ライフサイエンスコーパス: congenital malformation

1 rinatal mortality, prematurity, toxaemia and congenital malformation.

2 lopmental basis of this clinically important congenital malformation.

3 HD) are collectively the most common form of congenital malformation.

4 numerary digits, or polydactyly, is a common congenital malformation.

5 erinatal mortality in the absence of a major congenital malformation.

6 pathogenesis of spina bifida-a common human congenital malformation.

7 ion are at increased risk of fetal death and congenital malformation.

8 en raised about a potential association with congenital malformations.

9 between-group difference in the frequency of congenital malformations.

10 birth, stillbirth, neonatal death, and major congenital malformations.

11 gnant diseases such as carcinomas, trauma or congenital malformations.

12 xcess of these compounds are associated with congenital malformations.

13 ster exposure to modafinil and risk of major congenital malformations.

14 ing-Opitz syndrome characterized by multiple congenital malformations.

15 evere anterior neural tube defect-associated congenital malformations.

16 may explain the development of many sporadic congenital malformations.

17 king during pregnancy, preterm delivery, and congenital malformations.

18 t for gestational age, cesarean section, and congenital malformations.

19 phrenia, autism, intellectual disability and congenital malformations.

20 ere was no evidence for an increased risk of congenital malformations.

21 aternal to fetal circulation might attenuate congenital malformations.

22 ence after cardiac defects among major human congenital malformations.

23 splasia of the hip is one of the most common congenital malformations.

24 trimester of pregnancy only and the risk of congenital malformations.

25 is the role played by the human HOX genes in congenital malformations.

26 ve births, birthweight, and the frequency of congenital malformations.

27 eeks gestation) birth, and the occurrence of congenital malformations.

28 spring of irradiated females had one or more congenital malformations.

29 rnal use of folic acid antagonists and these congenital malformations.

30 omes characterized by mental retardation and congenital malformations.

31 ng data that mefloquine does not cause gross congenital malformations.

32 erebral hemorrhage due to ischemic stroke or congenital malformations.

33 infants were healthy at birth, with no major congenital malformations.

34 n associated with reduced incidence of other congenital malformations.

35 frequency of miscarriages or in the rate of congenital malformations.

36 of neural crest development can cause severe congenital malformations.

37 is directly linked to microcephaly and other congenital malformations.

38 terine development and a higher incidence of congenital malformations.

39 mong the 16 live-born infants, there were no congenital malformations.

40 not associated with increased risk of major congenital malformations.

41 nancy should be avoided owing to the risk of congenital malformations.

42 phaly, facial dysmorphism, and various other congenital malformations.

43 restriction, trace element deficiencies, and congenital malformations.

44 ariable behavioral anomalies with or without congenital malformations.

45 sis and may contribute to the development of congenital malformations.

46 s in families in which a person had multiple congenital malformations.

47 tal outcomes, such as microcephaly and other congenital malformations.

48 ver to severe neurological complications and congenital malformations.

49 h restriction, feeding problems, and various congenital malformations.

50 ion in fetal life could increase the risk of congenital malformations.

51 problems, musculoskeletal abnormalities, and congenital malformations.

52 testing of therapies and vaccines to prevent congenital malformations.

53 temisinin treatment on miscarriage and major congenital malformations.

54 case, and one newborn with microcephaly and congenital malformations.

55 mplications of intrapartum events" (15.0%), "congenital malformations" (13.1%), and "infection relate

56 d for 99% of 127 cases, leading causes being congenital malformations (18.9%), complications of prema

57 st trimester, 721 had an infant with a major congenital malformation (25.3 [95% CI, 23.5-27.1] cases

58 s to investigate the molecular basis of rare congenital malformations, a significant fraction of pati

59 In utero exposure to antibiotics and risk of congenital malformations: a population-based study.

60 Neural tube defects are severe congenital malformations affecting around one in every 1

61 Congenital malformations affecting multiple organ system

62 (cryptorchidism) is one of the most frequent congenital malformations, affecting 1-3% of newborn boys

63 e reading frame and lead to a broad range of congenital malformations, affecting craniofacial structu

64 s evidence of increased risk of diagnoses of congenital malformations after vaccination, possibly bec

65 k) (AHR, 4.46 [95% CI, 3.13-6.38]) and major congenital malformation (AHR, 1.36 [95% CI, 1.05-1.74])

66 We recorded no significant increased risk of congenital malformations, alopecia, or skin disorders.

67 dafinil use during early pregnancy and major congenital malformations among infants born in Norway an

68 ity as well as severe growth retardation and congenital malformations among surviving Atox1(-/-) prog

69 nital heart disease (CHD) is the most common congenital malformation and is associated with adverse n

70 de (NAD) synthesis pathway, are causative of congenital malformation and miscarriage in humans and mi

71 Any major congenital malformation and specific malformation subtyp

72 ders to migraine, neuropathic pain, and even congenital malformations and autism.

73 ng contributes to common diseases, including congenital malformations and cancer.

74 We examined the risk of major congenital malformations and cardiac defects associated

75 Aberrant HH signaling can lead to congenital malformations and diseases including cancer.

76 interrelationship between increased rates of congenital malformations and DNA mutations in the offspr

77 e genetic load and explains the high rate of congenital malformations and embryonic mortality associa

78 d both-parent exposure cases with a focus on congenital malformations and fetal loss.

79 While congenital malformations and genetic diseases are a lead

80 e Americas and the Caribbean associated with congenital malformations and Guillain-Barre syndrome in

81 bearing age, with an increased risk of major congenital malformations and possible cognitive difficul

82 ill experience significantly higher rates of congenital malformations and spontaneous miscarriages co

83 ts expand our understanding of the causes of congenital malformations and the importance of sufficien

84 ut SGA, minor congenital malformation, major congenital malformation, and congenital malformation com

85 sease manifestations including microcephaly, congenital malformation, and Guillain-Barre syndrome, Zi

86 rm labor, fetuses small for gestational age, congenital malformation, and the incidence of large plac

87 sorder characterized by bone marrow failure, congenital malformations, and cancer susceptibility.

88 medical records examined perinatal outcomes, congenital malformations, and developmental delay.

89 tidepressant exposure on perinatal outcomes, congenital malformations, and early growth and developme

90 x, maternal history of epilepsy, presence of congenital malformations, and gestational age.

91 is associated with reports of microcephaly, congenital malformations, and Guillain-Barre syndrome.

92 ious human diseases, including microcephaly, congenital malformations, and Guillain-Barre syndrome.

93 ncy and infect the developing fetus to cause congenital malformations, and its association with Guill

94 history, gestational age, birth weight, sex, congenital malformations, and parity).

95 g infertility, miscarriage, diabetes-related congenital malformations, and preeclampsia.

96 -for-gestational-age infants, preterm birth, congenital malformations, and stillbirth.

97 Congenital malformations (any and by organ system) were

98 mes more widely accessible, more subclinical congenital malformations are being detected.

99 Congenital malformations are defects of the morphogenesi

100 ny neurodegenerative or metabolic disorders, congenital malformations are rare.

101 oblems, epilepsy, neuropathies, obesity, and congenital malformations are similar to those described

102 age (ARR, 1.19), stillbirth (ARR, 1.11), or congenital malformation (ARR, 0.90).

103 ge (ARR, 1.30; 95% CI, 1.07-1.57) but not of congenital malformation (ARR, 1.00; 95% CI, 0.83-1.20) o

104 fections (aRR, 1.42; 95% CI, 1.17-1.73), any congenital malformation (aRR, 1.48; 95% CI, 1.35-1.62),

105 reases in blood glucose levels, suggest that congenital malformations associated with diabetic pregna

106 an increased risk of miscarriage or of major congenital malformations associated with first-line trea

107 age was associated with a high rate of major congenital malformations, at 21.7% (95% CI, 7.5%-43.7%;

108 Adjustment for epilepsy and congenital malformations attenuated the associations.

109 To date, tacrolimus has not been linked to congenital malformations but can cause reversible nephro

110 an important component, not only in cases of congenital malformations, but also in unexplained intrau

111 maternal and fetal complications (excluding congenital malformations) by comparing pregnant women wi

112 tion represents the only instance in which a congenital malformation can be prevented simply and cons

113 Causes for miscarriages and congenital malformations can be genetic, environmental,

114 Congenital malformations can be manifested as combinatio

115 Congenital malformations can originate from numerous gen

116 t doses lower than those required to produce congenital malformations can produce cognitive and behav

117 atenin signaling in human diseases including congenital malformations, cancer, and osteoporosis, and

118 our data improve the understanding of human congenital malformation causation.

119 al tube defects (NTDs) are a group of severe congenital malformations caused by a failure of neural t

120 This study demonstrates that congenital malformations caused by NAD deficiency can oc

121 autism spectrum disorders (ASD), and various congenital malformations (CM).

122 ormation, major congenital malformation, and congenital malformation combined with SGA or preterm com

123 irths not exposed to APs were diagnosed with congenital malformations compared with 44.5 (95% CI, 40.

124 facial features, short stature, and distinct congenital malformations comprising choanal atresia, ana

125 sease conditions were within the sections of congenital malformations, deformities, and chromosomal a

126 he longest-range human enhancers involved in congenital malformations, directly demonstrate that PRS

127 ge syndrome (CdLS) is a dominantly inherited congenital malformation disorder, caused by mutations in

128 ly is just one of the clinical signs of this congenital malformation disorder.

129 syndrome is an autosomal-recessive multiple-congenital-malformation disorder characterized by multis

130 om the Latin American Collaborative Study of Congenital Malformations (ECLAMC), 154 cases from Latvia

131 rugs were associated with increased rates of congenital malformations (eg, spina bifida, cardiac anom

132 hs in the VLBW and LBW groups, respectively; congenital malformations explained 36% and 23% in the LB

133 escent mortality, with perinatal factors and congenital malformations explaining many of the deaths.

134 unexposed fathers (3.4% prevalence of major congenital malformations), exposure to thiopurines (rela

135 en 26 and before 37 weeks' gestation without congenital malformations, fetal growth restriction, or s

136 However, the absolute risk of congenital malformations following prenatal exposure to

137 e evolution of pregnancies and occurrence of congenital malformations following treatment by ICSI wer

138 there is a need for evidence on the risk of congenital malformations for these medications.

139 l eligible babies (aged 1 h to 48 h, without congenital malformations) from hospital-based and commun

140 f Zika virus (ZIKV) and its association with congenital malformations has prompted the rapid developm

141 ic studies of Hirschsprung disease, a common congenital malformation, have identified eight genes wit

142 rtebrae to close at the midline, is a common congenital malformation in humans that is often synonymo

143 studies reporting varying risk estimates for congenital malformation in offspring of mothers undergoi

144 egnancy did not seem to be linked to overall congenital malformation in offspring, although risk incr

145 ression/anxiety, folate supplementation, and congenital malformation in the child.

146 ndromic craniosynostosis (NSC) is a frequent congenital malformation in which one or more cranial sut

147 xamined whether risk of hypospadias (i.e., a congenital malformation in which the opening of the peni

148 p vs 3 fetuses (1%) in the control group and congenital malformations in 17 neonates (5%) in the vita

149 Zika virus (ZIKV) caused an epidemic of congenital malformations in 2015-2016.

150 We sought to compare the risk of major congenital malformations in asthmatic women exposed to a

151 folic acid supplementation in prevention of congenital malformations in children born to women with

152 The prevalence of congenital malformations in children fathered by male re

153 drugs during pregnancy associated with major congenital malformations in children?

154 unifying etiology for the broad spectrum of congenital malformations in diabetic pregnancies.

155 NAD synthesis caused a deficiency of NAD and congenital malformations in humans and mice.

156 ing are hypothesized to underlie many common congenital malformations in humans including congenital

157 s been associated with some cases of cardiac congenital malformations in humans, also disrupts the pH

158 ects (NTDs), which are among the most common congenital malformations in humans.

159 d palate syndromes are among the most common congenital malformations in humans.

160 f Fallot, resembling some of the most common congenital malformations in humans.

161 fect of the penis, is one of the most common congenital malformations in humans.

162 P11 haploinsufficiency in the development of congenital malformations in humans.

163 been associated with microcephaly and other congenital malformations in infants as well as Guillain-

164 ications, birth weight, and the frequency of congenital malformations in live-born offspring.

165 Other congenital malformations in males (excluding those affec

166 Children with major congenital malformations in the first year of life and w

167 hildren (3.6%) received a diagnosis of major congenital malformations in the first year of life, and

168 orthobunyavirus that can cause abortions and congenital malformations in the offspring of ruminants.

169 on of an ataluren-based formulation reverses congenital malformations in the postnatal mouse eye, pro

170 h, stillbirth, small for gestational age, or congenital malformations) in women who underwent endosco

171 also characterized by growth retardation and congenital malformations, in particular craniofacial, up

172 ifficulties, structural brain abnormalities, congenital malformations including congenital heart dise

173 syndrome, a variable combination of multiple congenital malformations including heart defects.

174 gnant women with Zika virus (ZIKV) can cause congenital malformations including microcephaly, which h

175 velopment of 8 DS phenotypes, 4 of which are congenital malformations, including acute megakaryocytic

176 ch this region is deleted usually have major congenital malformations, including brain anomalies such

177 delay, persistent feeding difficulties, and congenital malformations, including brain anomalies.

178 lated families with a variety of overlapping congenital malformations, including cardiac, vertebral,

179 e/velo-cardio-facial syndrome) have multiple congenital malformations, including cardiovascular defec

180 l malformations suspected prenatally and all congenital malformations, including chromosome anomalies

181 tion reduces the occurrence of several human congenital malformations, including craniofacial, heart

182 In Brazil, the virus has been linked to congenital malformations, including microcephaly and oth

183 tes (types 1 and 2) induces a broad array of congenital malformations, including neural tube defects

184 Congenital malformations, including neural tube defects

185 growth restriction, developmental delay, and congenital malformations, including neural tube, heart,

186 autosomal recessive mutant with a myriad of congenital malformations, including polydactyly and faci

187 ons in TGFBR1 or TGFBR2 cause multiple human congenital malformations, including soft palate cleft, w

188 Major congenital malformations, including those affecting the

189 ild-type grandprogeny, and the appearance of congenital malformations independent of maternal environ

190 R7 function is associated with a spectrum of congenital malformations, intellectual impairment, epile

191 related transcriptional repressor Hey2 cause congenital malformations involving the non-chamber atrio

192 NAD deficiency as a cause of embryo loss and congenital malformation is not restricted to the rare ca

193 impact of genomic diagnosis in patients with congenital malformations is the lack of understanding re

194 The risk of congenital malformations is uncertain; the balance of ri

195 preterm, preterm with or without SGA, minor congenital malformation, major congenital malformation,

196 This important (but often unsuspected) congenital malformation may require alternative surgical

197 during pregnancy increases the risk of major congenital malformations (MCMs).

198 ts do not appear to be associated with major congenital malformations, more human data regarding pote

199 patients have had neonatal cardiomyopathy or congenital malformations, most commonly affecting the he

200 abortion secondary to a birth defect, major congenital malformations, neoplasia, or increased infect

201 of particular interest in view of the severe congenital malformations - 'neural tube defects' - that

202 left palate (CL/P) is one of the most common congenital malformations observed in humans, with 1 occu

203 ficantly associated with the risk of overall congenital malformations (odds ratio [OR], 0.88; 95% CI,

204 sociation between metronidazole exposure and congenital malformations (odds ratio, 0.96 [95% CI, 0.75

205 Periventricular heterotopia (PVH) is a congenital malformation of human cerebral cortex frequen

206 Based on MRI the congenital malformation of posterior fossa-rhombencephal

207 Interrupted aortic arch (IAA) is a rare congenital malformation of the aortic arch, which might

208 utosomal recessive disorder characterized by congenital malformation of the cerebellum and brainstem,

209 Hirschsprung disease is the most common congenital malformation of the enteric nervous system.

210 Holoprosencephaly (HPE) is the most common congenital malformation of the forebrain in human.

211 ated with holoprosencephaly, the most common congenital malformation of the forebrain.

212 Congenital malformation of the foregut is common in huma

213 sorder of connective tissue characterized by congenital malformation of the great toes and postnatal

214 muscle, tendon, ligament, and fascia and by congenital malformation of the great toes.

215 h or without cleft palate is the most common congenital malformation of the head and the third-most c

216 Congenital malformations of anorectal and genitourinary

217 e 22q11 and clinically by a constellation of congenital malformations of the aortic arch, heart, thym

218 ural tube defects (NTDs) are the most severe congenital malformations of the central nervous system.

219 na bifida (OSB) is one of the most prevalent congenital malformations of the CNS that often leads to

220 na bifida (OSB) is one of the most prevalent congenital malformations of the CNS.

221 Congenital malformations of the heart and circulatory sy

222 terized by early-onset diabetes mellitus and congenital malformations of the kidney, pancreas, and ge

223 In some patients, however, congenital malformations of the mitral apparatus may be

224 iated with an increase in infant deaths from congenital malformations of the nervous (NO2, 1.525 [1.1

225 ation suffering from heart disease caused by congenital malformations of the outflow tract, an ELC1v-

226 epidemiologic evidence, we used the rate of congenital malformations of the reproductive system as a

227 gly linked to population-normalized rates of congenital malformations of the reproductive system in m

228 l hypoplasia, cardiac defects, microcephaly, congenital malformations of the skeleton, hypogonadism,

229 ed individuals with intellectual disability, congenital malformations, ophthalmologic anomalies, feed

230 rth or small for gestational age, but not of congenital malformation or stillbirth.

231 c antidepressant or SSRI exposure and either congenital malformations or developmental delay.

232 I exposure was significantly associated with congenital malformations or developmental delay.

233 Although few congenital malformations or neonatal infections were see

234 We excluded infants with major congenital malformations or obvious chromosomal disorder

235 Denmark, no increased risk of major or minor congenital malformations or stillbirth was associated wi

236 Major congenital malformations overall and cardiac malformatio

237 TDF use does not increase the risk of major congenital malformations overall in the newborn compared

238 does not meaningfully increase the risk for congenital malformations overall or cardiac malformation

239 Primary outcomes were major congenital malformations overall, 20 individual malforma

240 not associated with increased risk of major congenital malformations overall, any of the 20 individu

241 g the first trimester were studied for major congenital malformations (overall and organ specific) an

242 (95% CI, 0.4 to 1.5), nor increased risk of congenital malformations, overall somatic or psychiatric

243 es have explored safety in relation to major congenital malformations, particularly in the first trim

244 ic stroke in cerebral palsy; birth asphyxia, congenital malformations, placental pathology, and genet

245 nditions (i.e., autism spectrum disorder and congenital malformations), potentially indicating some c

246 herited disorder clinically characterized by congenital malformations, progressive bone marrow failur

247 isorder characterized by genome instability, congenital malformations, progressive bone marrow failur

248 y tract (CAKUT) comprise a large spectrum of congenital malformations ranging from severe manifestati

249 was 3.6% (95% CI, 2.4%-5.2%), and the minor congenital malformation rate was 1.9% (95% CI, 1.0%-3.1%

250 Among offspring, the major congenital malformation rate was 3.6% (95% CI, 2.4%-5.2%

251 No significant differences were found in the congenital malformation rate, prematurity rate, and Apga

252 al growth and development: (low birthweight, congenital malformations, reduced head circumference), a

253 rmed at birth were identified from the local Congenital Malformation Register.

254 nd other risk factors were obtained from the Congenital Malformations Registry and vital records.

255 -control study by linking the New York State Congenital Malformations Registry to birth certificates

256 e adult population and as anomalies in human congenital malformations, reinforcing the idea that such

257 Hypospadias is a congenital malformation resulting from the disruption of

258 CE inhibitors had an increased risk of major congenital malformations (risk ratio, 2.71; 95 percent c

259 Adverse outcomes included 159 congenital malformations, six chromosomal abnormalities,

260 onatal intensive care unit (NICU) admission, congenital malformation, small for gestational age (SGA)

261 Drug exposure did not increase the rate of congenital malformations, spontaneous abortions, preterm

262 ary analysis was a comparison of 5 outcomes (congenital malformations, spontaneous abortions, preterm

263 may be involved in the pathogenesis of human congenital malformations such as HC and PKD.

264 All congenital malformations suspected prenatally and all co

265 en mutated in the germline, give rise to the congenital malformation syndrome fibrodysplasia ossifica

266 lated individuals presenting with a multiple congenital malformation syndrome in whom we identified h

267 3 of 55 cases (P < 5 x 10(-228)) of the rare congenital malformation syndrome.

268 ation of PPP1R12A pathogenic variants with a congenital malformations syndrome affecting the embryoge

269 perfamily members that cause disparate human congenital malformation syndromes interact genetically a

270 ects in such processes are a common cause of congenital malformation syndromes, and rapid progress is

271 We excluded infants with life-threatening congenital malformations, syndromic disorders, neurometa

272 ) is a common (1 in 3,000 live births) major congenital malformation that results in significant morb

273 like phenotype is one of the principal human congenital malformations that can be traced back to the

274 ion provides a mouse model for head and neck congenital malformations that frequently occur in humans

275 ations and delivered live singletons without congenital malformations (the analysis population).

276 unction of these signaling pathways leads to congenital malformation, the consequences of cardiac pro

277 cause of its causal relationship with severe congenital malformations, the ZIKV epidemic became an im

278 icrodeletion, causing developmentally linked congenital malformations, thymic hypoplasia, hypoparathy

279 CI 0.45-1.34]; p=0.3645) or in risk of major congenital malformations (two [2%] of 109 [95% CI 0.22-6

280 sulted from a problem with the aortic valve: congenital malformation unassociated with infective endo

281 Adjusted risk for congenital malformation was 4.98% in exposed offspring v

282 fter accounting for confounding, risk of any congenital malformation was higher for TMP-SMX (RR, 1.35

283 Results: Congenital malformation was observed in 2037 (4.97%) exp

284 The risks of fetal death and congenital malformation were not related to whether the

285 Such congenital malformations were barely significant for ID

286 Major congenital malformations were identified from linked vit

287 Congenital malformations were identified in the first ye

288 Two congenital malformations were identified: clubfoot in on

289 Despite placental transfer, no congenital malformations were noted.

290 In 2015, substantial congenital malformations were observed, with numerous in

291 Two congenital malformations were reported (one bilateral ca

292 ciated with selected somatic diseases nor to congenital malformations when compared with in utero exp

293 asphyxia-related neonatal complications, and congenital malformations, which in turn are associated w

294 eural tube defects (NTDs) are common, severe congenital malformations whose causation involves multip

295 tube defects (NTD) are clinically important congenital malformations whose molecular mechanisms are

296 cleft lip and/or palate (NSCLP) is a common congenital malformation with a multifactorial model of i

297 Jeune syndrome is a rare congenital malformation with a reported incidence of 1 i

298 Measurements: Congenital malformation, with subanalyses for congenital

299 virus (ZIKV) has caused an epidemic of fetal congenital malformations within the Americas.

300 wall (VBW) defects are among the most common congenital malformations, yet their embryonic origin and