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1 ibit Cas9 function spatially, temporally, or conditionally.
2 s9 genome editing temporally, spatially, and conditionally.
4 d the Wnt1(Cre) and Wnt1(Cre2SOR) drivers to conditionally ablate both Yap and Taz in the CNC of mice
5 Accordingly, we used the Cre-loxP system to conditionally ablate the murine huntingtin gene (Htt(flx
8 we developed a mouse model in which PDK1 is conditionally ablated in activated CD4 T cells, regulato
9 Cd4-cre Il6st(fl/fl) mice, in which gp130 is conditionally ablated in T cells, with acute lymphocytic
11 ancer of zeste homologs 1 and 2 (Ezh1/2) are conditionally ablated in the embryonic epidermal progeni
13 roxylase (TH), and thus DA biosynthesis, was conditionally ablated using either floxed Th mice or vir
15 n mice in which both BMP1 and TLL1 have been conditionally ablated, including malformed periodontal l
16 ining isoforms of Nrg1 (types I and II) were conditionally ablated, leaving the type III Nrg1 intact.
19 MHC class I-deficient C57BL/6 mice, thereby conditionally ablating MHC class I-restricted Ag present
20 s study, we investigated the consequences of conditionally ablating p53 in the highly relevant Lgr5(+
21 mutant plastid ferrochelatase two (fc2) that conditionally accumulates the ROS singlet oxygen ((1) O(
28 show that defects in tRNA thiolation can be conditionally advantageous, conferring resistance to end
33 ng space-time random effects in an intrinsic conditionally autoregressive model within a Bayesian fra
35 sefulness of synthetic lethal screening of a conditionally BCL6-deficient Burkitt lymphoma cell line,
36 present in only some lines are enriched for conditionally beneficial functions (e.g., defense and de
40 that significant correlations exist between conditionally carcinogenic trihalomethanes (THMs) levels
42 et transgene and stabilized beta-catenin are conditionally co-expressed in prostatic epithelial cells
43 integrated biclustering algorithm identifies conditionally co-regulated modules of genes (biclusters)
45 tone induction and Cre-loxP recombination to conditionally control the expression of oncogenic kras(V
47 roscience, most research is correlational or conditionally correlational; this research, in aggregate
53 rein, two different strains of cell-specific conditionally deficient mice were used to compare the ro
56 ss this issue we have generated a toolkit of conditionally degradable or stabilisable orthologous dCa
57 ock-in mouse will help to reliably track and conditionally delete C3aR expression in experimental mod
59 ock-in mouse will help to reliably track and conditionally delete C5aR2 expression in experimental mo
60 ge of Cre/loxP recombinase-based strategy to conditionally delete Cc2d1a exclusively from excitatory
62 ty we used Tie2CRE-mediated recombination to conditionally delete Id1 against global Id3 ablation (Id
63 ts functional role in HSCs, we used MxCre to conditionally delete Meg3 in the adult bone marrow of Me
64 tically engineered mouse models where we can conditionally delete Stk11 and autophagy essential gene,
65 compared them with two existing models that conditionally delete Tcf4 Our data identify a set of ove
66 ow loss of Top1 affected neurons in vivo, we conditionally deleted (cKO) Top1 in postmitotic excitato
68 orted by analyses of mutant mice in which we conditionally deleted a floxed allele of Podxl in vascul
71 y angiocrine Bmp2 signaling in the liver, we conditionally deleted Bmp2 in LSECs using EC subtype-spe
73 n blot analysis of final tumors derived from conditionally deleted E2f3(-/loxP) mammary glands reveal
76 d ER stress repressor chaperone Grp78 can be conditionally deleted from the intestinal epithelium.
77 some inactivation (XCI) in early embryos, is conditionally deleted from Xi in somatic cells (Xi(Xist)
78 olled by Hdac3 during T cell development, we conditionally deleted Hdac3 using the Lck-Cre transgene.
80 ansgenic was then created with Mx1-Cre which conditionally deleted HGD in liver in a dose dependent m
82 how that mice in which alpha2-Na/K ATPase is conditionally deleted in astrocytes display episodic par
84 in the bone marrow, Spi1 (encoding PU.1) was conditionally deleted in B cells by Cre recombinase unde
85 t mice in which the gene encoding Set7/9 was conditionally deleted in beta cells (Set(Delta)beta).
86 c role of TP53 pathway in DCM, Tp53 gene was conditionally deleted in cardiac myocytes in mice expres
88 subunit of the epithelial sodium channel was conditionally deleted in taste buds (alphaENaC knockout)
89 test whether LepR regulates SSC function, we conditionally deleted Lepr from limb bone marrow stromal
90 c stem cells (HSCs) in which Dnmt3a had been conditionally deleted markedly overexpress the histone 3
92 f mTOR can influence hematopoietic aging, we conditionally deleted mTOR in ECs (mTOR(ECKO)) of young
93 To specifically investigate such role, we conditionally deleted Nemo from osteoclast and myeloid p
96 The tracheal microvasculature of mice, with conditionally deleted or overexpressed HIF-1alpha or HIF
100 the synaptogenic functions of LAR-RPTPs, we conditionally deleted the genes encoding all three LAR-R
104 ts of endothelial CXCR7 in breast cancer, we conditionally deleted this receptor from vascular endoth
107 determine the role of uterine EZH2, Ezh2 was conditionally deleted using progesterone receptor Cre re
111 nt, we altered their genomic distribution by conditionally deleting Ep400, the central subunit of the
112 e explore the hepatic functions of GPRC6A by conditionally deleting Gprc6a in hepatocytes by cross br
117 ndochondral ossification of the epiphyses by conditionally deleting the Phd2 gene in osteoblasts and
118 nation as one such chromatin modification by conditionally deleting the Rnf40 subunit of the responsi
119 Using the "anchor away" (AA) technique to conditionally deplete select subunits within Mediator an
121 lated the severity of tissue injury, Id1 was conditionally depleted in the endothelium of mice, which
122 Experiments with granulocyte-specific CXCL12 conditionally depleted mice and a CXCR4 antagonist revea
123 proteomic analyses of Synechocystis mutants conditionally depleted of FtsH3 or FtsH1 grown under var
126 us inhibition of multiple binding sites, and conditionally destabilized dCas9 allows rapid reversibil
128 PRK are coregulated by the redox state of a conditionally disordered protein CP12, which forms a ter
129 ental evidence for the direct involvement of conditionally disordered regions in unfolded protein bin
130 for antibody-cytokine fusion proteins, which conditionally display "activity on demand" properties at
132 decipher the role of ERK1/2 in RPE cells, we conditionally disrupted the Erk1 and Erk2 genes in mouse
133 CGI methylation regulates transcription, we conditionally disrupted two major DNA methyltransferases
134 e, this approach will have broad utility for conditionally disrupting regulated secretion of diverse
136 analysis with 318 transcripts as primary and conditionally distinct secondary cis-eQTLs, including so
139 , taurine, some essential amino acids, and a conditionally essential amino acid and its precursor.
144 c inactivation approach with selection for a conditionally essential gene, a strategy termed CEN-SELE
145 uired for type IV pili function; and several conditionally essential genes encoding antitoxins and/or
146 ribe a new, efficient method for identifying conditionally essential genes in Tn-Seq experiments with
147 library scale, by systematically phenotyping conditionally essential genes involved in amino acid bio
148 methods have been described for identifying conditionally essential genes whose tolerance for insert
149 also use ZINB to perform a analysis of genes conditionally essential in H37Rv cultures exposed to mul
150 essential genome of this bacterium and genes conditionally essential in multiple environments - absce
151 a role in brain development, 3) carnitine, a conditionally essential nutrient with an important role
153 From 175 genes showing decreased fitness as conditionally essential under hypoxia, preferential carb
154 cothiol redox system were also identified as conditionally essential under hypoxia, which was further
158 course of dynamic network inputs, provides a conditionally exact and several orders-of-magnitude fast
159 ins, in which N-terminal glycine degrons are conditionally exposed after a failure of N-myristoylatio
160 y targeting adult neural precursor cells, we conditionally express an activated form of an FGF recept
161 kappaB kinase beta transactivated) mice that conditionally express an activator of the NF-kappaB path
164 ere, we generated human ES cells designed to conditionally express heterozygous and homozygous STXBP1
165 nerated a mouse line that would enable us to conditionally express Neurod1 in intestinal epithelial c
166 this system to trace lymphocyte fate and to conditionally express oncogenes or silence tumour suppre
168 eductase gene (nitA) regulatory sequences to conditionally express Streptococcus pyogenes Cas9, and V
170 11 signaling in vivo, we generated mice that conditionally express the human DLBCL-derived CARD11(L22
172 We employed mice with an inducible Cre, and conditionally expressed DTA to deplete or GFP to track S
173 stly euchromatic chromosome arms to suppress conditionally expressed genes involved in flowering or D
175 mouse in which channelrhodopsin-2 (ChR2) is conditionally expressed in vesicular glutamate transport
183 first clustering for warmth (no cost), then conditionally grooming (low cost), and eventually provid
184 duced epigenetic changes are associated with conditionally heritable adaptive phenotypic stress respo
185 mophila cells secrete HGA only when they are conditionally HGA-resistant, which allows these bacteria
186 of a genome to accumulate mutations that are conditionally hidden and only reveal phenotype-altering
189 ar heterogeneity, we have developed multiple conditionally immortalized clonal preadipocyte lines fro
190 ) signaling molecules were evaluated for two conditionally immortalized fetal NSC lines derived from
191 High-concentration thrombin directly injured conditionally immortalized human and rat podocytes.
194 e-induced mHtt IB formation is observed in a conditionally immortalized striatal neuron model of HD,
196 e that it is important for gliding motility, conditionally important for type IV pili-dependent motil
198 ck down Insr or its substrates Irs1 and Irs2 conditionally in 3T3-L1 murine preadipocytes/adipocytes
200 ere made in mice in which Piezo1 was deleted conditionally in ECs (Piezo1 (iDeltaEC) ), and lung micr
201 -associated Scn1a missense mutation (A1783V) conditionally in inhibitory neurons (Slc32a1(cre/+)::Scn
203 enetic silencing of PLD4, either globally or conditionally in proximal tubular epithelial cells, prot
204 encoding the essential GluN1 NMDA-R subunit, conditionally in SCs, to create a novel mouse model in w
205 the Mgat4d gene was inactivated globally or conditionally in spermatogonia, or mis-expressed in sper
209 nants in which both EBNA3A and EBNA3C can be conditionally inactivated or using virus completely lack
210 ect of its loss on outcomes in the brain, we conditionally inactivated the murine Pten gene in neonat
213 nhancers by the bromodomain inhibitor JQ1 or conditionally inactivating an EBV oncoprotein or NF-kapp
216 , partitioning strategies involve estimating conditionally independent models of molecular evolution
219 tudy meta-analysis, identifying 47 novel and conditionally-independent risk loci for dental caries.
221 SPC-rtTA(+/-)TetoCre(+/-)LoxP-VEGF-A(+/+) to conditionally induce VEGF-A isoform deletion specificall
222 uses and histopathology of exudative AMD, we conditionally induced hypoxia in a novel preclinical AMD
223 ntricular zone neural progenitor cells using conditionally-induced NEX/NeuroD6-Cre is sufficient to d
225 protein 1-mediated mitochondrial fission was conditionally interrupted in cardiac myocytes, we propos
227 fects, we engineered a mouse wherein Smc5 is conditionally knocked out (cKO) in the developing neocor
228 pmental processes, such as axon guidance, we conditionally knocked out Celsr3 in the hippocampus 1 we
232 signaling in bladder cancer progression, we conditionally knocked out the Tgfbr2 in mouse model afte
234 sion synergizes with PTEN deficiency in PTEN conditionally knockout mice (P < 0.05) and expressed sig
235 te and characterize RMs at different ages by conditionally labeling and ablating RMs populations in s
236 from ET(flox/flox);Tie2-Cre( + ) mice, which conditionally lack ET-1 in hematopoietic stem cells and
241 or sequences that function in vivo to rescue conditionally lethal mutants of Escherichia coli (auxotr
242 serA (3-phosphoglycerate dehydrogenase) were conditionally lethality in the M9-glucose medium supplem
243 ients with ursodeoxycholic acid intolerance, conditionally licensed add-on therapy is with the FXR (N
244 nes for safety and efficacy and is currently conditionally licensed for use for veterinary purposes i
245 uated vaccine for RVF, the MP-12 vaccine, is conditionally licensed for veterinary use in the United
247 receptor (GR)-based fusion protein system to conditionally localize GR-UVR8 to the nucleus, we have d
248 The Kv2.1 voltage-gated potassium channel is conditionally localized to large PM clusters that repres
249 /PTEN-deficient human cancers while p110beta conditionally mediates PI3K/AKT signaling only upon HER2
257 e, as of 2015, no other RVF vaccine has been conditionally or fully licensed for use in the United St
258 equence variant data can be generated either conditionally or unconditionally on pedigree members' qu
260 a Notch gain-of-function transgenic mouse by conditionally overexpressing the Notch1 intracellular do
261 a new and widely applicable tool to generate conditionally phosphorylated proteins to identify those
263 a human central nervous system (CNS)-derived conditionally proliferating cell line that can be differ
264 emented within the network itself but can be conditionally provided by extrinsic neuromodulatory inpu
266 steroids or hospitalization, for whom ICS is conditionally recommended as an additive therapy; 5) a c
270 talized and nonhospitalized medical patients conditionally recommends chemoprophylaxis for non-critic
273 nal landmarks that direct Rsr1p to bud sites conditionally regulated the fMAPK pathway, corresponding
274 provides significant insights into how light conditionally regulates plant growth through controlling
276 in female and male mice in which VGluT2 was conditionally removed established fewer striatal connect
280 inations were tested in primary cultures and conditionally reprogrammed cells generated from nasal br
286 ease heritability, but produced only limited conditionally significant results: non-tissue-specific a
287 Here we leveraged the TET-OFF system to conditionally silence Rit2 in Pitx3(IRES2-tTA) mouse DAN
288 Thus, growth-independent fermentation can conditionally stabilize or destabilize a mutualism, indi
289 ociated state, we introduce the concept of a conditionally stable motif, the stability of which is co
293 genesis in disrupted rats using oxytocin and conditionally suppressing the production of new neurons
294 ndent RNA substrate, a signal amplifier that conditionally synthesizes long fluorescent strands only
298 spikelets transmitted through gap junctions conditionally trigger postjunctional spikes, depending o
299 tion, LIG4 mainly expressed in the crypts is conditionally upregulated in ISCs, accompanied by Wnt/be
300 mutant lacking both of these proton pumps is conditionally viable and retains significant vacuolar ac