ライフサイエンスコーパス: congested

1 ale-free, such as random graphs, will become congested.

2 In this area, the microvasculature becomes congested.

3 ethods showed that the latter affords highly congested 1,8-diarylnaphthalenes in superior yields.

4 simultaneously simplify and resolve complex, congested (1)H NMR spectra with many overlapping spin mu

5 The highly strained and congested 11-membered macrocycle of coleophomones B (2)

6 ic alkylation to access a crucial and highly congested 3,3-disubstituted oxindole.

7 The congested a-amino acid motif decorating their presumed i

8 ned to 1.80 A resolution, revealing a highly congested active site region.

9 For more sterically congested alcohols, the use of a recently-developed isos

10 s observed in the construction of sterically congested all-carbon quaternary centers.

11 enantiospecific synthesis of the sterically congested all-cis 2,3,4,5-substituted pyrrolidines 4, 5,

12 ty of C-C bonds, the synthesis of sterically congested alpha-arylated carbonyl compounds remains a di

13 nprecedented approach for heteroarylation of congested alpha-bromoamides via electrophilic aromatic s

14 d highly efficient approach for synthesizing congested alpha-thioamides under mild reaction condition

15 The synthesis of the exceedingly congested amine tris(1,3-dihydroxy-2-propyl)amine, 9, wa

16 A short synthesis of exceedingly congested amines, with insertion of a rhodium carbenoid

17 midazole, while the somewhat more sterically congested analogue, N,N'-sulfurylbis-2-methylimidazole,

18 In fact, as ports become more congested and cargo volumes increase, the need for accur

19 reating various cancers is probably the most congested and challenging enterprise of pharmaceutical c

20 process affords an array of stereochemically congested and complex chiral secondary homoallylic alcoh

21 h computes the travel time differences under congested and free-flow conditions.

22 hetic precursors to a wide variety of highly congested and oxygenated polycyclic (nor)diterpenes (e.g

23 reagents, and provides access to sterically congested and unsaturated tetrazoles, which are difficul

24 cemic starting materials combine to form the congested angucycline bay region with control of regio-,

25 ions of ROESY spectra by moving them to less congested areas.

26 de insight into the reactivity of sterically congested aromatic systems and may help in designing new

27 ry-tertiary stereocenters, the generation of congested arylic quaternary stereocenters, and hydroxyal

28 nsaturated gamma-butyrolactams to sterically congested beta-substituted cyclic dienones with high sit

29 y on C4-C11 bond constructions to access the congested bicyclic framework of these elusive natural pr

30 eaction allows for the rapid construction of congested bicyclic systems from remarkably simple alkyne

31 A flexible approach to construct sterically congested bicyclo-alkenedione frameworks is reported.

32 Herein, the synthesis of a sterically congested bis-adamantane framework-based chiral alcohol,

33 of this amphiphile, indicating a sterically congested, but stable, folded conformation of the inclus

34 lcohols by preferential cleavage of the less congested C(2)-O(1) bond.

35 ted Corey-Yu allylic oxidation at the highly congested C-12 position of the enfumafungin core.

36 indrance and allowed us to efficiently forge congested C-C bonds.

37 trategy has been previously employed to form congested C-C, C-O, and C-S bonds; however, unsatisfacto

38 The highly congested C-N bond generated in this coupling, in conjun

39 obviates the need to directly forge either a congested C-N or C-C bond at the new nitrogenous stereoc

40 ereoselective installation of the sterically congested C13 alkyl chloride and control of the wayward

41 mbly of two advanced fragments to secure the congested C3a-C3a' linkage in three steps, followed by a

42 ed, muscular arteries within alveolar septa; congested capillaries within alveolar walls; and congest

43 ested capillaries within alveolar walls; and congested capillaries within the walls of medium-size, m

44 ion of a library of isoindolinones bearing a congested carbon in good to excellent yields under mild

45 f gamma-arylated alpha-aminoamides bearing a congested carbon in two steps.

46 e methide coupling reaction to form a highly congested carbon-carbon bond, and an acid-mediated intra

47 Leveraging congested catalyst scaffolds has emerged as a key strate

48 vely DNMT1 activity within these complex and congested cellular samples.

49 ecular alkenylation of a ketone to forge the congested central cycloheptene ring at the bridgehead en

50 d C12-C13 bond, an RCM reaction to close the congested central six-membered ring, and a hydroxy-direc

51 Sterically congested chiral alcohol and amines have gained tremendo

52 ted syn-selective cyclizations to sterically congested chloro- and bromohydrins, while SnCl4, SnBr4,

53 sence of drug treatment for heart failure or congested circulation before surgery and the duration of

54 The photochemistry of the sterically congested complex 4 was demonstrated by C-C bond forming

55 These congested compounds exhibit two cofacial aniline rings t

56 ential IMS, TIMS not only is able to resolve congested conformational features but also can be used t

57 transfer through conversion of a sterically congested contact ion pair to a solvent-separated ion pa

58 furnishing a diverse array of products with congested cores featuring C- or heteroatom-substituted s

59 The method is tolerant of sterically congested coupling partners, as well as those bearing ba

60 h epimerizable stereocenters, and sterically congested coupling partners.

61 ift of a hydrogen atom out of the sterically congested cove region to the radical center, cyclization

62 mpared to the slowest average speed and most congested cycles, optimal emission rates could be 50% lo

63 H(8)BINOL-AM compounds with sterically less congested cyclic or acyclic amino methyl substituents we

64 romatic Nazarov cyclization to construct the congested cyclopentane core revealed an unanticipated el

65 polyribosomes, as well as phages, inside the congested cytosol of the infected cell.

66 It was found that once sterically congested Dbg is at the peptide N-terminus, further chai

67 es are rarely extracted, in part because the congested density of states in the excited-state manifol

68 ytically relevant amino acid residues in the congested diamagnetic envelope have been assigned.

69 e well-controlled construction of sterically congested dihydrobenzo[e]indazole derivatives.

70 pectra of large proteins (>30 kDa) are often congested due to the overlapping isotopic distribution o

71 al, and enantioselective route to the highly congested ent-kaurane diterpene maoecrystal V is present

72 e dense object detection requirements in the congested environment of urban streets.

73 The urban street is a congested environment that contains a large number of oc

74 of these compounds, especially in sterically congested environments, remain a challenge to prepare.

75 roduction of functional groups in sterically congested environments.

76 species in a chemical system often creates a congested fluorescence spectrum that is difficult to int

77 tures of 20 K during ion preparation, with a congested Franck-Condon envelope showing partially resol

78 , eight contiguous stereocenters, and highly congested functionality.

79 hronic obstructive pulmonary disease [COPD], congested heart failure [CHF], cancer, and dementia).

80 Congested heart failure causes increased plasma levels o

81 averaging of psi was observed in the highly-congested hexasaccharide.

82 y diamondoid bromides gave highly sterically congested hydrocarbon (hetero)dimers with exceptionally

83 For the sterically congested ketenimine 1a, preferred hydroalumination of t

84 edented steric hindrance to produce a highly congested ketone, and a tandem Claisen-ene cascade that

85 ally presented with a two-month history of a congested left eye.

86 monitor, predict and control the fraction of congested links in the network over time.

87 o hours of NRP effectively cleared RBCs from congested livers.

88 prove the deconvolution of highly complex or congested mass spectra and are demonstrated here for the

89 orithm that can be used to deconvolve highly congested mass spectra for heterogeneous ion populations

90 nges in training and match exposure during a congested match play period.

91 An intensive period of congested match play significantly alterated immune cell

92 Synthesis of a sterically congested metallacyclobutene complex has led to the firs

93 These changes contrasted with dilated and congested microvasculature in the contralateral control

94 c fragment coupling to assemble a sterically congested molecular framework and provides a foundation

95 Although these polycycles are sterically congested, molecular dynamics simulations indicate that

96 rived polycarbonate from the sterically less congested monomer, methyl 3,4-epoxybutanoate, displayed

97 lst simultaneously constructing a sterically congested motif.

98 parated epithelium, inflamed lamina propria, congested muscularis mucosa, necrotized submucosa, and d

99 The congested N,C-biaryl bond establishes an axis of chirali

100 cut-off of 10, patients were dichotomized as congested (n = 115) or not congested (n = 125).

101 e dichotomized as congested (n = 115) or not congested (n = 125).

102 that will show normal stability; more highly congested naphthalenes will prefer to exist as the corre

103 The highly congested native mass spectra are deconvolved using Four

104 , the critical C4-C5 bond of this sterically congested natural product could never be forged.

105 The congested nature of quaternary carbons hinders their pre

106 he synthesis of various peptoids with highly congested NCalpha-gem-dimethyl side chains.

107 ely underestimates the network throughput of congested networks, and a rich phenomenology of path flo

108 In contrast, the more basic, more sterically congested NHOs minimize unfavorable interactions by part

109 provided internal protection for the highly congested nitrogen atom during side-chain elaboration.

110 Sterically congested o-terphenyl crown ethers with alkoxy substitue

111 mass spectra of these ions are often highly congested, obfuscating determination of charge state, to

112 Traffic in an urban network becomes congested once there is a critical number of vehicles in

113 e unsuitable for studying MNPs in spectrally congested or complex chemical environments.

114 ic examination of rims (portal inflammation, congested or compressed sinusoids, cell atrophy) correla

115 minant - state, the contralateral nostril is congested, or non-dominant.

116 A congested parallel diarylethene mechanophore in the (R(a

117 , HF readmission or mortality occurred in 42 congested patients (37%) compared with 18 noncongested p

118 Congested patients were more likely to have previous car

119 1.4 days vs 85.5 +/- 12.4 days; P < 0.01) in congested patients.

120 e diterpene glucoside with a rare and highly congested pentasubstituted cyclopropane and promising an

121 015), and SII (r= -0.63; p = 0.01) after the congested period of match play (i.e., T3).

122 ed period of match play and T2-T3: six weeks congested period of match play).

123 sical fitness of elite soccer players during congested periods of match play.

124 e meta-selective C-H arylation of sterically congested phenols.

125 rd and scaleable synthesis of the sterically congested pheromone of the longtailed mealybug, with two

126 Binding in this congested pocket accommodates four hydrogen bond contact

127 yclopentadiene-1-one (8) and produces highly congested polycyclic frameworks containing up to seven c

128 sentative of the broader class of sterically congested polyphenylenes.

129 red, suggesting the furan ring is bound in a congested portion of the binding pocket.

130 sible at low temperatures even at sterically congested positions, thus permitting formation and also

131 Emphasis is placed on generating sterically congested products and reaction of highly substituted al

132 functional groups, including very sterically congested products.

133 f the sunspot (3200 K) gave rise to a highly congested pure rotational spectrum in the 10-micrometer

134 vatives involving axial asymmetry around the congested pyrimidine C5-N5 bond.

135 ketyl radical cyclization to form the highly congested quaternary carbon at the center of these compl

136 kyl cross-coupled products, including highly congested quaternary carbon centers from the correspondi

137 0a by initial construction of the sterically congested quaternary center at C-3, followed by elaborat

138 stereoselective construction of a sterically congested quaternary center embedded in the densely func

139 A wide variety of sterically congested quaternary products can be accessed through th

140 The obtained products feature highly congested quaternary stereogenic spirocenters and are us

141 rk to predict the mechanism for constructing congested quaternary-quaternary carbon(sp(3))-carbon(sp(

142 In the most congested regions, many fragments cannot be confidently

143 for spectroscopic measurements in spectrally congested regions.

144 g and outdated vehicle fleet and to famously congested roads.

145 experimental technique distributes normally congested rotational-vibrational peaks along a series of

146 ability to separate and sort these normally congested rotational-vibrational peaks.

147 ed for crowd counting, including VGG, SANet, Congested Scene Recognition network (CSRNet), MARUNet et

148 of the intermediate ketyl to the sterically congested Sm(III)HMPA both stabilizes the intermediate a

149 lectron photodetachment (a-EPD) affords less congested spectra than UVPD alone and richer fragmentati

150 tational/vibrational states, yielding highly congested spectra that are difficult to assign.

151 edundant or uninformative, resulting in more congested spectra that complicate interpretation.

152 ill flow of energy, previously hidden within congested spectra, is faster than timescales predicted b

153 users to isolate suites of metabolites from congested spectra.

154 reveal the underlying features of the highly congested spectral profiles associated with the complexe

155 features of the bound pigments in the highly congested spectral profiles from these light-harvesting

156 the interpretation of the complex, and often congested, spectral maps delivered by modern non-linear

157 e sharp onset of predissociation in a highly congested spectrum.

158 .0.0(2,8)]decanone 5 efficiently install the congested spirooxindole functionality of gelsemine.

159 es or highly-functionalized carbocycles with congested stereocenters, remains challenging in organic

160 rcembranoid natural products are a family of congested, stereochemically complex, and extensively oxy

161 presence of sensitive functional groups and congested structural environments.

162 PM3 calculations of 2 and 3 suggest a highly congested structure exhibiting two parallel acridyl moie

163 The rigid, highly congested structure of 1,8-diacridylnaphthalenes has bee

164 ale, and calculations reveal that sterically congested substrates prefer the S(N)2X manifold over S(N

165 of stereocontrol for reactions of sterically congested substrates that lie outside of the traditional

166 f rich club regions were significantly under-congested, suggesting that macaque connectivity actively

167 developed a method for preparing sterically congested sulfonylureas based on N,N'-sulfuryldiimidazol

168 ed by the singlet, while in these sterically congested systems, the triplet led to di-pi-methane reac

169 teric hindrance to isomerization in a highly congested T-shaped transition state.

170 This strategy enables the creation of highly congested tertiary centers with preserved stereocontrol,

171 ditionally, this reaction provides access to congested tertiary ether formations through regioselecti

172 allyl complexes that facilitate formation of congested tertiary-quaternary C-C bonds.

173 ng partners in order to establish the highly congested tetracyclic core structure.

174 ocyclization of the dipole led to sterically congested thiirane products, even for very bulky systems

175 tions with alkyl carbastannatranes affording congested thioethers.

176 ese systems, in fact, linear spectra are too congested to be used to disentangle the many coupled vib

177 ibutable to asphyxiation brought on by fluid-congested tracheal tubes.

178 erivative spectroscopy for disentangling the congested transient absorption spectra of LH1 and LH2 co

179 ve Heck cyclization, to rapidly assemble the congested tricyclic core of the indoxamycins.

180 re with ketones, imines, and indoles to give congested trifluoromethylated homoallylic alcohols/amine

181 adione and alphaEE showed foci of tumor with congested tubules and atrophic glomeruli.

182 ng for the observation and interpretation of congested vibrational structure.

183 Highly congested vicinal stereocenters comprised of tertiary an

184 were observed in association with 1 or more congested vortex veins ampullas, suggesting that outflow

185 Subduction zones become congested when they try to consume buoyant, exotic crust

186 and has: iron deposition; immature sinusoids congested with blood; persistent erythropoietic elements

187 localization, but the resulting spectra are congested with fragment ions that may have overlapping i

188 Patients with permanent AF were more congested with greater pulmonary vascular disease and lo

189 ion falls within a m/z range already heavily congested with monoanions from more abundant glycerophos

190 high mass proteins (>30 kDa) the spectra are congested with overlapping isotope patterns of highly ch

191 Road networks are increasingly congested, yet traffic data is often expensive to obtain

192 stituted allylic alcohol are shown to afford congested Z alkenes with high diastereoselectivity.