ライフサイエンスコーパス: congenic

1 ne of these have been analyzed with interval congenics.

2 hat wild-type and galanin knockout mice on a congenic 129/OlaHsd background are responsive to the loc

3 To explore genetic contributions, a pair of congenic a and alpha mating type strains was generated b

4 ed into the XL280 background to generate the congenic a and alpha pair strains.

5 fection models of murine cryptococcosis, the congenic a and alpha strains displayed comparable levels

6 ant for its morphogenesis and pathogenicity, congenic a and alpha strains for a filamentous form were

7 Wild-type (WT) C57BL/6 mice, congenic A1-AdoR knockout (A1-KO) mice, and mice that ha

8 ghly autoreactive in vitro and are lethal in congenic adoptive transfer in vivo, demonstrating a crit

9 Using congenic analysis of alleles in NOD and NOD-resistant (N

10 Using congenic and allogeneic mice as recipients and depleting

11 the subcongenic mice, along with B6.TH-tabw2 congenic and B6-homozygous control mice were fed either

12 variation in genes and enhancer elements in congenic and backcross mouse models.

13 omotor activity was exhibited in B6.TH-tabw2 congenic and subcongenic mice compared to controls when

14 lipidemia and related metabolic disorders in congenic and subcongenic rat strains.

15 of iNKT cell over-representation: Vbeta8 TCR congenic and Valpha14 TCR transgenic NC mice.

16 cal congenic rats were generated (LEW.WCrgn1 congenic and WKY.LCrgn1 congenic), immunized with recomb

17 is a natural Rab38 knockout, supported by a congenic animal (FHH.BN-Rab38) having less proteinuria t

18 Because these congenic animals contain Brown Norway (BN) alleles for f

19 xtensive liver damage, and death, whereas WT congenic animals failed to develop disease.

20 Ly108-H1, which is absent in two lupus-prone congenic animals.

21 d for generations of backcrossing to achieve congenic animals.

22 mice were crossed with B6.129-Sle16 (Sle16)-congenic autoimmune mice to obtain Sle16.

23 econstitution of Rag1(null) mice with normal congenic B cells that have matured in vitro restores the

24 This phenotypic variability on a congenic B6 background has puzzled geneticists for decad

25 R3 and wildtype B6 mice and cotransferred to congenic B6 recipients of BALB/c heart allografts.

26 tory mouse strains are deficient in Mx1, but congenic B6-Mx1(r/r) mice that carry the wild-type Mx1 g

27 study evaluated the response of C57Bl/6 and congenic B6.129c1 mice (expressing the 129-derived Slam

28 MHC-mismatched H-2(b) C57BL/6 or MHC-matched congenic B6.H-2(g7) recipients, we demonstrate that NOD.

29 diminishes T cell-dependent autoimmunity in congenic B6.Sle1b mice.

30 pathologies of these SNV mice with those of congenic (B6.129S1-Cdh23(Ahl+) and 129S1.B6-Cdh23(ahl))

31 n the presence of endogenous self-Ag (IgH(a) congenic background), AM14 Tg Act1(-/-) B cells were spo

32 oprosencephaly phenotypes in mice, even on a congenic background.

33 (-/-)) were generated on outbred and C57BL/6 congenic backgrounds.

34 dose of oral kanamycin, Salmonella-infected congenic BALB/c.D2(NrampG169) mice, which carry a wild-t

35 ysis of islet-infiltrating T cells in Iddm30 congenic BBDP animals revealed that overexpression of pa

36 an F2(BBDP x ACI.1u.Lyp) cohort and Iddm26.2 congenic BBDP sublines has revealed an association of Pt

37 ce and their therapeutic potential following congenic bone marrow transplantation (BMT) in a proteogl

38 We used a congenic breeding program and comparative genomics to ex

39 bronchus of TLR4-defective (both C3H/HeJ and congenic C.C3-Tlr4(Lps-d)/J) and control mice to initiat

40 use TIM-3 showing a higher capacity than the congenic C.D2 Es-Hba-allelic variant.

41 cause of Fanconi syndrome, is reproduced in congenic C57BL/6 cystinosin knockout (KO) mice.

42 abrogates neurovirulence in neonatal H-2(d) congenic C57BL/6 mice.

43 ere we report that a commonly used CD45.1(+) congenic C57BL/6 mouse substrain is characterized by sel

44 press high levels of Pbx1-d as compared with congenic C57BL/6J (B6) MSCs.

45 Congenic C57BL/6J (B6-Mx1(r/r)) mice expressing a wild-t

46 ld be rescued by moving the transgene onto a congenic C57BL/6J background and recurred on reintroduct

47 nder- and genetic background-dependent, with congenic C57BL/6J male mice exhibiting the most aggressi

48 of NZB and 129S6 mtDNAs in the presence of a congenic C57BL/6J nuclear background.

49 evels of the genes of interest were noted in congenic C57BL/6J-Ah(d) allele mice, when compared to th

50 on when the IL-10 concentration is high into congenic CD45.2 recipients develop into the MHC II(lo) m

51 cancer progression, we analyzed a series of congenic cell lines that harbor single extra chromosomes

52 Using CD45 congenic cells, we show that induction of niT cells and

53 vels as a function of CGG-repeat length in a congenic (CGG-repeat knock-in) mouse model using 57 wild

54 tally to TCDD were mixed 1:1 with cells from congenic controls and used to reconstitute lethally irra

55 Here, we show that, very unexpectedly, congenic D2-Mx1(r/r) mice carrying the wild-type Mx1 gen

56 Most remarkably, congenic D2-Mx1(r/r) mice expressing a functional Mx1 wi

57 In this study, we used NZB.NZW-Lbw2 congenic (designated Lbw2 congenic) mice containing an i

58 background, we created and phenotyped DBA/2J-congenic Dmdmdx mice (D2-mdx) and compared them with the

59 We report that DBA/1 mice as well as congenic FcgammaRIII(-/-) and FcRgamma(-/-) mice immuniz

60 ammatory effect was similar in wild-type and congenic females.

61 Further analysis using mice congenic for chromosome 7 confirmed Pdcc1, demonstrating

62 e to MCMV infection in novel BALB substrains congenic for different MHC (or H-2 in mice) haplotypes,

63 DBA/2J mice, doubly congenic for the Bax mutant allele and the ganglion cell

64 thritis development was confirmed in B6 mice congenic for the C3H allele of Bbaa1 (B6.C3-Bbaa1), whic

65 C57BL/6 mice congenic for the C3H Gusb allele were prone to increased

66 Muscle cells from BALB/c mice congenic for the C57BL/6 Lsq-1 quantitative trait locus

67 utants in different strains of mice that are congenic for the H-2 locus indicates that CD4 T-cell rec

68 Compared with C57BL/6 mice congenic for the H2 gene complex from NOD mice (B6.g7),

69 Examination of BBDP sublines congenic for the Iddm26.2 locus that includes Ptpn22 has

70 megalovirus (MCMV) infection, using NOD mice congenic for the protective NK gene complex from C57BL/6

71 protection from tissue necrosis in a shorter congenic fragment of Lsq-1 (C.B6-Lsq1-3).

72 y, against a high degree of homogeneity in a congenic genetic background, selectively impaired active

73 Conversely, a second fully congenic group (F > 10) had less variable features patho

74 An MKS-like incipient congenic group (F6 to F10) manifested very variable neur

75 Furthermore, Lbw2 congenics had greater numbers of marginal zone B cells a

76 loci that had high (14%-32%) whereas 2 other congenics had low (4%) TGCT incidences.

77 .5 and surviving pups were transplanted with congenic hematopoietic cells on day of life 1.

78 bred (C57BL/6, BALB/c, and A/J) strains, one congenic (HLA-A2 on the C57BL/6 background) strain, and

79 ccelerated clearance of bacteria from H-2(k) congenic hosts.

80 Early after congenic HSCT, we found that Ly49G2(high) single-positiv

81 the virulence function of YopM, C57BL/6J or congenic IL-10(-)/(-) mice were infected intravenously w

82 enerated (LEW.WCrgn1 congenic and WKY.LCrgn1 congenic), immunized with recombinant rat alpha3(IV)NC1,

83 retaining the distal region of the TH donor congenic interval exhibited significantly larger fat mas

84 The 1.7-Mb congenic interval on chromosome 3, containing eight gene

85 ice bearing the Sle2(z) lupus-susceptibility congenic interval on chromosome 4 display high titers of

86 chow feeding map to the distal region of the congenic interval, whereas the diet-induced obesity medi

87 Congenic introduction of the susceptible Cdcs1 interval

88 The eyes of congenic IRBP knockout (KO) and C57BL/6J wild-type (WT)

89 Congenic knockout mice and mice overexpressing Sept5 in

90 Here, we generated a minimal congenic line (Rf-1a+4_a) to identify a 4.1-Mb region of

91 ility to renal disease, suggesting that this congenic line is an important model for studying pathway

92 ed a unique multimodal imaging strategy in a congenic line of DYT1 mutant mice that contain the Delta

93 ockout of the Rab38 gene on the FHH.BN-Rab38 congenic line recapitulated a proteinuric phenotype indi

94 assessment of a novel inbred BBDP.ACI-Iddm30 congenic line.

95 g B6.D2(Csnk1e) and D2.B6(Csnk1e) reciprocal congenic lines (78-86.8 and 78.7-81.6 Mb, respectively).

96 In GHS chromosome 1 congenic lines bred onto a WKY genomic background, we fo

97 We generated congenic lines carrying smaller intervals (subcongenics)

98 Five WF.COP congenic lines containing COP RN02 segments were compare

99 from advanced interval-specific recombinant congenic lines identified myostatin as uniquely upregula

100 By using congenic lines on the BN genomic background, we show tha

101 All other congenic lines tested were susceptible.

102 Advanced congenic lines were developed to reduce the physical siz

103 onto a WKY genomic background, we found that congenic males had significantly (P < 0.0001) higher CVs

104 In Pgia8-congenic males, arthritis severity was 30% less (P < 0.0

105 By combining the power of congenic mapping and nuclease-based gene targeting, we e

106 Congenic mapping and sequence analysis in rats suggested

107 We used congenic mapping to refine Candq1 and its candidate gene

108 n two inbred strains are usually followed by congenic mapping to refine the loci responsible for the

109 Then, by combining congenic mapping, in silico haplotype analyses, and comp

110 etected in progeny from a-alpha opposite-sex congenic mating; thus, both homothallic and heterothalli

111 total) to detect underlying genetic loci; 2) congenic mice (n = 23) to replicate the identified locus

112 Using B6.129c1 congenic mice and adoptive transfer, we found that diver

113 were compared between cohorts of B6.Sle2.lpr congenic mice and B6.lpr mice of ages up to 6 months.

114 to nearly those of wild-type B6 in the B6/B6 congenic mice as follows: 83% rescue of low pial collate

115 In an earlier study, we used Ly5.1 congenic mice as transplant recipients to investigate th

116 DCC-susceptible C3H/He and B6.C3H(Dyscalc1) congenic mice at day 3 after injury.

117 Congenic mice bearing the disease loci Sle1 or Sle1 and

118 moter and inhibits its expression in NOD.C3H congenic mice carrying C3H alleles at Idd6.3.

119 Congenic mice carrying the impulsivity locus (Impu1) con

120 ne phenotypes can be isolated in recombinant congenic mice containing both genes.

121 The B6.TH-tabw2 congenic mice developed increased adiposity that became

122 ntrol, and the bacteria were inoculated into congenic mice differing only at Nramp1.

123 Lbw2 congenic mice exhibited marked reductions in AEAs and sp

124 ogenitor responded equally to DMBA and BP in congenic mice expressing the PAH-resistant AhR (AhR(d)).

125 amine-induced locomotor activity in C57BL/6J congenic mice harboring DBA/2J polymorphisms.

126 Analyses of lupus-prone congenic mice have pointed to an important role for the

127 s (Tregs), and we found that B10.S-Eae5(SJL) congenic mice have significantly greater numbers of lymp

128 C57BL/6-congenic mice heterozygous for the F508del CFTR mutation

129 Bone marrow-derived macrophages from Bbaa1 congenic mice implicated this locus as a regulator of ty

130 Here, we showed that housing Mx1 congenic mice in low relative humidity makes mice more s

131 trains (often C57BL/6J) typically results in congenic mice in which the targeted gene is flanked by E

132 ated effector CD4(+) T cells into tumor-free congenic mice mediates rejection of tumor challenge 9 mo

133 Crry derived from B6.Sle1c congenic mice migrated at a higher m.w. by SDS-PAGE comp

134 Importantly, Ob-deficient and vic1 I/LnJ congenic mice on other genetic backgrounds produce antiv

135 dependency, we used genetically modified and congenic mice on the C57BL/10 background and in vitro T-

136 gene (designated Tnfrsf9) in NOD.B10 Idd9.3 congenic mice protected from type 1 diabetes (T1D).

137 Transplantation of Vk*MYC tumor cells into congenic mice selected for a more aggressive disease tha

138 As previously reported, B6.TH-tabw2 congenic mice showed a significantly larger fat mass tha

139 Analysis of a panel of subinterval congenic mice showed that the full effect of Lbw2 on AEA

140 prisingly discover that the UBC-GFP BALB/cBy congenic mice still retain the H-2(b) MHC haplotype of t

141 Here, we examined B6.Sst1(S) congenic mice that carry the 'susceptible' allele of the

142 have developed novel NOD.B10-Idd9 (line 905) congenic mice that predominantly harbor islet-reactive C

143 tations to the reported genetically modified congenic mice that were generated using 129-strain ESCs

144 Previous studies have used congenic mice to examine the function of major histocomp

145 esis of EAE, we generated phenotype-selected congenic mice using EAE-resistant B10.S and EAE-suscepti

146 lls, and Treg cells, a panel of C57BL/6 (B6) congenic mice was tested.

147 erived LSK(-) cells upon transfer into naive congenic mice were found to differentiate predominantly

148 We showed previously that C57BL/6 congenic mice with an introgressed homozygous 70 cM (125

149 e examined by inferior vena cava ligation in congenic mice with and without alpha2-antiplasmin (alpha

150 lated from the paws of male and female Pgia8-congenic mice with collagen antibody-induced arthritis.

151 producing the phenotype observed for DC from congenic mice with the NZB c1 70-100 cM interval.

152 in genetically resistant BALB/c.D2(Slc11a1) congenic mice with the wild-type Nramp1 locus.

153 Using congenic mice with varying levels of extracellular super

154 9S-Cdh23(c.753A) SNV and 129S1.B6-Cdh23(ahl) congenic mice, and a linkage backcross involving these s

155 B6.TH-tabw2 congenic mice, but not subcongenic mice, also had signif

156 Lyme arthritis in the reduced interval Bbaa1 congenic mice, formally implicating myostatin as a novel

157 NOD.B10 Idd9 congenic mice, in which the NOD Idd9 chromosomal region

158 In reciprocal chromosome 5 congenic mice, introgressed D2 alleles increased HSC num

159 strain mapping using autoimmune NOD.C57BL/6J congenic mice, we demonstrated previously that the type

160 Using H2-congenic mice, we show that the observed difference in f

161 Using NOD congenic mice, we validate that both the MHC and the chr

162 In this study, we used C57BL/6.S (B6.S) congenic mice, which carry H-2(s) MHC genes instead of H

163 nificantly increased in the B6.C3H(Dyscalc1) congenic mice, which carry only the Dyscalc1 locus with

164 neration compared with T cells from NOD.Idd3 congenic mice, which carry the protective Idd3 allele fr

165 on intratracheal adoptive cell transfer into congenic mice.

166 f them had fat mass as large as the original congenic mice.

167 controls, and comparable that to B6.TH-tabw2 congenic mice.

168 optively transferred into Rag1((-)/(-))Ly5.1 congenic mice.

169 ne marrow-derived dendritic cells from Cdcs1 congenic mice.

170 uence adaptive immunity to Salmonella in MHC congenic mice.

171 e measured in aging female gld and wild-type congenic mice.

172 leads to autoimmune cholangitis in NOD.Abd3 congenic mice.

173 g the systemic administered MDSC from CD45.1 congenic mice.

174 onding decrease in hnRNP H protein in 114 kb congenic mice.

175 ficantly dysregulated in arthritic joints of congenic mice; expression of these genes was also sex sp

176 used NZB.NZW-Lbw2 congenic (designated Lbw2 congenic) mice containing an introgressed fragment of Ne

177 the widely used B6-CD45.2 and B6.SJL-CD45.1 congenic model, identifying substantial differences in S

178 Here, we used congenic models and comparative genomics to refine the R

179 By combining congenic models and cross-species studies, we narrowed t

180 stem to track haematopoietic cells following congenic mouse bone marrow transplants.

181 A novel NOD congenic mouse expressing aberrant Pkhd1, but lacking th

182 In this study, we generated a congenic mouse model carrying a mutated Nnt(C57BL/6J) al

183 and mucin (TIM) proteins, identified using a congenic mouse model of asthma, critically regulate inna

184 Here, we used the NOD.NK1.1 congenic mouse model to examine the role of NK cells in

185 Here we use an MHC congenic mouse model to test the hypothesis that genetic

186 We used two congenic mouse models that differ at the Ahr gene and en

187 Here, we generated the corresponding congenic mouse strain by introgression of a segment of C

188 For this, we generated a congenic mouse strain carrying the A2G wild-type Mx1 res

189 8Mit293-D8Mit137)/Mx (NOD-Idd22) recombinant congenic mouse strain was generated in which NOD mice ca

190 We previously established a congenic mouse strain with TALLYHO/Jng (TH) donor segmen

191 CD8 T cells accelerate clearance in some MHC congenic mouse strains and could therefore represent an

192 widespread genetic variation in widely used congenic mouse strains and provide a simple method to id

193 We generate two NOD.H2(k).B10-Chr9 congenic mouse strains and validate the role of this gen

194 c lupus erythematosus patients and of murine congenic mouse strains associate genes in a DNA segment

195 usters, and it provides a large array of new congenic mouse strains for the study of HAT/DESC proteas

196 rgeting, we generated a library of 18 unique congenic mouse strains lacking combinations of HAT/DESC

197 The use of congenic mouse strains permits the use of immunofluoresc

198 The systematic analysis of lupus-prone congenic mouse strains suggests a role for two isoforms

199 in murine epidermolysis bullosa acquisita in congenic mouse strains with the disease-permitting H2s o

200 between diabetes-susceptible and -resistant congenic mouse strains.

201 ne target and/or insulitis trigger in NOD or congenic mouse strains.

202 the same collection of mutants was tested in congenic mouse-derived primary macrophages, a major Nram

203 tudies demonstrate the inimitable benefit of congenic MSC therapy in reversing experimental type 1 di

204 ell-free filtrate of their blood to immunize congenic naive mice.

205 d3/Il2 or Idd5 are able to partially protect congenic NOD mice from insulitis and diabetes, and to pa

206 Congenic normal mdr2 (+/+) hepatocytes were isolated by

207 II (as revealed in immunized intra-H-2(d/b) congenic or CD154(-/-) H-2(d) strains, and by selective

208 ), hESC line expressing no MECP2 (MECP2-KO), congenic pair of wild-type and mutant RTT patient-specif

209 The congenic pair was used to investigate three traits: mito

210 60, the incompatibility depended on breeding congenic pairs or the introduction of H60 by transgenic

211 Compared with the congenic parental strain (Ahr(Fx/Fx)), non-fasted Cre(Al

212 vation in vitro was assessed in parental and congenic rat bone marrow-derived macrophages (BMDMs).

213 ction of nephrotoxic nephritis in the double-congenic rats (WKY.LCrgn1,2) produced markedly fewer glo

214 Congenic rats expressing lower levels of Mcl and Mincle

215 ole of this QTL in EAG induction, reciprocal congenic rats were generated (LEW.WCrgn1 congenic and WK

216 reserved in DA.F344(Cia3) and DA.F344(Cia3d) congenic rats with PIA, while DA rats had pronounced syn

217 , a Vdr expression signature was detected in congenic rats, along with up-regulation of mediators of

218 significantly lower levels in DA.ACI(Cia25) congenic rats.

219 nor B cells were adoptively transferred into congenic recipients and allowed to remain for 1 mo in th

220 ls with germline VRC01 B cell receptors into congenic recipients to elucidate the roles of precursor

221 hich were confirmed, were located within the congenic region and contained several sequence variants.

222 and to exclude other genes within the 1.5 Mb congenic region from involvement in causing the FHH phen

223 0Sn (B10)-derived diabetes resistance Idd9.3 congenic region has been shown to enhance accumulation o

224 Because the original Rf-4 congenic region is 61.9 Mbp, it is necessary to reduce t

225 T1D as the result of a NOR-derived 44.31-Mb congenic region on distal Chr.

226 the large effects that strain background and congenic regions have on the hearing loss associated wit

227 mory impairment, memories in GluA3-deficient congenics remained unaffected.

228 Using a strain of congenic SAMP mice engineered to lack global expression

229 measurements were made in C57BL6/J mice and congenic Sftpd-/- mice at 8, 27 and 80 weeks of age (n =

230 ncidences were combined, males of the double congenic showed lower than expected TGCT incidence (nega

231 rate the matted and Flg mutations to produce congenic single-mutant strains for genetic and immunolog

232 ially controls lupus-related autoimmunity in congenic Sle1b mice; for instance, the presence of the p

233 Developmental processes were investigated in congenic Sox10(Dom) mice, an established Hirschsprung di

234 ensitive hypertension, and salt-insensitive, congenic SS.13(BN26) rats fed a high-salt diet.

235 lla of SS rats, but not the salt-insensitive congenic SS.13(BN26) rats, was significantly increased w

236 Our study demonstrates that the MAIThi congenic strain allows phenotypic and functional charact

237 ts of Crgn1 and Crgn2, we generated a double-congenic strain by introgressing these loci from glomeru

238 asured in B6-Ldlr(-/-)Cdkn2a(+/-) mice and a congenic strain carrying the region of homology with the

239 We generated an A/J congenic strain lacking c-Kit by introgression of the Wv

240 By congenic strain mapping using autoimmune NOD.C57BL/6J co

241 Interestingly, in a congenic strain of mice carrying low-affinity, ligand-bi

242 Using a newly discovered congenic strain of mice, we show a previously unrecogniz

243 ificantly to TGCT, when combined in a double congenic strain resulted in greater than expected TGCT i

244 s in ischemic tissue injury, and generated a congenic strain set with wide allele dose-dependent vari

245 We generated a MAIThi congenic strain that was then crossed to a transgenic Ro

246 For the triple congenic strain, depending on the analysis, the overall

247 imilar results were observed in an SS.5(Lew)-congenic strain, in which a smaller region of chromosome

248 s test focused on the obesity-resistant 6C2d congenic strain, which carries the Obrq2a(A/J) allele on

249 as their F(1) generation and six recombinant congenic strains (RCSs) with varied susceptibility to MD

250 Through the use of a series of novel congenic strains containing the Idd3/Il2 region and diff

251 The congenic strains each with their characteristic TGCT inc

252 Mice from recombinant congenic strains expressing Sle1c2 exhibited increased C

253 Immunized H-2(d)-congenic strains had more rapid, sustained, and elevated

254 ify and map tumor loci from M19 we generated congenic strains harboring MOLF chromosome 19 segments o

255 significant muscle inflammation in multiple congenic strains of C57BL/6 and NOD mice.

256 to appropriate control proteins) in various congenic strains of mice.

257 Six congenic strains possessing portions of Candq1 introgres

258 In summary, the congenic strains provide a new resource for the explorat

259 The C. gattii congenic strains represent a new resource for exploring

260 The two congenic strains show the same virulence in different mo

261 fluence on selection of KLRH1(+) NK cells in congenic strains suggested that KLRH1 may have an MHC li

262 We found 3 congenic strains that each harbored tumor promoting loci

263 esponses to the HIV-1 Envelope, we have used congenic strains to identify a critical role for MHC cla

264 The resulting congenic strains were then used to test the impact of ma

265 and protein, and decreased TCR signaling in congenic strains with B6-derived Idd18.2 susceptibility

266 mouse strains (AcB/BcA panel of recombinant congenic strains) created from influenza-susceptible A/J

267 candidate gene-methods used include creating congenic strains, comparative genomics and gene expressi

268 n and virulence gene regulation by utilizing congenic strains, each harboring a unique S. aureus agr

269 nterval within the MHC-II locus of three MHC-congenic strains, of which two were protected from sever

270 CT development, we created double and triple congenic strains.

271 dominant when 2 loci were combined in double congenic strains.

272 owed with genetic and phenotypic analysis of congenic, subcongenic, and subsubcongenic strains, we id

273 Protective alleles in the Idd9.2 congenic subregion are required for the maximal reductio

274 We characterized its genomic architecture by congenic substitution mapping, targeted next-generation

275 c inherited glaucoma, using as a control the congenic substrain DBA/2J Gpnmb(+/SjJ) (D2G), which is n

276 ng factors, this original demonstration used congenic/syngeneic dam and foster pup pairs.

277 ight on the limitations of the CD45.1/CD45.2 congenic system for tracking lymphocyte development.

278 ve smaller lesions, and adoptive transfer of congenic T cells into athymic nude mice prior to infecti

279 Congenic Tbx1 heterozygous (HT) mice were impaired in so

280 durable donor-derived HSC engraftment after congenic transplantation.

281 Using fetal liver and BM congenic transplantations and deleting IKKalpha from ear

282 Congenic transplants into T(FH)-deficient CD4(-/-) mice

283 Both the C57BL/6 inbred and BALB/cBy congenic UBC-GFP lines are commercially available and ha

284 ve interpretations of previous studies using congenic UBC-GFP mice and focuses attention on the neces

285 transgenic (Valpha14(Tg)) but not Vbeta8 TCR congenic (Vbeta8(Cg)) NC mice exhibited reduced AD devel

286 anting lethally irradiated C57BL/6 mice with congenic VDR or wild type BM.

287 tome analysis of striatal tissue from 114 kb congenics vs Hnrnph1 mutants identified a nearly perfect

288 Female KO and congenic wild type (WT) mice were treated with racemic P

289 RR Z/DeltaLRR Z) mice, Cryo(-Z/-Z) mice, and congenic wild-type (WT) mice were challenged with endoto

290 ermeability during JEV infection compared to congenic wild-type (WT) mice, indicating that enhanced v

291 on, mice were simultaneously inoculated with congenic wild-type and luxS strains, and bacterial numbe

292 Compared to congenic wild-type animals, Irf5-/- and CMV-Cre Irf5fl/f

293 Compared to congenic wild-type controls, Ifit2(-/-) mice showed enha

294 ary changes, Lck(-/-) mice and corresponding congenic wild-type mice were chronically exposed to ciga

295 e and following ozone exposure compared with congenic wild-type mice.

296 2/TLR-4-double-knockout, MyD88-knockout, and congenic wild-type mice.

297 mice are fully functional: upon transfer to congenic, wild type mice at controlled frequencies, such

298 as the sequenced reference (CC-503) are not congenic with respect to sta6 (CC-4348), underscoring th

299 However, when congenic with the C57Bl/6 strain, 80% of ADAMTS9+/- mice

300 tive strategies, such as the construction of congenics with very small donor regions.