ライフサイエンスコーパス: conformation

1 t portion of the S4 segment in alpha-helical conformation).

2 deactivating conformation and an activating conformation.

3 crystalized conformation to a membrane-bound conformation.

4 ate structurally resembles the inward-facing conformation.

5 ns of the fold that support the gene-off RNA conformation.

6 ognized an induced and distinct G12D decamer conformation.

7 ion on how to stabilize this ADCC-vulnerable conformation.

8 s used to explore the active site of the out conformation.

9 ontinuously stabilized in its closed, native conformation.

10 RNA when the ribozyme folds into its active conformation.

11 tion but retained after heat-denaturation of conformation.

12 reveal adopts a predominantly alpha-helical conformation.

13 nadditivity depends markedly on the receptor conformation.

14 (H) is sufficient to drive the FAD to the in conformation.

15 genetic adaptations for both physiology and conformation.

16 n-binding domain (ACB), influences the Nterm conformation.

17 red region, fixing the channel in its closed conformation.

18 minimally perturbing method for probing DNA conformation.

19 ereas acidic pH affects the carboxy-terminal conformation.

20 ns, where each promoter remains in the basal conformation.

21 bound linker histones adopt a single compact conformation.

22 , strongly promoted a pH-dependent activated conformation.

23 ucleosome interfaces in the nucleosome-bound conformation.

24 d subunit with another, distinct, cross-beta conformation.

25 no binding is detected with the closed-gate conformation.

26 a pH adjustment without changing the protein conformation.

27 leotide-binding domains in the inward-facing conformation.

28 e a-loop is extended and kalpha11 in the OUT conformation.

29 t and promotes a dynamic, partially unfolded conformation.

30 is transferred to substrate from the closed conformation.

31 he effector-binding site of Ras in an active conformation.

32 hannel to adopt an open, fluoride-conducting conformation.

33 interactions that stabilize this permissive conformation.

34 by positioning the CDK7 T-loop in its active conformation.

35 ly influencing pharmacokinetics, potency and conformation.

36 into the evolution of eukaryotic chromosome conformation.

37 omains, which bind to nucleic acids in the Z-conformation.

38 n stabilizing an active (i.e. conductive) SF conformation.

39 s from iTTP patients induce an open ADAMTS13 conformation.

40 the ArpC3 subunit in stabilizing the active conformation.

41 neutralization resistance, and native trimer conformation.

42 odification site with an appropriate protein conformation.

43 f SOCS2 and FLT3 through changes in promoter conformation.

44 ed at acidic pH in both pre- and post-fusion conformations.

45 ide hydrolysis site or multiple intermediate conformations.

46 distinguishes between closed and alternative conformations.

47 d KASH-peptide adopts at least two different conformations.

48 occur in both domain-swapped and nonswapped conformations.

49 cking SYD-2 (Y741E) primarily exists in open conformations.

50 fferentiating between these two intermediate conformations.

51 utually exclusive productive or unproductive conformations.

52 with enumerating the low-energy ensemble of conformations.

53 ) can also exist in both extended and docked conformations.

54 formation of non-filamentous pathogenic tau conformations.

55 ket to favor either of the two intracellular conformations.

56 ioselectivity through Dio type-specific loop conformations.

57 ests the presence of 41 unique CI-2 solution conformations.

58 the complex can adopt a variety of different conformations.

59 ealed that they correspond to the downstream conformations.

60 , and drug-driven changes of kinase activity conformations.

61 d their complexes, very often adopt multiple conformations.

62 cysteine loop are rigidly constrained to cis conformations.

63 nomeric effect) or the preference for gauche conformations about the C1-O5 bond in carbohydrates.

64 redicted to alter the HLA Trp-167 side-chain conformation abrogated TCR binding, indicating that this

65 it was homogeneous in terms of size, charge, conformation, absence of glycosylation, and containing p

66 Simultaneous optimization of side chain conformations across all conformations increased sequenc

67 In this solvent-exposed conformation, AdoCbl undergoes facile transfer to MCM.

68 ceptors transition to the open state via two conformations, an "unconstrained pre-active" state that

69 Therefore, the BSA conformation and 3D water structure directly affected th

70 ding to a significant change in its solution conformation and a reduced chaperoning function.

71 at peptidiscs stabilize them in their native conformation and allow for high-resolution structure det

72 4 of the selectivity filter of the open-gate conformation and also the site S2, but no binding is det

73 client can transition between a deactivating conformation and an activating conformation.

74 ional calculations indicate that for any PPy conformation and any amino-acid location in the protein,

75 back to the kinetically preferred misfolded conformation and are not observed, we estimate that each

76 ose forces act through control of the ribose conformation and are transmitted to the sulfur via the S

77 e of the GPI-anchor in driving the aggregate conformation and disease phenotype.

78 ge domains of cohesin adopt an "open washer" conformation and dock onto the STAG1 subunit.

79 Subunits in the ClpX hexamer assume a spiral conformation and interact with two-residue segments of s

80 closed conformation shifts to a more compact conformation and is the major component.

81 and is hypothesized to be controlled by the conformation and nucleotide state of tubulin dimers with

82 is displaced from the solvent-exposed active conformation and occupies the orthosteric ligand-binding

83 s, and the influence of the host cell on the conformation and properties of pathological seeds.

84 activity, chromatin accessibility, chromatin conformation and readouts from functional experiments, s

85 Alternative splicing regulates ECR conformation and receptor signaling, while mutagenesis o

86 cular dichroism to confirm its alpha-helical conformation and transmembrane alignment.

87 Proteins must maintain proper folding conformations and express the correct post-translational

88 isting of four systems with different glycan conformations and one system without glycans.

89 C exists as a mixture of active and inactive conformations and that functional regulation is achieved

90 thyretin tend to unfold and sample nonnative conformations and that the edge strands in one beta-shee

91 e better captured by RECON MSD over multiple conformations and thus multiple local residue environmen

92 Chain length distribution, chain conformation, and flexibility can also be accessed withi

93 ing site of SERT, stabilize the outward-open conformation, and inhibit serotonin transport.

94 us gnavus GUS with 2-7 explained how charge, conformation, and substituent of iminocyclitols affect t

95 ow BAX monomers assemble into a higher-order conformation, and the structural determinants essential

96 nt lengths, and their chain length and chain conformation are often experimentally characterized by e

97 heir local environment across an ensemble of conformations are more likely to be conserved.

98 In contrast, "looping" conformations are prevalent for A blocks of BAB amphiphi

99 les from simulations, even when the relevant conformations are rarely observed.

100 Thr-381 is locked into a single conformation as an acyl bond forms between the substrate

101 ey conserved antigenic site to stabilize its conformation, as well as redesigns of an immunogenic reg

102 t pH 5.5, resolving into a solitary all-down conformation at lower pH.

103 The cis conformation at the Cys(6)-Pro(7) peptide bond was essen

104 nique binding mode with a more open receptor conformation at the extracellular face.

105 drug discovery and boost the development of conformation-based pharmacological approaches.

106 e, the more aggregation prone monomeric aSyn conformations become.

107 e element (TAR) RNA, such that the native GS conformation becomes a low-abundance ES.

108 However, we observe the complex in a conformation before PCNA opening, with the clamp loader

109 id bilayer, driving mechanosensors to assume conformations better matched to the altered membrane.

110 the F229A cluster is mostly (60%) in the "A" conformation but with ~20% each of the WT conformer and

111 ed with ligands having different lengths and conformations can have large differences in interactions

112 v) trimers, stabilized in a prefusion-closed conformation, can elicit humoral responses capable of ne

113 tin structure, through the use of Chromosome Conformation Capture (3C), we identified sequences at th

114 Here we employ circular chromosome conformation capture (4C) analysis to identify genome-wi

115 High-resolution chromosome conformation capture (Hi-C) analysis revealed multiplex,

116 Recently, high-resolution chromatin conformation capture (Hi-C) assays in lymphoblastoid cel

117 Chromosome conformation capture (Hi-C)(1,2) analysis has revealed a

118 mized single-cell high-throughput chromosome conformation capture (HiC) protocol(12,13), during preim

119 Chromatin-conformation capture and dCas9 mediated enhancer blockin

120 Chromatin conformation capture assay revealed direct contact betwe

121 Recent advances in chromosome conformation capture experiments provide partial informa

122 Chromosome conformation capture experiments show that cohesin turno

123 inly relies on crosslinking-based chromosome conformation capture techniques, but resolution and sign

124 ng Hi-C, a technique that combines chromatin conformation capture with high-throughput sequencing.

125 Here, we use high-resolution chromosome-conformation-capture carbon-copy sequencing (5C-seq) to

126 crotubule stability and that the microtubule conformation changes gradually in the cap as GTP is hydr

127 nes bound to STK17B revealed a unique P-loop conformation characterized by a salt bridge between R41

128 hat uses long, accurate reads and long-range conformation data for single individuals to generate a c

129 tures have provided snapshots on a number of conformations, data on substrate states and populations

130 , the disulfide in M88 stabilizes the closed conformation, decreasing k(off) 260-fold relative to str

131 metry, CD, SDS-PAGE, and immunoblotting with conformation-dependent and -independent mAbs, which conf

132 The nucleocapsid conformation depends on the reverse transcription status

133 than the remainder of the filament and has a conformation distinct from G-actin, meaning that incomin

134 In the absence of ACE2, single-RBD-up conformations dominated at pH 5.5, resolving into a soli

135 Such proteins adopt native conformations early on during the translation process, w

136 Myosin conformations establish work-energy equipoise that is es

137 The two conformations exhibit different TM crossing angles, rese

138 xistence of an optimal ligand-binding pocket conformation for capsaicin-mediated TRPV1 activation gat

139 peptide with adoption of an 'in-line' attack conformation for catalysis.

140 ization of solvent molecules and alternative conformations for multiple amino acids, and unambiguous

141 ites to investigate the in-aqueo ensemble of conformations for the longest-lived looped DNA intermedi

142 lagen losing its original triple alpha-helix conformation, further confirming the diagenetic decay of

143 We find that the ensembles of bound peptide conformations generated by the programs MODELLER and Ros

144 hus forcing nBA side groups to adapt L-shape conformations, generating stronger dipole-dipole interac

145 in N(2), CCS values for the most compact ion conformations have an interinstrument variability of <=3

146 t residues 11-42 and 69-102 adopt beta-sheet conformation in patient protein fibrils.

147 onformation to a more native, membrane-bound conformation in silico.

148 vealed a higher percentage of the 1-RBD "up" conformation in the G614 spike, suggesting increased epi

149 The AtMC4 structure exhibits an inhibitory conformation in which a large linker domain blocks activ

150 We demonstrate that SurA samples an array of conformations in solution in which P2 primarily lies clo

151 SAXS), we elucidate the ensemble of Bvht RNA conformations in solution, revealing that Bvht lncRNA ha

152 known about their extracellular domain (ECD) conformations in the absence of orthosteric ligands, whi

153 titis B surface antigen, and adopts multiple conformations in the course of the viral life cycle.

154 e small ribosomal subunit, assumes different conformations in the five classes, revealing how contact

155 ne (TM) domain of EphA2 adopts two alternate conformations in the ligand-dependent and the ligand-ind

156 The cyclophanes all adopt butterfly-like conformations in the solid state with the P-organyl subs

157 open (O-) and closed (C-), based on the ring conformations in the vicinity of the N-O bond.

158 ned space has on the chromophore's molecular conformation (including disruption of strong hydrogen bo

159 es having different molecular structures and conformations, including four small ligands and one poly

160 ation of side chain conformations across all conformations increased sequence conservation when compa

161 ated, and the pesticides were represented by conformation-independent molecular descriptors.

162 (GTP), and we describe the changes in BBSome conformation induced by ARL6(GTP) binding.

163 We show that BsYetJ conformation is pH-sensitive in apo state (lacking calci

164 This inactive conformation is stabilized by binding of SARM1's own sub

165 part a much greater diversity of side chain conformations is observed.

166 Such dynamics are governed by the conformation landscape whose study requires characteriza

167 The third TCR engaged a flipped peptide conformation, leading to the recognition of off-target p

168 ed to wild-type mice, indicating a chromatin conformation less prone to transcription in mdx mice.

169 with only part of the complex in a "closed" conformation matching the microtubule geometry.

170 Upon gastrulation, this conformation matured into conventional A/B compartments.

171 ty of methods to better characterize protein conformation may improve detection of counterfit and unl

172 f DSS1 to RAD52 changes the RAD52 oligomeric conformation, modulates its DNA binding properties, stim

173 ll-RBDs 'down' position or adopts 'up' state conformations more readily than the wild-type S-protein.

174 domain-swapped and nondomain-swapped ASIC M2 conformations need to be considered.

175 ith acylated ceftazidime both favor a closed conformation not conducive for catalysis.

176 RSV G complexed with 3G12 adopts a distinct conformation not observed in previously described RSV G-

177 CDTb is observed in a preinsertion state, a conformation observed in the transition of prepore to be

178 ance Energy Transfer (smFRET) to measure the conformation of a FRET labelled E2~Ub conjugate, which d

179 The three-dimensional conformation of a genome can be profiled using Hi-C, a t

180 the cyclization does not perturb the overall conformation of backbone and key side-chain residues.

181 At the closed conformation of CD81, however, EC2 disengages from EC1 a

182 m by which cholesterol binding regulates the conformation of CD81.

183 t EC1-EC2 interaction also supports the open conformation of CD81.

184 These proteins bind to and modulate the conformation of chromatin, thereby regulating transcript

185 the proposal that the RING dependent closed conformation of E2~Ub represents the active form that me

186 The conformation of each kinetoplast is dictated by its netw

187 , we evaluated the effects of BMS-806 on the conformation of Env on the surface of cells and virus-li

188 sed on these results, the predicted inactive conformation of GSK3beta can facilitate the identificati

189 or determinant of the activation-resistant T-conformation of hPg.

190 this Pfr-like state and that the PHY-tongue conformation of IsPadC is partially uncoupled from the i

191 action with the bilayer does not perturb the conformation of membrane-embedded gA.

192 ally relevant calcium ion to investigate the conformation of monomeric aSyn in relation to its aggreg

193 In contrast to OVA and nOVA, the conformation of nOVAmax was substantially changed.

194 ly-unseen compact fold, the helix-turn-helix conformation of pUL51 resembles the cellular endosomal c

195 Supporting work using smFRET to study the conformation of RNA duplexes bound to the core also show

196 esistance occurs by destabilizing the closed conformation of the active site.

197 ired for the maintenance of an extended-open conformation of the beta leg.

198 nactive state, which reveals a unique closed conformation of the ECD.

199 cyclopentane derivatives with fixed envelope conformation of the five-membered ring.

200 evidence that the SERINC5 protein alters the conformation of the HIV-1 Env proteins and that this act

201 The conformation of the homotrimeric AcrB remains the same w

202 breakdown is dependent upon the ordering and conformation of the KPC Omega loop.

203 A stabilize first the open, and then closed, conformation of the PIC to influence the accuracy of ini

204 COVA1-16 binds to a flexible up conformation of the RBD on the spike and relies on antib

205 This stabilizes the distorted conformation of the retinal after photoactivation and de

206 These results demonstrate that the conformation of the S-protein can be controlled via rati

207 ion up to amino acid residue 209 altered the conformation of the S1-S2 linker and made it no longer s

208 nactivation is attributed to a nonconductive conformation of the selectivity filter (SF).

209 pulation and characterize the topography and conformation of the silk in situ.

210 on intermediate by mimicking a "flipped-out" conformation of the target cytosine bypass the SNF2 doma

211 al stability of Env (i.e. induced a "closed" conformation of the trimer) increased virus resistance t

212 We demonstrate that the gate conformation of the two opposite ends of 20S are coupled

213 ters interdomain separation and the internal conformation of the WW domain.

214 s studies to elucidate slipping dynamics and conformations of (CAG)n TR hairpins.

215 concentration-dependent stoichiometries and conformations of assembling human MutSalpha-MutLalpha-DN

216 o those of MHC-restricted TCR, including the conformations of CDR1 and 2.

217 le bound CDTa in the prepore and beta-barrel conformations of CDTb.

218 Solution conformations of lipid-bound and lipid-free mSAA1 at pH~

219 l and kinetic data illustrates how different conformations of MRP1 are temporally linked and how subs

220 Structural studies have revealed distinct conformations of S, but real-time information that conne

221 The structures and conformations of soluble, overexpressed, purified S prot

222 an ensemble of models covering the potential conformations of the binding site.

223 ynamics simulations were performed with four conformations of the channel: two closed state structure

224 By analyzing and simulating inactive conformations of the highly homologous dopamine D(2) and

225 ctural analysis reveals open and closed gate conformations of the KcsA channel.

226 ility is explained in terms of the intrinsic conformations of the three trapezoidal substructures.

227 tion states stemming from the two half-chair conformations of their lithium chelate.

228 ting that the structures represent different conformations of these functionally similar metazoan cha

229 The receptor adopts two major signaling conformations, one of which couples almost exclusively t

230 lar to 8-oxo-dGTP, r8-oxo-GTP adopts an anti conformation opposite a templating cytosine and a syn co

231 ion opposite a templating cytosine and a syn conformation opposite adenine.

232 compete with ATP, stabilize inactive kinase conformations, or act through allosteric sites.

233 g aggregation, but how they affect substrate conformations remains poorly understood.

234 s with a strong tendency to adopt a specific conformation, represent unique platforms for efforts to

235 The observed relevance of open conformations resolves the debate about the roles of ope

236 d pinch motions were observed in an open ORC conformation revealing a hinge at the ORC5.ORC3 interfac

237 osed change from an overtwisted to an active conformation reveals an additional regulatory mechanism

238 In this conformation, ring sigma(C-O)* orbitals oriented antiper

239 in N(2), while CCS for the most compact ion conformations sampled on the 6560 are systematically sma

240 presence of RyRp at high Ca(2+), the closed conformation shifts to a more compact conformation and i

241 R seven-transmembrane bundle, which adopts a conformation similar to that in the M2R-heterotrimeric G

242 P2/T507K exists in the closed, autoinhibited conformation similar to the WT enzyme, the interactions

243 The conformation space of any molecule that can be electrosp

244 decoys are needed to explore satisfactorily conformation spaces.

245 s characterization of the ground and excited conformation states.

246 s an amyloid that can adopt several distinct conformations (strains) that confer distinct phenotypes

247 and demonstrate that these FRET pairs enable conformation studies of DNA and RNA.

248 Quantitative analysis of their conformations suggested that turns corresponded to half

249 At pH 5.5, the NTD exhibits two conformations, suggesting the motion for cholesterol del

250 tion of the complex adopt markedly different conformations than in a structure of a human MCU-EMRE co

251 R) induces an allosteric response favoring a conformation that can bind specific DNA motifs, thereby

252 vantage of substrate flexibility to induce a conformation that facilitates the acyl formation step of

253 acids induce TcdB into a compact "balled up" conformation that is no longer able to bind cell surface

254 ns on the donor cell surface in their native conformation that is not impacted by rituximab, anti-thy

255 The Si-TPP complex presents a saddle-shaped conformation that is stable under STM manipulation.

256 Sec61-translocon, and captures it in an open conformation that is translocation-incompetent.

257 ic CSPs exhibit a chimeric hydrophobic patch conformation that resembles the hydrophobic patches requ

258 GPCRs (such as chemokine receptors) to adopt conformations that are capable of activating beta-arrest

259 versus APC result in unique active receptor conformations that bias PAR1 signaling.

260 t iScore, a novel approach to scoring docked conformations that combines HADDOCK energy terms with a

261 ix orientations and relatively flexible loop conformations that connect the helices.

262 of RNA display pronounced sequence-dependent conformations that relate to the unique ion atmospheres

263 e of protein contacts, oxoA:G forms a wobble conformation, the formation of which is suppressed in th

264 ts salt and/or osmolyte-induced more ordered conformation, the NTD interacts with several proteins, i

265 In the widened channel in the open conformation, these same residues establish a constricti

266 quilibration of a pLGIC from its crystalized conformation to a membrane-bound conformation.

267 pLGICs from their artificial and crystalized conformation to a more native, membrane-bound conformati

268 ta indicates that S4 undergoes alpha-helical conformation to a short-lived different secondary struct

269 suggesting that it stabilizes the productive conformation to allow maturation.

270 peptidomimetics, which have similar folding conformation to alpha-peptides, making them an ideal mol

271 ch G-quadruplexes transition from one folded conformation to another are currently unknown.

272 toleoylated peptides, these glypicans change conformation to create a hydrophobic space.

273 as the disulfide in M112 disrupts the closed conformation to increase k(off), the disulfide in M88 st

274 ative nanodiscs in closed-like and open-like conformations using the copolymer diisobutylene/maleic a

275 The "out" conformation was not sampled in the KPC-4 acyl-enzyme, i

276 erences between its prefusion and postfusion conformations, we hypothesized that the HR3 modulates tr

277 Three distinct conformations were identified, two of which adopt unique

278 FANCD2-FANCI adopts a closed conformation when the FANCD2 subunit is monoubiquitinate

279 MCT1 exhibits similar outward-open conformations when complexed with lactate or the inhibit

280 creased the proportion of myosins in the SRX conformation, whereas pathogenic variants destabilized t

281 ture amplifies small local changes in linker conformation, which are strongly coupled to the guest pa

282 creased the proportion of myosins in the DRX conformation, which enhanced cardiomyocyte contractility

283 e n -> pai* bands between the trans- and cis-conformations, which allows for the generation of unusua

284 tunes catalyst solubility, aggregation, and conformation while modulating substrate reactivity and s

285 de rotamer propensities irrespective of ring conformation, while a novel residue, gamma-oxo-delta-aza

286 es the physiological relevance of the closed conformation, while electron microscopy (EM) and molecul

287 ion or bacterial attachment, but their chain conformation, while vital for this effect, was never cha

288 SYD-2 (Y741F) exists predominately in folded conformations, while phosphomimicking SYD-2 (Y741E) prim

289 ry, as limiting a virtual screen to a single conformation will miss relevant ligands.

290 phorylated BAK1 transitions into an inactive conformation with a "cracked" activation loop and with t

291 ghtly different renditions of the rigor-like conformation with a citrate of crystallization at the nu

292 ting that VX-770 might allow an open-channel conformation with an alternative arrangement of domain i

293 formance and a high possibility of finding a conformation with both a low binding free energy and a s

294 spectrometry analysis, reveals an asymmetric conformation with only part of the complex in a "closed"

295 can be independently transformed between two conformations with a few DNA "trigger" strands.

296 nding both low-energy and small-RMSD docking conformations with high robustness in most cases.

297 in the highly immunogenic prefusion (pre-F) conformation, with or without replacement of its transme

298 ds premature activation by assuming a packed conformation, with ordered inner and peripheral rings, t

299 This method reports only on the RNA conformation within the complex and suggests that the pr

300 ted clones exhibited an accessible chromatin conformation within the IRF8 locus that was accompanied