ライフサイエンスコーパス: conformational selection

1 ing the spontaneously generated R* state by "conformational, selection".

2 activated DNA binding by HpNikR is driven by conformational selection.

3 ts indicate that the binding mechanism obeys conformational selection.

4 might be involved in target binding through conformational selection.

5 conservation of symmetry and ligand-directed conformational selection.

6 e in the increased activity of Cel7A through conformational selection.

7 t is whether the mechanism is induced fit or conformational selection.

8 ree enzyme and likely involve some degree of conformational selection.

9 ion including lock-and-key, induced-fit, and conformational selection.

10 eaction, precluding rate enhancement through conformational selection.

11 a previously unseen cooperative mechanism by conformational selection.

12 asing substrate concentration, a hallmark of conformational selection.

13 1(-) CBr(4) CM-1(-) pathway corresponding to conformational selection.

14 uch opposite patterns are also diagnostic of conformational selection.

15 ligand binding according to the mechanism of conformational selection.

16 , P450 17A1 binds its steroid substrates via conformational selection.

17 which the ligand selects the optimal fit via conformational selection.

18 relaxation, a key distinguishing feature of conformational selection.

19 g of [Formula: see text] that occurs through conformational selection.

20 ally distinct topologies that may facilitate conformational selection.

21 ensemble and thus fine-tune activity through conformational selection.

22 en two classical mechanisms: induced-fit and conformational selection.

23 ds first and then assembles with the core by conformational selection.

24 /TM6 hole is apparently not involved in this conformational selection.

25 e opportunities and limitations of design by conformational selection.

26 ed-fit and of specific hydrogen bonds during conformational selection.

27 target via an induced-fit pathway instead of conformational selection.

28 esults from a combination of induced fit and conformational selection.

29 ired for polypyrimidine-tract recognition by conformational selection.

30 discordance in the parameters, indicative of conformational-selection.

31 multiple ligand occupancy, induced-fit, and conformational-selection.

32 s ligand rolapitant in a mechanism involving conformational-selection.

33 Zymogen autoactivation is explained by conformational selection, a basic property of the trypsi

34 lded OMPs to chaperones and, by facilitating conformational selection after release from chaperones,

35 gand gating, cooperativity, induced fit, and conformational selection all from the same set of MISC d

36 earlier studies have also found cases where conformational selection alone could not adequately expl

37 the preservation of antibody binding through conformational selection, altered ACE2 recognition and i

38 be targeted by small ligands always includes conformational selection, although other recognition mec

39 , stabilizing conformational changes through conformational selection and frequently modulates local

40 TCR binding, incorporating elements of both conformational selection and induced fit in a manner tha

41 With both conformational selection and induced fit models consider

42 s that underpin DA systems, which fall under conformational selection and induced fit models, and whi

43 ingle-molecule FRET experiments suggest that conformational selection and induced fit of the U2AF(65)

44 We find that both conformational selection and induced fit play a role in

45 These studies support a model in which conformational selection and induced fit play important

46 competing mechanisms of ligand recognition, conformational selection and induced fit, have dominated

47 nition in solution involves a combination of conformational selection and induced fit, rather than bi

48 elative tendencies to fold via mechanisms of conformational selection and induced fit, respectively.

49 ings illustrate the subtle interplay between conformational selection and induced fit.

50 that binding occurs through a combination of conformational selection and induced-fit mechanisms that

51 kinetic measurements to distinguish between conformational selection and induced-fit models.

52 ts suggest that ADP binding to F1 occurs via conformational selection and is preceded by the transiti

53 Mutual conformational selection and population shift followed b

54 According to the "conformational selection and population shift" theory, l

55 data showed that the interaction occurred by conformational selection and the peptide acquired simila

56 the smFRET distributions are consistent with conformational selection and with inter-state exchange l

57 g, are strong determinants of the mechanism (conformational selection and/or induced fit) of molecula

58 ligand and receptor structural elements for conformational selection, and support co-evolution of Gn

59 6, 3A4, 4A11, and 21A2 was best described by conformational-selection, and P450 2E1 appeared to fit e

60 Our data provide strong evidence supporting conformational selection as a major mechanism for substr

61 Our results highlight both local and global conformational selection as a means for universal 3' spl

62 We conclude that conformational selection as a mechanism for a ligand bin

63 study emphasizes the preexisting equilibrium/conformational selection as a mechanism for protein-prot

64 d the phosphoprotein Dishevelled, supporting conformational selection as a prerequisite for functiona

65 CypA interacts with its substrate via conformational selection as the configurations of the su

66 This observation suggests conformational selection as the general mechanism of all

67 These results identify conformational selection as the mechanism for inhibiting

68 450 4A11 bound the substrate lauric acid via conformational-selection, as did P450 2C8 with palmitic

69 We propose that conformational selection at microtubule ends favors long

70 nsitive to their chemical environments, with conformational selection available as an evolved mechani

71 establish that dark reversion is governed by conformational selection between two substates, whereby

72 Constrained by the disulfide, conformational selection between weak and tight binding

73 These data suggest a conformational selection binding mechanism in which the

74 lical conformations, possibly facilitating a conformational selection binding mechanism.

75 nded FKBP51 domain is more consistent with a conformational selection binding process.

76 n k(obs) with [L] is unequivocal evidence of conformational selection, but an increase in k(obs) with

77 r-CBD interface is dispensable for intra-CBD conformational selection, but is indispensable for full

78 ptor activation involves ligand induction or conformational selection, but the molecular basis of the

79 Conformational selection by small molecules expands inhi

80 0 muM Mg(2+) generally shifts docking toward conformational selection by stabilizing a folded-like co

81 "induced fit" mechanism (binding first) or "conformational selection" (conformational change first).

82 is populated to only ~1.3%, indicating that conformational selection contributes negligibly to the c

83 is only accessible to Abl and not to c-Src (conformational selection control).

84 ing point in the mechanism is established by conformational selection, controlled by the interaction

85 ng conditions, folding was found to follow a conformational selection (CS) mechanism.

86 o shed light on the long debate over whether conformational selection (CS) or induced fit (IF) is the

87 that include protein conformational change, conformational selection (CS) or induced fit (IF), best

88 ompetent conformations to which ligands bind conformational selection (CS) or whether ligands induce

89 molecular recognition, induced fit (IF) and conformational selection (CS), play a central role in al

90 anism of binding obeying induced fit (IF) or conformational selection (CS).

91 biomolecular switches: induced fit (IF) and conformational selection (CS).

92 In summary, our results indicate that conformational selection dictates stable retinal binding

93 nding protein (ChoX) to be approximately 90% conformational selection dominant under experimental con

94 loosely coupled to the ATPase reaction, with conformational selection driving the motor mechanism.

95 rbations is reminiscent of binding events by conformational selection encountered in other riboswitch

96 ore enables 627-NLS to bind importin through conformational selection from a temperature-dependent eq

97 Our data suggest that conformational selection guides beta-arrestin recruitmen

98 Discussion concerning "induced fit" versus "conformational selection" has, however, ignored detoxica

99 Na(+) binding and functional selectivity by conformational selection (i.e., preference of the allost

100 like configurations--that implies a role for conformational selection in ligand binding.

101 and active site dynamics, with evidence for conformational selection in the kinase core of 2P-ERK2 b

102 bstrate access, which extends the concept of conformational selection in trypsin-related proteases.

103 tems agree with our recently proposed hybrid conformational selection/induced-fit models.

104 Conformational selection is an established mechanism in

105 It has been speculated that conformational selection is an integral component of sub

106 Here we show that conformational selection is associated with a rich reper

107 ins bind their substrates via induced fit or conformational selection is not understood.

108 A reaction-controlled model invoking conformational selection is proposed to explain the slow

109 f human P450-substrate interactions and that conformational-selection is a dominant feature of many o

110 ton follows a combination of induced-fit and conformational-selection-like mechanisms, via partial bi

111 onformational changes, i.e."induced fit" or "conformational selection," mainly determined by the inte

112 r dynamics-generated ensembles suggests that conformational selection may play a hitherto unappreciat

113 host and provides the first observation of a conformational selection mechanism (as opposed to induce

114 The latter is shown to be controlled by a conformational selection mechanism and also by differenc

115 tion that facilitates drug binding through a conformational selection mechanism and increases the bin

116 Pyrophosphorolysis occurs via a conformational selection mechanism as the pyrophosphate

117 This conformational selection mechanism contrasts with the lo

118 here indicate that the RNA aptamer employs a conformational selection mechanism for binding theophyll

119 osed" and "open" conformations, suggesting a conformational selection mechanism for pilus binding.

120 This favors a conformational selection mechanism for release of the fi

121 librium dynamics within the domain suggest a conformational selection mechanism in the rapid associat

122 esults provide strong evidence that VcINDY's conformational selection mechanism is a result of the so

123 A conformational selection mechanism is proposed to accoun

124 , suggesting that either an induced fit or a conformational selection mechanism should contribute to

125 hese findings can be explained in light of a conformational selection mechanism that dictates that co

126 are also affected by calreticulin through a conformational selection mechanism that facilitates MHC-

127 se, beta-rich conformers self-assemble via a conformational selection mechanism to form energetically

128 Ly49H/m157 and Ly49I/m157 interactions is a conformational selection mechanism where only the extend

129 ation through a significant component of the conformational selection mechanism, because they may inc

130 c and computational studies that show that a conformational selection mechanism, in which POT1 bindin

131 related with ligand efficacies, supporting a conformational selection mechanism.

132 transition pathway, thus precluding a simple conformational selection mechanism.

133 unknown, and activation proceeds through the conformational selection mechanism.

134 and suggest that glucagon binds to GCGR by a conformational selection mechanism.

135 which seems to be in contradiction with the conformational selection mechanism.

136 selects the most complementary one, via the conformational selection mechanism?

137 hat binding specificity was controlled by a "conformational selection" mechanism.

138 ng scenarios with the potential to show that conformational selection might be the design principle o

139 The data support a passive conformational selection model by which the protein sele

140 ide direct structural evidence in favor of a conformational selection model for basal activity in bet

141 slational T-box riboswitches; and supports a conformational selection model for NCCA recognition.

142 sic flexibility of proteins, which follows a conformational selection model for protein-protein inter

143 ur comparative NMR analyses lead to a double conformational selection model in which each apo CBD dyn

144 on, the structural data demonstrate that the conformational selection model is not sufficient to expl

145 tion to the WT-like state, consistent with a conformational selection model of ligand binding, but st

146 This agrees with the conformational selection model of molecular recognition,

147 On the contrary, the conformational selection model postulates that prion iso

148 Alternatively, a conformational selection model proposes that a minor pop

149 The conformational selection model requires that the protein

150 Based on these findings, we established a conformational selection model that governs substrate bi

151 A conformational selection model that includes equilibrium

152 The proposed inverse conformational selection model will extend also to lipid

153 vel model of protein regulation, the "Double-Conformational Selection Model", which demonstrates how

154 In the conformational selection model, a protein samples a scar

155 effect is readily interpreted in terms of a conformational selection model, in which p51(L289K) has

156 hat allostery in TetR is well described by a conformational selection model, in which the apo state s

157 ation is adequately explained by a two-state conformational selection model, the partial agonism of c

158 e catalytic data confirm an extension of the conformational selection model, wherein different substr

159 rst is the induced fit and the second is the conformational selection model.

160 he induced fit model and not required by the conformational selection model.

161 3A4 was consistent with an induced-fit or a conformational-selection model, but the concentration de

162 ne to P450 21A2 was also best described by a conformational-selection model.

163 ccurring after the conformational change via conformational selection of an energetically disfavored

164 model where specificity is generated through conformational selection of an intrinsically bent DNA se

165 ss-seeding of amyloid species is governed by conformational selection of compatible (complementary) s

166 Nb binding involves conformational selection of LacY molecules with exposed

167 that complex formation may be facilitated by conformational selection of residual structure in the ac

168 and that capsid assembly likely proceeds via conformational selection of sparsely populated configura

169 Moreover, the robustness of the conformational selection of the dynamic ensemble is eval

170 Enzyme kinetics data are consistent with conformational selection of the ensemble of active domai

171 usion-limited k(on) ~ 10(11) M(-1) s(-1) via conformational selection of the wobble conformation, whi

172 ited protein states originate primarily from conformational selections of loops AB and GH, a portal r

173 Previously, conformational selections of the AB and GH loops have be

174 o equilibrium, k(obs), becomes diagnostic of conformational selection or induced fit based on whether

175 g to P450 2E1 could be described by either a conformational-selection or an induced-fit model.

176 formational heterogeneity is present before (conformational selection) or after (induced fit) ligand

177 These studies validate the conformational selection paradigm for the pleiotropic fu

178 chanism switches from being dominated by the conformational selection pathway at low ligand concentra

179 s formed in the rate-limiting step along the conformational selection pathway but after the rate-limi

180 scription of a high-energy enzyme state in a conformational selection pathway by an experimental stra

181 Strikingly, the assembly rate along the conformational selection pathway resembles that of an is

182 find evidence for the existence of canonical conformational selection pathways.

183 rget molecules through either induced fit or conformational selection pathways.

184 Conformational selection plays a key role in the polymer

185 equired to form the E-S complex suggest that conformational selection plays a role in substrate recog

186 The induced fit and conformational selection/population shift models are two

187 This framework predicts that conformational selection prevails on ubiquitin's paradig

188 to form complexes with G proteins through a conformational selection process.

189 ing may proceed largely through a process of conformational selection rather than induced fit.

190 Binding of Sox2 to DNA thus involves conformational selection, rather than exclusively induce

191 ignaling pathways, which could be related to conformational selection, signaling amplification, and p

192 In the apo protein, an allosteric conformational selection step comprising almost 60% of t

193 ng adrenodoxin results in enhancement of the conformational selection step.

194 closed model containing both induced fit and conformational selection steps.

195 esembled the response of proteins undergoing conformational selection, suggesting an energy landscape

196 nt simulations strongly support an "extended conformational selection" synergistic folding mechanism

197 ation modeling was also more consistent with conformational selection than with an induced-fit mechan

198 d cross-bridges that appear to result from a conformational selection that occurs during the weak bin

199 with the previously suggested role of E3 in conformational selection, the large positive entropy sug

200 rstood and proposed to primarily operate via conformational selection, the mechanism underlying allos

201 nal shift" or "deformed templating" and the "conformational selection." The conformational shift hypo

202 the accuracy of their widths needed to drive conformational selection thereby increasing the experime

203 all three collagen chains and binds through conformational selection to a sequence that is one tripl

204 the binding mechanism gradually shifts from conformational selection to induced fit.

205 t between the two TCRs: whereas A6 relies on conformational selection to select and bind different li

206 Adk suggests a two-step mechanism combining conformational selection to this state, followed by an i

207 ding support for adaptive recognition via a 'conformational selection' type mechanism.

208 imetic camelid antibody fragment isolated by conformational selection using yeast surface display.

209 Here we show that the "conformational selection versus induced fit" distinction

210 apid kinetics support a binding mechanism of conformational selection where the Na(+)-binding site is

211 anges are realized through the mechanisms of conformational selection (where a higher-energy minimum

212 model of molecular recognition dominated by conformational selection, whereas only minor structural

213 ollows an integrated mechanism that combines conformational selection with induced folding steps.

214 folding, which continues to follow "extended conformational selection" with multiple stages of select

215 ts suggest that glycan recognition occurs by conformational selection within the ground state; this m