conditional knockout (cKO) is crucial for determining it

125 tinal vascular disease, we generated a Kif11 conditional knockout (CKO) mouse and investigated the co

126 ring meiotic resumption, we developed a Plk1 conditional knockout (cKO) mouse to specifically mutate

127 Using a Thy1-Nampt(-/-) projection neuron conditional knockout (cKO) mouse, we studied the impact

128 eport that loss of ROBO2 in podocytes [Robo2 conditional knockout (cKO) mouse] is protective from glo

129 dy, we showed that pyramidal-neuron specific conditional knockout (cKO) of syntaxin-4 significantly r

130 all interfering RNA (siRNA), lentivirus, and conditional knockout (CKO) techniques were employed to m

131 Adult FOXA2 conditional knockout (cKO; Ltf (iCre/+) Foxa2 (f/f) ) mi

132 city of brain FAO using a pan-brain-specific conditional knockout (KO) mouse incapable of FAO due to

133 Here, we describe in vivo conditional knockout analyses of murine Ars2, which has

134 us to easily and rapidly generate AID-based conditional knockout cells in a wide range of vertebrate

135 In Sox2 conditional knockout embryos, the oral epithelium failed

136 s of gene depletion by CRISPR-Cas9, RNAi, or conditional knockout for melanoma modeling.

137 repinephrine reuptake inhibitor, observed in conditional knockout male mice supports deficient 5-HT t

138 d LATS2 kinases in NEX-Cre lineage in double conditional knockout mice also generates similar tumours

139 Although analyses of Fgf8 conditional knockout mice did not reveal developmental p

140 We generated conditional knockout mice in which brain AMPKalpha isofo

141 retion is abolished in acute brain slices of conditional knockout mice in which Synaptotagmin-1 is re

142 To test this model, we studied conditional knockout mice in which the vast majority of

143 ess these questions we generated a series of conditional knockout mice lacking one or both house-keep

144 To test this hypothesis, we used conditional knockout mice with DORs deleted from forebra

145 In Cyp26b1 conditional knockout mice, formation of striolar/central

146 es synaptic and behavioral deficits in Mecp2 conditional knockout mice, whereas about 12-fold decreas

147 reading depression model of migraine aura in conditional knockout mice.

148 anism of alpha6-associated apoptosis using a conditional knockout model of alpha6 in murine BCR-ABL1+

149 reduced in CHARGE patient-derived iPSCs and conditional knockout mouse brains.

150 ptors (V1R) in dominance behavior by using a conditional knockout mouse for G protein subunit Galphai

151 Here, we generate a brain specific conditional knockout mouse model deficient for Pogz, an

152 We created a Ewsr1 conditional knockout mouse model to deplete EWSR1 before

153 The combination of conditional knockout mouse models and viral vector-media

154 Using different Smad4 conditional knockout mouse models, we disrupted canonica

155 ofiling and single-cell transcriptomics of a conditional knockout mouse, we demonstrate that Kat2a co

156 We found that conditional knockout of Grp in sensory neurons results i

157 Conditional knockout of host WNT5A significantly reduced

158 Conditional knockout of miR-17~92 in keratinocytes as we

159 erage is significantly impaired in mice with conditional knockout of PDGFB in platelets.

160 ched in the quiescent and inactive HSCs, and conditional knockout of Sel1L in hematopoietic tissues d

161 Conditional knockout of TAK1 in microglial/infiltrated m

162 Here, we report that conditional knockout of the chromatin remodeling enzyme

163 We show that conditional knockout of the key ciliary trafficking gene

164 in CeA neurons, we performed region-specific conditional knockout of these genes and assessed the eff

165 Here, we show that conditional knockout of Ttbk2 in adult mice results in d

166 Finally, myofibroblast-restricted OASIS conditional knockouts resulted in resistance to kidney f

167 gesia/medication overuse headache in Dlx-DOR conditional knockouts.

168 mouse line, Camk2a-CreERT2, obtaining a Tet3 conditional KO (cKO) mouse line.

169 Using a conditional KO approach, we further demonstrate that Bax

170 r pilocarpine SE was nearly abolished in EP2 conditional KO mice.

171 rodegeneration was not alleviated in myeloid conditional KOs.

172 ter SE in EP2-sufficient mice but not in EP2 conditional KOs.

173 In the adjusted analyses, participants with conditional length >=1 z score at 1 y had mean intellige

174 (95% CI: 1.08, 7.92) higher than those with conditional length <=-1 at 1 y.

175 Genetically modified conditional lethal strains have been created to improve

176 In Escherichia coli, conditional lethality of the yggS and glyA (encoding ser

177 Employing conditional lineage-specific genetic ablation studies in

178 g Spearman correlation coefficients (r), and conditional logistic regression (odds ratios [ORs] and 9

179 In multivariable-adjusted conditional logistic regression analyses, better adheren

180 multivariable odds ratios (OR) for CAD from conditional logistic regression analyses.

181 Odds ratios were estimated using conditional logistic regression by comparing the occurre

182 gap, we take advantage of the fact that the conditional logistic regression model (i.e. the SSF) is

183 Multivariable conditional logistic regression modeling compared the od

184 We used conditional logistic regression models adjusted for HDL

185 Conditional logistic regression models were used to adju

186 tios (ORs) were computed using multivariable conditional logistic regression models, according to cen

187 Using multivariable-adjusted conditional logistic regression models, caffeic acid (OR

188 athogens and moderate-to-severe diarrhoea in conditional logistic regression models.

189 Conditional logistic regression odds ratios (ORs) accoun

190 We used conditional logistic regression to analyze interactions

191 We used multivariable conditional logistic regression to calculate odds ratios

192 We used conditional logistic regression to estimate odds ratio (

193 time-stratified case-crossover analysis with conditional logistic regression to estimate the associat

194 We used conditional logistic regression to estimate unadjusted a

195 Conditional logistic regression was used to create model

196 Conditional logistic regression was used to estimate odd

197 child health outcomes were determined using conditional logistic regression within surveys, adjustin

198 New York State, a case-crossover design, and conditional logistic regression, we examined the associa

199 Vaccine effectiveness (VE) was estimated by conditional logistic regression, with adjustment for rep

200 Here, we show that conditional loss of a Mediator complex subunit protein,

201 Further, conditional loss of the Yap gene in the inner ear result

202 here the role of Lsh in hematopoiesis using conditional Lsh knockout mice with expression of Mx1 or

203 Importantly, conditional Mef2c heterozygosity in forebrain excitatory

204 a subset of the Mef2c-Het phenotypes, while conditional Mef2c heterozygosity in microglia reproduced

205 Conditional metastasis-free survival (cMFS) and conditio

206 Using conditional mice models lacking the autophagy gene Atg7

207 roblasts using either bafilomycin, inducible conditional mice, or CRISPR/Cas9 gene editing decreased

208 tive dysfunction, we used a genetic approach-conditional, microglia-selective C1q (Flox) knockdown mi

209 Conditional mislocalization of PyrKII resulted in decrea

210 Both the unconditional model (base) and conditional model including smoking as a cofactor were i

211 ly ablating GPI production in the CNS with a conditional mouse allele of phosphatidylinositol glycan

212 We combined conditional mouse genetics, unbiased transcriptomic and

213 s-correction." Here we create and validate a conditional mouse model for cell-autonomous expression o

214 Our results with a new Lpar1 conditional mouse mutant expand an understanding of LPA(

215 renal inflammation, and cyst growth, we used conditional murine models involving postdevelopmental ab

216 We used conditional mutagenesis to test whether these errors are

217 We explore EGFR-mutant glioma evolution in conditional mutant mice by whole-exome sequencing, trans

218 We also find that the Ttbk2 conditional mutant mice quickly lose cilia throughout th

219 logical significance of CBFs, we generated a conditional mutant mouse model in which granulosa cell e

220 Using null and conditional mutants, we demonstrate that the P. falcipar

221 on, we used a combination of viral shRNA and conditional mutation to produce cell-specific knockdown

222 Overexpression suppressors of a conditional myo2 smy1 mutant identified a novel F-BAR (F

223 ystem, we introduced a C181S mutation into a conditional NrasG12D "knock-in" allele.

224 report the generation of an Lpar1(flox/flox) conditional null mutant mouse that allows for cre-mediat

225 n single-risk factor race-adjusted analyses (conditional odds ratio [cOR] = 2.99; 95% confidence inte

226 e the FBAT haplotype algorithm to obtain the conditional offspring genotype distribution under the nu

227 usions from statistical analysis of data are conditional on a hypothesis, sometimes implicit, for the

228 a 20% increase in cell type-specific signal conditional on annotations from the baseline-LD model (P

229 We observed genetic enrichment in PD conditional on associations with SCZ and vice versa, ind

230 abilities under a liability threshold model, conditional on case-control status and family history (L

231 ctor and a class variable reverses sign upon conditional on each of the values of a third (confounder

232 mixed model genome-wide association testing (conditional on genetic-relatedness matrix), gene and gen

233 significant positive effect on growth, even conditional on human capital, in line with the conventio

234 Conditional on prior achievement, polygenic scores faile

235 dds of receipt of LVADs, as well as outcomes conditional on receiving an LVAD, for the sociodemograph

236 e from a randomized trial of a cash transfer conditional on school attendance among AGYW (ages 13-21

237 However, biodiversity responses are conditional on the baseline climate, such that in initia

238 Recommendations are conditional on the basis of histology, PD-L1 status, and

239 to understand and interpret this probability conditional on the information we have concerning a syst

240 or individual fitness with outcomes that are conditional on the overall genetic diversity of the popu

241 Conditional over-expression of Toll-2 and wek at the adu

242 ditional metastasis-free survival (cMFS) and conditional overall survival were calculated based on th

243 tory and vestibular sensory epithelia, while conditional overexpression of a constitutively active ve

244 s was cell-intrinsic and could be rescued by conditional overexpression of the constitutively active

245 Here we employ conditional overexpression of translation initiation fac

246 gotic twinning is the outcome of an adaptive conditional ovulatory strategy of switching from single

247 contribute to the complex modulation of the conditional pF(L) oscillator for active expiration.

248 s of data arrangement, species filtering and conditional prediction, to enhance the selected models.

249 Species filtering and conditional predictions substantially benefited the pred

250 ors, it is increased in others, indicating a conditional pro-survival function of caspase-8 in cancer

251 antitative feature extraction algorithms and conditional probabilities were fine-tuned on a training

252 mate was obtained by Bayes's rule of reverse conditional probabilities.

253 By mapping given conditional probability tables to the circuit hardware,

254 SGLT-2 inhibitors were matched by using time-conditional propensity scores to 208 757 recipients of D

255 Conditional random forest algorithms confirmed mountaino

256 We experimentally parameterized conditional rate constants for aqueous U uptake, dietary

257 d NSCs that were genetically labeled through conditional recombination driven by the regulatory eleme

258 lly recommended as an additive therapy; 5) a conditional recommendation against the use of maintenanc

259 or more exacerbations in the past year; 3) a conditional recommendation for ICS withdrawal for patien

260 severe and frequent exacerbations; and 6) a conditional recommendation for opioid-based therapy in p

261 PD and dyspnea or exercise intolerance; 2) a conditional recommendation for the use of triple therapy

262 ents with hypercapnic COPD on long-term NIV (conditional recommendation, low certainty).Conclusions:

263 sment for NIV at 2-4 weeks after resolution (conditional recommendation, low certainty); 4) we sugges

264 tients with chronic stable hypercapnic COPD (conditional recommendation, moderate certainty); 2) we s

265 ep apnea before initiation of long-term NIV (conditional recommendation, very low certainty); 3) we s

266 ble hypercapnic COPD who are initiating NIV (conditional recommendation, very low certainty); and 5)

267 unction who want to improve sexual function (conditional recommendation; low-certainty evidence).

268 , vitality, physical function, or cognition (conditional recommendation; low-certainty evidence).

269 ation for baseline serum calcium testing, 13 conditional recommendations, and 1 best practice stateme

270 uding models without random slopes and mixed conditional regression models fit using a two-step algor

271 Conditional removal of one copy of Sox9 in Jag1(+/-) liv

272 In conditional, RGC specific Opa1-deficient mice, depletion

273 AAV-mediated, conditional Rit2 knockdown in DAergic neurons impacted b

274 In this study, we uncover a conditional role for the endodermal and pulmonary specif

275 proved genetic definition of ILC2s via IL-7r-conditional Rora gene targeting and takes advantage of a

276 anule layer in the cerebellum of control and conditional SnoN knockout mice.

277 eries of mouse mutants with constitutive and conditional Sox10 deficiencies to show that Sox10 has mu

278 Conditional Sox9 expression in the mouse BP lineage, whe

279 proactive and reactive inhibition using the conditional stop-signal task, and applied transcranial m

280 This conditional strategy, when coupled with the well-known d

281 roach allows the roles of essential genes in conditional stress survival to be inferred by altering t

282 Conditional survival analysis can provide specific guida

283 ry classification framework, specifically, a conditional survival approach for weighting censored obs

284 ally, the local invariances method using the conditional survival approach is the most robust method

285 tients greater than or equal to 75 years old conditional survival continued to decline with increasin

286 In all three cohorts, conditional survival declined over the first 5-10 days a

287 Conditional survival estimates of uveal melanoma improve

288 Outputted conditional survival probabilities gave individualised r

289 Conditional survival represents the probability of futur

290 Conditional survival suggests that patients have signifi

291 Neurons from conditional syntabulin(-/-) mice (stb cKO) display impai

292 ation fidelity, our data are consistent with conditional teleportation of spin eigenstates, entanglem

293 of personality pathology, maladaptive LPF is conditional to the diagnosis of personality disorder.

294 GFbeta concentration in vivo, we developed a conditional transgenic mouse model (Flpo/Frt system) exp

295 We used mice with conditional tubule-specific overexpression of periostin

296 Conditional urothelial deletion of Fgfr2 (Fgfr2KO) did n

297 cy revealed significant overlap with several conditional uterine knockout mouse models, including Fox

298 ption points were given, which we defined as conditional waitlist outcomes.

299 ethality, we developed two mouse models of a conditional Xlf KO in a Paxx(-/-) background.

300 Effector and memory CD8 T cells with conditional Zbtb20 deficiency displayed enhanced mitocho