ライフサイエンスコーパス: conformational flexibility

1 le ligands to protein complexes that display conformational flexibility.

2 mational dynamics, many of which increase in conformational flexibility.

3 It exhibits substantial conformational flexibility.

4 characterized by having repeat units and low conformational flexibility.

5 ns tend to be located at positions with high conformational flexibility.

6 he structural basis for the bulk of enzyme's conformational flexibility.

7 ely potent, despite retaining germ line-like conformational flexibility.

8 ii) its solvent accessibility, and (iii) its conformational flexibility.

9 clusively targets activation loops with high conformational flexibility.

10 ibitors has proven challenging, due to their conformational flexibility.

11 r out into solution and providing additional conformational flexibility.

12 sorder of the ISP extrinsic domain indicates conformational flexibility.

13 ameters between 0.8 and 0.95, suggesting low conformational flexibility.

14 f aldehyde substrates as a function of their conformational flexibility.

15 ly suited to macromolecules with significant conformational flexibility.

16 identical contact surfaces, but differing in conformational flexibility.

17 borated by MD simulation to have significant conformational flexibility.

18 as well as Cys(154), which is important for conformational flexibility.

19 nteractions and which are more important for conformational flexibility.

20 these modifications often entail restricting conformational flexibility.

21 onformation with limited surface contact and conformational flexibility.

22 ng inhibitors (K(d) = 5-9 pM) have increased conformational flexibility.

23 d dimer, binding results in increased global conformational flexibility.

24 o the critical glycine residue marked by its conformational flexibility.

25 nd TM7 to their respective bundles and their conformational flexibility.

26 ngle X-ray scattering (SAXS), confirmed this conformational flexibility.

27 and complement-activating C1q by considering conformational flexibility.

28 and solubility using their solvent-dependent conformational flexibility.

29 ained by dynamic protein properties, such as conformational flexibility.

30 ling virions that are stable and maintaining conformational flexibility.

31 e conformations, while Ca(2+) uptake reduces conformational flexibility.

32 trate that the complex exhibits considerable conformational flexibility.

33 nits in yeast and 26 subunits in humans) and conformational flexibility.

34 Enzymes are known to exhibit conformational flexibility.

35 ity of hydrophobic E1-E2 interactions and E1 conformational flexibility allow one E1 to charge multip

36 Two modes of conformational flexibility allow TRIM5alpha to accommoda

37 s protein is a highly dynamic molecule whose conformational flexibility allows it to transiently asso

38 Conformational flexibility allows proteins to adopt mult

39 Additionally, we show that conformational flexibility alone is insufficient to expl

40 ed in the periplasm, but the preservation of conformational flexibility also enables efficient secret

41 Our results provide strong evidence that the conformational flexibility also plays an important role

42 Nucleotide-bound structures showed the same conformational flexibility, although ADP and ATP seemed

43 Molecular dynamics simulations support conformational flexibility and a leaky interface.

44 ta show that binding of one agonist leads to conformational flexibility and an increase in conformati

45 AMP releases from the two sites (A and B) in conformational flexibility and chemical shift perturbati

46 regions involved in the interaction possess conformational flexibility and conformational exchange o

47 demonstrate the effect of protein density on conformational flexibility and dimensions of the recepto

48 and determine the high-resolution structure, conformational flexibility and distribution of S trimers

49 g the beta-strand would be essential for the conformational flexibility and DNA minor groove binding

50 his hinge region has been implicated in both conformational flexibility and dynamic protein-DNA inter

51 metal-metalloporphyrin gel, maintains enough conformational flexibility and features a binding pocket

52 Protein function depends on conformational flexibility and folding stability.

53 mutations are all mapped onto the regions of conformational flexibility and functional importance, in

54 e); and screening charge correlations reveal conformational flexibility and interactions among chroma

55 small molecule ligands, indicating that its conformational flexibility and intrinsic dynamics play i

56 To assess the conformational flexibility and its role in allosteric pa

57 y of HH8 may be mediated by a combination of conformational flexibility and less specific intermolecu

58 h better rheological characteristics (higher conformational flexibility and lower rigidity) and great

59 is often hampered by multiple interactions, conformational flexibility and other complex features of

60 in the Fab elbow region impacts interdomain conformational flexibility and paratope plasticity durin

61 The conformational flexibility and programmed assembly of a

62 ich has been quite successful in elucidating conformational flexibility and Quantitative Stability/Fl

63 o investigate the effects of pressure on the conformational flexibility and relaxation dynamics of IP

64 S cleavage) led to a significant increase in conformational flexibility and resulted in rapid amyloid

65 itiation complexes remains opaque due to its conformational flexibility and size.

66 they complement ordered proteins, and their conformational flexibility and structural plasticity all

67 provide additional insights into the role of conformational flexibility and structural properties of

68 These variations in conformational flexibility and substituent position are

69 and-DNA interactions, demonstrating both DNA conformational flexibility and the ability of two DNA-bo

70 input variables that accounted for both the conformational flexibility and the energetic factor of b

71 poor pharmacokinetic properties due to their conformational flexibility and the interaction of protea

72 oped over the years in order to modulate the conformational flexibility and the peptide character of

73 Together with their conformational flexibility and the transient nature of t

74 have been limited to smaller glycans, since conformational flexibility and thermal activation during

75 To further explore this apparent IgE-Fc conformational flexibility and to potentially trap a clo

76 We hypothesized that conformational flexibility and transient exposure of non

77 er, low sequence identity between receptors, conformational flexibility, and chemical diversity of li

78 o sapiens fascin-1, and examine its packing, conformational flexibility, and evolutionary sequence co

79 sults suggest that TF possesses considerable conformational flexibility, and in an attempt to provide

80 cterize experimentally owing to their higher conformational flexibility, and thus intrinsic instabili

81 In particular, changes in conformational flexibility are assessed using a Distance

82 ns and their unique inhibitory mechanism and conformational flexibility are exploited to control prot

83 of the R515A mutant protein revealed greater conformational flexibility around the bridge and C-termi

84 nzyme function and support the hypothesis of conformational flexibility as a limiting factor for cata

85 Our results suggest that HCV utilizes conformational flexibility as an immune evasion strategy

86 demonstrated their larger size and increased conformational flexibility as compared to the parent het

87 l structural integrity of antigens and local conformational flexibility at antigenic sites, which may

88 These results point to conformational flexibility at the interface, which have

89 ith model membranes, notably their differing conformational flexibility at the N-terminus, ability to

90 nce of non-bonding interactions limiting the conformational flexibility at the peptide backbone that

91 Conformational flexibility at this RRE region has been s

92 ons, largely accounts for the differences in conformational flexibility between LEN and SMA.

93 The greatest conformational flexibility between monomers is found in

94 Conformational flexibility between structural ensembles

95 The linker-helix modulates the conformational flexibility between the two domains, regu

96 successfully capture and compare the role of conformational flexibility between two structural homolo

97 p regulate polymerase traffic and that their conformational flexibility buffers the effect of collisi

98 ruption of hydrogen bonding and/or increased conformational flexibility C-terminal to the Ser site wh

99 experimental and computational evidence that conformational flexibility can assist the emergence and

100 This conformational flexibility can be a critical aspect of h

101 ers of millisecond dynamics, suggesting that conformational flexibility can be conserved among analog

102 holo-HpNikR and H74A reveal a high degree of conformational flexibility centered at the DNA-binding d

103 Conformational flexibility currently hinders the structu

104 This study indicates a conformational flexibility-dependent mechanism to contro

105 of this epitope in patients, similar to the conformational flexibility described for other enveloped

106 itch through the introduction of conditional conformational flexibility designed to increase the conf

107 els where their electrostatic properties and conformational flexibility determine gating.

108 Ca(2+)-bound form of Syt1 revealed that Syt1 conformational flexibility drastically increased upon Ca

109 a dual binding mode that may allow increased conformational flexibility during cellulosome assembly.

110 the electrostatic environment due to protein conformational flexibility enables direct excitation of

111 ted by analyzing its collective dynamics and conformational flexibility, enhancing our understanding

112 ile many studies emphasize the importance of conformational flexibility for IDP recognition, it was r

113 N relaxation data indicated a high degree of conformational flexibility for the linker connecting the

114 de bond to demonstrate that limiting protein conformational flexibility greatly reduced the polymeriz

115 Ubiquitin's conformational flexibility has been postulated to underl

116 al aromatic linkage and displaying different conformational flexibility has been synthesized from the

117 Capturing such conformational flexibility has been technically challeng

118 Maintaining conformational flexibility improves AMP potency and sele

119 104C and A128C in the PhoQ PD that restrains conformational flexibility in alpha-helices 4 and 5.

120 Conformational flexibility in dipyridylethene 9 is clear

121 Our results identified the role of conformational flexibility in IL-1ra aggregation and she

122 These results illustrate the role of conformational flexibility in modulating RT kinetics by

123 8 is shown to be located in a region of high conformational flexibility in monomeric Abeta, which upo

124 gands with overlapping binding sites and the conformational flexibility in multi-specific ligand asse

125 Conformational flexibility in regions of intrinsic disor

126 weight), heterogeneity (polydispersity), and conformational flexibility in solution.

127 The observation of conformational flexibility in terminal loop regions coul

128 ntial kinetics, suggesting a large degree of conformational flexibility in the [Re]-Y-betaC19-alpha2

129 e review the role of structural disorder and conformational flexibility in the different aspects of d

130 To investigate whether conformational flexibility in the dsRBD regulates the bi

131 amino acids in the dipeptide that locks its conformational flexibility in the framework.

132 The insert region has larger conformational flexibility in the GDP-bound Cdc42 than i

133 hydrophobic chain maintains a high level of conformational flexibility in the membrane.

134 This study highlights the importance of conformational flexibility in the molecular recognition

135 94H mutant reveals a significant increase in conformational flexibility in the mutant protein.

136 A and 2.0 A resolution that show significant conformational flexibility in the N-terminal alpha-helix

137 Locally, conformational flexibility in the native state is reduce

138 Kinase activity stemmed from conformational flexibility in the region C-terminal to t

139 try data suggest the importance of intrinsic conformational flexibility in the schistosome eIF4E that

140 tivity in binding, despite a large degree of conformational flexibility in the structure.

141 Structural studies demonstrated conformational flexibility in this antigenic region, whi

142 Our results suggest that the observed conformational flexibility in this conserved antigenic r

143 h-resolution analysis, apparently because of conformational flexibility in this region of Gag.

144 s some activity, indicating a high degree of conformational flexibility in this ribonucleoprotein com

145 The role of conformational flexibility in topological enforcement of

146 eling reveal several sites with considerable conformational flexibility in TsaC that may be important

147 of MBL, implying considerable rotational and conformational flexibility in unbound MBL.

148 have been shown to exhibit a high degree of conformational flexibility, in that they are able to seq

149 Many receptors display conformational flexibility, in which the binding pocket

150 IgE-Fc conformational flexibility indicated that inhibition cou

151 ddition, the C-terminal portion of gp7 shows conformational flexibility, indicating an induced fit on

152 ut there is still no understanding about how conformational flexibility influences structure, cofacto

153 cale data sets and found that the side-chain conformational flexibility is closely related to the exp

154 Such conformational flexibility is consistent with structural

155 s finding supports the idea that active site conformational flexibility is essential to the acquisiti

156 The redistribution of conformational flexibility is largely controlled by nons

157 f CCs are available, information about their conformational flexibility is limited.

158 We demonstrate that such conformational flexibility is necessary for binding of L

159 These results support the hypothesis that conformational flexibility is partly required for cataly

160 Conformational flexibility is therefore revealed as a ke

161 of current computational methods in modeling conformational flexibility, it suggests that the experim

162 S exhibits extensive conformational flexibility: it modulates exposure of its

163 l residues, exon 1 displays a high degree of conformational flexibility leading to a scaling of the N

164 the complete coatomer and reveal substantial conformational flexibility likely to be critical for its

165 This conformational flexibility may be essential for the biol

166 fined structural changes, regions subject to conformational flexibility may be important in fine-tuni

167 Changing this conformational flexibility may thus change the pattern o

168 Together, these data suggest that sigma1 conformational flexibility modulates the efficiency of r

169 ion between the differential binding and the conformational flexibility, molecular geometry, and hydr

170 nvironmental conditions, while retaining the conformational flexibility necessary to uncoat and deliv

171 The ensemble clarifies the conformational flexibility observed in stem IIB, reveals

172 liposome binding assay both suggest that the conformational flexibility observed in the C-terminal lo

173 in complex with PFA1 shows that the greatest conformational flexibility occurs at residues 2 to 3 and

174 unctions and translocation activity requires conformational flexibility of a loop sequence in the pal

175 The short timescale conformational flexibility of Abeta(1-38) is suggested t

176 carboxypeptidases, and suggest a coupling of conformational flexibility of active site loops to the r

177 These structures reveal conformational flexibility of an auxiliary domain (amino

178 The MD simulations revealed considerable conformational flexibility of antimycin and significant

179 tions, we find that solution pH controls the conformational flexibility of apo BACE-1, whereas bound

180 s not only a tool to probe the impact of the conformational flexibility of Ar-Au-Ar intermediates, vi

181 embly of the NuRD complex, and increases the conformational flexibility of Arg-4, Lys-5 and Gln-6 of

182 d only Asn is able to precisely modulate the conformational flexibility of Arg244 required for succes

183 To examine the conformational flexibility of Bfrs in a native-like envi

184 ntroduce proline mutations that restrict the conformational flexibility of CDRs and enhance the kinet

185 ngle x-ray scattering were used to probe the conformational flexibility of different forms of PMM/PGM

186 s diffuse within the selectivity filter, the conformational flexibility of E177 side chains underpins

187 otein engineering approaches, we uncovered a conformational flexibility of E3 that is required for su

188 detailed characterization of changes in the conformational flexibility of EF-G in response to FusB b

189 ing causes changes in both the structure and conformational flexibility of EF-G, but which of these c

190 Our work shows that the reduced conformational flexibility of eosinophil cationic protei

191 se in protein multidomain rigidity, reducing conformational flexibility of F-actin-binding domains vi

192 Xpot to study a range of features including conformational flexibility of free and cargo-bound Xpot

193 Due to inherent conformational flexibility of GPCR, stabilization of the

194 We found that the conformational flexibility of GRK1 was reduced in the pr

195 This conformational flexibility of human apo-CRBP1 facilitate

196 combines the multivalency of dendrimers and conformational flexibility of linear polymers for optima

197 Thus, restricting the conformational flexibility of Lipid A by fixing the mole

198 d ribosomal complexes allowed conclusions on conformational flexibility of mRNA in these complexes.

199 Pepped up: Notwithstanding the intrinsic conformational flexibility of peptides, [Zn(Gly-Thr)(2)]

200 ces for POR A and POR B and suggest a higher conformational flexibility of POR B in the surrounding a

201 This review underscores the conformational flexibility of porphyrinoids, a unique cl

202 MS) was used to map the local changes in the conformational flexibility of procaspase-6 at the discre

203 Internal cavities are crucial for conformational flexibility of proteins and can be mapped

204 At low coverage, conformational flexibility of surface-tethered alkyl cha

205 Here, we show that conformational flexibility of synaptobrevin-2 TMD is ess

206 The conformational flexibility of target proteins continues

207 cocatalyst for the H2 liberation, enabled by conformational flexibility of the acridine-based pincer

208 Notably, it reduces the normal conformational flexibility of the adjacent substrate bin

209 ructural data that also helped to assess the conformational flexibility of the allosteric activation

210 d within or near the binding site, increased conformational flexibility of the binding site, a change

211 seven PR-substrate complexes to estimate the conformational flexibility of the bound substrates.

212 CNs is mainly ascribed to the high degree of conformational flexibility of the butadiynyl functionali

213 fferential recognition is facilitated by the conformational flexibility of the C-lobe-binding site.

214 glycan sialylation, suggests that increased conformational flexibility of the CH2 domain is associat

215 e domain (Fc) glycan, resulting in increased conformational flexibility of the CH2 domain with corres

216 Steric effects originating in the conformational flexibility of the chlorin macrocycle dir

217 structural insights into the composition and conformational flexibility of the ClpP active site, no r

218 on mobility spectrometry, we demonstrate the conformational flexibility of the CP149 dimer.

219 They also displayed the high degree of conformational flexibility of the Cys364-loop lining thi

220 layer and a plasma membrane environment, the conformational flexibility of the delta-loop initiates C

221 c effects with their ability to restrict the conformational flexibility of the E2.SUMO thioester.

222 cessing of the HIV-1 Env precursor decreases conformational flexibility of the Env trimeric complex,

223 This significant conformational flexibility of the histone tails suggests

224 These structural determinants regulate the conformational flexibility of the IgG Fc domain and affe

225 of apelin-17 reveals that the integrity and conformational flexibility of the KFRR motif are necessa

226 ogen bond contributing to a reduction of the conformational flexibility of the Le(x) core represents

227 two other Pt(IV) complexes featuring greater conformational flexibility of the ligand scaffold, we sh

228 puter simulation techniques to elucidate the conformational flexibility of the Man-alpha(1-->2)-Man-a

229 by an alkenyl diester bridge to restrict the conformational flexibility of the molecules and reduce t

230 inferred to mainly be involved in enhancing conformational flexibility of the open-closed transition

231 th a diproline segment designed to limit the conformational flexibility of the peptide backbone and r

232 ress with experimental techniques due to the conformational flexibility of the polysaccharide.

233 The conformational flexibility of the protease is essential

234 e protein environment and understand how the conformational flexibility of the protein influences the

235 unnel as a consequence of the high degree of conformational flexibility of the protein.

236 ific microenvironment, solvent exposure, and conformational flexibility of the protein.

237 any biochemical systems characterized by the conformational flexibility of the reactants.

238 he achievement of the desired objectives the conformational flexibility of the selected cis-enones th

239 It is proposed that the conformational flexibility of the seven-membered ring al

240 thylene group attached to C-22 restricts the conformational flexibility of the side chain, which can

241 Fusion promotion appears linked to the conformational flexibility of the stalk, which must be t

242 Depending on the conformational flexibility of the stator part (the carbo

243 on, a rotamer library was set up to take the conformational flexibility of the tether between the Gd(

244 g tightens the active site and restricts the conformational flexibility of the thiyl radical, leading

245 These structures suggest that the conformational flexibility of the TNpP ligand plays a ke

246 yr-33 and the lipid headgroups can influence conformational flexibility of the trimerization domain a

247 We also established that conformational flexibility of the two HEPN domains is im

248 forms of CCR and CAD2 highlight substantial conformational flexibility of these SDR enzymes, which p

249 The localization and conformational flexibility of this loop seems to be impo

250 ange mass spectrometry gave insight into the conformational flexibility of this split protein and the

251 hy of a core TRCF-UvrA complex and probe the conformational flexibility of TRCF in the absence and pr

252 minished, but not abolished, by reducing the conformational flexibility of trimers via targeted seque

253 only enhanced the solvent accessibility and conformational flexibility of Trp159 in the holo protein

254 ne the solution structure and to analyze the conformational flexibility of two overlapping N-terminal

255 nalyses were carried out to characterize the conformational flexibility of TyrH65-159.

256 Collectively, these structures reveal conformational flexibility of unphosphorylated IRAK4 and

257 able insights into regulatory mechanisms and conformational flexibility of uPA and trypsin-like serin

258 The conformational flexibility of Y731 and the hydrogen-bond

259 rmational changes, and the resulting protein conformational flexibility often hinders their structura

260 rate of deuterium exchange, an indicator of conformational flexibility, only decreased during an acc

261 ifferent target molecules, restricting their conformational flexibility or changing their subcellular

262 that nuclear accumulation of Elk-1 involves conformational flexibility prior to its phosphorylation

263 ird of all proteins and are characterized by conformational flexibility, protease sensitivity, and th

264 ed in a single conformation, suggesting that conformational flexibility regulates TnsE activity.

265 the complex-induced DNA bending, facilitate conformational flexibility required for specific cleavag

266 We demonstrate that conformational flexibility results in an unexpected bind

267 Encouraged by the conformational flexibility revealed by these structures,

268 Loop regions that exhibit the most conformational flexibility show the least sequence conse

269 These dynamics require conformational flexibility, such that the peptide produc

270 ower concentrations increased the radius and conformational flexibility, suggesting a distortion of t

271 would not fold correctly and would lack the conformational flexibility that animates their three-dim

272 Comparison with homologous structures shows conformational flexibility that appears to be a recurrin

273 ations, suggests that the epitope displays a conformational flexibility that contributes to neutraliz

274 latter membrane fusion requires an S protein conformational flexibility that is facilitated by proteo

275 d in a cross-over loop that is known to have conformational flexibility, the results described here s

276 This intrinsic large-scale conformational flexibility therefore enables 627-NLS to

277 x nature of correlations between light-chain conformational flexibility, thermodynamic stability and

278 d that nonduplex structural elements and the conformational flexibility they support are necessary fo

279 ious conformations disclosed the antibody 3D conformational flexibility through the distribution of i

280 y importance of noncovalent interactions and conformational flexibility to COF crystallinity and poro

281 trimer of gp120-gp41 heterodimers, relies on conformational flexibility to function in fusing the vir

282 We propose that cyclophilin binding provides conformational flexibility to HIV-1 capsid facilitating

283 culate that the nascent H2 helix may provide conformational flexibility to initiate binding, whereas

284 nsport, suggesting that kinesin exploits its conformational flexibility to interact with microtubules

285 ate that the peptide must possess sufficient conformational flexibility to switch between a hairpin a

286 Importin alpha3 uses its greater conformational flexibility to wedge the RCC1 beta-propel

287 PO monomeric and oligomeric states and their conformational flexibility, together with ligand-binding

288 Here, we investigate one aspect of this conformational flexibility using two domain-specific mon

289 show that pleurocidin displays much greater conformational flexibility when compared with magainin 2

290 hy individuals (Gly299:Pro306) exhibits high conformational flexibility, whereas the loop carrying am

291 HIV-1 CA capsid protein possesses intrinsic conformational flexibility, which is essential for its a

292 tain a high degree of structural freedom and conformational flexibility, which is expected to enhance

293 acteristics of this modified PNA, possessing conformational flexibility while maintaining sufficient

294 d/receptor scaffolds, intended to vary their conformational flexibility, will affect their associatio

295 mportance of mutations that optimize protein conformational flexibility with function during evolutio

296 polyglutamine regions, demonstrated dramatic conformational flexibility, with an accessible hinge sep

297 Furthermore, the state of CI affects the conformational flexibility within CIII(2), demonstrating

298 e alpha-helix C is responsible for increased conformational flexibility within the active site and co

299 the scissile bond and acts as an inducer of conformational flexibility within the carboxyl-terminal

300 ps in these structures show a high degree of conformational flexibility within the three crystal form