ライフサイエンスコーパス: congenic strain

1 rrowed the region to 2.7 cM in a reduced MHC congenic strain.

2 ts identified in heterozygotes from a D2-cpk congenic strain.

3 e of Szf1 in both an independent cross and a congenic strain.

4 ze a series of recombinants derived from the congenic strain.

5 their chromosomal location on Chr 19 in each congenic strain.

6 in size on the linkage map using a series of congenic strains.

7 provided by the examination of knock-out and congenic strains.

8 CT development, we created double and triple congenic strains.

9 al backcrossing and intercrossing to produce congenic strains.

10 cell responses are elicited in H13a and H13b congenic strains.

11 recognize only the H4 Ag from this panel of congenic strains.

12 dominant when 2 loci were combined in double congenic strains.

13 njury in mice with the lpr mutation, but not congenic strains.

14 enic interval in three independently derived congenic strains.

15 ntervals that have been isolated in separate congenic strains.

16 and HG.CAST-(D11Mit260-D11Mit255)N(6) (HG11) congenic strains.

17 tal BXSB strain, developed in three of these congenic strains.

18 ime-consuming to generate and backcross onto congenic strains.

19 ually requiring years to develop and analyze congenic strains.

20 on of either recombinant inbred, consomic or congenic strains.

21 Our study demonstrates that the MAIThi congenic strain allows phenotypic and functional charact

22 In these congenic strain analyses, the Nppa and Fv1 loci, in addi

23 In this study, using both linkage and congenic strain analyses, we demonstrate contributions f

24 Congenic strain analysis narrowed the genetic interval s

25 of PIA was investigated using F1 hybrid and congenic strain analysis to determine the influence of M

26 werful techniques of microarray analysis and congenic-strain analysis may greatly facilitate unravell

27 nterval of 0.15 cM by a combination of novel congenic strains and an ancestral haplotype analysis app

28 Using Ly5-marked congenic strains and B6 host mice, additional experiment

29 After breeding BALB- and B6a-rd3/rd3 congenic strains and finding significant differences in

30 ng a combination of novel, interval-specific congenic strains and recombinant progeny testing.

31 tic map is relatively well defined, and both congenic strains and recombinant strains are available t

32 ng Scg5 expression in two mouse chromosome 2 congenic strains and three additional F2 intercrosses.

33 maps, rapid marker-assisted construction of congenic strains, and evolutionary comparisons.

34 itions), four NOD-derived diabetes-resistant congenic strains, and two nondiabetic control strains.

35 enetic background which affects arthritis in congenic strains appears to also regulate BMD.

36 nes involved in sex determination, we used a congenic strain approach to determine which chromosomal

37 Congenic strains are constructed by repeated backcrossin

38 In the analysis of complex traits, congenic strains are powerful tools because they allow c

39 Experiments involving a congenic strain (B6.D2-Mtv7(a)/Ty) enabled more precise

40 The resulting congenic strain, B6.kd, was mated with partners homozygo

41 tly on a C57BL/6 background to produce three congenic strains: B6.NZMc1 carrying Sle1, B6.NZMc4 carry

42 The availability of B6-based congenic strains bearing individual NZW-derived lupus su

43 was equivalent between the B3501 a and alpha congenic strains but the alpha strain was more virulent

44 ed in a cross between B6 and a B6.SPRET Ath1 congenic strain, but was unaffected in a B6 x B6.H Ath1

45 ts of Crgn1 and Crgn2, we generated a double-congenic strain by introgressing these loci from glomeru

46 at hg and D10Mit69 cosegregate in a cross of congenic strains C57BL/6J-hghg x C57BL/6J.

47 A congenic strain (called 'ZORI' here) with defects in Rag

48 reeding to construct two sets of overlapping congenic strains, called genome-tagged mice (GTMs), that

49 Congenic strains can now be constructed guided by the tr

50 Congenic strains can then be developed to fine-map a tra

51 We subsequently produced B6.NZMc1, a congenic strain carrying the NZM2410-derived Sle1 genomi

52 asured in B6-Ldlr(-/-)Cdkn2a(+/-) mice and a congenic strain carrying the region of homology with the

53 ts is to localize them in crosses, construct congenic strains carrying individual QTLs, and finally m

54 We previously produced three congenic strains carrying lupus susceptibility genes (Sl

55 Immunization of congenic strains carrying the entire chr15 and separatel

56 The analysis of congenic strains carrying these loci is now providing fu

57 In this article, we analyze data from congenic strains carrying two chromosome intervals (a do

58 candidate gene-methods used include creating congenic strains, comparative genomics and gene expressi

59 ines from the B6.CAST Ldlr(-/-) chromosome 6 congenic strain (CON6.Ldlr(-/-)) and analyzed aortic les

60 and nonepileptic ABP mice identified, and a congenic strain confirmed, a quantitative trait locus (Q

61 le and phenotypically indistinguishable from congenic strains containing proteasomes.

62 s for gene identification include the use of congenic strains containing QTL regions introduced from

63 The construction of NOD congenic strains containing selected segments of the dia

64 , two of which were confirmed by analysis of congenic strains containing the donor genomic segment fr

65 Through the use of a series of novel congenic strains containing the Idd3/Il2 region and diff

66 Only macrophages from the congenic strains containing the Idd4 locus showed IL-12p

67 Using congenic strains containing the LEW rat chromosomal segm

68 s between CAST/Ei and C57BL/6, the resulting congenic strains cover about 80% of the autosomal chromo

69 mouse strains (AcB/BcA panel of recombinant congenic strains) created from influenza-susceptible A/J

70 fts prime for accelerated rejection of 11/13 congenic strains defining single BALB/c minor H Ags indi

71 Analysis of congenic strains demonstrated that the FcgammaR and SLAM

72 For the triple congenic strain, depending on the analysis, the overall

73 A WF.COP-D2Mit29/D2Rat201 homozygous congenic strain derived at the N10 generation was treate

74 ty, we created a panel of single- and double-congenic strains derived from 129.MOLF-Chr19.

75 t harbor susceptibility genes and a panel of congenic strains derived from a selected CSS to determin

76 l characterization of a genome-wide panel of congenic strains derived from the donor strain DBA/2J on

77 ilar to the Swiss-derived intercrosses, nine congenic strains, derived from 129S6/SvEvTAC, AKR/J, APN

78 The congenic strains described here provide a foundation upo

79 of 5-LO mRNA were reduced about 5-fold in a congenic strain, designated CON6, containing the resista

80 The congenic strain, designated S.R(chr 9), had a lower bloo

81 ) integrins (SAMP1/YitFc Itgb7(-/-)) using a congenic strain developed via marker-assisted selection.

82 to distinguish between the urinary odours of congenic strains differing only in single genes within t

83 The congenic strains each with their characteristic TGCT inc

84 n and virulence gene regulation by utilizing congenic strains, each harboring a unique S. aureus agr

85 te this process is to construct a library of congenic strains encompassing the entire genome of one s

86 del is dramatically altered depending on the congenic strain examined.

87 F1 hybrids between resistant and susceptible congenic strains exhibit a reduced tumor incidence and a

88 Mice from recombinant congenic strains expressing Sle1c2 exhibited increased C

89 surface levels of Ly-49s3 were lower, in MHC congenic strains expressing the putative Ly-49s3 ligand(

90 on these chromosomes, but the chromosome 17 congenic strain failed to trap a contrasting QTL allele.

91 in this case, alcohol preference) and (ii) a congenic strain for identification of cis regulation.

92 istence of such an interaction, we developed congenic strains for Chr 2 and 10 by introgressing the l

93 Congenic strains for chromosomes 1, 5, and 10 had signif

94 carrying two chromosome intervals (a double congenic strain) for two pairs of loci: Idd3 and Idd10 a

95 strain and the diabetes-resistant NOD.Idd3/5 congenic strain, genome-wide microarray expression analy

96 Immunized H-2(d)-congenic strains had more rapid, sustained, and elevated

97 C.D2-Chr 4 congenic strains harboring DBA/2 alleles associated with

98 ify and map tumor loci from M19 we generated congenic strains harboring MOLF chromosome 19 segments o

99 Traditionally, the development of a congenic strain has been a time-consuming endeavour, req

100 Analysis of additional congenic strains has also localized Idd5.2 to a small re

101 reviously showed that the recombinant inbred congenic strain HcB-19 has a spontaneous mutation of the

102 rmal placental development, we characterized congenic strains homozygous for the hypomorphic Egfr(wa2

103 this study, using a series of novel NOD.B10 congenic strains, Idd5.1 has been defined to a 2.1-Mb re

104 The locus was confirmed by constructing a congenic strain in which the chromosome 6 segment from C

105 cell death susceptibility was observed in a congenic strain in which the highly susceptible FVB/N st

106 on the maze, anxiety levels were tested in a congenic strain in which the rdl allele has been replace

107 Thus, we have tested a number of knockout/congenic strains in a series of behavioral tests in whic

108 n virulence was observed between a and alpha congenic strains in multiple inbred-mouse genetic backgr

109 imilar results were observed in an SS.5(Lew)-congenic strain, in which a smaller region of chromosome

110 A congenic strain introgressing the R low-blood-pressure Q

111 e diabetes, and demonstrates that the use of congenic strains is an effective mapping strategy, even

112 We generated an A/J congenic strain lacking c-Kit by introgression of the Wv

113 distribution of these response phenotypes in congenic strains linked control of phenotypes with speci

114 By congenic strain mapping using autoimmune NOD.C57BL/6J co

115 eral meta-analysis was further filtered by a congenic strain microarray set, from which cis-regulated

116 However, no difference between NOD and the congenic strain NOD.B10 Idd9R1, which has the B10 allele

117 In this investigation, two congenic strains, NZM2328.C57L/Jc1 (NZM.C57Lc1) and NZM2

118 hether dietary responsiveness is involved, a congenic strain of C3H carrying an apoE-null allele (apo

119 Interestingly, in a congenic strain of mice carrying low-affinity, ligand-bi

120 Using a newly discovered congenic strain of mice, we show a previously unrecogniz

121 Here we generate congenic strains of Anopheles stephensi, edited to carry

122 significant muscle inflammation in multiple congenic strains of C57BL/6 and NOD mice.

123 Incipient congenic strains of D2R-deficient mice demonstrated an o

124 Congenic strains of mice deficient in TLR4 demonstrated

125 ce as well as in SWXJ recombinant inbred and congenic strains of mice derived from SWR and SJL showed

126 interval-specific bidirectional recombinant congenic strains of mice were generated and studied for

127 gion of approximately 0.5 megabases by using congenic strains of mice, constructed by placing the Pas

128 etected by genome scanning using recombinant congenic strains of mice.

129 benz(a)anthracene (DMBA) was investigated in congenic strains of mice.

130 to appropriate control proteins) in various congenic strains of mice.

131 s, we conducted infection experiments in MHC-congenic strains of mice.

132 Two purebred congenic strains of PPARalpha-null mice were developed t

133 nterval within the MHC-II locus of three MHC-congenic strains, of which two were protected from sever

134 stituted chromosomes; (2) to rapidly develop congenic strains over a narrow region using several appr

135 Six congenic strains possessing portions of Candq1 introgres

136 methods that can reduce the time needed for congenic-strain production by 18-24 months.

137 In summary, the congenic strains provide a new resource for the explorat

138 Metabolite profiling in congenic strains provided evidence of QTL replication.

139 the form of 10 interval-directed recombinant congenic strains (RCS), with NON/Lt as the background st

140 This review focuses on two new recombinant congenic strains (RCSs) developed by introgressing multi

141 as their F(1) generation and six recombinant congenic strains (RCSs) with varied susceptibility to MD

142 A series of congenic strains recombinant for regions of mouse chromo

143 lar among CIA-susceptible and nonsusceptible congenic strains, regardless of class II haplotype.

144 The C. gattii congenic strains represent a new resource for exploring

145 ificantly to TGCT, when combined in a double congenic strain resulted in greater than expected TGCT i

146 A congenic strain, S.R(chr9), constructed by introgressing

147 strains were constructed from the progenitor congenic strain, S.R(chr9).

148 s in ischemic tissue injury, and generated a congenic strain set with wide allele dose-dependent vari

149 The two congenic strains show the same virulence in different mo

150 lated on a C57BL/6 background in the B6.Sle1 congenic strain, Sle1 results in the production of high

151 the construction of two sets of heterozygous congenic strains spanning the mouse genome.

152 fluence on selection of KLRH1(+) NK cells in congenic strains suggested that KLRH1 may have an MHC li

153 e location of Gct4, we created an additional congenic strain (SWR.CAST-X) that contains most of the g

154 d stem cell frequency in B6.C-H25, a C57Bl/6 congenic strain that carries a portion of chromosome 1 d

155 We have generated a congenic strain that contains the suppressor allele from

156 In contrast, BM from a B6 congenic strain that expresses the H-2T(a) allele, B6.A-

157 t in DBA/2 or C.D2-Pctr1, a resistant BALB/c congenic strain that harbors DBA/2 chromatin surrounding

158 all of these compounds were stimulatory in a congenic strain that overexpresses TraR and no compound

159 useful tools we have developed thus far is a congenic strain that possesses a segment of chromosome 4

160 We generated a MAIThi congenic strain that was then crossed to a transgenic Ro

161 analysis and the generation of novel Idd5.1-congenic strains that differ at the disease-associated C

162 and BALB/c.DBA2 Idh-lb-Ityr-Pep-3b mice are congenic strains that differ at the Ity/Lsh/Bcg locus an

163 Congenic strains that differ from C57BL/10 at (1) H3a, (

164 We found 3 congenic strains that each harbored tumor promoting loci

165 similar levels of holo-APP expression in the congenic strains, the levels of APP C-terminal fragments

166 pertaining to T1D; descriptions of NOD mouse congenic strains; the Beta Cell Gene Expression Bank, wh

167 knockout strains have been bred to be B6.129 congenic strains, they can be used to test for QTLs in t

168 e additional selection capacity should allow congenic strains to be produced in fewer generations tha

169 As in NOD mice and in diabetes-resistant NOD congenic strains to characterize the association of auto

170 In this study, we used newly developed congenic strains to further localize Idd10.

171 esponses to the HIV-1 Envelope, we have used congenic strains to identify a critical role for MHC cla

172 lso discuss a strategy for using recombinant congenic strains to separate and reassemble interacting

173 The congenic strain was almost completely resistant to diet-

174 A double congenic strain was also constructed with both the Chr 2

175 The BALB-Min (C.B6-Apc(Min/+)) congenic strain was generated by backcrossing into BALB/

176 overt, obese phenotype in either of the two congenic strains was not observed.

177 Using a chromosome 1 congenic strain, we improved the genetic analysis and ma

178 From crosses of the SWR.CAST-X and SWR.SJL-X congenic strains, we derived males carrying unique combi

179 Using NOD.B10 Idd5 congenic strains, we determined that a 2.1-Mb region con

180 By using congenic strains, we have been able to show that iron up

181 Congenic strains were constructed by introgressing Lewis

182 The resulting congenic strains were then used to test the impact of ma

183 s test focused on the obesity-resistant 6C2d congenic strain, which carries the Obrq2a(A/J) allele on

184 ort the development of a small-donor-segment congenic strain, which confirms capture of a gene affect

185 are in agreement with the data on the SHR.4 congenic strain, which suggested that the QTL containing

186 This congenic strain will be invaluable for determining wheth

187 and protein, and decreased TCR signaling in congenic strains with B6-derived Idd18.2 susceptibility

188 susceptible C57BL/6J background to generate congenic strains with CAST alleles encompassing 67-162 M

189 In NOD congenic strains with genes that contribute to protectio

190 Studies of other B10 congenic strains with hybrid H-2 loci and selected F1 an

191 The congenic strain, with normal vision, had higher levels o

192 reviously isolated this region in reciprocal congenic strains (WKY.SHR-Sa and SHR.WKY-Sa) derived fro