ライフサイエンスコーパス: conformational transition

1 nsively and to elucidate their effect on the conformational transition.

2 -binding residue Ile-25 is critical for this conformational transition.

3 ow a single protein, pH-induced, reversible, conformational transition.

4 network structural model of the cAMP-induced conformational transition.

5 preceded by a Ca(2+)- and membrane-dependent conformational transition.

6 easonable pathway between two endpoints of a conformational transition.

7 e "spring-loaded" model proposed for the HA2 conformational transition.

8 ng at a faster rate than the inactive/active conformational transition.

9 and F286A) that are known to be defective in conformational transition.

10 to the resting SecYEG channel triggers this conformational transition.

11 sition state for the His79-mediated alkaline conformational transition.

12 gether to assemble a connectivity map of the conformational transition.

13 ant for the low rate of the Ca(2)E1P --> E2P conformational transition.

14 this density correlated to the mucin mimic's conformational transition.

15 its Ca(2+)-dependent activator-to-inhibitor conformational transition.

16 (2+) binding site that can regulate the slow conformational transition.

17 n undergoes a major antiparallel-to-parallel conformational transition.

18 e state and another to facilitate subsequent conformational transitions.

19 d inhibition of DA transport and transporter conformational transitions.

20 by fusion inhibitors (FIs) that disrupt Env conformational transitions.

21 plex which can explain biologically relevant conformational transitions.

22 the spike proteins are regulated to undergo conformational transitions.

23 hedral intermediate sub-states implicated in conformational transitions.

24 nner domain, W69, as being involved in these conformational transitions.

25 uctase domain, and increased the rate of its conformational transitions.

26 ded to investigate a large number of protein conformational transitions.

27 regulated in mouse cells by targeting these conformational transitions.

28 , and to provide a new approach to analyzing conformational transitions.

29 the design of inhibitors targeting critical conformational transitions.

30 by a unique combination of electrostatic and conformational transitions.

31 ubdomain suffice to account for the observed conformational transitions.

32 imer's disease assembles through a series of conformational transitions.

33 ntermediates are provided in our database of conformational transitions.

34 transports dopamine (DA) through a series of conformational transitions.

35 ntra-LBD (cleft closure) and inter-LBD dimer conformational transitions.

36 of symmetry breaking in facilitating channel conformational transitions.

37 he distance to the transition state, for the conformational transitions.

38 geting these interactions and the associated conformational transitions.

39 x, indicating this mutant alters transporter conformational transitions.

40 r functions by reshaping the kinetics of RNA conformational transitions.

41 nucleotide state seems to control proteasome conformational transitions.

42 f proteins to nucleic acids as well as their conformational transitions.

43 , and the consequences of mutations on these conformational transitions.

44 nt sampling of pathways associated with rare conformational transitions.

45 Complete description of thin filament conformational transitions accompanying muscle regulatio

46 edox changes of the iron-sulfur clusters and conformational transitions across complex I.

47 Strain-dependent divergence in Env conformational transitions allows different outcomes, in

48 mer-stabilizing mutations that resist trimer conformational transition and exposure of CD4i epitopes.

49 entry inhibitor BMS-626529 restricts trimer conformational transition and improves the immunogenicit

50 CS dominates at slow conformational transition and low ligand concentration.

51 em, we demonstrate that both the rate of the conformational transition and the concentration of ligan

52 ransmembrane domain (gp150) prevented trimer conformational transitions and enhanced their immunogeni

53 used for elucidation of peptide and protein conformational transitions and folding equilibria.

54 which active-site side chains influence the conformational transitions and free-energy landscape tha

55 led description of the dynamics of base-step conformational transitions and of the first steps to the

56 Applications used to investigate DNA conformational transitions and secondary structure forma

57 ydration level occur in the absence of major conformational transitions and serve to stabilize needed

58 lytical approaches that can identify protein conformational transitions and simultaneously characteri

59 EA proteins, is necessary and sufficient for conformational transitions and that their protective fun

60 to bottlenecks in understanding redox-driven conformational transitions and their interplay with the

61 of dynamics (i.e., ligand diffusion, protein conformational transition, and binding reaction), the ov

62 ation with fuel strands, environment induced conformational transitions, and covalent chemistry of ol

63 ning effects arise from two distinct coupled conformational transitions, and the transition within th

64 This is where the largest conformational transitions appear.

65 e interactions potentially important for the conformational transition are also identified.

66 cular-level picture of how E1P to E2P enzyme conformational transitions are coupled to changes in ion

67 Biomolecular conformational transitions are essential to biological f

68 imental data, we propose a model wherein the conformational transitions are important for the mannosy

69 The coverage- and temperature-controlled conformational transitions are reversible and are driven

70 These two conformational transitions are well described by stepwis

71 landscapes to sample specific ligand-induced conformational transitions, as defined by the effector-b

72 To explore the conformational transition associated with oxygenation of

73 However, atomic-level details on the conformational transitions associated with memory consol

74 iments, e.g. analysis of protein folding and conformational transitions, be done in cells?

75 ly suggests that the HIV-2 RRE undergoes two conformational transitions before assuming the energetic

76 ch a ligand binding event gates a reversible conformational transition between alternate forms of a f

77 Since kinases are tightly regulated by a conformational transition between an active and inactive

78 This binding mode predicts a conformational transition between an ultra-stable closed

79 ulation of chain alignment resulted from the conformational transition between planar (trans) and non

80 two insert regions are also involved in the conformational transition between the active and inactiv

81 n the second case, the rate constants of the conformational transition between the inside and the out

82 following its large-scale alternating access conformational transitions between an inward-facing (IF)

83 ng protein synthesis, the ribosome undergoes conformational transitions between functional states, re

84 r in modulating the allosteric interface and conformational transitions between SBD and the nucleotid

85 To study conformational transitions between these states, all six

86 and RegA at distinct loci by undergoing slow conformational transitions between two metastable states

87 nonadditivity arises not only from concerted conformational transitions, but also from conformer-spec

88 dence for potential intermediates during the conformational transition by following hemifusion of WNV

89 re we further explored the importance of the conformational transition capability of alpha1 Na/K-ATPa

90 enerate high ESI charge states, resulting in conformational transitions caused by intramolecular elec

91 first or second) directed the open-to-closed conformational transition, changes in the dominant mode

92 Thus, this membrane curvature-dependent conformational transition, combined with curvature-sensi

93 HIV-1 envelope glycoprotein (Env) undergoes conformational transitions consequent to CD4 binding and

94 broaden our mechanistic understanding of how conformational transitions control ligand recognition by

95 In principle, the nature of conformational transition could be modelled in silico vi

96 The conformational transition depends upon a Ca(2+)binding s

97 The reversibility of their fusogenic conformational transitions differentiates them from many

98 tate of Y101 is uncorrelated with the global conformational transition during activation.

99 ility of the beta8-beta9 loop is crucial for conformational transitions during opening and closing of

100 sing the dye RH421 show that FXYD1 slows the conformational transition E2(2K)ATP --> E1(3Na)ATP but d

101 nzyme undergoes an ATP-modulated endothermic conformational transition (ECT) believed to involve simi

102 proximately 10 kilobases) reveal large-scale conformational transitions elicited by supercoiling.

103 AlkB depends upon the dynamics of a specific conformational transition, establishing another paradigm

104 Importantly, the conformational transitions executed by telethonin in sim

105 ng device on the force-dependent rate of the conformational transition extracted from the time depend

106 that a microsecond-to-millisecond time scale conformational transition facilitates the proper sequent

107 brand factor is activated through a two-step conformational transition: first, elongation from compac

108 has been proposed that HIV-1 Gag undergoes a conformational transition from a compact conformation in

109 Conformational transition from a symmetric to an asymmet

110 tease inhibition by serpins requires a large conformational transition from an active, metastable sta

111 , we discovered that the peptide undergoes a conformational transition from an extended to a beta-hai

112 he Na2 site that occurs concomitantly with a conformational transition from an outward-facing to an i

113 ue and provide structural information on the conformational transition from closed to open channel.

114 rotonation of a conserved aspartate triggers conformational transition from outward-facing to inward-

115 The peptide exhibits a conformational transition from random coil to beta-sheet

116 the structure of CMG-DNA, we suggest how the conformational transition from the loaded, post-catalyti

117 yrococcus horikoshii suggested that the slow conformational transition from the outward- to the inwar

118 s to target cells and a pH shift trigger the conformational transition from the soluble prepore state

119 tubule after the first and before the second conformational transition has occurred, positioning it s

120 simulations to accurately describe concerted conformational transitions identifying the overall struc

121 dered loops important in capsid assembly and conformational transitions, (iii) in surfaces charges, a

122 nal relaxation but exhibits a faster rate of conformational transition in a more restricted conformat

123 Here the ligand-induced conformational transition in a widely studied model syst

124 and demonstrate pathways for the closed-open conformational transition in both directions by computin

125 differentially elicit an inactive-to-active conformational transition in K-Ras4B-GTP; in K-Ras4B(G12

126 -limiting step of the overall mechanism is a conformational transition in Ly49 from its backfolded to

127 inding to MinD is sufficient to trigger this conformational transition in MinE.

128 termine the slowest implied timescale of the conformational transition in sST2 and ST2.

129 work of domain contacts that imposes a major conformational transition in the catalytic domain that i

130 Our structures present a trajectory of the conformational transition in the elevator model, reveali

131 ansition-state ensemble of the rate-limiting conformational transition in the enzyme adenylate kinase

132 Decoding is thought to be governed by a conformational transition in the ribosome-open (off) to

133 and dynamic light scattering indicate that a conformational transition in the tetramer species is a c

134 Shear forces in the blood trigger a conformational transition in the von Willebrand factor (

135 binding to a PC-deficient membrane involves conformational transitions in a helix pair (alphaE) that

136 ransport can be inhibited simply by blocking conformational transitions in a properly folded transpor

137 duced, indicating a lower energy barrier for conformational transitions in A(1)R-G279S(7.44) (73 +/-

138 lation moving windows (PCMW) to characterize conformational transitions in antibodies.

139 The high-resolution insight obtained into conformational transitions in both protein and nucleotid

140 dynamic equilibrium in the absence of global conformational transitions in CBD alignment.

141 provides an effective framework to represent conformational transitions in complex biomolecular syste

142 tting, we have studied the effects of EB1 on conformational transitions in growing microtubule ends a

143 tion of methods that can directly reveal how conformational transitions in macromolecular machines ar

144 In turn, the SWAXS data accelerates conformational transitions in MD simulations and reduces

145 r with mutagenesis studies, we elucidate the conformational transitions in MurJ that mediate lipid fl

146 Evidencing subtle conformational transitions in proteins occurring upon sm

147 at govern the thermodynamics and kinetics of conformational transitions in proteins, which in turn ar

148 e mass spectrometry was used to monitor slow conformational transitions in RD, using disordered regio

149 Investigation of beta-sheet-oriented conformational transitions in silk proteins at the nanos

150 tional changes in PSD-95 and demonstrate how conformational transitions in supertertiary structures c

151 roughout the StART-like PITP family; and (v) conformational transitions in the C-terminal helix have

152 wing microtubule ends reveal two consecutive conformational transitions in the microtubule end region

153 ore conjugated backbone planar to non-planar conformational transition) in the observed thermochromic

154 ing in a highly concerted fashion during the conformational transitions, including six conformational

155 Binding leads to a series of conformational transitions, including the closure of the

156 the femtosecond timescale, thus undergoing a conformational transition increasing the available space

157 f kinetically accessed intermediates of fast conformational transitions induced by common relaxation

158 ormance free-energy methods, the sequence of conformational transitions involved in a functional cycl

159 uced by dNTP binding and a subsequent global conformational transition involving all domains of Taq P

160 cleoproteins F and H that may interfere with conformational transitions involving the antisense targe

161 Here we show that this conformational transition is dependent on phosphatidylin

162 anged nucleotide simulations reveal that the conformational transition is more accessible in the GTP-

163 d the outward-facing NCX_Mj suggest that the conformational transition is triggered by the rotation o

164 , the accurate description of macromolecular conformational transitions is crucial for understanding

165 force nor the underlying pathways for these conformational transitions is known.

166 the microscopic dynamics of proteins during conformational transitions is set by the intrachain diff

167 This conformational transition leads to changes in the pai-pa

168 et exhibits frequent backsteps and undergoes conformational transitions manifested in 5-bp backward a

169 r-template DNA, which comprises DNA binding, conformational transition, nucleotide binding, phosphoes

170 Altogether, we propose a model in which conformational transitions observed in PimA might reflec

171 Important conformational transitions occurring during this cycle h

172 ion spectroscopy measurements show that this conformational transition occurs early in the assembly p

173 lar dichroism and fluorescence reveal that a conformational transition occurs in anionic lipid vesicl

174 ed that ATP binding to SynI is mediated by a conformational transition of a flexible loop that opens

175 The modified Cys-242 prevents a conformational transition of a loop adjacent to the ADP/

176 MS platform is demonstrated by exploring the conformational transition of a monoclonal antibody by in

177 ne and the nucleotide-binding domains in the conformational transition of ABC exporters.

178 erstanding of the multistaged, force-induced conformational transition of alpha-catenin to the activa

179 a provides a global view that shows stepwise conformational transition of an ensemble as a function o

180 We observed a highly cooperative conformational transition of beta-sheet to alpha-helix u

181 Conformational transition of calmodulin from the Ca(2+)-

182 We disclose the conformational transition of Cas9 from its apo form to t

183 tion immediately preceded or accompanied the conformational transition of CXCR4.

184 , might be a prerequisite to the large scale conformational transition of CXCR4.

185 We report on a conformational transition of dengue virus when changing

186 les of DIMS MD and FRODA trajectories of the conformational transition of diphtheria toxin, a particu

187 (gated ET) experiments to study the alkaline conformational transition of K79H variants of yeast iso-

188 Our model recapitulates the pH-dependent conformational transition of M2 from closed to open stat

189 of mechanistically distinct pathways for the conformational transition of MsbA, a bacterial ABC expor

190 e explore the mechanism of the alpha-to-beta conformational transition of RfaH in the full-length pro

191 Previously, we showed that a conformational transition of Syx, related to calcium-tri

192 n of whether TcB-TcC has an influence on the conformational transition of TcA.

193 prothrombinase complex is linked to a large conformational transition of the entire protein.

194 und nhTMEM16 we find that the mechanism of a conformational transition of the groove from membrane-ex

195 ed by NMR in real-time, demonstrate that the conformational transition of the N-terminal 13 residues

196 benzenes, the complexity of the photoinduced conformational transition of the pentameric foldamer 105

197 nce between the two scenarios is whether the conformational transition of the protein from the unboun

198 et in the kinase domain potentially drives a conformational transition of the R-loop, which is essent

199 ral requirements followed by a rate-limiting conformational transition of the substrate and protein.

200 s time scale of the His79-mediated alkaline conformational transition of these variants.

201 ng (~100 angstrom height)-reminiscent of the conformational transition of viral fusion proteins.

202 We identify key ligand-induced conformational transitions of a conserved tryptophan sid

203 ions are complementary approaches that probe conformational transitions of biomolecules in solution,

204 However, the concurrent structural and conformational transitions of cyt c remain undercharacte

205 al basis for LPS recognition, delineates the conformational transitions of MsbA to flip LPS, and pave

206 probe the structural dynamics, topology and conformational transitions of regulatory membrane protei

207 Our data illustrates conformational transitions of Slc26a9, supporting a rapi

208 cal properties, including the elasticity and conformational transitions of the double-stranded (dsRNA

209 ign of inhibitors, targeting active-inactive conformational transitions of the enzyme, can be aided b

210 nt models of transport, which invoke various conformational transitions of the FG nucleoporins induce

211 ar dynamics (aMD) simulations to explore the conformational transitions of the GPCR from the active s

212 ptide shows that surface interactions induce conformational transitions of the monomer, which facilit

213 The conformational transitions of the oxidized and non-oxidi

214 the absence of SAM, frequent open-to-closed conformational transitions of the pseudoknot occur, akin

215 our observations suggest that "open/closed" conformational transitions of the TL may be linked to in

216 Conformational transitions of the transcription initiati

217 Here we investigated the conformational transitions of this domain during oligome

218 cally important chaperonin, such as that the conformational transitions of this protein complex in it

219 Thermally induced conformational transitions of three proteins of increasi

220 and critical conditions for electron-induced conformational transitions, offering new rules to design

221 t also perturb lipid structure by undergoing conformational transitions or by zipping up into the bil

222 a significant impact on the dynamics of the conformational transitions or on the binding properties

223 Finally, by examining the conformational transition pathway between the allosteric

224 omputational strategy for characterizing the conformational transition pathway is presented to bridge

225 models of the intermediate states along the conformational transition pathway reveal that the free e

226 r intermediate state is identified along the conformational transition pathway, and the key structura

227 it is necessary to gain knowledge about the conformational transition pathways connecting the crysta

228 We performed a detailed analysis of conformational transition pathways for a set of 10 prote

229 sically disordered proteins (IDPs) and their conformational transitions play an important role in neu

230 Hence, there appears to be a number of conformational transitions possible in HIV-1 monomeric g

231 transient residue-residue contacts along the conformational transitions predicted by the computations

232 processes are carried out through molecular conformational transitions, ranging from the structural

233 ging from solvation free energies to protein conformational transition rates, we showcase how the pro

234 ns affect zoospore transmission by affecting conformational transitions rather than directly affectin

235 he divalent metal ions affect the HNH domain conformational transition remains elusive.

236 the mechanism of the His73-mediated alkaline conformational transition requires three ionizable group

237 detailed understanding of their photoinduced conformational transitions, resembling similar processes

238 all-atom transition pathways for three main conformational transitions responsible for the alternati

239 The conformational transitions result in three supercoiling

240 pon dsDNA binding, cGAS is activated through conformational transitions, resulting in formation of a

241 looped-out of the duplex, with the resulting conformational transitions shifting the cleavable phosph

242 across the binding groove of a PDZ domain, a conformational transition, similar to the one occurring

243 9 and accelerates the rate-limiting E1P-E2P conformational transition (site B).

244 Gq/11 pathway is associated with a specific conformational transition stabilized by the agonist, whe

245 xperimental observations, and proceeds via a conformational transition state, with Huckel pi-bond shi

246 ergy hill, on the way to a cumulenic, purely conformational transition state.

247 Computational methods can identify conformational transition states from structural changes

248 In the presence of Mn(2+), a conformational transition step from non-productive to pr

249 studies of the mechanisms of macromolecular conformational transitions such as protein folding are e

250 ration the initially formed fibers undergo a conformational transition that becomes only "visible" by

251 auto-inhibitory interactions, engendering a conformational transition that facilitates clustering of

252 Important conclusions are that the conformational transition that leads to occlusion with b

253 t the kinetic rates of RNA folding and other conformational transitions that are also important for c

254 of these ligand-gated receptors is driven by conformational transitions that are induced by the assoc

255 ing an ensemble approach to characterise the conformational transitions that are often responsible fo

256 Domain III flexibility enables large-scale conformational transitions that are part of the EF-G fun

257 With this approach, we study the conformational transitions that arise due to supercoilin

258 le to the intra- and extracellular milieu by conformational transitions that confer marked changes in

259 he gut, have several structural features and conformational transitions that distinguish them from ot

260 eage commitment, discussing TCR force-driven conformational transitions that may optimally expose the

261 yptophan fluorescence, reveals the concerted conformational transitions that occur during substrate t

262 assemble into large transmembrane pores via conformational transitions that remain to be structurall

263 Elucidation of the conformational transitions that the HIV-1 envelope prote

264 These models enable visualization of the conformational transitions that Ycg1 has to undergo to a

265 rocess of Rho through a 0.1 millisecond-long conformational transition, the time scale seen also in e

266 ing-dissociation events are fast compared to conformational transitions, the rate of approach to equi

267 s well as to account for regions involved in conformational transitions through the correct sampling

268 a a Dynamic mode, followed by an SRP-induced conformational transition to a Stable mode that activate

269 onsistent with the Nterm domain undergoing a conformational transition to an ordered structure upon n

270 A protein will often undergo a conformational transition to form the functional complex

271 the beta2-alpha2 loop and the propensity for conformational transitions to disease-related forms of P

272 e dynamic assemblies that undergo controlled conformational transitions to perform various biological

273 form at the CD4 interface during large-scale conformational transitions to the CD4-bound state from t

274 Na2 binding and release associated with the conformational transition toward the inward-open state,

275 mber of complex biological processes-protein conformational transitions, (un)binding, and assembly pr

276 s indicates that each CmeB subunit undergoes conformational transitions uncoordinated and independent

277 esults provide a physical explanation of the conformational transitions underlying this behavior.

278 into understanding the molecular basis of TL conformational transition upon substrate binding during

279 matically interrogated and scrutinized these conformational transitions using a panel of antibody pro

280 crucial iso-parallel dimer that mediates the conformational transition was discovered computationally

281 solve the dynamic features of Ca(2+)-induced conformational transitions we analyze here distinct spli

282 f propofol binding sites affects the channel conformational transition, we performed a total of 1.5 m

283 To explore structural dynamics during the conformational transition, we studied simulations of a m

284 effects on the kinetics or thermodynamics of conformational transitions were observed.

285 but Na(+) binding and the voltage-dependent conformational transitions were unaffected.

286 fundamental question about such large-scale conformational transitions, whether the closed state exi

287 s work highlights an important hairpin to G4 conformational transition which can be used in manipulat

288 al for their functions and may include large conformational transitions which can be studied by molec

289 This conformational transition, which has not been observed p

290 s, moss, and green algae can undergo dynamic conformational transitions, which have been correlated t

291 n the stochastic modulation of J-coupling by conformational transitions, which in the case of aziridi

292 antiapoptotic Bcl-2 family member, undergoes conformational transitions, which leads to two conformat

293 membrane, it is expected that blocking these conformational transitions will prevent transport activi

294 Notably, we predict a conformational transition with increasing polymer length

295 , our study correlates ACKR3 ligand-specific conformational transitions with chemokine-dependent rece

296 omic normal mode analysis, and simulation of conformational transitions with our coarse-grained virtu

297 ates viral-host cell fusion via a network of conformational transitions, with allosteric elements in

298 Our findings support the notion that a conformational transition within the Munc18-1 domain 3a

299 ATP-driven conformational transitions within the D2 ring alter the

300 ay represent general features for functional conformational transitions within the folded state.