ライフサイエンスコーパス: congenital heart disease

1 a devastating complication in patients with congenital heart disease.

2 V) dysfunction in patients after surgery for congenital heart disease.

3 r heart disease, pulmonary hypertension, and congenital heart disease.

4 ng, and particularly on PHVD associated with congenital heart disease.

5 nsights into the etiology and treatments for congenital heart disease.

6 red in the growing and aging population with congenital heart disease.

7 urrently performed to treat single-ventricle congenital heart disease.

8 raniofacial gestalt, skeletal anomalies, and congenital heart disease.

9 ome (HLHS) is among the most severe forms of congenital heart disease.

10 Familial Ebstein anomaly is a rare form of congenital heart disease.

11 n for the management of vascular stenosis in congenital heart disease.

12 a exist on the long-term prognosis of simple congenital heart disease.

13 plement a program dedicated to children with congenital heart disease.

14 affecting the interaction may contribute to congenital heart disease.

15 bodies and that their perturbation leads to congenital heart disease.

16 ifferences between patients with and without congenital heart disease.

17 n was detected in an individual with SIT and congenital heart disease.

18 ion in the transcription factor GATA4 causes congenital heart disease.

19 sight to the complex genetic architecture of congenital heart disease.

20 ms underlying normal cardiac development and congenital heart disease.

21 teins in the pathology of L-R patterning and congenital heart disease.

22 in female patients with PAH associated with congenital heart disease.

23 jor contributor to mortality for adults with congenital heart disease.

24 sting as a cell source for heart failure and congenital heart disease.

25 morbidity and mortality among patients with congenital heart disease.

26 proportion of inpatient care costs in adult congenital heart disease.

27 monary arterial hypertension associated with congenital heart disease.

28 and in all patients with PAH associated with congenital heart disease.

29 ntal follow-up for all children with complex congenital heart disease.

30 lopmental disorders such as cleft palate and congenital heart disease.

31 lopment, and thus potential underpinnings of congenital heart disease.

32 pediatric cardiopulmonary bypass surgery for congenital heart disease.

33 erse event after cardiac catheterization for congenital heart disease.

34 e that includes developmental delay, but not congenital heart disease.

35 s with ischemic, valvular, hypertensive, and congenital heart disease.

36 can occur in both syndromic and nonsyndromic congenital heart disease.

37 by surgical repair in childhood versus adult congenital heart disease.

38 ond heart field is a predisposing factor for congenital heart disease.

39 mother can meaningfully reduce their risk of congenital heart disease.

40 ic dysfunction, or both, or various forms of congenital heart disease.

41 tual disability and genetic risk factors for congenital heart disease.

42 risk, and predictors in patients with adult congenital heart disease.

43 and defects in AVC maturation can result in congenital heart disease.

44 ival and improve RV failure in patients with congenital heart disease.

45 t heart support; and (3) adults with complex congenital heart disease.

46 he treatment of arrhythmias in patients with congenital heart disease.

47 Both cases had underlying congenital heart disease.

48 y to deeper understanding of pathogenesis of congenital heart disease.

49 craniofacial appearance, short stature, and congenital heart disease.

50 o fetal echocardiography in the diagnosis of congenital heart disease.

51 heart failure, valvular heart diseases, and congenital heart diseases.

52 hat are associated with cardiomyopathies and congenital heart diseases.

53 ascular access, high infection risk, or some congenital heart diseases.

54 r research with translational implication in congenital heart diseases.

55 ay also help to gain molecular insights into congenital heart diseases.

56 throat surgery; 15.6 (95% CI 9.57-25.4) for congenital heart disease; 1.74 (95% CI 1.33-2.29) for di

57 carditis (14%), valvular heart disease (8%), congenital heart disease (2%), hypertrophic cardiomyopat

58 ion and intervention for pediatric and adult congenital heart disease (20,169 procedures in 76 hospit

59 0% of probands in our cohort-4 with familial congenital heart disease, 4 with compound heterozygosity

60 Nearly 90% of patients with adult congenital heart disease (ACHD) die after the age of 40

61 The number of patients with adult congenital heart disease (ACHD) is rapidly increasing.

62 Adult congenital heart disease (ACHD) patients have ongoing mo

63 (SCD) is a major cause of mortality in adult congenital heart disease (ACHD) patients.

64 lformations constitute the majority of adult congenital heart disease (ACHD), the long-term risks of

65 mmon end-stage syndrome for many adults with congenital heart disease (ACHD).

66 cterizing disease activity among adults with congenital heart disease (ACHD).

67 e study of 29 638 Quebec patients with adult congenital heart disease aged 18 to 64 years between 199

68 with 22q11.2DS, a total of 62% (n=906) have congenital heart disease and 36% (n=326) of these have t

69 2013, there were 2734 deaths due to critical congenital heart disease and 3967 deaths due to other/un

70 for future studies of cardiac morphogenesis, congenital heart disease and arrhythmogenesis.

71 nter cohort study enrolled 482 patients with congenital heart disease and atrial arrhythmias, age 32.

72 oach enables multiscale studies in models of congenital heart disease and beyond.

73 Most frequently reported birth defects were congenital heart disease and cataracts.

74 Among the birth defects, congenital heart disease and craniofacial malformations

75 h leakage as a cause of PLE in patients with congenital heart disease and elevated central venous pre

76 valve tracking in patients with acquired or congenital heart disease and healthy volunteers.

77 In a patient with congenital heart disease and heterotaxy, a disorder of l

78 sional flow MRI in patients with acquired or congenital heart disease and in healthy volunteers.

79 tate newborn screening policies for critical congenital heart disease and infant death rates.

80 enital heart disease only vs a syndrome with congenital heart disease and learning disability).

81 ence concerns both families of children with congenital heart disease and medical providers.

82 hrough next-generation sequencing focused on congenital heart disease and neurodevelopmental disorder

83 myocardial wall can lead to various forms of congenital heart disease and non-compaction cardiomyopat

84 ies of 18 patients with surgically corrected congenital heart disease and plastic bronchitis who pres

85 d a retrospective review of 25 patients with congenital heart disease and post-operative chylothorax

86 y, and manifestations of HF in children with congenital heart disease and presents the clinical, gene

87 In patients with congenital heart disease and right bundle branch block,

88 the knowledge on epidemiology of adults with congenital heart disease and their complications during

89 y hypertension is frequently associated with congenital heart disease and various infectious disorder

90 ruption of PITX2 expression in humans causes congenital heart diseases and is associated with atrial

91 hildren, including 60% <1 year old, 60% with congenital heart disease, and 54% after cardiac surgery.

92 of whole-exome sequence data in epilepsy and congenital heart disease, and demonstrate EvoTol's abili

93 patients with Eisenmenger syndrome, complex congenital heart disease, and Fontan physiology had much

94 ng of Notch function in cardiac development, congenital heart disease, and heart regeneration.

95 genation in healthy fetuses and fetuses with congenital heart disease, and it selectively increased c

96 eeding, malnutrition, younger than 6 months, congenital heart disease, and lower hematocrit were risk

97 malities, congenital malformations including congenital heart disease, and musculoskeletal features.

98 of Fallot (TOF) is the most common cyanotic congenital heart disease, and sudden cardiac death repre

99 onsiderations for data integration models in congenital heart disease, and the short- and long-term v

100 Infants with complex congenital heart disease are at high risk for poor neuro

101 Children with congenital heart disease are at risk for developmental d

102 Adults with congenital heart disease are increasingly being exposed

103 ut clinical performance data for adults with congenital heart disease are limited.

104 patients with restrictive heart disease and congenital heart disease are more likely to die while aw

105 e-threonine kinase family, in a patient with congenital heart disease associated with abnormal LR dev

106 hy is the primary technique used to diagnose congenital heart disease before birth.

107 ied as important contributors to the risk of congenital heart disease, but relatively small numbers o

108 imary tricuspid regurgitation in adults with congenital heart disease, but the prevalence and prognos

109 Studies have shown that patients with congenital heart disease can improve physical exercise c

110 other comorbidities and no family history of congenital heart disease, cardiomyopathy, arrhythmia, or

111 Next we evaluate known human congenital heart diseases: cardiomyopathy and heterotaxy

112 For many women with complex congenital heart disease, carrying a pregnancy carries a

113 stic left heart syndrome (HLHS) is a complex congenital heart disease characterized by abnormalities

114 Congenital heart disease (CHD) accounts for ~40% of deat

115 Congenital heart disease (CHD) affects up to 1% of live

116 Pre-natal diagnosis of congenital heart disease (CHD) allows anticipation of ur

117 creen and show that 29% of mutations causing congenital heart disease (CHD) also cause renal anomalie

118 2q11DS), of whom 89 case subjects had severe congenital heart disease (CHD) and 95 control subjects h

119 ioventricular nodal reentrant tachycardia to congenital heart disease (CHD) and the outcome of cathet

120 Patients with congenital heart disease (CHD) are assumed to be vulnera

121 as become evident that individuals born with congenital heart disease (CHD) are at risk of developing

122 Adults with congenital heart disease (CHD) are exposed to increasing

123 ed ALRI (RSV-ALRI) severity in children with congenital heart disease (CHD) are lacking, thus warrant

124 Most cases of congenital heart disease (CHD) are sporadic and nonsyndr

125 Patients with congenital heart disease (CHD) comprised 57% of the coho

126 Congenital heart disease (CHD) constitutes the most prev

127 The number of patients surviving with congenital heart disease (CHD) has soared over the last

128 ancy and quality of life for those born with congenital heart disease (CHD) have greatly improved ove

129 Genomic analyses of patients with congenital heart disease (CHD) have identified significa

130 Congenital heart disease (CHD) is a leading cause of mor

131 Congenital heart disease (CHD) is an enigma.

132 Congenital heart disease (CHD) is an independent risk fa

133 Congenital heart disease (CHD) is associated with abnorm

134 The genetic architecture of sporadic congenital heart disease (CHD) is characterized by enric

135 Our understanding of the genetics of congenital heart disease (CHD) is rapidly expanding; how

136 Congenital heart disease (CHD) is the leading cause of m

137 Congenital heart disease (CHD) is the most common birth

138 Congenital heart disease (CHD) is the most common birth

139 Congenital heart disease (CHD) is the most common type o

140 Congenital heart disease (CHD) is the most common type o

141 Congenital heart disease (CHD) is the most prevalent bir

142 om medical procedures among individuals with congenital heart disease (CHD) is unknown.

143 Women with congenital heart disease (CHD) may be at increased risk

144 d Impaired brain development in fetuses with congenital heart disease (CHD) may result from inadequat

145 ities in cilial function underlie heterotaxy congenital heart disease (CHD) occurring in individuals

146 Congenital heart disease (CHD) patients have an increase

147 The number of adult congenital heart disease (CHD) patients undergoing heart

148 reen candidate disease genes identified from Congenital Heart Disease (CHD) patients.

149 Congenital heart disease (CHD) represents the most preva

150 Congenital heart disease (CHD) survivors are at risk for

151 ement, there are now more adults living with congenital heart disease (CHD) than children.

152 ial septal defects (ASDs) are a common human congenital heart disease (CHD) that can be induced by ge

153 Studies of neuropsychiatric disorders and congenital heart disease (CHD) which use de novo mutatio

154 lationship of prenatal diagnosis of critical congenital heart disease (CHD) with brain injury and bra

155 Congenital heart disease (CHD), a prevalent birth defect

156 the diagnosis and treatment of children with congenital heart disease (CHD), allowing for longer life

157 cardiac transcription factor gene TBX5 cause congenital heart disease (CHD), although the underlying

158 In contrast to the adult population with congenital heart disease (CHD), arrhythmia mechanisms an

159 genomics is identifying candidate genes for congenital heart disease (CHD), but discovering the unde

160 tics is a significant factor contributing to congenital heart disease (CHD), but our understanding of

161 t common comorbidity associated with complex congenital heart disease (CHD), while the underlying bio

162 is identified for one-third of patients with congenital heart disease (CHD), with 8% of cases attribu

163 l and regional brain volumes in infants with congenital heart disease (CHD).

164 for atrial tachyarrhythmias in patients with congenital heart disease (CHD).

165 gnificant source of morbidity in adults with congenital heart disease (CHD).

166 s a central role in caring for patients with congenital heart disease (CHD).

167 zed by multiple congenital defects including congenital heart disease (CHD).

168 defects (AVSDs) are a common severe form of congenital heart disease (CHD).

169 iomyopathy is a common cause of mortality in congenital heart disease (CHD).

170 f regionalized systems of care for pediatric congenital heart disease (CHD).

171 About 1% of all newborns are affected by congenital heart disease (CHD).

172 y of transcriptional regulators causes human congenital heart disease (CHD); however, the underlying

173 monary arterial hypertension associated with congenital heart disease (CHD-PAH) has serious consequen

174 ecember 2014 identified 52,200 patients with congenital heart diseases (CHD) referred for CCTA, echoc

175 The genetics of many congenital heart diseases (CHDs) can only unsatisfactori

176 Congenital heart diseases (CHDs), including hypoplastic

177 risk factors (early and late preterm birth, congenital heart disease, chronic lung disease, intensiv

178 by pre-HTx diagnosis into cardiomyopathy and congenital heart disease cohorts.

179 on of arrhythmias due to IART increased with congenital heart disease complexity from 47.2% to 62.1%

180 sk factors, and the successful management of congenital heart disease conditions.

181 main to ensure that children and adults with congenital heart disease continue to benefit from an exp

182 yopathies/Myocardial & Pericardial Diseases, Congenital Heart Disease, Coronary Disease & Interventio

183 yopathies/Myocardial & Pericardial Diseases, Congenital Heart Disease, Coronary Disease & Interventio

184 Part One includes the sections: Congenital Heart Disease, Coronary Disease & Interventio

185 Part One includes the sections: Congenital Heart Disease, Coronary Disease & Interventio

186 ial & Pericardial Diseases, Cardio-oncology, Congenital Heart Disease, Coronary Disease & Interventio

187 Patient phenotypes include congenital heart disease, craniofacial malformations, an

188 s report summarizes the current landscape of congenital heart disease data, data integration methodol

189 Among 24,833 patients from the Quebec Congenital Heart Disease Database, 602 had incident canc

190 The study population derived from the Quebec Congenital Heart Disease Database.

191 Critical congenital heart disease death rates in states with mand

192 cessful outcome in the care of patients with congenital heart disease depends on a comprehensive mult

193 case of left ventricular non-compaction with congenital heart disease, disturbance of the NOTCH signa

194 II, Mayo Clinic Bipolar Disorder, and Quebec Congenital Heart Disease EHR datasets.

195 Maternal age is a risk factor for congenital heart disease even in the absence of any chro

196 normalities associated with single-ventricle congenital heart disease exposes these patients to a var

197 Prenatal detection of congenital heart disease facilitates the opportunity for

198 However, implementation of dedicated congenital heart disease follow-up programs presents imp

199 present a common but heterogeneous subset of congenital heart disease for which gene identification h

200 iac transcription factor MEF2C and the human congenital heart disease gene TDGF1.

201 e complex (NPC) and has been implicated as a congenital heart disease gene through an ill-defined fun

202 e sequencing as part of the CHD GENES study (Congenital Heart Disease Genetic Network).

203 CRT patients were <21 years of age or had congenital heart disease, had systemic ventricular eject

204 Palliative surgery for congenital heart disease has allowed patients with previ

205 ver the past decades, the landscape of adult congenital heart disease has changed dramatically, which

206 transcription factor that has been linked to congenital heart disease has wider effects than previous

207 Percutaneous therapies for congenital heart disease have evolved rapidly in the pas

208 Patients with adult congenital heart disease have high rates of readmission,

209 e an indispensable tool in the evaluation of congenital heart disease, heart failure, cardiac masses,

210 tly not recommended for patients with simple congenital heart disease; however, only a few data exist

211 r than 50% (HR, 0.57; 95% CI, 0.34-0.97) and congenital heart disease (HR, 0.78; 95% CI, 0.64-0.96).

212 test for associations between this locus and congenital heart disease in adult survivors of left vent

213 esin genes may be causative of a fraction of congenital heart disease in human populations.

214 Mutations in NOTCH signaling elements cause congenital heart disease in humans and mice, demonstrati

215 ns in CCDC11 disrupt L-R asymmetry and cause congenital heart disease in humans, yet the molecular an

216 Patients diagnosed with simple congenital heart disease in the 1960s have substantially

217 OF), comprising the largest subset of severe congenital heart disease in the cohort.

218 hyltransferase, has been implicated in human congenital heart disease in the context of Kabuki syndro

219 lastic left heart syndrome (HLHS) is a fatal congenital heart disease in which the left side of the h

220 and translational research studies of HF in congenital heart disease including at the genome, transc

221 nced heart failure therapies for adults with congenital heart disease, including the general approach

222 lant recipients with PRA greater than 50% or congenital heart disease, induction therapy is associate

223 a new group of patients, those who survived congenital heart disease into adulthood, emerged.

224 About two-thirds of human congenital heart disease involves second heart field-der

225 Post-operative chylothorax in patients with congenital heart disease is a challenging problem with s

226 age of branching arteries without coexisting congenital heart disease is a very rare anomaly.

227 esis, it is not surprising that some form of congenital heart disease is present in approximately 1 p

228 Although congenital heart disease is reported in families with mu

229 Congenital heart disease is the leading cause of death i

230 Congenital heart disease is the most common birth defect

231 Congenital heart disease is the most common birth defect

232 Congenital heart disease is the most frequently occurrin

233 , in mediating RV hypertrophy and failure in congenital heart disease is unknown.

234 hase of heart development, during which many congenital heart disease malformations likely arise, we

235 whether advances in the management of adult congenital heart disease may reduce this substantial str

236 uplicate the centriole with implications for congenital heart disease mechanisms.

237 the 114 patients, 33 had acquired and 81 had congenital heart disease (median age, 17 years; interqua

238 3 megabase (Mb) deletion from LCR22A-D have congenital heart disease, mostly of the conotruncal type

239 recurrence was associated with younger age, congenital heart disease, multiple AP, AP location (righ

240 ral pediatric critical illness (n = 87), and congenital heart disease (n = 72).

241 of CVD included arrhythmia (n = 88, 28.8%), congenital heart disease (n = 72, 23.5%), and cardiomyop

242 in patients with cardiomyopathy (n=896) and congenital heart disease (n=965).

243 selective causes of infant death, pneumonia, congenital heart disease, neural tube defects, preterm b

244 e disorders: autism spectrum disorder (ASD), congenital heart disease, neurodevelopmental disorders w

245 terogeneity of interventional procedures for congenital heart disease, new procedure-type risk catego

246 Congenital heart disease occurred in six subjects; addit

247 owth, and which is typically associated with congenital heart diseases of heterogeneous origin, such

248 nts with left ventricular non-compaction and congenital heart disease often need surgical or catheter

249 romic and non-syndromic fetal anomalies (eg, congenital heart disease only vs a syndrome with congeni

250 patients 10 to 35 years of age undergoing a congenital heart disease operation in the Society of Tho

251 Thus, among patients with previous congenital heart disease or cardiomyopathy, disease-spec

252 ours and 6 months of age) coded for critical congenital heart disease or other/unspecified congenital

253 cardiac arrhythmia, cerebrovascular disease, congenital heart disease, or admissions with cardiac sym

254 ongenital malformation, with subanalyses for congenital heart disease, oral cleft, and limb deficienc

255 (IPAH/FPAH) and 105 had PAH associated with congenital heart disease (PAH-CHD).

256 umber variants are enriched in patients with congenital heart disease, particularly those with extra-

257 ilencing of Tgf-beta1, a causative factor in congenital heart disease pathogenesis, in a deacetylase-

258 native to surgical valve replacement for the congenital heart disease patient with right ventricular

259 e effect of BMI on perioperative outcomes in congenital heart disease patients has not been evaluated

260 zation therapy (CRT) studies in pediatric or congenital heart disease patients have shown an improvem

261 e useful for the diagnosis and management of congenital heart disease patients with pulmonary overcir

262 In pediatric and congenital heart disease patients with symptomatic systo

263 e follow-up study of a cohort of 1241 simple congenital heart disease patients, diagnosed from 1963 t

264 thod is further validated within a cohort of congenital heart disease patients, providing a novel too

265 rt transplant-free survival in pediatric and congenital heart disease patients, using a propensity sc

266 ICD implantation is feasible for adults with congenital heart disease patients.

267 In the care of patients with congenital heart disease, percutaneous interventional tr

268 the evaluation of structural heart diseases, congenital heart diseases, peri-procedural electrophysio

269 Patients with extreme prematurity, cyanotic congenital heart disease, pulmonary hypertension, home r

270 and 60% to 70% of affected individuals have congenital heart disease, ranging from mild to severe.

271 ly due to the increased number of women with congenital heart disease reaching childbearing age and t

272 Infants with congenital heart disease requiring sternotomy often unde

273 s >/=48 hours, admission >/=14 days of life, congenital heart disease requiring surgical repair at <7

274 es related to an integrated data network for congenital heart disease research.

275 latory disease conditions (including stroke, congenital heart disease, rhythm disorders, subclinical

276 autosomal dominant disorder characterized by congenital heart disease, skeletal abnormalities, and fa

277 In patients with complex congenital heart disease, such as those with tetralogy o

278 women, however, do not have access to adult congenital heart disease tertiary centers with experienc

279 LV dilation and dysfunction, hypertrophy, or congenital heart disease, the genetic cause may overlap.

280 Early infant deaths from critical congenital heart disease through December 31, 2013, decr

281 with known cardiovascular pathology, such as congenital heart disease, timely counselling is possible

282 ic-health guidelines recommend patients with congenital heart disease to exercise.

283 children born with univentricular physiology congenital heart disease to survive into adulthood.

284 In patients with congenital heart disease undergoing open-heart surgery,

285 ry referral centers with a specialized adult congenital heart disease unit.

286 , aortic valve disease, atrial fibrillation, congenital heart disease, various cardiomyopathies, obes

287 In 2011, critical congenital heart disease was added to the US Recommended

288 policies for newborn screening for critical congenital heart disease was associated with a significa

289 men carrying a fetus with known or suspected congenital heart disease were recruited via a tertiary f

290 XD flow, is demonstrated for (a) evaluating congenital heart disease, where the impact of bulk motio

291 We studied 2517 patients with congenital heart disease who had undergone whole-exome s

292 Patients with complex congenital heart disease, who may have undergone previou

293 ontemporary era, nearly 85% of children with congenital heart disease will reach adulthood.

294 Today, most female children born with congenital heart disease will reach childbearing age.

295 tients with liver lymphatic embolization and congenital heart disease with elevated central venous pr

296 In patients with repaired congenital heart disease with preserved ventricular func

297 atheter approach for an adult with untreated congenital heart disease with severe cyanosis and signif

298 resenting atrial arrhythmia in patients with congenital heart disease, with a predominantly paroxysma

299 is most commonly attributable to coexistent congenital heart disease, with different risks depending

300 Patients with congenital heart disease, with endocarditis, and undergo