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1 gesia/medication overuse headache in Dlx-DOR conditional knockouts.
2 , all of which are upregulated in Hand2 limb conditional knockouts.
3 ither individually or in combinations, using conditional knockouts.
4 or recombinases) or gene replacement (e.g., conditional knockout alleles containing exons flanked by
10 n profiles of embryonic day 14.5 (E14.5) Yap conditional knockout and YAP transgenic mouse tooth germ
18 myocyte-specific deletion of Atf6 (ATF6 cKO [conditional knockout]) blunted transverse aortic constri
21 us to easily and rapidly generate AID-based conditional knockout cells in a wide range of vertebrate
22 reported up to 16% efficiency in generating conditional knockout (cKO or floxed) alleles by microinj
23 the subventricular zone of both FIP200hGFAP conditional knockout (cKO) and FIP200;p53hGFAP 2cKO mice
28 ate a gene in a given tissue by generating a conditional knockout (cKO) is crucial for determining it
30 ntrol and heterozygous mice, Depdc5-Emx1-Cre conditional knockout (CKO) mice demonstrated macrocephal
31 e neuroligins, we analyzed single and triple conditional knockout (cKO) mice for all three major neur
32 ency contributes to ASD, we generated CTNNB1 conditional knockout (cKO) mice in parvalbumin interneur
33 ms associated with Parkinson's disease using conditional knockout (cKO) mice in which Ndufs4 was sele
36 inations of these deletions in the pleura of conditional knockout (CKO) mice, focusing on the contrib
41 tinal vascular disease, we generated a Kif11 conditional knockout (CKO) mouse and investigated the co
43 ring meiotic resumption, we developed a Plk1 conditional knockout (cKO) mouse to specifically mutate
44 Using a Thy1-Nampt(-/-) projection neuron conditional knockout (cKO) mouse, we studied the impact
45 eport that loss of ROBO2 in podocytes [Robo2 conditional knockout (cKO) mouse] is protective from glo
47 metabolomic analysis in mice with inducible conditional knockout (cKO) of BMAL1, which is critically
49 is perinatal lethal in mice, we generated a conditional knockout (cKO) of Fst in the uterus using pr
50 phenotypes of females with a Zp3-Cre-driven conditional knockout (cKO) of Smc5 demonstrated that mat
51 dy, we showed that pyramidal-neuron specific conditional knockout (cKO) of syntaxin-4 significantly r
54 all interfering RNA (siRNA), lentivirus, and conditional knockout (CKO) techniques were employed to m
55 e, using tissue-specific dynamin-1 knockout [conditional knockout (cKO)] mice at a fast central synap
56 me (APC/C) ubiquitin ligase in neurons [Cdh1 conditional knockout (cKO)], disrupts dendrite arborizat
58 l TEC-defective (resulting from FoxN1-floxed conditional knockout [cKO]) and naturally aged mouse mod
59 ele, allowing for conditional gene ablation (conditional knockout [cKO]) when crossed with Cre recomb
61 yt11 in excitatory forebrain neurons using a conditional knockout did not affect life span but impair
67 educes the DNA manipulation needed to make a conditional knockout gene targeting vector to only two s
68 cations that have used tamoxifen to generate conditional knockouts have not reported even the minimum
69 ue to downregulation of TbIPMK expression by conditional knockout, have reduced levels of polyphospha
72 nt receptor, Ryk, in mice and rats by either conditional knockout in the motor cortex or monoclonal a
76 city of brain FAO using a pan-brain-specific conditional knockout (KO) mouse incapable of FAO due to
77 HL2 in oral mucosal barrier, we used a Grhl2 conditional knockout (KO) mouse model, which allows for
81 V-Neu transgenic female mice with or without conditional knockout (KO) of Tcfap2c, the mouse homolog
85 ea, we used an Nkx2.1-Cre driver to generate conditional knockouts (KOs) in mice of leptin receptor (
86 ikewise, mice harboring liver-specific Lats2 conditional knockout (Lats2-CKO) displayed constitutive
87 cell type-specific Cre-drivers and a Gnptab conditional knockout line, we found that only astrocyte-
88 repinephrine reuptake inhibitor, observed in conditional knockout male mice supports deficient 5-HT t
92 le Cre ( UBC-Cre/ER(T2)) line crossed to Ret conditional knockout mice ( Ret(fx/fx)), Ret was deleted
95 ecting tubule/collecting duct-specific Dot1l conditional knockout mice (Dot1l(AC) ), Dot1l and Edn1 d
96 1 connecting tubule/collecting duct-specific conditional knockout mice (Edn1(AC) ), under three exper
98 ng cell type-specific Myf5-cre;Lipin1(fl/fl) conditional knockout mice (Lipin1(Myf5cKO) ) shows that
101 , administration of Notch inhibitors in Fbw7 conditional knockout mice alleviated progressive bone re
102 d LATS2 kinases in NEX-Cre lineage in double conditional knockout mice also generates similar tumours
105 ity alterations were normalized in GABA-CB1R conditional knockout mice and after subchronic treatment
106 or adipogenesis in culture and in vivo Using conditional knockout mice and derived white and brown pr
109 ermore, RBCs from blood-cell-specific Piezo1 conditional knockout mice are overhydrated and exhibit i
110 Sirt-1 in GVHD induction by employing Sirt-1 conditional knockout mice as well as a pharmacological S
111 s of Stx3 and -4 in fully developed MCs from conditional knockout mice by electrophysiology and EM, a
112 cultured neural stem cells derived from Cic conditional knockout mice bypassed an EGF requirement fo
113 ent tissue- and developmental stage-specific conditional knockout mice carrying Smarcb1 and/or Nf2 de
114 cantly different in the fetal brain of Foxa2 conditional knockout mice compared with control mice.
117 p(nestin) conditional knockout and Yap(GFAP) conditional knockout mice displayed fewer neocortical as
118 elial injury, we demonstrate that myeloid AC conditional knockout mice exhibit impairment of neutroph
119 ucture-related gene expression, whereas Tsc1 conditional knockout mice exhibited changes in genes reg
120 mice, whereas hepatocyte and macrophage Bmp6 conditional knockout mice exhibited no iron phenotype.
124 We further generated germ-cell-specific, conditional knockout mice for the key histone acetyltran
125 In vivo, megakaryocyte-specific Munc18-2 conditional knockout mice had a severe hemostatic defect
126 retinal ganglion cell death, similar to Nf1 conditional knockout mice harboring a neomycin insertion
128 nses to TLR stimulation in vitro, and alphav-conditional knockout mice have elevated antibody respons
130 retion is abolished in acute brain slices of conditional knockout mice in which Synaptotagmin-1 is re
133 sence of NF186, they fail to do so in double conditional knockout mice lacking both NF186 and the par
134 ess these questions we generated a series of conditional knockout mice lacking one or both house-keep
135 induced SNS injury, while NPY injection into conditional knockout mice lacking the Y1 receptor in mac
136 in vivo replacement strategies in quadruple conditional knockout mice of all neuroligins to avoid he
137 Both whole-body (Lgr4(-/-)) and monocyte conditional knockout mice of Lgr4 (Lgr4 CKO) exhibit ost
140 man cells and astrocytes derived from AP-2mu conditional knockout mice revealed a significant impairm
141 cell type datasets from Nova2-cTag and Nova2 conditional knockout mice revealed differential NOVA2 re
145 stomorphometric analysis revealed that STAT5 conditional knockout mice showed reduced bone mass, with
146 dedicated to controlling the forelimb in Ryk conditional knockout mice than in controls (wild-type or
147 ifferentiation less effectively in the STAT5 conditional knockout mice than in the wild-type mice aft
150 n2 expression, surgical transplant and novel conditional knockout mice were super-ovulated and analyz
151 Pten in hematopoietic cells by crossing Pten conditional knockout mice with a knock-in mouse expressi
152 In our current study, we crossed our Lpd conditional knockout mice with a mouse line expressing C
154 ramatically reduced in the absence of EpCAM, conditional knockout mice with EpCAM-deficient LCs and c
156 s to externally applied proteins, we studied conditional knockout mice with EpCAM-deficient LCs.
158 ignificantly reduced in both Raptor and Tsc1 conditional knockout mice, albeit with variations in sev
160 ANP fell sharply in PAM myosin heavy chain 6 conditional knockout mice, and RNA sequencing analysis i
164 validated in vivo in the liver of IRE1alpha conditional knockout mice, revealing broad implications
171 es synaptic and behavioral deficits in Mecp2 conditional knockout mice, whereas about 12-fold decreas
182 velopmental role, Dbx1 hypothalamic-specific conditional-knockout mice display attenuated responses t
184 dress this question, we produced triple cKO (conditional knockout) mice that allow ablating all neure
185 equires a great amount of effort to create a conditional knockout model for each individual gene of i
186 address this, the authors generated a unique conditional knockout model involving the major CLP gene,
187 anism of alpha6-associated apoptosis using a conditional knockout model of alpha6 in murine BCR-ABL1+
189 brain, we have generated a new beta-catenin conditional knockout mouse (beta-cat cKO) with targeted
192 re, we address this question by generating a conditional knockout mouse for Dpy30, which is a common
193 ptors (V1R) in dominance behavior by using a conditional knockout mouse for G protein subunit Galphai
195 ferentiation and development by generating a conditional knockout mouse in which the protein is deple
196 n the formation of new discs, we generated a conditional knockout mouse lacking its essential ArpC3 s
199 development, we generated and analyzed three conditional knockout mouse lines, in which the essential
200 f Prdm16 in adult HSCs, we generated a novel conditional knockout mouse model and deleted Prdm16 in a
203 le of inducing inflammaging, we used a Foxn1 conditional knockout mouse model that induces accelerate
206 circumvent this problem, we have used a WASH conditional knockout mouse model to investigate the role
207 of Rbfox1 in muscle function, we developed a conditional knockout mouse model to specifically delete
209 sing a temporally controlled neuron-specific conditional knockout mouse model, recapitulated cellular
218 lusively in GC B cells by crossing the Gna13 conditional knockout mouse strain with the GC-specific A
220 cell differentiation and function, an Ikaros conditional knockout mouse was developed such that Ikaro
221 formed normally after depletion of OCT2 in a conditional knockout mouse, but their proliferation is r
222 ur studies using an N-cadherin lens-specific conditional knockout mouse, N-cad(Deltalens), show that
223 ofiling and single-cell transcriptomics of a conditional knockout mouse, we demonstrate that Kat2a co
226 e model of pancreatic adenocarcinoma-whereas conditional knockout of another RCP cargo, alpha5 integr
228 generated a mouse model with kidney-specific conditional knockout of Arl13b Deletion of Arl13b in the
231 rofiling of genome architecture reveals that conditional knockout of Chd4 strengthens interactions am
240 an osteogenic tumor mouse model based on the conditional knockout of liver kinase b1 (Lkb1; also know
245 roduced a marked synaptic phenotype, whereas conditional knockout of neuroligin-3 during early develo
248 trate that smooth muscle cell (SMC)-specific conditional knockout of Oct4 in Apoe(-/-) mice resulted
256 rom female mice with dendritic cell-specific conditional knockout of Prdm1 (CKO mice) altered the pre
258 ched in the quiescent and inactive HSCs, and conditional knockout of Sel1L in hematopoietic tissues d
265 Here, we report that in vivo knockdown or conditional knockout of the autism-linked ubiquitin liga
267 ping granule neurons (Sync-TRAP) showed that conditional knockout of the core NuRD subunit Chd4 impai
271 ing in macrophages causes hypertension using conditional knockout of the myeloid vitamin D receptor i
272 ed the functional impairments resulting from conditional knockout of the ubiquitin-conjugating E2 enz
273 in CeA neurons, we performed region-specific conditional knockout of these genes and assessed the eff
277 sr3 conditional knockouts, we found that the conditional knockout of Vangl2 in the hippocampus 1 week
279 physiology and animal behavior by generating conditional knockouts of Atg7 in either dSPNs or iSPNs.
280 Using novel cell-type- and region-specific conditional knockouts of the GABAA receptor alpha2 subun
282 Ldlr knockout mice transplanted with XBP1-conditional knockout (or wild-type control littermate) b
283 macological Cdk5 inhibition, brain-wide Cdk5 conditional knockout, or viral-mediated dorsolateral str
284 We developed and dynamically characterized a conditional knockout Prss8(fl/fl), p-Villin-Cre(+) mouse
285 Finally, myofibroblast-restricted OASIS conditional knockouts resulted in resistance to kidney f
286 he ependymal cell layer does not form in the conditional knockout, revealing an unrecognized role of
289 all interfering RNA-treated DCs, or DCs from conditional knockout (Sirt1(f/f)-CD11c-Cre(+)) mice show
290 veolar epithelial cell (AECII)-specific TERT conditional knockout (SPC-Tert cKO) mice by crossing flo
292 transcriptional factor, RBP-Jkappa, using a conditional knockout strategy in the mice delayed PDL ma
295 ody VDR(-/-) mice, intestinal epithelial VDR conditional knockout (VDR(DeltaIEC)) mice, and cultured
296 undant function of Smad2 and Smad3, a double-conditional knockout was generated using progesterone re
299 (X-box binding protein-1) floxed mice (XBP1-conditional knockout), with antibody-mediated depletion