ライフサイエンスコーパス: conduction system

1 um during the development of the specialized conduction system.

2 r and atrial myocardium, and the specialized conduction system.

3 lated ion channel dysfunction on the cardiac conduction system.

4 s that originate from defects in the cardiac conduction system.

5 ing, maturation, and function of the cardiac conduction system.

6 ciency causes apoptosis, particularly in the conduction system.

7 mechanisms that control the formation of the conduction system.

8 d embryonic specification of the ventricular conduction system.

9 ex-to-base conduction after emergence of the conduction system.

10 ex network of specialized cells: the cardiac conduction system.

11 to direct distinct functions of the cardiac conduction system.

12 is required for specification of the cardiac conduction system.

13 lar tachycardia (VT) originating high in the conduction system.

14 tention of embryonic cardiac myocytes in the conduction system.

15 different effects of these treatments on the conduction system.

16 in development and maturation of the cardiac conduction system.

17 he atrioventricular bundle and bundle branch conduction system.

18 evelopment of the relevant structures in the conduction system.

19 e reflect a developmental abnormality of the conduction system.

20 onsistent with a recruitment of cells to the conduction system.

21 omyocytes to differentiate into cells of the conduction system.

22 etal muscles, major tendons, and the cardiac conduction system.

23 ialized cells in the sinoatrial node and the conduction system.

24 ene are indeed components of the specialized conduction system.

25 1 years) to assess its effects on the AP and conduction system.

26 n of pacemaking impulses through the cardiac conduction system.

27 t cationic channels found in human atria and conduction system.

28 nsmitted from Purkinje fibers of the cardiac conduction system.

29 than with other, more distal elements of the conduction system.

30 ning patterning and induction of the central conduction system.

31 n through specialized tissues of the cardiac conduction system.

32 t as a myocardial tube without a specialized conduction system.

33 rm mRNA is also expressed in the rat cardiac conduction system.

34 ng formation of the myocardial walls and the conduction system.

35 ntricular myocytes, and cells of the cardiac conduction system.

36 clusive subset of cardiac cells comprise the conduction system.

37 filling, chamber dilation, and disruption of conduction system.

38 usps, and houses important components of the conduction system.

39 nction depends on a highly efficient cardiac conduction system.

40 lex developmental biology of the ventricular conduction system.

41 d in epidermal keratinocytes and the cardiac conduction system.

42 iomyocytes known collectively as the cardiac conduction system.

43 ting the critical role of Slc26a6 in cardiac conduction system.

44 for survival and is regulated by the cardiac conduction system.

45 roliferation of working myocytes but not the conduction system.

46 tivate transcription in the atrioventricular conduction system.

47 l the precise pattern of Tbx3 in the cardiac conduction system.

48 lized myocytes of the impulse generation and conduction system.

49 fication to development of the valve and the conduction system.

50 3 in development and function of the cardiac conduction system.

51 that plays an important role in the cardiac conduction system.

52 pression mainly is restricted to the cardiac conduction system.

53 d specifically in the cardiac pacemaking and conduction system.

54 ts in the atrioventricular and bundle branch conduction systems.

55 ur histological examination of their cardiac conduction systems.

56 l that connexin40 (Cx40) is prominent in the conduction system [4].

57 The risk of conduction system abnormalities (CSA) after transcathete

58 and X-linked dilated cardiomyopathy, whereas conduction system abnormalities that cause heart block,

59 m recordings in Mybphl mice revealed cardiac conduction system abnormalities with aberrant atrioventr

60 eduction, extent of myocardial necrosis, and conduction system abnormalities with each technique were

61 mice demonstrated structural and functional conduction system abnormalities, including left bundle b

62 dium, valves, coronary arteries, and cardiac conduction system across length scales.

63 malian ventricles that includes the Purkinje conduction system and 214 PMJs distributed throughout th

64 vide insight into development of the cardiac conduction system and accessory pathways.

65 and had normal specification of the cardiac conduction system and apparently normal electrocardiogra

66 kinje networks are a fundamental part of the conduction system and are known to initiate a variety of

67 compound heterozygous mutant mice and found conduction system and cardiac output defects.

68 est genetic heterogeneity within the central conduction system and coronary smooth muscle.

69 o the electrophysiological properties of the conduction system and govern contraction of the surround

70 tion of circadian control across the heart's conduction system and inherent susceptibility to arrhyth

71 g migrating neural crest, the origins of the conduction system and initial embryonic heartbeat, and t

72 lmonary bypass, intraoperative injury to the conduction system and myocardium, postoperative metaboli

73 er of Nkx2.5 in the maintenance of the adult conduction system and rescue of Nkx2.5 conduction diseas

74 tribute to the mature valves and the cardiac conduction system and retain multipotent characteristics

75 icacy and safety of procedures targeting the conduction system and structures in its proximity.

76 imensional relationships between the cardiac conduction system and surrounding structures, we provide

77 r role in the development of the ventricular conduction system and that electrical propagation across

78 include normal morphogenesis of the cardiac conduction system and the normal postnatal involution of

79 ethamphetamine, have measured effects on the conduction system and through several direct and indirec

80 , is preferentially expressed in the cardiac conduction system and ventricular myocytes in the heart.

81 iology and development of the murine cardiac conduction system and will also serve as a baseline for

82 sis and ultimately lead to scar of the fetal conduction system and working myocardium.

83 Tbx5 and Gata4 for proper expression in the conduction system, and Gata4(+/-) mice have short PR int

84 , radiation can damage the heart valves, the conduction system, and pericardium, which may take years

85 r Cx40-independent patterning of the cardiac conduction system, and suggest that the electrophysiolog

86 o the heart muscle tissue, the pacemaker and conduction system, and the coronary vasculature is a cen

87 complex between cardiac myocytes, the heart conduction system, and the NMJ.

88 study, is expressed in the mouse ventricular conduction system, and treatment with a selective SCN10A

89 rt abnormalities; disturbance of the cardiac conduction system; and lethality between the second and

90 nital heart disease patients presenting with conduction system anomalies and recent genome-wide assoc

91 Although pathologies of this specialized conduction system are common in humans, especially among

92 hile it has been shown that the cells of the conduction system are derived from myocytes, additional

93 elopment, maturation, and maintenance of the conduction system are not well understood.

94 The heterogeneous cell types of the cardiac conduction system are responsible for coordinating and m

95 A-V node and the His-Purkinje regions of the conduction system are specifically compromised by DMPK l

96 histological abnormalities of their cardiac conduction systems are best interpreted as resulting fro

97 m (e.g. the nodes and bundles of the central conduction system) are controversial, with some proposin

98 ave suggested that components of the cardiac conduction system arise from progressive recruitment of

99 urkinje fibers of the peripheral ventricular conduction system arise from working myocytes during car

100 tricular chamber properties, the ventricular conduction system, as well as heterogeneity of the ventr

101 entricular node and the proximal specialized conduction system (AVCS) would enhance planning for tran

102 nt to direct expression to the developing AV conduction system (AVCS).

103 CMs that reside within the atrioventricular conduction system (AVCS).

104 kedly prolonged the QRS duration, leading to conduction system block in cFgf13(KO) but not in wild-ty

105 ancer elements in skeletal muscle and in the conduction system but not in cardiac muscle.

106 ession of SCN5A and formation of the cardiac conduction system, but its absence does not cause baseli

107 t and heterogeneity of the mammalian cardiac conduction system by revealing a new cardiomyocyte popul

108 eins, and the interplay between cells in the conduction system, cardiomyocytes, fibroblasts, and the

109 Nkx2-5 mutations are associated with cardiac conduction system (CCS) defects.

110 veral transcription factors regulate cardiac conduction system (CCS) development and function but the

111 transcriptional mechanisms governing cardiac conduction system (CCS) development and working cardiomy

112 ellular electrical activity, altered cardiac conduction system (CCS) development, and increased arrhy

113 Cardiac conduction system (CCS) disease, which results in disrup

114 The cardiac conduction system (CCS) ensures regular contractile func

115 lso leads to increased expression of cardiac conduction system (CCS) genes Tbx5, Cx40, and Cx43 throu

116 The cardiac conduction system (CCS) is a network of specialized card

117 The cardiac conduction system (CCS) orchestrates the electrical impu

118 of the heart's cellular biomass, the cardiac conduction system (CCS) unfailingly coordinates every li

119 The heartbeat is organized by the cardiac conduction system (CCS), a specialized network of cardio

120 resulting from abnormalities in the cardiac conduction system (CCS).

121 ts in the transition between ventricular and conduction system cell lineages.

122 cells differentiated into cardiomyocytes and conduction system cells.

123 te to all CNC derivatives, including cardiac conduction system cells.

124 s to convert contractile cardiomyocytes into conduction-system cells as measured by ectopic reporter

125 The cardiac conduction system comprises a specialized tract of elect

126 The cardiac conduction system coordinates electrical activation thro

127 Remnants of the developing specialized conduction system could be the underlying substrate of t

128 Conduction system defects and slowed ventricular conduct

129 hypertrophy, ventricular pre-excitation and conduction system defects coexist.

130 findings of reduced ventricular function and conduction system defects in Mybphl mice support that MY

131 get of Tbx5, did not account for morphologic conduction system defects in Tbx5(del/+) mice.

132 n cardiac death and a complete penetrance of conduction system defects, including spontaneous ventric

133 potential explanation for Holt-Oram syndrome conduction system defects, suggest mechanisms for intraf

134 ants with potential structural or functional conduction system defects.

135 yopathies may also be accompanied by cardiac conduction-system defects that affect the atrioventricul

136 Left bundle branch block may be due to conduction system degeneration or a reflection of myocar

137 lectrical pathways but not cardiomyopathy or conduction system degeneration.

138 rdiomyopathy, ventricular preexcitation, and conduction system degeneration.

139 ) developed AV block while tamoxifen-induced conduction system deletion of Tjp1 distal to the AV node

140 of these gene regulatory networks in cardiac conduction system development and discusses how they pro

141 he molecular circuitry controlling mammalian conduction system development and should be invaluable i

142 ased on the current understanding of cardiac conduction system development and the observation that a

143 atively little is known about the process of conduction system development in mammalian species, espe

144 he role of Endothelin signaling in mammalian conduction system development is less clear, and the dev

145 portant differences between murine and avian conduction system development.

146 icating minK expression as an early event in conduction system development.

147 The murine conduction system develops in close association with the

148 Purkinje fibers of the cardiac conduction system differentiate from heart muscle cells

149 familial syndrome of atrial tachyarrhythmia, conduction system disease (CSD), and DCM vulnerability.

150 tions in LMNA is dilated cardiomyopathy with conduction system disease (DCM-CD1).

151 ac clinical history or prevalence of cardiac conduction system disease (PEA, 31.6% versus VF, 32.2%;

152 al lupus include anti-SSA/Ro-SSB/La-mediated conduction system disease and endocardial/myocardial dam

153 d by ventricular pre-excitation, progressive conduction system disease and left ventricular hypertrop

154 echanical dissociation, or indicating severe conduction system disease eventually leading to complete

155 In-utero management of tachyarrhythmias and conduction system disease has improved postnatal outcome

156 Conduction system disease impairs cardiac function, whic

157 y with dilated cardiomyopathy and associated conduction system disease in whom prior clinical cardiac

158 other family members, especially so when the conduction system disease occurs at a younger age.

159 In addition, the patient developed cardiac conduction system disease requiring pacing at the age of

160 The outcome of fetal conduction system disease secondary to maternal Sjogren'

161 essive ECG monitoring strategies looking for conduction system disease should be ongoing in all patie

162 with long QT syndrome, Brugada syndrome, and conduction system disease with deletion of lysine 1500 (

163 2 causing Wolff-Parkinson-White syndrome and conduction system disease with onset in childhood and th

164 lamin A/C loci associated with familial AF, conduction system disease, and dilated cardiomyopathy.

165 frequent premature ventricular contractions, conduction system disease, and early onset atrial fibril

166 atic patients, the course is malignant, with conduction system disease, atrial fibrillation, heart fa

167 the long-QT syndrome, Brugada syndrome, and conduction system disease, have been associated with het

168 n involving multiple accessory pathways, and conduction system disease, including sinus and atriovent

169 ld lead to improved diagnosis and therapy of conduction system disease.

170 on, which leads to glycogen accumulation and conduction system disease.

171 syndrome (WPW) and progressive degenerative conduction system disease.

172 ar dystrophy and cardiomyopathy with cardiac conduction system disease.

173 g indications to treatment of other forms of conduction system disease.

174 entricular conduction system hypoplasia, and conduction system disease.

175 sidered in patients with HCM and progressive conduction system disease.

176 MD (EDMD-AD) and dilated cardiomyopathy and conduction-system disease (CMD1A).

177 Each mutation caused heritable, progressive conduction-system disease (sinus bradycardia, atrioventr

178 s responsible for dilated cardiomyopathy and conduction-system disease are observed in the rod domain

179 utosomal dominant dilated cardiomyopathy and conduction-system disease on chromosome 1p1-q21, where n

180 electively cause dilated cardiomyopathy with conduction-system disease or autosomal dominant Emery-Dr

181 er involving dilated cardiomyopathy, cardiac conduction-system disease, and adult-onset limb-girdle m

182 (EDMD-AD) and in dilated cardiomyopathy and conduction-system disease.

183 utosomal dominant dilated cardiomyopathy and conduction-system disease.

184 oncompaction, which is often associated with conduction system diseases.

185 vents in the absence of skeletal myopathy or conduction system disorders.

186 c death, and absence of skeletal myopathy or conduction system disorders.

187 tion site were studied to assess the risk of conduction system disturbance and were found highest in

188 A family history of conduction system disturbance or pacemaker insertion sho

189 rt, calcification of cardiac muscle leads to conduction system disturbances and is one of the most co

190 r severe prosthetic valve regurgitation, and conduction system disturbances resulting in a permanent

191 ogether, these data suggest that the cardiac conduction system does not develop by outgrowth from a p

192 ly engraft at high levels in the ventricular conduction system during fetal development in sheep.

193 tructural changes that could lead to cardiac conduction system dysfunction were seen.

194 wever, cells labeled in the proximal cardiac conduction system exhibited neurogenic and gliagenic mar

195 in altered myocyte action potential and mild conduction system expansion but does not alter conductio

196 Specifically, all levels of the conduction system expressed alpha3 immunoreactive protei

197 tes the developing and mature murine cardiac conduction system, extending proximally from the sinoatr

198 ons cause cardiac sudden death syndromes and conduction system failure.

199 effect of septal reduction therapies on the conduction system for patients with hypertrophic cardiom

200 ing the regulatory networks that orchestrate conduction system formation and their role in cardiac rh

201 lysis of the molecular mechanisms underlying conduction system formation should inform our understand

202 lly, the ability to distinguish cells of the conduction system from neighboring working myocytes pres

203 a role in AV node formation, we investigated conduction system function and AV node morphology in adu

204 Thus, our results implicate Gata4 in conduction system function and provide a clearer underst

205 Although several genes involved in mature conduction system function have been identified, their a

206 nduction system expansion but does not alter conduction system function or promote spontaneous arrhyt

207 s in TBX3 expression affect atrioventricular conduction system function.

208 techniques for evaluating in vivo embryonic conduction system function.

209 In Nkx2-5 haploinsufficiency, the conduction system has half the normal number of cells.

210 involved in regional differentiation of the conduction system has provided insight into how lineage

211 into the formation of the cardiac pacemaker-conduction system, heart valves and atrial septum, and u

212 of Tbx3 in adults reveal its requirement for conduction system homeostasis.

213 and reduced cardiomyocyte size, ventricular conduction system hypoplasia, and conduction system dise

214 elopment, maturation, and homeostasis of the conduction system in a highly dosage-sensitive manner.

215 ss clear, and the development of the cardiac conduction system in mice lacking Endothelin signaling h

216 we assessed the specification of the cardiac conduction system in mouse embryos lacking all Endotheli

217 yocardial cells and cells of the specialized conduction system in order to synchronize the cardiac cy

218 ly evaluated the effects of ibutilide on the conduction system in patients with accessory pathways (A

219 d the presence of the developing specialized conduction system in the MA-Ao region starting at embryo

220 he electrophysiologic characteristics of the conduction system in these patients with PJRT, particula

221 electively governs Cacna1g expression in the conduction system in vivo.

222 birth with hyperplastic working myocytes and conduction system including two nodes and internodal tra

223 Cells of the conduction system, including Purkinje fibers, terminally

224 hat Tbx5 is expressed throughout the central conduction system, including the atrioventricular bundle

225 escent reporter gene in cells of the cardiac conduction system, including the distal Purkinje fiber n

226 Components of the murine conduction system, including the peripheral Purkinje fib

227 Development of the cardiac conduction system is a complex biological process that c

228 The cardiac conduction system is a complex network of cells that tog

229 The cardiac conduction system is a network of cells responsible for

230 The cardiac conduction system is a specialized tract of myocardial c

231 ther and to what extent the atrioventricular conduction system is affected by Tbx3 dose reduction, we

232 The cardiac conduction system is an anatomically discrete segment of

233 mice that the number of cells in the cardiac conduction system is directly related to Nkx2-5 gene dos

234 topological shift marking maturation of the conduction system is sensitive to variation in hemodynam

235 es is controlled by the terminal part of the conduction system known as the Purkinje fiber network.

236 dial-specific CHF1/Hey2-KO mice with cardiac conduction system LacZ reporter mice and stained for con

237 of ventricular myocytes into the ventricular conduction system lineage.

238 le exit of specified cardiomyocytes toward a conduction system lineage.

239 nd often unpredictable sites of the specific conduction system, loss of traditional anatomic landmark

240 other tissues including the atrioventricular conduction system, lungs, and liver.

241 ngenital heart diseases that include cardiac conduction system malformations.

242 preserved expression of previously described conduction system markers.

243 isoform-specific antibodies and histological conduction system markers.

244 nd T-box proteins, are essential for cardiac conduction system morphogenesis and activation or repres

245 insufficiency caused a maturation failure of conduction system morphology and function.

246 ll lineage specification into trabecular and conduction system myocytes is a new mechanistic pathway

247 Martin Flack and Arthur Keith studied the conduction system of a mole and found a structure in the

248 ion of conduction defects in the specialized conduction system of Cx40(-/-) mice and provide new insi

249 gnaling connects a sagittally-oriented, fast-conduction system of the deep layers with the transverse

250 umentation of amyloid deposits involving the conduction system of the heart.

251 the arrhythmogenic beats originate from the conduction system or the ventricular working myocardium.

252 Conduction system pacing (CSP) has been used successfull

253 Conduction system pacing (CSP) is a promising pacing str

254 terns, including atrio-biventricular pacing, conduction system pacing by His-bundle pacing, left bund

255 We analyzed the Rush conduction system pacing registry on LBBP to assess the

256 ntractility modulation, leadless pacing, and conduction system pacing therapies are frequently consid

257 rged as a promising alternative modality for conduction system pacing.

258 es that mHTT could cause progressive cardiac conduction system pathology that could increase the susc

259 ation targets involving careful recording of conduction system potentials and pacing/entrainment mane

260 ols for generation and isolation of specific conduction system precursors.

261 hniques exclude pathways outside the central conduction system, preventing the visualization of abnor

262 ical mapping revealed a loss of VCS-specific conduction system propagation.

263 ly differentiates as cells of the peripheral conduction system (Purkinje fibers) and that this occurs

264 ther AF variants have diverse effects on the conduction system, ranging from none to extensive.

265 e, we assessed the genome-wide occupation of conduction system-regulating transcription factors TBX3,

266 ent of specific subcomponents of the cardiac conduction system remains challenging.

267 oral patterning of Hcn4 expression in the AV conduction system required cis-regulatory elements with

268 t expression of a unique panel of atrial and conduction system-restricted target genes, as well as th

269 potential characteristics of the specialized conduction system (SCS).

270 V nodes differ, and this renders the cardiac conduction system sensitive to decoupling during abrupt

271 The cardiac pacemaking and conduction system sets and maintains the rhythmic pumpin

272 Mice with tamoxifen-induced conduction system-specific deletion of Tjp1 (Tjp1(fl/fl)

273 iched gene, and in Cacna1g, a down-regulated conduction system-specific gene.

274 ike phenotype based on ectopic expression of conduction system-specific genes and cell autonomous cha

275 Conduction-system-specific expression for Id2, a member

276 gulation by Nkx2-5 and Tbx5 in vitro and for conduction-system-specific gene expression in vivo.

277 Conduction system stimulation prevents LVEF deterioratio

278 ed cells incorporated within any part of the conduction system suggest that such cells share closer l

279 In the ventricular conduction system, Tbx5 haploinsufficiency caused patter

280 escribe a novel marker of the murine cardiac conduction system that identifies this specialized netwo

281 he AV junction region contains a specialized conduction system that is anatomically isolated from ord

282 explore early steps in the patterning of the conduction system that previously have been inaccessible

283 or specification and function of the cardiac conduction system, this work has important implications

284 on system LacZ reporter mice and stained for conduction system tissue.

285 selectively in either cardiomyocytes or the conduction system to achieve cell type-specific, noninva

286 dings indicate that Tbx3 is required for the conduction system to establish and maintain its correct

287 it appears that different components of the conduction system utilize unique modes of developmental

288 atrial myocardium (PAM) and the ventricular conduction system (VCS) and is essential for maintaining

289 the CCS into atrial node versus ventricular conduction system (VCS) components with distinct physiol

290 n of Tbx5 from the mature murine ventricular conduction system (VCS), including the AV bundle and bun

291 the embryonic heart) a lack of a ventricular conduction system (VCS).

292 block pattern, CCB within the proximal left conduction system was observed in 64% (n=46) and intact

293 that is coexpressed with Cx45 in the cardiac conduction system was posttranscriptionally reduced by 7

294 Fibrosis affecting the cardiac conduction system was responsible for the universal leth

295 lecular composition of the mouse ventricular conduction system we used microdissection and transcript

296 on delineates the embryonic and fully mature conduction system, we tested the ability of several endo

297 mprise the main gap junctions in the SAN and conduction system, were unchanged by TBX18.

298 es the structure and function of the cardiac conduction system, which may underlie the differences in

299 t of macrophages residing within the cardiac conduction system, which orchestrates cardiac rhythm.

300 3-dimensional representations of the cardiac conduction system within the intact human heart.