ライフサイエンスコーパス: conformationally

1 sphine oxides as radical precursors, and the conformationally accelerated Truce-Smiles rearrangement

2 Furthermore, divergent reactivity of a conformationally accelerated, intramolecular Mannich cyc

3 and E3 enzymes directly remove this brace to conformationally activate Atg3 and elicit Atg8 lipidatio

4 Such substantial energies have been shown to conformationally activate, or unfold, beta-barrel and al

5 poptosome, in which each subunit needs to be conformationally activated by its ligand before assembly

6 e metalloprotease ADAMTS13, which in turn is conformationally activated by VWF.

7 ADAMTS13 becomes conformationally activated on demand through interaction

8 EscV recruits and conformationally activates the tightly membrane-associat

9 ts of the apoptosome, or overexpressing only conformationally active caspase-9.

10 Expression of acetylated p53 and the conformationally active form of Bax were found to be sig

11 stering of beta1 integrins, and enhances the conformationally active population of surface beta1 inte

12 ors by blocking promoter access of SHP-bound conformationally active Rgg proteins.

13 rred from static structures in the nature of conformationally active structural domains, the sequence

14 We find that the 5 TcA protomers conformationally adapt to fit around the cocoon during t

15 ocal unfolding that enables the A1 domain to conformationally adapt to shear flow while maintaining i

16 Thus, the data indicate how harnessing a conformationally adaptive dimer can drive large-scale ca

17 ng promise for use as protonation-dependent, conformationally adaptive, "smart" accelerated antidotes

18 method was applied to the quantification of conformationally altered p53 peptide Alzheimer's disease

19 SBD suppress domain communication defects by conformationally altering the allosteric interface, ther

20 oxic alpha-synuclein oligomers, resulting in conformationally and functionally modified species.

21 n the cytosol-accessible surface loop and/or conformationally assembled acidic Asp/Glu clusters, lead

22 iation intermediated by hole delocalization (conformationally assisted and thermally dependent) formi

23 x, the GroEL:GroES2 football complex differs conformationally at the GroEL-GroES interface and also a

24 We report an NMR chemical shift study of conformationally challenging seven-membered lactones (1-

25 ggest that three adjacent HA trimers and one conformationally changed HA trimer are minimally require

26 debated how many HA trimers, w, and how many conformationally changed HA trimers, q, are minimally re

27 between the NADPH/FAD and FMN domains in the conformationally closed structure to allow cross-domain

28 em (nN --> sigma*S-X) in 32 was exploited to conformationally constrain a biaryl linkage and allow co

29 RAcP, whereas IL-33 binds to ST2 in order to conformationally constrain the cognate receptor in an IL

30 e substrate binding site; incorporation of a conformationally constrained 4-phenylpiperidine linker g

31 Using conformationally constrained acpcPNA probes, double stra

32 In this work, we developed conformationally constrained alpha-RgIA analogues with h

33 analogue in which Pro32 was replaced by the conformationally constrained amino acid alpha-methylprol

34 Control of chi-space utilizes conformationally constrained amino acids that favor, dis

35 Homologated and conformationally constrained analogues were prepared.

36 the aryl substitution pattern and developing conformationally constrained analogues, selectivity for

37 identification of novel hot loop mimics with conformationally constrained and biologically relevant s

38 In contrast, Asn-21 substitution with the conformationally constrained and turn-inducing residue P

39 These conformationally constrained antagonists are therefore p

40 noglobulin molecule as a scaffold to present conformationally constrained B-cell epitopes.

41 ic replacement of native alpha residues with conformationally constrained beta-amino acid residues.

42 cell-penetrating motif and converted into a conformationally constrained bicyclic structure through

43 Conformationally constrained bithiazoles were previously

44 the peptidolactone core structure with more conformationally constrained counterparts.

45 Conformationally constrained derivative 36 emerged as th

46 selectivity of glycosylation reactions using conformationally constrained glycosyl donors, with a foc

47 The conformationally constrained HDAC8 inhibitors present an

48 a noncovalent ligand, we appended a chiral, conformationally constrained linker, which orients an ar

49 It is found that nanomaterials containing conformationally constrained lipids form stable LNPs, he

50 The X-ray crystal structure of a conformationally constrained mutant of the Escherichia c

51 ng interesting perspectives in the design of conformationally constrained peptidomimetics.

52 d linker DNA and showed that tails may adopt conformationally constrained positions due to the insert

53 Evaluation of the conformationally constrained series in a [(35)S]GTPgamma

54 acologically augmented by converting it to a conformationally constrained tetrahydrofuran to improve

55 noethylamide ligands, the flexible chain was conformationally constrained to reproduce the bioactive

56 we describe a series of rationally designed, conformationally constrained, benzanilide foldamers whic

57 e their stability, and surface coated with a conformationally-constrained, cyclic arginine-glycine-as

58 nthetic biology toolbox lacks extendable and conformationally controllable yet easy-to-synthesize bui

59 torsion balance concept was applied to a new conformationally controlled scaffold and synthesized to

60 own that the site of ubiquinone reduction is conformationally coupled to the NqrB subunit, which also

61 bled proteins, but the rules that govern how conformationally defective proteins in the secretory pat

62 Efficient uptake of these conformationally defined constructs directly correlated

63 itors and rationally extended our library of conformationally defined proline-derived modules (ProMs)

64 experiments link amyloid persistence to the conformationally defined size of the Sup35 nucleation se

65 We herein report the development of a conformationally defined, electron-rich, C(2) -symmetric

66 r an experimentally determined evaluation of conformationally dependent (pi) and conformationally ind

67 eptor/beta-arrestin2 trafficking and suggest conformationally dependent beta-arrestin-mediated MAPK a

68 r E2 conformation and recognition for all 14 conformationally dependent E2 antibodies and subsets the

69 y assessed for the first time, demonstrating conformationally dependent RT rates that increase from 0

70 at, in the kinase-on state, the HAMP is more conformationally destabilized compared with the PIR, whe

71 We found that reduced, conformationally destabilized proteins are released from

72 Ionotropic glutamate receptors comprise two conformationally different A/C and B/D subunit pairs.

73 Moreover, the gI within these structures was conformationally different from the typical form of gI,

74 eved through the genetic fusion with a long, conformationally disordered chain of the natural amino a

75 nhanced ssNMR data reveal that conversion of conformationally disordered melittin monomers at low pH

76 ) transcription factor is autoinhibited by a conformationally disordered serine-rich region (SRR) tha

77 he N-terminal portion of M13 converts from a conformationally disordered state to an alpha-helix and

78 opagated forms of misfolded tau can exist as conformationally distinct "strains" with unique biochemi

79 entified a second, energetically similar but conformationally distinct binding mode in which the alph

80 ed, these results describe a system in which conformationally distinct forms of P450 3A4 bind inhibit

81 The seven-transmembrane helices, conformationally distinct from those of G-protein-couple

82 uppressors implies that Tsr-HAMP has several conformationally distinct kinase-active output states an

83 en hypothesized to result from the spread of conformationally distinct pathological protein aggregate

84 nte Carlo docking trajectories on each of 10 conformationally distinct ROMK comparative homology mode

85 Here we present two conformationally distinct structures of C. elegans GluCl

86 rging evidence also suggests the presence of conformationally diverse 'strains' of each type of disea

87 Using a conformationally diverse collection of natively folded a

88 ch to discern protein unfolding pathways for conformationally diverse proteins.

89 Conformationally diverse zwitterions that could act as s

90 of the complex, which may be related to the conformationally driven coupling mechanism and to the ac

91 r results demonstrate that alpha-syn is more conformationally dynamic at the membrane interface than

92 s seek to provide atomic-level insights into conformationally dynamic biological systems at experimen

93 Analogues of the conformationally dynamic Claritin (loratadine) and Clari

94 e to facilitate protein folding and organize conformationally dynamic client proteins.

95 ery that the catalytic subunits of APC/C are conformationally dynamic cullin and RING proteins, many

96 r coactivator CREB binding protein/p300 is a conformationally dynamic domain that complexes with tran

97 structure: both nanoribbons incorporate two conformationally dynamic double-[4]helicene termini and

98 en underappreciated significance of discrete conformationally dynamic elements within the context of

99 a codon-anticodon interaction and contains a conformationally dynamic loop.

100 ificantly extending the range for modeling a conformationally dynamic loop.

101 Hsp90 is a conformationally dynamic molecular chaperone known to pr

102 s show pervasive positive epistasis within a conformationally dynamic network of residues.

103 icant enzymatic activity, suggesting Y731 is conformationally dynamic on the time scale of turnover.

104 Rather than a clamp, a conformationally dynamic protein assembly typically cont

105 iption of equilibrium folding/unfolding in a conformationally dynamic protein.

106 from others indicating that the on rates of conformationally dynamic proteins approach the limits of

107 e stabilizers to target important regions of conformationally dynamic proteins.

108 ted by subtle domain movements, which reveal conformationally dynamic regions and match biochemical d

109 aspase-6 is inherently and dramatically more conformationally dynamic than closely related caspase-7.

110 to understand binding of small-molecules to conformationally dynamic transporters like SERT often re

111 tein (Env) trimer mediates cell entry and is conformationally dynamic(1-8).

112 ns on the surface of intact viruses remained conformationally dynamic, responsive to state-stabilizin

113 t after binding, the 40S:HCV IRES complex is conformationally dynamic, undergoing slow large-scale re

114 ess both receptor and coreceptor binding and conformationally entrap the protein in a destabilized st

115 ts and a simple strategy for studies of such conformationally excited states based on measurement of

116 r, it emphasizes the potential importance of conformationally excited states in directing both foldin

117 ly populated, NMR-visible native state and a conformationally excited, NMR-invisible state, correspon

118 ariable regions to preferentially expose the conformationally fixed CD4bs.

119 explore the pharmacophoric features of these conformationally fixed groups, we have synthesized a ser

120 ctionally conserved - but also intrinsically conformationally flexible - scaffolds for translocation

121 obtained by choosing a relatively large and conformationally flexible 1-benzyl-1-phenylsemicarbazide

122 Gd), have established that the P-cluster is conformationally flexible and can undergo substantial st

123 k the in vitro exploration to identify novel conformationally flexible and constrained RBP4 antagonis

124 require m-IL-1beta to be unfolded or remain conformationally flexible and is dependent on two KFERQ-

125 that trans-tetra-ortho-chloro azobenzene is conformationally flexible and thus subject to molecular

126 w that RALF23 recognition is governed by the conformationally flexible C-terminal sides of LLG1, LLG2

127 The presence of a conformationally flexible C6 oxygen atom in the sugar-de

128 omprise stereochemically complex acyclic and conformationally flexible carbon chains make such a task

129 A series of conformationally flexible furan-derived allocolchicinoid

130 The conformationally flexible host molecule, ABTPA, adapts i

131 gid macrocyclic scaffold with the bulky, yet conformationally flexible isonitrile.

132 ecular dynamics simulations indicate several conformationally flexible loops that contribute to the n

133 mical shifts tractable for a large number of conformationally flexible metabolites.

134 antimicrobial activity, the structure of the conformationally flexible molecules was determined large

135 enesis of prion diseases, is indicative of a conformationally flexible native (N) state.

136 ly applicable to HIV-1 Env and also to other conformationally flexible pathogen antigens.

137 Ag(111) via a preprogrammed isomerization of conformationally flexible polymer chains followed by deh

138 to parametrize and predict the solubility of conformationally flexible tris(dialkylamino)cyclopropeni

139 ra-phosphonate calix[4]pyrrole cavitands are conformationally flexible, always adopting a conformatio

140 However, these trimers are conformationally flexible, potentially reducing B-cell r

141 irs a hydrophobic core of Ig20, generating a conformationally fluctuating molten globule-like state.

142 indicated that compared with WT filamin, the conformationally fluctuating state of the Ig20 mutant ma

143 ase the chance of active-site collision with conformationally fluctuating substrates, and enable regu

144 echanistic model is that the regulatory cues conformationally gate NADPH-binding, implicitly providin

145 he NDI stacks in a manner reminiscent of the conformationally gated charge transfer observed in DNA.

146 e in coordination has been implicated in the conformationally gated electron transfer in nitrogenase.

147 The generality of the approach of using conformationally gated small molecule binding aptamers i

148 characterization of these highly dynamic and conformationally heterogeneous ensembles has remained ch

149 Our simulation studies revealed a conformationally heterogeneous glycan shield with a netw

150 the last two BamA beta-strands forms weaker, conformationally heterogeneous interactions with the fir

151 an emerging tool for resolving structures of conformationally heterogeneous particles; however, each

152 ctively, the data show that Ric-8A induces a conformationally heterogeneous state of Galphai and prov

153 s determination of structure and dynamics of conformationally heterogeneous systems by integrating ex

154 mble of slowly (>100 ms) interconverting and conformationally heterogeneous unfolded states that lack

155 e pASK1-CD.14-3-3zeta complex is dynamic and conformationally heterogeneous.

156 f enzymatic cleavage was located at the less conformationally hindered position distant from the turn

157 We describe here two conformationally homogeneous Envs derived from difficult

158 CD data reported here are the first for any conformationally homogeneous helical peptoids containing

159 nging, requiring the formation of stable and conformationally homogeneous ligand-receptor complexes.

160 ze viruses are thought to be more stable and conformationally homogeneous trimers than those of easy-

161 brane-bound CH120.6 Env is indeed stable and conformationally homogeneous.

162 is Integrin-Integrin complex correlates with conformationally inactive Integrin.

163 ation of conformationally dependent (pi) and conformationally independent (sigma) contributions to th

164 uestrin in termination of calcium release by conformationally inducing closure of SR channels.

165 CoPoP bilayer results in a serum-stable and conformationally intact display of the RBD on the liposo

166 We demonstrate that conformationally intact L1 protein, likely still arrange

167 strated the maturing epitope to focus on the conformationally invariant portion of the CD4bs.

168 ere designed to anchor the fusion peptide to conformationally invariant residues of the F head.

169 why some inhibitory serpin families are more conformationally labile than others.

170 These inhibitors are conformationally less flexible, target gatekeeper mutate

171 illustrate how the ligand-binding pocket is conformationally linked to this conserved triad.

172 ctions between topographically distinct, yet conformationally linked, domains.

173 Conformationally locked cis diastereomers of bis(sulfide

174 ctronic structure properties indicative of a conformationally locked iron carbyne unit.

175 s between these RRE 'conformers', we created conformationally locked mutants by site-directed mutagen

176 Synthesis of the corresponding conformationally locked sugar modified uridine and guano

177 line chimeras 4 and 5, which represent rigid conformationally locked three-dimensional structures whe

178 nd was found to display a dual behavior as a conformationally locked/flexible molecular host, being a

179 that connects its C-Mad2-binding site to the conformationally malleable C-terminal region.

180 bound Eis in the AG-binding pocket held by a conformationally malleable region of Eis (residues 28-37

181 e stable than those obtained with the native conformationally mobile calix[6]arene wheel, as a conseq

182 s is a straightforward strategy to constrain conformationally mobile motifs, but forging a macrocycle

183 Evidence is presented for a conformationally mobile protein framework, which is link

184 chitecture for human CNTs, revealed extended conformationally mobile regions within transport-domain

185 strongly indicative of the involvement of a conformationally mobile transient glycosyl oxocarbenium

186 in variable domains and has been shown to be conformationally mobile.

187 , PH-Tau) mouse model to study the effect of conformationally modified tau in vivo.

188 vealed that the Delta12 variant homodimer is conformationally more stable and incapable of FMN-to-hem

189 Using membrane mimetics to generate conformationally open AP2, we find that a second domain

190 an allosteric site primes the active site by conformationally "opening" a tyrosine gate allowing enha

191 troduction of the W24A/E262A mutation, which conformationally "opens" CB2SH3+ and allows the pleckstr

192 ur data show that most of the CA sequence is conformationally ordered and relatively rigid in tubular

193 In total, we show that the conformationally orthogonal reactions of these two carba

194 sically disordered regions (IDRs), which are conformationally plastic and do not appear to adopt sing

195 nd) were the source and therefore impart the conformationally plastic character of native EmrE capabl

196 Furthermore, a conformationally preserved "cysteine lock"-Trp116(23.50)

197 We propose that AdoMet binding conformationally "primes" the enzyme for DNA binding.

198 A surprising prediction is that a conformationally produced pseudo-enantiomerism in 1,3-bu

199 proteins allow us to propose a model of the conformationally protected ternary complex of nitrogenas

200 tructural basis for further investigation of conformationally regulated models of transbilayer TCR si

201 Each novel CAR exhibited conformationally relevant expression on the surface of t

202 How AAA+ chaperones conformationally remodel specific target proteins in an

203 ligases interact with protein substrates and conformationally restrain the ubiquitin-E2-conjugating e

204 This strategy led to the synthesis of new conformationally restrained boron-methylated BODIPY phot

205 l and a carboxylic acid, were grafted onto a conformationally restrained spirocyclic scaffold, and to

206 of a wide variety of structures, including a conformationally restrained subset of indolines (compoun

207 entropic gain resulting from releasing these conformationally restrained waters to the bulk solvent i

208 Appending conformationally restraining ring systems to the cyanine

209 with the procapsid during DNA translocation conformationally restrict the nuclease domain, inhibitin

210 chemical modifications to Ang II to generate conformationally restricted (disulfide-crosslinked) pept

211 Conformationally restricted 2'-spironucleosides and thei

212 d for complete regioselective 5-O-opening of conformationally restricted 3,5-O-di-tert-butylsilylene-

213 hybridization strategy was used based on the conformationally restricted 3-hydroxycyclopent-1-enecarb

214 of oriented bilayers in conjunction with the conformationally restricted amino acid L-3-(trifluoromet

215 In this paper, 42 conformationally restricted analogues of the prototypica

216 ained compounds can be considered as achiral conformationally restricted analogues of threonine with

217 immunologically by their reactivities with a conformationally restricted anti-F protein monoclonal an

218 mylin and its disruption by a novel class of conformationally restricted beta-sheet breaker hybrid pe

219 ve 3,9-diazatricyclo[5.3.0.0(1,5)]decanes as conformationally restricted bis-pyrrolidines.

220 a loss in entropy as chains transition to a conformationally restricted bridged state.

221 ex units, large flexible substituents become conformationally restricted by the interactions leading

222 Additionally, we used the unique chiral and conformationally restricted character of the (PhPro)4 sh

223 d a Lewis base, with highly preorganized and conformationally restricted chiral cavities of [2]rotaxa

224 ynthesis and evaluation of both flexible and conformationally restricted compounds derived from salvi

225 ues to arrive at a novel series containing a conformationally restricted core.

226 e incorporation of the previously unexplored conformationally restricted cyclic systems into peptides

227 Here, a series of conformationally restricted derivatives of the previousl

228 y while storing an enzyme subpopulation in a conformationally restricted form that is readily activat

229 to the stereoselective synthesis of four new conformationally restricted Glu analogues, 2a-d.

230 Conformationally restricted H stems remained capable of

231 ituted perhydroquinoxalines were designed as conformationally restricted kappa-opioid receptor agonis

232 LR4.MD-2-specific ligands, we have developed conformationally restricted Lipid A mimetics wherein the

233 The properties of this state, such as conformationally restricted loop regions and positioning

234 ild method for the synthesis of strained and conformationally restricted macrocycles.

235 oligonucleotides modified with LNA or other conformationally restricted monomers.

236 ast to wild-type LacY, the properties of the conformationally restricted mutant Cys154-->Gly do not c

237 tions to the sugar ring of affinity-inducing conformationally restricted nucleotide building blocks s

238 Conformationally restricted nucleotides such as locked n

239 Oligonucleotides modified with conformationally restricted nucleotides such as locked n

240 A conformationally restricted P2' methyl group provided in

241 Herein, we introduced a novel strategy for conformationally restricted peptide design adopting a mi

242 ent FDA approval of Symlin, which is a large conformationally restricted peptide.

243 Importance of the conformationally restricted peptides for drug design aga

244 ional methods for accurate de novo design of conformationally restricted peptides, and the use of the

245 by dehydrogenative coupling of a tertiary or conformationally restricted secondary alcohol with dieth

246 ers of these PBIs are kinetically trapped in conformationally restricted states through intramolecula

247 We have designed a series of conformationally restricted tetrahydrothiophene-based GA

248 Preactivation of conformationally restricted thioglycoside 6 employing p-

249 he beta-barrel protein is underpinned by its conformationally restricted transition state ensemble, r

250 ts sigma-dimer, which was shown to possess a conformationally restricted two-layer structure both in

251 data also show that the VCBC complex is more conformationally restricted when bound to the antiviral

252 tion preferences of hnRNPK for C-patches are conformationally restricted within the hairpin, these st

253 ke particle (VLP) vaccine platform (PP7) for conformationally-restricted presentation of a modified A

254 2,5-diketopiperazine, an acylhydrazide-based conformationally rigid 2,5-DKP scaffold having exocyclic

255 cedure to a variety of chiral lipophilic and conformationally rigid amines and heterocycles by decarb

256 Two hitherto unknown conformationally rigid Huckel aromatic ethynylene-cumule

257 highly conserved across Class A GPCRs and is conformationally rigid in both the inactive and active s

258 re sought, but their design is hampered by a conformationally rigid portrait of AChE extracted exclus

259 [Ar2N3]Mo(N)(O-t-Bu), which contains the conformationally rigid pyridine-based diamido ligand, [2

260 drogen bonding and leads to macrocycles with conformationally rigid turn structures.

261 in the lectin domain that would otherwise be conformationally rigid.

262 We report here such a unique class of conformationally robust modularly tunable folding molecu

263 x with a covalent noradrenaline analog and a conformationally selective antibody (nanobody) verified

264 Here we use conformationally selective inhibitors as chemical probes

265 Here, we monitor by NMR the effect of conformationally selective inhibitors on kinase backbone

266 oop to allow control of dephosphorylation by conformationally selective inhibitors.

267 Effective clinical application of conformationally selective kinase inhibitors requires ta

268 We conclude that CCL17 and CCL22 are conformationally selective ligands of CCR4 and interact

269 sting that the MAPK1-vinculin interaction is conformationally selective.

270 formational extension of FN as assessed by a conformationally sensitive antibody.

271 These data suggest a conformationally sensitive determinant on DRalpha1-MOG t

272 We previously demonstrated that a conformationally sensitive domain of one G protein, i.e.

273 try and flow cytometry using antibodies with conformationally sensitive epitopes supports proteolysis

274 receptor surface trafficking, reactivity to conformationally sensitive monoclonal antibodies, and li

275 d residues in those proteins were located in conformationally sensitive regions that underlie contrac

276 mbrane-impermeant sulfhydryl reagent was not conformationally sensitive.

277 Conformationally stabilized alpha-helical peptides are c

278 C38.01-11, by using virus-like particles and conformationally stabilized Env trimers as B cell probes

279 cellular penetration by different classes of conformationally stabilized peptides.

280 the IL-2:IL-2Ralpha interaction, while also conformationally stabilizing the IL-2:IL-2Rbeta interact

281 The threading of conformationally stable 1,2,3-alternate calix[6]arenes i

282 DRPs appeared to be conformationally stable as intact conglutins.

283 ions also in single-molecule measurements on conformationally stable beta-peptides with non-polar sub

284 nted here will undoubtedly help achieve more conformationally stable helical peptoids with desired fu

285 gle-crystal X-ray analyses indicate that the conformationally stable host/guest metal adducts display

286 ein design can generate small, thermally and conformationally stable protein scaffolds that accuratel

287 f kinase inhibitors through the synthesis of conformationally stable pyrrolopyrimidines.

288 these distorted regions can assume different conformationally stable states.

289 The resulting rationally designed, conformationally stable template enables further optimiz

290 MUPs are highly polymorphic and conformationally stable.

291 omatin, which has typically been viewed as a conformationally static entity.

292 Utilization of Ag complexes of conformationally strained trans-cyclooctenes should grea

293 Our opinion is that in conformationally suitable systems macrocycles are an ana

294 ed and copolymerized with fluorene to give a conformationally switchable conjugated copolymer.

295 Rhodium complexes derived from conformationally transformable alpha,omega-bisphosphite

296 scalable approach to the total synthesis of conformationally unrestricted, electronically isolated a

297 r across the substrate access channel, and a conformationally unstable catalytic loop in Rpn11.

298 emical chaperones to restore the function of conformationally unstable p53 cancer mutants, to the dev

299 through the measurement of distances between conformationally well-defined spin labels.

300 irtue of the strategic placement of an added conformationally well-defined, rigid, and extended C20'