ライフサイエンスコーパス: conformational state

1 ansitions between the RNA-free and RNA-bound conformational state.

2 ependent on the specific GPCR as well as its conformational state.

3 which mimics the bound phosphate in the E2P conformational state.

4 l in which fluctuations occur about a single conformational state.

5 structural characterization of this unknown conformational state.

6 ions take place in the context of an ordered conformational state.

7 to the SH3-GK domain tandem depending on its conformational state.

8 haetomium thermophilum RNase PNK in multiple conformational states.

9 nd disassembly of protein aggregates in both conformational states.

10 teasome, and their correlation with observed conformational states.

11 s in equilibrium between "open" and "closed" conformational states.

12 amples multiple discrete, rapidly exchanging conformational states.

13 cell membranes by alternating among distinct conformational states.

14 ferent peptide sequences revealed a range of conformational states.

15 remote isoform-specific residues that affect conformational states.

16 analysis of endogenous proteins in discrete conformational states.

17 ensemble of molecules sampling at least two conformational states.

18 uires that the transporter traverses several conformational states.

19 there are known structures for the different conformational states.

20 Hs, access is gained to phosvitin in various conformational states.

21 lecules that can transiently adopt different conformational states.

22 transporters, Na(+) stabilizes outward-open conformational states.

23 es are used by experimentalists as reference conformational states.

24 binding preference of the dimer in different conformational states.

25 evaluate the plasticity of low-lying protein conformational states.

26 trum of drug-target interactions and dynamic conformational states.

27 xicity depends on their partially structured conformational states.

28 , we have trapped the enzyme in a variety of conformational states.

29 the heme group and the enzyme visits several conformational states.

30 lectively stabilize discrete cytochrome P450 conformational states.

31 spontaneous transitions between two distinct conformational states.

32 ons adopted, including transiently populated conformational states.

33 ciated Env but nevertheless sample different conformational states.

34 m, and the transport cycle involves multiple conformational states.

35 tions determine RNA-bound versus ssDNA-bound conformational states.

36 dergoes transitions between two (or several) conformational states.

37 ariety of ligands and captured in a range of conformational states.

38 T has been crystallized in several different conformational states.

39 elements rather than through a few discrete conformational states.

40 d four extended arms that exhibit a range of conformational states.

41 oportional to the ratio of affinities of the conformational states.

42 ional dynamics and the binding affinities of conformational states.

43 hods to derive structural models of specific conformational states.

44 fferent ligands and the receptors in various conformational states.

45 anes, LHCII complexes are locked in specific conformational states.

46 S dynamically samples at least four distinct conformational states.

47 cision therapeutics targeting a continuum of conformational states.

48 ing the kinetic and dynamic interplay of the conformational states.

49 tural models of weakly populated alternative conformational states.

50 of Escherichia coli spirosomes in different conformational states.

51 he 5'UTR can transition between at least two conformational states.

52 gulatory and can exist in extreme rotational conformational states.

53 HIV-1 Env is flexible, sampling different conformational states.

54 ample both highly solvated and self-solvated conformational states.

55 f the system often depends critically on its conformational state a rigorous understanding of the cor

56 mutagenesis studies, these structures reveal conformational states accessed during KS catalysis.

57 ented reversible interconversion between two conformational states, accomplished by selective vibrati

58 identifying at each time point the specific conformational state adopted by the protein.

59 hich can dramatically alter the abundance of conformational states adopted by a protein.

60 iscoveries have refined our knowledge of Env conformational states, allowing characterization of the

61 t to induce and stabilize an active integrin conformational state and that this requires intact talin

62 experimental data of proteins with multiple conformational states and demonstrate an accuracy of ~3

63 robust to determine the affinities of three conformational states and detect even modest differences

64 ence detection, which allows us to study the conformational states and dynamics in the submillisecond

65 y greatly narrowing the distributions of the conformational states and fluctuation rates.

66 Structural information on the alternate conformational states and knowledge of the detailed mech

67 iction methods lack an analysis of the major conformational states and might underestimate the impact

68 ions reveal that BACE1 mainly occupies three conformational states and that the relative populations

69 ly determine both binding affinities for the conformational states and the rate constants of conforma

70 l assemblies (hierarchical folding, multiple conformational states and their clustering), RNA motifs,

71 Long-lived conformational states and their interconversion rates cr

72 nning different levels of classification and conformational states and totaling to 1 ms of simulation

73 microtubules, how dynamics connect different conformational states, and how these interactions and dy

74 ns, shortens the lifetimes of the individual conformational states, and instills conformational disci

75 ion from the inward-facing to outward-facing conformational states, and its absence in the reverse di

76 second timescales, show complex manifolds of conformational states, and often show state-dependent ph

77 ver, protein chains can adopt a multitude of conformational states, and their biologically active con

78 slower than, the lifetimes of the metastable conformational states, and when the highly anharmonic re

79 The relative probabilities of each conformational state are sensitive to the membrane envir

80 These conformational states are finely tuned by substrate avai

81 Distinct low-energy intermediate conformational states are identified for the IXO- and AR

82 of channel structures captured in different conformational states are now being determined; however,

83 These conformational states are proposed to be rich in non-can

84 Different side chain conformational states are stabilized in response to bind

85 binding, and also identifies non-native RRE conformational states as new targets for the development

86 ry under low ionic conditions and revealed a conformational state at intermediate ionic conditions pr

87 substrate-engaged human proteasome in seven conformational states at 2.8-3.6 angstrom resolution, ca

88 ient 2.5 +/- 0.5), suggesting at least three conformational states (ATP-bound, ADP-bound, and empty)

89 Both conformational states bound a CRIPT peptide with similar

90 ognition of the target-bound hairpin aptamer conformational state by a specific RNA hairpin probe.

91 allows direct, real-time readout of the AMPK conformational state by fluorescence resonance energy tr

92 Ligand binding favors higher-affinity conformational states by increasing forward conformation

93 s of methemoglobin demonstrate that distinct conformational states can be identified within a dataset

94 s provide a means by which aggregation-prone conformational states can be readily determined experime

95 nd provide the first evidence that transient conformational states can control optical properties of

96 ty of deubiquitinases and indicates that new conformational states can occur when a true substrate, s

97 possibility that switchable phosphoinositide conformational states can serve as lipid recognition and

98 d its cancer mutants sample a similar set of conformational states, cancer mutants could introduce bo

99 ine the role of the N-peptide binding in two conformational states ("closed" vs. "open") of syntaxin-

100 b5 to CYP17A1.pregnenolone induced a set of conformational states closely resembling those of CYP17A

101 due to the transient nature of intermediate conformational states, conformational fluctuations, and

102 tors and chemical probing to define ribosome conformational states corresponding to differently sized

103 The ability to predictively model various conformational states could accelerate selective inhibit

104 rovide evidence showing that these different conformational states determine whether tTG promotes, or

105 as PrP amino acid sequence variants and PrP conformational state), determine the polymorphic depende

106 Each domain adopts multiple conformational states differing on an angstrom scale.

107 , have revealed that GP1 adopts two distinct conformational states distinguished by differences in th

108 ividual mRNA molecules alternate between two conformational states, distinguished by 'bursts' of prob

109 ransfer (FRET) spectroscopy to elucidate the conformational states distribution and associated confor

110 form a heterogeneous ensemble with multiple conformational states, each stabilized by characteristic

111 own orientation and may be in one of several conformational states, each with a different molecular s

112 have been shown to transiently form excited conformational states (ESs) that remodel local aspects o

113 scale, we show that there are at least three conformational states explored by the LBD: the low FRET,

114 erview of the current understanding of these conformational states, focusing on (i) the events during

115 ng with SNARE assembly by requiring a single conformational state for both of these processes to occu

116 mplex landscape that includes four different conformational states for the unliganded receptor.

117 Protein conformational states-from intrinsically disordered ense

118 pins of the coiled coil and between receptor conformational states generated by adaptational modifica

119 ences in key structural elements between the conformational states give rise to multiple intrinsic re

120 volves transient sampling of a higher energy conformational state, greatly increasing the product dis

121 This metastable conformational state has high affinity for Cdc37 and for

122 Notably, the open exchange-competent conformational state has not been identified.

123 ed secondary transporter (Mhp1) in its major conformational states, i.e., the outward-facing (OF) and

124 ition of STIM1 from a quiescent to an active conformational state, (ii) cytoplasmic STIM1 oligomeriza

125 dase active state, which is a key non-native conformational state in apoptosis.

126 the clock, switching KaiC between an active conformational state in which its phosphorylation level

127 identity of the synergistic anion(s) and the conformational state in which sTf binds Ti(IV) are not k

128 eceptor, and a coreceptor, capturing an open conformational state in which the fusion machinery on gp

129 losteric proteins transition among different conformational states in a ligand-dependent manner.

130 rts on functionally significant but distinct conformational states in a native environment without th

131 ew strategy for directly observing transient conformational states in large RNAs, we find that stem I

132 ap1A binding induces and stabilizes discrete conformational states in PLCepsilon variants that can be

133 e MDM2 lid region is shown to adopt distinct conformational states in the presence of different small

134 5), caused by the presence of multiple local conformational states in this portion of the protein; (i

135 is dynamic in solution, transiently visiting conformational states in which Domain 1 at the dimer int

136 e 26S proteasome into an intermediate-energy conformational state, in particular upon the addition of

137 tion factor G1 (EF-G1(mt)) in three distinct conformational states, including an intermediate state a

138 02A1 is highly dynamic, existing in multiple conformational states, including open and closed states.

139 le-point mutant integrins to explore various conformational states, including the initiation of separ

140 ain how Tom1, when in a different VHS domain conformational state, interacts with downstream effector

141 T via a more complex mechanism involving two conformational states interconverting on the second time

142 the transporter into an as-yet-unidentified conformational state, involving rearrangement of the sub

143 to a UvrD monomer-DNA complex, a rotational conformational state is favored that is intermediate bet

144 The knowledge of multiple conformational states is a prerequisite to understand th

145 an ensemble of low Mg(2+), open, asymmetric conformational states is, thus, the key structural signa

146 appear to be able to adopt different stable conformational states, known as protein strains, which c

147 ysis cycle that differ dramatically from the conformational states observed for Cdc48/p97.

148 The discrete, but relatively few, conformational states observed here, and their energetic

149 ith enhanced chemical diversity to probe the conformational state of 12 recombinant human erythropoie

150 iophysical experiments, we show here how the conformational state of buried ion-pairs and water molec

151 FRET) can simultaneously report on e.g., the conformational state of double stranded DNA (dsDNA) foll

152 The application of smFRET to assess the conformational state of existing Env constructs and liga

153 The application of smFRET to test the conformational state of existing Env constructs and liga

154 conformations associated with the rotational conformational state of its 2B subdomain, and its helica

155 een UvrD subunits that affect the rotational conformational state of its 2B subdomain.

156 ADP from CI slows down, making the inactive conformational state of KaiC more stable.

157 Upon target cell recognition, the conformational state of LFA-1 changed in educated NK cel

158 gative-stain EM, we found that the prefusion conformational state of LT5.J4b12C trimeric Env was larg

159 Linking the conformational state of many CTPS2 subunits in a filamen

160 minimal temperature dependence of the global conformational state of PGR in solution as measured by a

161 periments show that the extended beta-strand conformational state of PHF6((*)) is readily populated u

162 ) on the C-terminal tail serves to alter the conformational state of PTEN from an open active state t

163 ed transition from a dynamic to a more rigid conformational state of the C-terminal domain stabilizes

164 that are sufficient to characterize a minor conformational state of the C-terminal region of DHFR.

165 Here we show that the conformational state of the HNH nuclease domain directly

166 e found a novel high affinity outward-facing conformational state of the human SERT induced by seroto

167 s constitutes the first example in which the conformational state of the nascent polypeptide chain ha

168 ual steps of the processing pathway, and the conformational state of the proteasome itself.

169 lay between the syntaxin-1 N-peptide and the conformational state of the protein.

170 e to refine a three-dimensional model of the conformational state of the protein.

171 Reliable and reproducible monitoring of the conformational state of therapeutic protein products rem

172 ing of syntaxin-1, which is dependent on the conformational state of this protein.

173 How substrate binding influences the conformational state of VcINDY is currently unknown.

174 ificial target data reflecting the two major conformational states of a binding protein.

175 rmination of atomic structures of individual conformational states of a given protein.

176 utilized to directly probe and localize the conformational states of a GPCR within the membrane at n

177 functional, and normal-mode analysis of two conformational states of a multidomain pLGIC, called DeC

178 Phe enabled the characterization of multiple conformational states of a phospho-beta2 adrenergic rece

179 e a computational method to sample different conformational states of a structure.

180 tion that gamma acts by coupling the extreme conformational states of beta subunits within the alpha3

181 ding of a short hydrophobic sequence selects conformational states of clients to favor their producti

182 n labeling for the identification of various conformational states of CueR during transcription is sh

183 Defining the conformational states of cytochrome P450 active sites is

184 Here we use smFRET to compare the conformational states of Env trimers used for structural

185 rtion of the protein and plays a key role on conformational states of hGFAT2.

186 Our data reveal an equilibrium between two conformational states of hTDG-DNA complexes, assigned as

187 We also probe conformational states of human P-gp during the catalytic

188 nted three-dimensional information about the conformational states of intact, full-length integrin wi

189 We show that the three conformational states of integrin alpha5beta1 have discr

190 vant PDB structures (which may span multiple conformational states of interest), reconstruction of mi

191 tein structures in the context of individual conformational states of interest.

192 on causes a shift in the population of local conformational states of K-Ras, especially in Switch-II

193 It is known that the conformational states of Lck control enzymatic activity;

194 s the functional role of Q925 in the various conformational states of Na(+), K(+)-ATPase by examining

195 ave been invaluable tools to isolate defined conformational states of proteins, and we reasoned that

196 RNA substrate via a population shift of the conformational states of Rho; upon hydrolysis product re

197 ered in residues that participate in dynamic conformational states of sarcomere proteins.

198 /or ATP concentrations) promoting particular conformational states of SERCA, we found that the effect

199 translocation are performed by two distinct conformational states of SNF2h.

200 cence microscopy, we examined the rotational conformational states of the 2B subdomain of fluorescent

201 scently labelled RNA samples reveal multiple conformational states of the adenine riboswitch.

202 Thus we have investigated various conformational states of the alpha9 dimer in a MOM model

203 In this work, we explored possible conformational states of the CFTR gating cycle by means

204 Axl crystal structure revealed two distinct conformational states of the enzyme, providing a first g

205 Furthermore, we were able to detect two conformational states of the Galpha Ras domain in slow e

206 o-quinazoline ligands bound to the different conformational states of the HSP70 nucleotide binding do

207 nst cleavage, suggesting a relay between the conformational states of the hydrophobic core and the N

208 tein-protein interface, "freezes" one of the conformational states of the intrinsically disordered Cd

209 Conformational states of the metastable drkN SH3 domain

210 r dynamics (MD) simulations, we revealed the conformational states of the peripheral stalk and assign

211 nsic mobility correlates well with different conformational states of the Pol I cleft, in addition to

212 d on opposite surfaces of LacY to assess the conformational states of the protein complexed with each

213 termediates, sampling various membrane-bound conformational states of the protein, and their intimate

214 that amino acids 1753 to 1852 influence the conformational states of the proximal carboxy-terminal d

215 e revealed detailed snapshots of a subset of conformational states of the RNAP as they exist in cryst

216 M. thermoresistibile GlgE we observe several conformational states of the S domain and provide eviden

217 epitopes on the S(RBD), as well as distinct conformational states of the S trimer.

218 ble among coronaviruses and they define four conformational states of the trimer wherein each recepto

219 identification of previously uncharacterized conformational states of this duplex which can explain b

220 ncreases across virus panels) and identified conformational states of virion-bound spikes.

221 this effect requires the description of the conformational states of water and protein molecules at

222 ng affinity and free energy of each integrin conformational state on the cell surface, together with

223 phaS molecules are forced to access a hidden conformational state on the phospholipid bilayer in whic

224 ture the influence of various membrane-bound conformational states on the lipid and cholesterol dynam

225 between two approximately equally populated conformational states, one corresponding to the closed s

226 owed that IscU populates two interconverting conformational states: one structured (S) and one largel

227 equential domain closure, resulting in three conformational states (open, semiclosed, and closed).

228 rae in a ligand-free form in three different conformational states: open, intermediate and closed.

229 ine is very similar regardless of either the conformational state or the protonation of E115, presuma

230 nd preventing transitions between functional conformational states or by destabilizing the enzyme and

231 ess sparsely populated and transiently lived conformational states--or excited conformational states-

232 cal tools, we characterize three short-lived conformational states over the ns-ms timescale.

233 our data suggest that previously unobserved conformational states play a role in regulating antitoxi

234 rter P-glycoprotein (P-gp) in three distinct conformational states: predominantly inward-facing apo P

235 One of three conformational states previously predicted by smFRET was

236 Transitions between different conformational states range between microseconds to mill

237 omodimer that has been shown to exist in two conformational states related to one another by two larg

238 sence of the ligand, which allows to capture conformational states relevant in the activation process

239 The model incorporates only three conformational states (resting, open, and desensitized)

240 alogs, we were able to observe four distinct conformational states (s1 to s4).

241 ng groove, to selectively recognize discrete conformational states sampled by MHC-I alleles, toward e

242 t that the mode of production influences the conformational states sampled by OMPs and thereby affect

243 Each inhibitor alters the conformational states sampled by the enzyme, either by r

244 Whether beta1 integrin ectodomains visit conformational states similarly to beta2 and beta3 integ

245 protein regulation works by fine-tuning the conformational state space of proteins.

246 me the orientation of an alpha-helix that is conformational-state-specific.

247 article cryo-electron microscopy in distinct conformational states, stabilized by individual disulfid

248 ion but also through accommodating different conformational states such as DNA breathing and dimer sp

249 exit route, differentially affect DraNramp's conformational state, suggesting that His(232) serves as

250 is hormone are available and fall into three conformational states: T6, T3R(f)3, and R6 As there is s

251 can cycle back and forth between two extreme conformational states termed the closed and open states.

252 Furthermore, two UvrD conformational states, termed "closed" and "open," corre

253 inesin heavy chains, KLCs exist in a dynamic conformational state that is regulated by self-interacti

254 Conformational states that are competent to bind immune-

255 structural biology by identifying transient conformational states that are highly abundant in biolog

256 that Czon1107 exists in equilibrium between conformational states that are the result of a key Ser(4

257 r kidney cells, that G12V-KRAS samples three conformational states that correspond to the predicted o

258 ries also provide insights into intermediate conformational states that could be relevant to catalysi

259 ion and potential modulation of the relevant conformational states that influence structural communic

260 his work provides direct evidence for unique conformational states that occur in E. coli ATP synthase

261 ing around the DNA slowly, it is instead the conformational states that rotate around the ring as the

262 ere, we report the discovery of two distinct conformational states that slowly exchange within the dy

263 er (smFRET) to investigate the cleft closure conformational states that the glycine-binding domain of

264 nhibitory antibodies to beta1 integrins, the conformational states that these antibodies stabilize, a

265 ntly lived conformational states--or excited conformational states--that play important roles in dive

266 One of these conformational states, the open state, binds to the GPCR

267 nformational transitions, which leads to two conformational states: the cytoplasmic and membrane-boun

268 A Helix-X segment is poised in an open conformational state; the heme a farnesyl sidechain is H

269 c constants provide glimpses of intermediate conformational states, time scales for motion, and assoc

270 minal tail switches from a relaxed, flexible conformational state to an ordered state upon MMOH reduc

271 tial configurations that span the accessible conformational states to aid sampling.

272 t, c) Identification of kinetically distinct conformational states to be used for the rational design

273 Proteins commonly sample a number of conformational states to carry out their biological func

274 ies suggest the protein may sample different conformational states to enable the binding of two very

275 t that active PARP2 cycles through different conformational states to exchange NAD(+) and substrate,

276 when mutated, lock DNGR-1 in one of the two conformational states to potentiate cross-presentation.

277 Pase that cycles between active and inactive conformational states to regulate a variety of cell sign

278 n multiple conformations illustrate dramatic conformational state transitions and diverse regulatory

279 Transient conformational states triggered by pH are of emerging in

280 thermodynamic model of the different stable conformational states underlying this system at the nucl

281 erent rates, and the distribution of the two conformational states was slightly shifted upon CRIPT bi

282 Five conformational states were identified, elucidating the f

283 e sensor loop has fewer discrete equilibrium conformational states when reconstituted in membranes.

284 c complex are closely associated in a stable conformational state, whereas nonamer regions are perpen

285 to Syt1 may induce major changes in the Syt1 conformational state, which in turn may initiate the fus

286 signs of chemical shift changes between the conformational states, which are difficult to obtain in

287 and rates of exchange between these multiple conformational states, which are essential for the multi

288 in TADs can easily fluctuate between several conformational states, which are hierarchically organize

289 uctures for all these functionally important conformational states with conventional high-resolution

290 ein kinases intrinsically sample a number of conformational states with distinct catalytic and bindin

291 n inhibitory interaction with multiple SERCA conformational states with distinct effects on SERCA's k

292 biomolecular assemblies are emerging as new conformational states with functionality.

293 ansport by Atm1 may involve a limited set of conformational states with minimal separation of the nuc

294 iving single molecules of GFP into different conformational states with optical tweezers and simultan

295 gives rise to the stabilization of open-like conformational states with overall increased backbone dy

296 he solution is represented by an ensemble of conformational states with tightly coupled domains.

297 and thus, the transitions between its three conformational states, with effective standard deviation

298 ic agonists induce transitions between these conformational states, with efficacy determined by occup

299 ces, indicating the coexistence of different conformational states within the fibril.

300 the simulations captured all major types of conformational states without the use of a target struct