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1 ia is the first example of a morpheein-based conformational disease.
2 te polymerization and prevent the associated conformational disease.
3 ontrol, thus increasing the risk for protein conformational disease.
4 stress in the pathogenesis of this inherited conformational disease.
5 ibute to the loss-of-expression phenotype of conformational diseases.
6 e mechanisms to rescue bystander proteins in conformational diseases.
7 eutic strategies targeting the modulation of conformational diseases.
8 al, but poorly understood, aspect of protein conformational diseases.
9 havior in protein misfolding is triggered in conformational diseases.
10  a hallmark of a large and diverse number of conformational diseases.
11 xpansion disorders collectively known as the conformational diseases.
12 sensitivity diagnosis of a number of protein conformational diseases.
13 uable strategy for therapies against protein conformational diseases.
14 sponse as a therapeutic strategy for protein conformational diseases.
15 p to explain how mutations alter toxicity in conformational diseases.
16 as a critical conformational element in many conformational diseases.
17  to develop effective treatments for protein conformational diseases.
18 buting to the complex pathologies of protein conformational diseases.
19 study establishes LGI1-related epilepsy as a conformational disease and suggests new therapeutic opti
20 dominant as well as recessive inheritance of conformational diseases and offer opportunities for the
21 standing the pathophysiology of prototypical conformational diseases and protein polymerization in th
22 herapies against aging, degenerative protein conformational diseases, and specific cancers.
23                                      Protein conformational diseases are associated with the aberrant
24                                              Conformational diseases are associated with the conversi
25                                              Conformational diseases are caused by a structural rearr
26  of cataract, Alzheimer's disease, and other conformational diseases are explored.
27 pheein assemblies broadens the definition of conformational diseases beyond the prion disorders and t
28 nderlying type 2 diabetes mellitus-a protein conformational disease characterized by the aggregation
29 ions on cellular phenotypes and introduces a conformational disease component in LS.
30                                      In some conformational diseases, evidence suggests that misfolde
31                                      Protein conformational diseases exhibit complex pathologies link
32 ts that studies of the biophysical origin of conformational disease in one member of a superfamily of
33 odel for the fibril and amyloid formation of conformational diseases in general as well as for the in
34       Prion diseases are so far unique among conformational diseases in that they are transmissible,
35     To date, prion diseases are unique among conformational diseases in that they are transmissible-e
36                                      Protein conformational diseases, including Alzheimer's, Huntingt
37                  The inherent variability of conformational diseases is demonstrated by two families
38                    However, for many protein conformational diseases, it is unclear why this quality-
39 patients with various immunoglobulin-related conformational diseases may provide insight into structu
40 ing, and human diseases suggest that protein conformational diseases may result not only from protein
41                        Protein misfolding in conformational diseases often displays a threshold behav
42  acid variations in V(L) account for various conformational disease outcomes, including amyloidosis.
43           Furthermore they demonstrate how a conformational disease process can be selectively inhibi
44                                              Conformational diseases result from the failure of a spe
45 nd causing common and specific phenotypes (a conformational disease scenario).
46                                              Conformational diseases such as amyloidosis, Alzheimer's
47 n of recombinant proteins, but also to treat conformational diseases such as cystic fibrosis, and Alp
48 y due to its pivotal role in the etiology of conformational diseases (such as Parkinson's and Alzheim
49                                      Protein conformational diseases, such as Alzheimer's, Parkinson'
50                                              Conformational diseases, such as Alzheimer, Parkinson an
51 t cause of numerous diseases called "protein conformational diseases," such as myofibrillar myopathy
52 n mutation responsible for PH1, is a protein conformational disease that may benefit from new therapi
53 ng mechanisms of amyloidosis and etiology of conformational diseases to development of safe and effic
54                           Recently, the term conformational diseases was applied to a whole group of
55 amyloid deposition of proteins seen in other conformational diseases, with the ordered array of polym