ライフサイエンスコーパス: conformational switch

1 a sophisticated biofunctional system using a conformational switch.

2 mation that regulates ribosome function as a conformational switch.

3 ing a late transition state for the WC-to-HG conformational switch.

4 The subdomain IIa behaves as an RNA conformational switch.

5 the HHM motif as a copper- and pH-dependent conformational switch.

6 and not glucose, sets up the transporter for conformational switch.

7 domain could function as a phosphoregulated conformational switch.

8 e heme iron, as a distinctive feature of the conformational switch.

9 JM-3064 undergoes a monovalent ion-dependent conformational switch.

10 tructure that attains the native state via a conformational switch.

11 igand binding energy that contribute to this conformational switch.

12 an be modulated independently using the same conformational switch.

13 iminating the histidine-dependent pH-induced conformational switch.

14 shed results on a system that incorporates a conformational switch.

15 ATP-binding domain (LID) in controlling the conformational switch.

16 luding phosphorylation sites and a potential conformational switch.

17 phosphorylation activates SMO by inducing a conformational switch.

18 acterized the kinetics and energetics of the conformational switch.

19 ural elements of IF2 drive and regulate this conformational switch.

20 , whose cAMP-binding domain is an archetypal conformational switch.

21 the activating potential of the short-pitch conformational switch.

22 repeat proteins with function regulated by a conformational switch.

23 signaling proteins functioning as allosteric conformational switches.

24 on when looking for suboptimal structures or conformational switches.

25 portant to develop algorithms to predict RNA conformational switches.

26 tematically characterize the role of PTMs as conformational switches.

27 n experimentally known structures of several conformational switches.

28 que subunits must undergo position-dependent conformational switches.

29 ants for a series of hydrogen-bond-dependent conformational switches.

30 powerful template for the design of protein conformational switches.

31 tivity of the alphabeta TCR is controlled by conformational switches.

32 ne environment, revealing putative sites for conformational switching.

33 lding stability, such as cofactor binding or conformational switching.

34 lts suggest a novel mechanistic paradigm for conformational switching.

35 equence space underpinned by binding-induced conformational switching.

36 GTPases but is incapable of GTP-binding and conformational switching.

37 to probe the action of these ATP analogs on conformational switching.

38 truncating the expression domain to suppress conformational switching.

39 lectively to the noncanonical NBD to prevent conformational switching.

40 they fail to undergo pH- or ligand-dependent conformational switching.

41 esses by undergoing reversible energetic and conformational switching.

42 s predicted by structural modeling to enable conformational switching.

43 es of molecular defects, protein binding and conformational switching, a novel phenotype.

44 deling constitutes a previously unrecognized conformational switch accompanying ligand-dependent PPAR

45 favors vesicle formation by inhibiting this conformational switch, acting to regulate endophilin A1-

46 y relevant conformational changes, including conformational switches, allosteric coupling, and crypti

47 This ODN-induced conformational switch allows for the transition from an

48 This Arg-Asp conformational switch allows identical ZF modules to rec

49 binding to an A-type template and that this conformational switch allows or enhances subsequent poly

50 This conformational switching alters the energetic contributi

51 osome assembly involves a set of coordinated conformational switches among U2 snRNP components.

52 losed state, thereby promoting the resulting conformational switch and autophosphorylation of EI.

53 H257 as a major component of the T domain's conformational switch and b) suggested the possibility o

54 Ca(2+) influx, Cpx is predicted to undergo a conformational switch and collapse onto a single SNARE c

55 rylation at these additional sites induces a conformational switch and is essential for high-affinity

56 ning-defective 1 (Par1) kinases, regulates a conformational switch and is important for bidirectional

57 lding protein induces a single, coat protein conformational switch and not a series of sequential rea

58 e hydrogen bonds between H1 and DNA act as a conformational switch and show that the presence of DNA

59 In this work, the dynamics of this proposed conformational switch and the factors that regulate it w

60 ucose 1-phosphate concentration, couples the conformational switch and the phosphorylation step, resu

61 Together, context-dependent conformational switches and biased dephosphorylation sug

62 ing pathways between secondary structures of conformational switches and outperforms the existing heu

63 regulate the activity of the LC ribozyme by conformational switching and suggest a mechanism by whic

64 or absence of the ATP pyrophosphates as the conformational switch, and elucidated new mechanistic de

65 iate protein oligomerization, intramolecular conformational switch, and protein-target interactions.

66 bipartite MDC1-binding scaffold, an extended conformational switch, and the molecular consequences as

67 control cell proliferation, its well-studied conformational switching, and abundance of documented mu

68 onformation varied according to pH, and this conformational switch appeared to correspond to a change

69 Our results suggest that prion-like conformational switches are evolutionarily conserved and

70 Conformational switches are macromolecules that toggle b

71 Consequently, conformational switches are often defined by comparing t

72 ved residue, Phe396, appears to serve as the conformational switch, because flipping of the stacked a

73 rs and present a more refined model of their conformational switching behavior.

74 del in which the tubulin monomer undergoes a conformational switch between a "straight" form found in

75 We observed a conformational switch between a stacked and nonstacked s

76 ediction, AmyloidMutants identifies a global conformational switch between Abeta and its highly-toxic

77 P/PAP interactions are linked to a two-state conformational switch between biologically active and in

78 mily to play an active role in mediating the conformational switch between inward-open and outward-op

79 dentified two major kinetic pathways for the conformational switch between open and closed states thr

80 e propose that this regulation could drive a conformational switch between the dimeric structures of

81 we report a theoretical investigation of the conformational switch between the Huckel planar and the

82 We also show that the conformational switch between the outward- and inward-op

83 to investigate the kinetic mechanism for the conformational switches between bistable RNA hairpins.

84 t intra- and intermolecular interactions and conformational switches between more ordered and less or

85 ions sets the stage for creating large-scale conformational switches between structurally divergent f

86 gnaling through G proteins normally involves conformational switching between GTP- and GDP-bound stat

87 as an allosteric site of hTS to regulate the conformational switching between the active and inactive

88 ere evaluated for their propensity to induce conformational switching between the kite and vase forms

89 Conformational switching between these forms allows adop

90 he lasso peptide benenodin-1, which exhibits conformational switching between two distinct threaded c

91 ational echo chemical-exchange spectroscopy, conformational switching between two well defined substa

92 ouple steps in ATP binding and hydrolysis to conformational switching both in and remote from the act

93 We reveal that a single conformational switch by ATP binding drives unidirection

94 d for a candidate segment that supported the conformational switch by serial truncation removing 22 (

95 ships between the two bistable hairpins, the conformational switch can follow single or multiple domi

96 embles into a dimer in which a metal-induced conformational switch can occur independently in the two

97 noxic conditions and that the aforementioned conformational switch can protect nitrogenase from such

98 The role of these residues as conformational switches can be rationalized based on a m

99 rements suggest that the previously proposed conformational switch caused by Cu(II) binding includes

100 Through such conformational switches compatible with rapid diffusion

101 The observed proximal cluster conformational switch, concomitant with the proton trans

102 ot due to the loss of R 507 methylation as a conformational switch-containing peptide reacted under s

103 ctroscopy to demonstrate that a pH-dependent conformational switch controls an equilibrium between th

104 mophoric chelator, and the concerted binding-conformational switch detected by SPR at equilibrium rev

105 y RNAborMEA, provide additional tools toward conformational switch detection.

106 obal motion that is specifically linked to a conformational switch distant from the binding interface

107 Consequently, the LHCII conformational switch does not involve changes in A/B he

108 new structures provide direct evidence of a conformational switch driven by alphaKG leading to chlor

109 bility of H3, which is proposed to undergo a conformational switch during 30S assembly.

110 bidopsis NLR protein ZAR1, which undergoes a conformational switch during resistosome activation.

111 core to retain the flexibility required for conformational switching during procapsid assembly and m

112 light-inducible gating of calcium channels, conformational switch, dynamic protein-microtubule inter

113 ons that render the protein stable despite a conformational switch emphasizes the complexities in dif

114 Y313 represents a phosphorylation-sensitive conformational switch, engaged early after client loadin

115 odifications are similar conceptually to the conformational switching events seen in some marginally

116 We show that the conformational switch from 4beta+alpha to 3-alpha struct

117 ther and provide insights into this enzyme's conformational switch from a nonspecific search mode to

118 l Kv7 channels involving a calcium-dependent conformational switch from an apo-CaM form that bridges

119 e chain and ring formation is facilitated by conformational switching from a C3h to Cs symmetry of mT

120 at the DEP domain of Dishevelled undergoes a conformational switch, from monomeric to swapped dimer,

121 this latter context, as well as others, the conformational switching, from 1,3-alternate to cone upo

122 eriments demonstrate that GEM binding to the conformational switch II causes structural changes that

123 lenging IgM complexes is dictated by a local conformational switch in a peptide extension.

124 s on either side of the membrane to induce a conformational switch in both FtsA and the FtsBLQ subcom

125 ts reveal the critical function of W571 as a conformational switch in Env allostery and receptor-medi

126 esidues in beta strand S2 of FtsZ affect the conformational switch in FtsZ that underlies assembly co

127 l retraction of the L1 stalk is coupled to a conformational switch in Nmd3 that allows the uL16 P-sit

128 uggests that ParB binding to parS triggers a conformational switch in ParB that overcomes a nucleatio

129 al a mechanism that couples a heme-dependent conformational switch in PhuS to protein-protein interac

130 excises this sequence element, leading to a conformational switch in pre-18S rRNA, by which the ribo

131 rate-limiting step in protein folding and a conformational switch in protein function.

132 This suggests a model by which a conformational switch in Sro7 acts to coordinate Rab-med

133 Our results suggest a general model for the conformational switch in the cyclic nucleotide-binding s

134 requires H-bonding to Ser119 and a dramatic conformational switch in the F-G fragment, which transmi

135 trong constraints on any proposed role for a conformational switch in the FtsZ monomer.

136 ivity and provide insight into the role of a conformational switch in the functional regulation of th

137 We propose a helix-to-loop conformational switch in the helices flanking the inner

138 interaction with cholesterol may regulate a conformational switch in the large extracellular domain

139 Prion diseases are associated with a conformational switch in the prion protein (PrP) from it

140 Specifically, TPP binding triggers a conformational switch in the RNA from a transcriptionall

141 An intracellular conformational switch in the serpentine transmembrane pr

142 Capsid expansion is associated with a conformational switch in the spine helix that is propaga

143 We propose that Ran induces an allosteric conformational switch in the tail that exposes the histo

144 Nonetheless, the implementation of protein conformational switches in protein design applications h

145 elates well with the experimentally observed conformational switches in rhodopsin and other class A G

146 P*Mg2+, IDP*PO4, and dGDP*PO4-that highlight conformational switches in the G-loop (which recognizes

147 y located proline and lysine residues act as conformational switches in the in vitro formation of tra

148 iX174 internal scaffolding protein B mediate conformational switches in the viral coat protein.

149 We have discovered ligand-responsive conformational switches in viral IRES elements.

150 Mutations designed to inhibit conformational switching in alpha-helix 3 were introduce

151 Simultaneous examination of conformational switching in Eg5, in parallel with cataly

152 These results reveal conformational switching in KSR as a druggable regulator

153 ssibility for triggering protonation-coupled conformational switching in proteins at membrane interfa

154 These experiments furnish a means to observe conformational switching in real time and enable the pre

155 Metabolite-dependent conformational switching in RNA riboswitches is now wide

156 residues has been implicated in pH-dependent conformational switching in several systems, including t

157 as shown to act as an allosteric effector of conformational switching in the coat protein during in v

158 for the hypothesis that substrate-controlled conformational switching in the SRP provides a mechanism

159 asparagine (N)-linked disaccharides drive a "conformational switch" in a model peptide.

160 To shed light on how the Swi1 conformational switch influences Swi1 function and to de

161 o loss of H5/H4b interaction and promoting a conformational switch interrupting translation and promo

162 The conformational switching involves motion of the distal h

163 A conformational switch involving the haem c(n) propionate

164 f biological information using a prion-based conformational switch is an evolutionary conserved mecha

165 A conformational switch is envisaged that enables the in-l

166 This PHD conformational switch is impaired by a centronuclear myo

167 or challenge with testing designs of protein conformational switches is the need for experimental pro

168 Conformational switching is an overarching paradigm in w

169 pH-induced conformational switching is essential for functioning of

170 Such assembly-coupled conformational switching is reminiscent of viral particl

171 membrane regions of nSMase2 rather acts as a conformational switch leading to interdomain interaction

172 sted that this proton binding also prompts a conformational switch, leading to a loss of affinity for

173 ediated translational termination in which a conformational switch leads to peptide release only when

174 A conformational switch may also favor release rather than

175 CD81 interactome analysis also suggests that conformational switching may modulate the assembly of CD

176 These studies demonstrate a conformational switch mechanism for PDZ domain function

177 with mutagenesis to probe the ligand-induced conformational switching mechanism.

178 We propose that this conformational switch might control DNA template engagem

179 These methods reveal that conformational switches modulate normal and abnormal inf

180 This conformational switch modulated by cholesterol has impor

181 sults reveal that the trypsinogen to trypsin conformational switch modulates cleavage susceptibility

182 The conformational switch mutations kinetically trapped asse

183 and RNAbor, can be used to predict potential conformational switches; nevertheless, no existent tool

184 The conformational switch occurred when the amino acid seque

185 SRCD measurements confirm that the same conformational switch occurs in solution.

186 How this conformational switch occurs is not known.

187 occur via two distinct mechanisms: a unique conformational switch of a highly flexible disulfide-anc

188 urface exists in different states and that a conformational switch of aromatic side-chains fine-tunes

189 f p14(ARF) exclusively triggers a N-terminal conformational switch of Bak, but not Bax, which allows

190 charge complementarity and anticipation of a conformational switch of CXCR4 upon activation.

191 dicate unambiguously that the open-to-closed conformational switch of EI is triggered by complete sup

192 A conformational switch of highly conserved residues on a

193 otoga maritima, here we report a pH-mediated conformational switch of HK853 that shuts off its phosph

194 he region corresponding to the "safety belt" conformational switch of Mad2, suggesting conformational

195 These results suggest that a prion-like conformational switch of MAVS activates and propagates t

196 a regulatory Raf molecule in cis to induce a conformational switch of MEK, facilitating MEK's phospho

197 potential contribution of an Mg(2+)-mediated conformational switch of MicA for the regulation of MicA

198 Thus, current views on the pH-induced conformational switch of PBPs hold true only for the lig

199 Ubiquitin binding induces a conformational switch of Rpn11's Insert-1 loop from an i

200 e assays were performed, which confirmed the conformational switch of the aptamer rather than the apt

201 Here, we investigate the conformational switch of the human mitochondrial transcr

202 and that it might also enforce a favourable conformational switch of the trans-amide group into the

203 ding domains provides a power stroke for the conformational switch of the two membrane domains from t

204 We also detected a conformational switch of this motif between the non-MT-b

205 es, the pyridine ring of ZnClTerp blocks the conformational switch of Trp-248 required for receptor a

206 of the residues around position 28 modulate conformational switches of the AB loop relevant to ligan

207 ic operator site and defines a mechanism for conformational switching of a key residue (Gln56) to acc

208 By physically evoking conformational switching of AMPK, HSF1 impairs AMP bindi

209 is based on the principle of target-induced conformational switching of an aptamer linked to an elec

210 Thus, thermally induced conformational switching of benenodin-1 may also be rele

211 The subsequent addition and conformational switching of coat proteins to the growing

212 sembly requires a homodimerization-dependent conformational switching of CTD.

213 und room temperature, frequent bidirectional conformational switching of individual molecules from co

214 We observe and induce conformational switching of individual molecules via sca

215 Here, we identified a novel spontaneous conformational switching of nucleosomes under physiologi

216 Pseudouridylation impacts conformational switching of stem II by Mg(2+) or the U2

217 uridine 56 and 93 pseudouridylation impacts conformational switching of stem II.

218 the proteasome side, binding of Ubp6 favors conformational switching of the 26S proteasome into an i

219 vidences that very affine ligands can induce conformational switching of the human telomeric G-quadru

220 a stabilized ATP-binding site indicates fast conformational switching of the original aptamer before

221 the mobile C terminus of cTnI ensures proper conformational switching of troponin-tropomyosin.

222 We show that the conformational switching of VcSiaP is strictly substrate

223 Conformational "switching" of the riboswitch aptamer dom

224 between the head and stalk plays a role in "conformational switching" of the head group to facilitat

225 cogenic Neu* mutant appears to inhibit this "conformational switching" of TM dimers, as we observe th

226 se hydrogen-bond contacts serve as potential conformational switches offering new opportunities for f

227 results paint a picture of peptide flips as conformational switches, often enabled by glycine flexib

228 ligand binding and the subsequent allosteric conformational switch on mRNA transcript length has not

229 Gentamicin works by flipping a conformational switch on the ribosome, disrupting the re

230 indicate that certain DNA/RNA coronae act as conformational switches on SWCNTs, which reversibly modu

231 le-molecule assays, we demonstrate that this conformational switch operates during replication and pr

232 Protein conformational switches or allosteric proteins play a ke

233 onized nucleobases are required for folding, conformational switching, or catalysis in a number of fu

234 We find three types of conformational switch pathways for RNA hairpins: refoldi

235 sent study we focus on the role the putative conformational switch plays in arginine methylation.

236 This conformational switch positions the nuclease Nob1 for cy

237 ment in the expression platform controls the conformational switching process.

238 preserve nitrogenase activity, including a "conformational switch" protein (FeSII, or "Shethna") tha

239 We propose that this conformational switch provides a mechanical feedback sys

240 Discovery of such dynamic conformational switching provides insight into how a rib

241 use they do not support NBD dimerization and conformational switching, rather than by limiting enzyma

242 t sorafenib may affect SHP-1 by triggering a conformational switch relieving its autoinhibition.

243 gle, deep free-energy minimum, the design of conformational switches remains challenging.

244 ic regulation of PDHK2 activity serving as a conformational switch required for communication between

245 234, Gly237, and Gly241, probably forming a "conformational switch" requisite for substrate turnover;

246 for FMRP arginine methylation and a role for conformational switch residues in arginine modification.

247 cts as a major component of the pH-dependent conformational switch, resulting in destabilization of t

248 west step (bottleneck) of the hexane-induced conformational switch seems to be correlated with the sl

249 velopment of additional algorithms to detect conformational switches seems important, especially sinc

250 to contain a global, or local, pH-dependent conformational switch should be possible.

251 nd RNA, localized at one of the two backbone conformational switch sites.

252 Z13e1 and 4E10 epitope structures reveals a conformational switch such that neutralization can occur

253 tructure, supporting a nucleotide-controlled conformational switch that allosterically modulates the

254 tructural details of a nucleotide-controlled conformational switch that allosterically modulates the

255 We propose that the CXC motif functions as a conformational switch that couples Site-I and Site-II in

256 Such motif repositioning may serve as a conformational switch that creates the docking site for

257 main and show that the DFG motif serves as a conformational switch that drives LRRK2 activation.

258 nd direction of RNA helix motions, guiding a conformational switch that enforces the hierarchy of pro

259 rgy transfer signal, we directly observe the conformational switch that is associated with IF2 activa

260 h ribosomal protein L13a and GAPDH induces a conformational switch that rescues mRNA binding and rest

261 h a precursor-receptor complex and undergo a conformational switch that results in activation for pro

262 single active site that is transformed by a conformational switch that toggles its competency for ca

263 structure experiences a quadruplex-promoted conformational switch that triggers not only its quadrup

264 -hand domain and the IQ domain as a possible conformational switch that underlies CDI.

265 These structures illustrate a mechanism of conformational switches that accompany formation of sign

266 group of ATP during step 1, and the protein conformational switches that accompany substrate binding

267 Heterotrimeric G proteins are conformational switches that turn on intracellular signa

268 tion within the RyR1 3D architecture and the conformational switching that underlies CaM regulation o

269 ese noncatalytic regions work together as a "conformational switch" that modulates kinase activity in

270 During the conformational switching, there occurred a significant r

271 1-microtubule ternary complex functions as a conformational switch to control outer arm activity.

272 thioglycoside building blocks, exploiting a conformational switch to control reactivity, and thus re

273 sm by which CheY(P) binding could induce the conformational switch to CW rotation.

274 lving His453, a key residue that undergoes a conformational switch to directly interact with and opti

275 Mutating R 507 in the conformational switch to K also truncates the first stra

276 agement-competent state and coordinating the conformational switch to processing states upon substrat

277 and showed that PHD movements function as a conformational switch to regulate dynamin self-assembly,

278 The [2.2.2] lactonization acts as a conformational switch to superdisarm iduronate component

279 chanism of FtsZ modulation by PC190723 and a conformational switch to the high-affinity state that en

280 These data uncover a novel ligand-induced conformational switch to trigger filamin phosphorylation

281 at the ribosome uses local as well as remote conformational switches to govern induced-fit mechanisms

282 Thus, conformational switching to an alternative monomeric fol

283 atively bind to actin, thus facilitating Tpm conformational switching to cooperatively propagate alon

284 peripheral anchoring, nanopore behavior, and conformational switching to reveal membrane-binding unit

285 This conformational switching towards the OFF state is observ

286 ion of protein function is often linked to a conformational switch triggered by chemical or physical

287 ular spur gears due to the linear-to-helical conformational switching triggered by complexation/decom

288 terminus to the exosite of IDE and undergo a conformational switch upon binding to the catalytic cham

289 simulation gives indications for a possible conformational switch upon cleavage of the disulphide bo

290 The present work investigates this conformational switch via extensive atomically detailed

291 The subtle bidirectional t-SNARE conformational switch was mediated by the ionic layer.

292 To link ligand/aptamer binding to conformational switching, we constructed models of an S-

293 To identify a simplified code for conformational switching, we have redesigned two natural

294 release the intercalating doxorubicin via a conformational switch when in an ATP-rich environment.

295 ptors, CPR5 undergoes an oligomer to monomer conformational switch, which coordinates CKI release for

296 is a key requirement for the binding-induced conformational switching, which allows for direct naked-

297 propose that the extension domain acts as a conformational switch with differential response options

298 easing AMP and ADP concentrations involves a conformational switch within the heterotrimeric complex.

299 tial of amyloid structures and suggests that conformational switching within individual fibrils may a

300 id is capable of accommodating a significant conformational switching within individual fibrils.