ライフサイエンスコーパス: conformational stability

1 entropic contributions of tertiary motifs to conformational stability.

2 important effects of vesicle size on protein conformational stability.

3 se in kcat, which appears to be unrelated to conformational stability.

4 B region contribute jointly to controlling F conformational stability.

5 with little change to catalytic activity or conformational stability.

6 AMX binds to FGF-1 and enhances its conformational stability.

7 cent segments exhibiting somewhat diminished conformational stability.

8 and thermodynamic data for interpretation of conformational stability.

9 changes are accompanied by perturbations in conformational stability.

10 ion but also cell-surface residence time and conformational stability.

11 n a hydrophobic core, the segment has a high conformational stability.

12 disulfide bond contributes substantially to conformational stability.

13 121A RNase A are approximately equivalent in conformational stability.

14 er histones and of histone H3 in determining conformational stability.

15 ay of N-terminal and C-terminal domains, and conformational stability.

16 g of the enzyme but it may contribute to the conformational stability.

17 the e/e' position, is required for enhanced conformational stability.

18 ve class 2 are identical in terms of overall conformational stability.

19 ol, indicating only a slight contribution to conformational stability.

20 this minimum results in a large increase in conformational stability.

21 ing the full-length proteins with impressive conformational stability.

22 nto plaques, was highly soluble, and had low conformational stability.

23 e unchanged in different buffers to indicate conformational stability.

24 ce of the ancillary domain for catalysis and conformational stability.

25 be a useful strategy for increasing protein conformational stability.

26 system to probe the impact of PEG on protein conformational stability.

27 titive selection of those with lower initial conformational stability.

28 ciency observed for strains with the highest conformational stability.

29 a different pathway, primarily by perturbing conformational stability.

30 shown to endow a protein with extraordinary conformational stability.

31 ray of recombinant PrP amyloids with varying conformational stabilities.

32 y adopted shorter incubation times and lower conformational stabilities.

33 nsitive/R33-incompetent prions had different conformational stabilities.

34 Protein conformational stabilities against chaotropes and temper

35 We investigated herein the conformational stability, amyloid fibrillation kinetics,

36 ulations of PrP(Sc) particles with different conformational stabilities and aggregate sizes, which fr

37 model of alpha1(IV)1263-1277 to evaluate (a) conformational stability and (b) cellular responses base

38 cally requires one set of residues to ensure conformational stability and an orthogonal set, with cha

39 cidate the impact of the C(19)-C(25) bond on conformational stability and binding mode.

40 ns two functional domains, one necessary for conformational stability and biological activity (residu

41 e contribution of each disulfide bond to the conformational stability and catalytic activity of RNase

42 three measurements can be used to assess the conformational stability and conformational heterogeneit

43 were used to probe the relationship between conformational stability and cytotoxicity in a methodica

44 y redesigned an important protein for better conformational stability and desirable orientation on gr

45 g(2+) are important determinants of both the conformational stability and dimerization of dephospho-E

46 Conformational stability and dynamics of the cancer-asso

47 te features of the seeds, as demonstrated by conformational stability and electron microscopy studies

48 omotion, revealing a balance between H stalk conformational stability and F-triggering activity.

49 proteins to maintain a balance between their conformational stability and flexibility.

50 uctural consequences that would diminish the conformational stability and folding efficiency of the p

51 We studied conformational stability and folding kinetics of a three

52 slational modification, which may affect WRN conformational stability and function, contributing to f

53 id fibrils that show dramatic differences in conformational stability and have characterized them by

54 We have compared the conformational stability and inhibitory activity of 3 pl

55 ng molecules with respect to their predicted conformational stability and interactions with the targe

56 se enzymes by heat and urea to determine the conformational stability and its dependence on temperatu

57 This result suggests a link between PrP(Sc) conformational stability and its fragmentation rate and

58 prompted us to investigate the link between conformational stability and ligand binding properties o

59 molecular dynamics simulations to study the conformational stability and lipid-binding properties of

60 l) molecular dynamics simulations to explore conformational stability and loop dynamics of this quadr

61 The relationship between conformational stability and methionine oxidation in rec

62 on with locked nucleic acids (LNA) increased conformational stability and nuclease resistance.

63 In this study, the conformational stability and physical properties of a si

64 T-cell epitopes, we demonstrate that reduced conformational stability and protease resistance were re

65 k domain of G plays an important role in the conformational stability and receptor binding-triggered

66 r to study directly the relationship between conformational stability and reductive unfolding kinetic

67 The DeltaP34 variant retains high conformational stability and remains a substrate for thi

68 9D/R91D variant of RNase 1, is shown to have conformational stability and ribonucleolytic activity si

69 2 provided hints of the remarkably different conformational stability and substrate specificity.

70 ing that the F escape mutants have a reduced conformational stability and that the inhibitors stabili

71 h conditions, we found a correlation between conformational stability and the smallest possible fragm

72 ic structure of URO-D is required to achieve conformational stability and to create a large active-si

73 lations reveal how this ion pairing enhances conformational stability and, at the same time, reduces

74 tural properties as determined by NMR, their conformational stabilities, and their affinities for the

75 nine oxidation in the structural properties, conformational stability, and aggregation behavior of im

76 e guanidine hydrochloride-induced unfolding, conformational stability, and structure of active, circu

77 nt biophysical properties with regard to the conformational stability, and these differences mainly r

78 enaturation experiments also show that their conformational stabilities are intact.

79 tories, indicating that their elasticity and conformational stability are different.

80 ecause the determinants of membrane receptor conformational stability are still poorly understood, id

81 isulfide bonds, which are least important to conformational stability, are most important to catalyti

82 nd, and the magnitude of its contribution to conformational stability, are uncommon to the best of ou

83 Both S- and R-fibrils, however, shared high conformational stability, arguing that the energy landsc

84 These findings highlight conformational stability as a key factor governing membr

85 acile atroposelective construction and broad conformational stability as the minimalist scaffold for

86 eukaryotic KatGs have a significantly higher conformational stability as well as a different unfoldin

87 act contributes to the energetics of protein conformational stability as well as protein-ligand inter

88 ials can modulate macromolecular folding and conformational stability, as well as rates of catalysis

89 d a conformation-dependent immunoassay and a conformational stability assay, together with Western bl

90 Using conformational-stability assays, we determined the guani

91 mers in bulk solution had increasingly lower conformational stability at higher temperatures within t

92 gine or alanine residue results in a loss of conformational stability at pH 6.0 of deltadeltaG(o) = 2

93 lphaLA-IIIA, and (d) to clarify the relative conformational stability between alphaLA-IIIA and alphaL

94 eet core size do not underlie differences in conformational stability between strains of mammalian pr

95 The methods exploit the difference of conformational stability between the native and scramble

96 thermodynamic analysis of the differences in conformational stability between the single and double m

97 that maintained ribonucleolytic activity and conformational stability but had a 2.8 x 10(3)-fold lowe

98 is not only critical for preservation of the conformational stability, but also involved in intermole

99 T(m) of rat beta by 3.2 degrees, decreasing conformational stability by 0.74 kcal/mol.

100 e effects of IRKD autophosphorylation on the conformational stability by guanidine hydrochloride (Gdn

101 ribe a strategy for significantly increasing conformational stability by optimizing beta-turn sequenc

102 ics simulations to investigate ligand-linked conformational stability changes associated with this ca

103 esults indicate that the dominant effects on conformational stability come from the electrostatic fre

104 Specifically, conformational stability correlates directly with cytoto

105 mber of residues and has a similar effect on conformational stability, decreasing the midpoint of the

106 Measurements of the change in conformational stability, delta (delta G), for the mutat

107 Measurements of the change in conformational stability, delta(delta G), upon mutation

108 We measured the change in conformational stability, Delta(DeltaG), for hydrophobic

109 It also has a modest conformational stability despite mutations at 12 out of

110 First, the conformational stability determined at or extrapolated t

111 The conformational stability (difference between the free en

112 as glycosylated and trimeric and displayed a conformational stability different from that of Post-F-X

113 Gelatin, on the other hand, retains its conformational stability even at a saturating co-solute

114 , T(m), and deltaC(p), that characterize the conformational stability for each homologue.

115 trometry to provide quantifications of local conformational stability for HIV-1 gp120 in unliganded a

116 263K(R+), which is characterized by very low conformational stability, high sensitivity to proteolyti

117 beta(3)-->cyclic replacements is to enhance conformational stability; however, a crystal structure o

118 lity of the PEG oligomer to increase protein conformational stability; however, the current understan

119 n subjects using two-dimensional immunoblot, conformational stability immunoassay and sucrose gradien

120 The use of different antibodies and of the conformational stability immunoassay indicated that the

121 ) characteristics analyzed by immunoblot and conformational stability immunoassay were indistinguisha

122 ing receptor cell-surface residence time and conformational stability in addition to its previously r

123 riers, bis-MTX proved to possess substantial conformational stability in aqueous solution (-3.8 kcal/

124 r unique side-chains contribute favorably to conformational stability in certain beta-turn positions.

125 quivocally reveals a significant decrease of conformational stability in the degraded protein, while

126 ences a significant decrease in beta-hairpin conformational stability in the presence of 150 mM NaCl.

127 a direct coupling of disulfide reduction to conformational stability in this set of protein variants

128 Correlations between spectral changes and conformational stability indicate that the latter measur

129 vide a framework for understanding how local conformational stability influences entropic change, con

130 veals phenotypes for receptor activation and conformational stability intermediate between the wild-t

131 These data indicate that conformational stability is a key determinant of RNase A

132 Characterization of a protein's conformational stability is a key step in the developmen

133 Protein conformational stability is an important concern in many

134 ced by the knob-into-hole framework, and the conformational stability is similar to the wild-type (WT

135 ancreatic ribonuclease A (RNase A) with high conformational stability, is cytotoxic and has efficacy

136 imilar structural basis for strain-dependent conformational stability may apply to brain-derived PrP(

137 s in each variant agree with the equilibrium conformational stability measured by urea denaturation (

138 e of SHa(Sc237), as demonstrated by relative conformational stability measurements.

139 The results showed that conformational stability, monitored using the Cm value,

140 Intrigued by this result, we measured the conformational stabilities of 30 prion isolates from syn

141 dduct is found to be related to the relative conformational stabilities of bicyclic radical intermedi

142 While the conformational stabilities of bovine-derived and Tg(BoPr

143 The conformational stabilities of eight proteins in terms of

144 At pH 7 and 25 degrees C, the conformational stabilities of the ribonucleases are (kca

145 ide chain and was influenced by the relative conformational stabilities of the turn structure and the

146 The conformational stabilities of the vnd (ventral nervous s

147 ly for the differential effects of pH on the conformational stabilities of the wild-type and variant

148 tein A (OmpA) were measured to determine the conformational stabilities of this model system for memb

149 ium (TPA(+)) and guanidinium (Gdm(+)) on the conformational stabilities of tryptophan zipper (trpzip)

150 Herein, we report the kinetics and conformational stabilities of two unique fusion proteins

151 Here, the pH dependencies of the conformational stabilities of wild-type RNase A and the

152 The conformational stability of 1,8-diquinolylnaphthalenes i

153 yp residue is known to increase markedly the conformational stability of a collagen triple helix.

154 l assessment of the relationship between the conformational stability of a eukaryotic membrane protei

155 In the present study, we evaluated the conformational stability of a group of cyclin-dependent

156 of high concentrations on the colloidal and conformational stability of a particular protein.

157 ly characterized the functional activity and conformational stability of a PorB class 2 protein from

158 Comparison of the conformational stability of a series of 1,8-dipyridylnap

159 cy to the native alpha-helical forms and the conformational stability of alpha-PrP.

160 te here the unfolding-refolding pathways and conformational stability of alphaLA-IIIA using the metho

161 ion or modification of helix A decreases the conformational stability of APRin as assessed by thermal

162 Literature studies have speculated that the conformational stability of beta-peptides is greater tha

163 In this study, we examine the effect on conformational stability of beta-sheet lengthening perpe

164 cular chaperone required for maintaining the conformational stability of client proteins regulating c

165 ies on the ability of Cdc37 to challenge the conformational stability of clients by locally unfolding

166 en identified as contributing factors to the conformational stability of collagen-mimetic peptide seq

167 nderstanding of environments that affect the conformational stability of collagen.

168 rsal sites may be the key determinant of the conformational stability of cyt c.

169 olesterol from HIV-1 particles decreases the conformational stability of Env.

170 C termini (residues 4 and 118) increases the conformational stability of G88R RNase A and C65A/C72A/G

171 of hydrogen bonding by peptide groups to the conformational stability of globular proteins was studie

172 Here we report the conformational stability of homodimeric desulfoferrodoxi

173 ine residue can have dramatic effects on the conformational stability of HPr.

174 KAI1/CD82, the TM interactions maintain the conformational stability of KAI1/CD82, evidenced by the

175 I-bound precursors by ERAP1/2 increases the conformational stability of MHC I/peptide complexes.

176 rgent micelles have been used to explore the conformational stability of Mistic as a function of its

177 an amino acid substitution that affected the conformational stability of neuroserpin.

178 sulfide bond plays a significant role in the conformational stability of ONC.

179 terms of a superior chemical, structural and conformational stability of PBTTT, which can be ascribed

180 This higher conformational stability of Pdx might be due to the pres

181 by the presence of ions and its role on the conformational stability of peptides remains only partia

182 ond results in a loss of 2-3 kcal/mol in the conformational stability of PLA2.

183 s for this correlation, we proposed that the conformational stability of prion fibrils controls their

184 t the proposed hypothesis that a decrease in conformational stability of prions results in an increas

185 ct specific noncovalent contributions to the conformational stability of proteins [alanine-based heli

186 irs and hydrogen bonds can contribute to the conformational stability of proteins and peptides.

187 e used to directly measure the colloidal and conformational stability of proteins in highly concentra

188 rent understanding of how PEG influences the conformational stability of proteins is incomplete.

189 t strategy will be useful for increasing the conformational stability of proteins.

190 backbone amides have been implicated in the conformational stability of proteins.

191 rsion revealed that monensin also alters the conformational stability of PrP(C), leading to increased

192 ive strategy that specifically addresses the conformational stability of PrP(Sc) and that has been us

193 define differences between strains has been conformational stability of PrP(Sc) as defined by resist

194 tained in both hosts, but the solubility and conformational stability of PrP(Sc) differed for the CWD

195 We characterized the conformational stability of recombinant human NGAL and t

196 Conformational stability of rhIL-1ra was monitored by eq

197 P, and Q77G) that significantly increase the conformational stability of RNase Sa.

198 Comparison of the conformational stability of ryanodine- and Imperatoxin A

199 ealed a startling asymmetry in the intrinsic conformational stability of secondary structure in the t

200 ible explanation for the correlation between conformational stability of synthetic prions and incubat

201 n the incubation period to prion disease and conformational stability of synthetic prions.

202 309V) and a type 2M mutation (G1324S) on the conformational stability of the A1 domain and the single

203 al changes exhibited at the active site, the conformational stability of the activation loop is decre

204 apoE aggregation in which differences in the conformational stability of the amino-terminal domain me

205 Decreasing the conformational stability of the amino-terminal domain of

206 A decrease in conformational stability of the amino-terminal domain of

207 Investigation of the conformational stability of the atropisomers at enhanced

208 The conformational stability of the C40A/G88R/C95A and C65A/

209 translocator chaperones, we investigated the conformational stability of the chaperone LcrH (Yersinia

210 ied Asn residues and these contribute to the conformational stability of the coiled-coil peptides.

211 t unfavorable steric dispositions affect the conformational stability of the collagen triple helix mo

212 demanding groups at proline residues on the conformational stability of the collagen triple helix wa

213 3-Hyp and 4-Hyp have distinct effects on the conformational stability of the collagen triple helix.

214 Conformational stability of the complex is evaluated bas

215 ned and served as a relative measure for the conformational stability of the corresponding collagen t

216 reased the folding efficiency as well as the conformational stability of the DeltaF508-CFTR, manifest

217 e in the testis enzyme, and as a result, the conformational stability of the domain is increased.

218 egation-prone states being controlled by the conformational stability of the domain.

219 grees of freedom involved in maintaining the conformational stability of the duplex and the related s

220 bond to ERDD RNase 1 not only increases the conformational stability of the enzyme but also increase

221 ore the role of the subunit interface in the conformational stability of the enzyme.

222 or determining both site-specific and global conformational stability of the fibrillar form.

223 ibe several approaches to characterizing the conformational stability of the human adenosine A(2)a re

224 direct comparison of sites critical for the conformational stability of the human and E. coli enzyme

225 In addition, aminoglycoside binding enhanced conformational stability of the human mitochondrial heli

226 The conformational stability of the I variant has been chara

227 de new, to our knowledge, information on the conformational stability of the junction and distributio

228 he differential agretopic index, and (b) the conformational stability of the MHC I-peptide interactio

229 The conformational stability of the mutant was lower than th

230 Y73.D99 H-bond correlates directly with the conformational stability of the mutant.

231 The conformational stability of the mutants is also unpertur

232 copy to analyze the structural integrity and conformational stability of the mutants.

233 tructure is thermodynamically coupled to the conformational stability of the native envelope glycopro

234 His119 for catalysis and (2) to enhance the conformational stability of the native enzyme.

235 y to aggregate correlates inversely with the conformational stability of the native state of the prot

236 ecific hydrogenation driven by thermodynamic conformational stability of the product, and regioselect

237 sp 76 was replaced by Asn, Ser, and Ala, the conformational stability of the protein decreased by 3.1

238 u at position 49 in E.coli HPr increased the conformational stability of the protein substantially be

239 conformation and do not appear to affect the conformational stability of the protein.

240 drogen bonds make large contributions to the conformational stability of the proteins.

241 stent a greater contribution by Arg50 to the conformational stability of the reactive-site loop in CM

242 stro-intestinal digestion, combined with the conformational stability of the resulting DRPs provide c

243 cle have been shown to result in the loss of conformational stability of the sarcoplasmic reticulum (

244 eins, we observed that calcium increases the conformational stability of the scavenger-rich cysteine

245 d exerts a critical role in the dynamics and conformational stability of the selectivity filter and m

246 our results support the hypothesis that the conformational stability of the SMI is a critical determ

247 We determined the shift in relative conformational stability of the SRP upon substrate bindi

248 nergy of the T1 tetramer as a measure of the conformational stability of the structure is also pH-dep

249 suggested that this modification affects the conformational stability of the Switch II domain, which

250 gnition through affects on the structure and conformational stability of the switch regions.

251 We also characterized the conformational stability of the thermophilic HPr protein

252 The chirality and relative conformational stability of the three ferric complexes o

253 ese observations led us to conclude that the conformational stability of the trans-enamine form is cr

254 The effect of the soluble tail on the conformational stability of the transmembrane domain of

255 azide-alkyne cycloaddition can increase the conformational stability of the WW domain due to a favor

256 ke large but comparable contributions to the conformational stability of these proteins.

257 anar tryptophan indole group, perturbing the conformational stability of trpzip peptides.

258 dissociation (CAD)] is used to evaluate the conformational stability of various protein segments spe

259 termine whether the alterations affected the conformational stability of wtr-K2tPA.

260 The decrease in the conformational stability of X28-PR and X28-delta TF*PR*d

261 c and spectroscopic techniques to assess the conformational stability of zwittergent-solubilized clas

262 fied the regions of LUSH that show increased conformational stability on binding alcohols.

263 ty and dynamics in molecular recognition and conformational stability, our understanding of these rel

264 This covalent construct offered conformational stability over the noncovalent complexes

265 The specific structural, conformational, stability, reactivity and interaction fe

266 These results suggest that conformational stability represents a further dimension

267 SEC and far-UV CD for aggregate content and conformational stability, respectively.

268 We conclude that decreased conformational stability shared by all of these mutant S

269 rminal globular domain in the fragment has a conformational stability similar to that of the same reg

270 n the MD simulations revealed that they have conformational stability similar to that seen for compar

271 Conformational stability studies showed that the half-ma

272 We have used NMR spectroscopy and conformational stability studies to quantify changes in

273 s from scrapie strains in sheep by combining conformational stability studies with studies using nove

274 The PSAM retained high conformational stability, suggesting that the flat beta-

275 ceptor-mediated proliferative activities and conformational stabilities than those which had the L0 l

276 dow the collagen triple helix with much more conformational stability than do hyp residues.

277 The domains of abatacept exhibit different conformational stabilities that are highly pH dependent,

278 the three isoforms have large differences in conformational stability that can influence aggregation

279 rates of H/D exchange) revealed decreases in conformational stability that correlate with the observe

280 x conformation and presumably contributes to conformational stability through a hydrogen-bonding netw

281 network in bound PMI that contributed to its conformational stability, thus enhanced binding to the 2

282 Zinc also provides conformational stability to hAGT that may influence its

283 t this smaller pore range may offer enhanced conformational stability to immobilised enzymes while no

284 synthetic nonnative lipid, which can provide conformational stability to the protein complex, may be

285 ne the correlations of the dipole moment and conformational stability to the self-assembly and solar

286 e hypothesized that the lactam ring promoted conformational stability to yield analogues with increas

287 nges to side chains can confer extraordinary conformational stability upon a protein without perturbi

288 t of temperature and pressure on polypeptide conformational stability using a two-dimensional square

289 g of the intermediate as well as the overall conformational stabilities varied among aminolevulinate

290 Comparative analysis of conformational stabilities was performed for two widely

291 Conformational stability was assessed by differential sc

292 uration experiments revealed that the fibril conformational stability was controlled by the region th

293 rotective antibody, its vaccine efficacy and conformational stability were significantly reduced with

294 d function, but contributes significantly to conformational stability when its stabilizing potentials

295 affecting cell-surface receptor turnover and conformational stability, whereas mutation at TM7(N422D)

296 of Cu(2+) at His-13 has little effect on the conformational stability, whereas the copper-binding sit

297 for proper subunit interactions that provide conformational stability which in turn is necessary for

298 chains appears to contribute to beta-hairpin conformational stability, which is consistent with resul

299 description of the allosteric coupling of A1 conformational stability with the force dependent catch

300 the possibility that alternative folding or conformational stability within these regions contribute