ライフサイエンスコーパス: conjugate addition

1 -lived state in dimethyl maleate using thiol conjugate addition.

2 h electrocyclization, cycloisomerization, or conjugate addition.

3 intermediate that supports the Stetter-like conjugate addition.

4 e modest diastereoselectivity of the radical conjugate addition.

5 enable general oxetane construction via oxa-conjugate addition.

6 xetanes that could undergo similar retro-oxa-conjugate addition.

7 he anticipated facile ring opening retro-oxa-conjugate addition.

8 disfavor the breaking of conjugation by oxa-conjugate addition.

9 on, and fluoride ion elimination followed by conjugate addition.

10 nifying the mechanisms of these two kinds of conjugate addition.

11 tituted amino acid precursors via asymmetric conjugate addition.

12 alkoxy group elimination, and intramolecular conjugate addition.

13 tom-attached alkyl group affects the rate of conjugate addition.

14 addition to the quinone is favored over 1,4-conjugate addition.

15 the Barton decarboxylation and Giese radical conjugate addition.

16 ganocatalyst N-methylpyrrolidine catalyzes a conjugate addition.

17 mine formation and subsequent intramolecular conjugate addition.

18 followed by a regioselective intramolecular conjugate addition.

19 ne reduction, hydration, hydroamination, and conjugate addition.

20 rd highly efficient catalysis for asymmetric conjugate additions.

21 Highly stereoselective conjugate additions (97:3 to 99:1 dr) were observed betw

22 cid based ligands in Cu-catalyzed asymmetric conjugate addition (ACA) reactions and a relatively rare

23 nyl monomers, proceeding exclusively through conjugate addition across the methacrylic C horizontal l

24 hat the most favorable pathway is a stepwise conjugate addition-Aldol sequence via the dual hydrogen-

25 Collectively, the conjugate addition-alkylation generates highly substitut

26 nzylic perborylation with a new deborylative conjugate addition-alkylation method enables a one-pot p

27 The first conjugate addition/alkylation to alkenyl isocyanides is

28 n to complete the 6-5-6-6 ring system, and a conjugate addition, all of which overcome considerable s

29 The reaction mechanism of a tandem conjugate addition/alpha-alkylation of enals leading to

30 ner to alternately switch ON/OFF a catalytic conjugate addition and a click reaction.

31 eaction results in a highly enantioselective conjugate addition and a diastereoselective proton trans

32 ing blocks by the pairwise use of asymmetric conjugate addition and aldehyde dehydration protocols.

33 The enantioselective 1,4-conjugate addition and enantioselective lactone formatio

34 ge of reaction processes including nitronate conjugate addition and formal [4+2] cycloadditions.

35 n activated 1,1'-difluoroolefin, followed by conjugate addition and hydrolysis.

36 was competition between the desired radical conjugate addition and undesired alkene reduction mediat

37 These Abeta modifications result from 1,4 conjugate addition and/or Schiff base formation, they oc

38 rode arrays with the use of both thiol-based conjugate additions and Cu(I)-coupling reactions between

39 olecular Knoevenagel condensation, a radical conjugate addition, and a SmI(2)-mediated nitro reductio

40 e atoms, have been synthesized using Wittig, conjugate addition, and asymmetric aldol reactions and f

41 gh proton transfer vs polymerization through conjugate addition, and mapped out extensive energy prof

42 products, including substitution at sulfur, conjugate addition, and N-functionalization.

43 n MoOPH-mediated oxidative cyclization, then conjugate addition, and redox processes to complete the

44 tereoselectivities in Diels-Alder reactions, conjugate additions, and aldol reactions employing these

45 iles and aldol reactions initiated via enone conjugate addition are not covered.

46 enic cascade reaction, iminium chemistry and conjugate additions are added to the emerging repertoire

47 1,6-Conjugate additions are otherwise limited to substrates

48 Nonetheless, catalytic enantioselective 1,6-conjugate additions are uncommon, and ones that incorpor

49 omethylthio-diarylmethane derivatives by 1,6-conjugate addition/aromatization under mild reaction con

50 beta-unsaturated aldehydes towards selective conjugate additions as well as activation of an unsatura

51 The tandem Friedel-Crafts conjugate addition/asymmetric protonation reaction betwe

52 nCl(4), and is the first example of a tandem conjugate addition/asymmetric protonation reaction using

53 A conjugate addition/asymmetric protonation/aza-Prins casc

54 that DeltaAla-containing peptides underwent conjugate addition at room temperature, while Z-DeltaAbu

55 minations, 1,2-addition to carbonyl, and 1,6-conjugate addition at the spiramycin aglycone, proceeds

56 metal-free enantioselective method for boron conjugate addition (BCA) to alpha,beta-unsaturated carbo

57 Lewis base catalyzed enantioselective boryl conjugate additions (BCAs) that generate products contai

58 Rapid conjugate addition between thiol-terminated tetravalent

59 consecutive hetero-Diels-Alder reactions (or conjugated additions) between nitrosoalkenes and dipyrro

60 Meanwhile, the same conjugate addition but followed by enolate oxidation wit

61 uce a vinyl gold(I) carbene, which undergoes conjugate addition by the nitrogen pronucleophile.

62 PPBenzene ligand effectively promotes direct conjugate additions by perfluoroarenes.

63 reactions, Morita-Baylis-Hillman reactions, conjugate additions, carbonylations, methylations, silyl

64 on/regioselective intramolecular cyclization/conjugate addition cascade reaction and provides a strai

65 of a key strategy-level intramolecular aldol/conjugate addition cascade that led, in a single operati

66 ed ketone dehydrogenation with organocuprate conjugate addition chemistry allows for the introduction

67 Surfaces constructed with the conjugate addition chemistry were not stable at neutral

68 e methides followed by an intramolecular 1,6-conjugate addition/cyclization and oxidation sequence.

69 One is a 1,6-conjugate addition/cyclization sequence with incorporati

70 pha-functionalization of amines and ketones, conjugate additions, cycloadditions etc.

71 mplementing an enantioselective Pd-catalyzed conjugate addition developed by Stoltz.

72 e key element of the synthesis consists of a conjugate addition-dipolar cycloaddition of 2,3-bis(phen

73 Since catalytic enantioselective conjugate addition (ECA) reactions directly generate the

74 A new class of enantioselective conjugate addition (ECA) reactions that involve aryl- or

75 They can be removed highly effectively via a conjugate addition-elimination mechanism using pyrrolidi

76 th the thiol group on C319 of RAD51, using a conjugate addition-elimination mechanism.

77 ional thiourea catalyst through a sequential conjugate-addition-elimination-tautomerization.

78 ey steps in stereocontrol were an asymmetric conjugate addition employing a proline-based catalyst an

79 n a novel DNA-based catalytic Friedel-Crafts conjugate addition/enantioselective protonation reaction

80 KODE-(E)-I adducts were confirmed to reflect conjugate addition (epoxide ring remains intact) through

81 Conjugate addition followed by enolate protonation gener

82 An alternative method to copper-catalyzed conjugate addition followed by enolate silylation for th

83 with 2,5-dimethylpyrrole through an initial conjugate addition followed by intramolecular O- and N-n

84 nd pyrrole to afford two isomeric oximes via conjugate addition followed by rearomatization of the py

85 te one quaternary stereocenter and a cuprate conjugate addition for the establishment of the other.

86 in situ oxidation of the enolate formed upon conjugate addition, giving access to the corresponding a

87 While oxa-conjugate additions have been shown to provide direct an

88 We hypothesize that a transannular oxa-conjugate addition in a macrocyclic laulimalide precurso

89 ive carbonyl anion species in situ allow for conjugate additions in good yield to sensitive nitroalke

90 etates selectively undergo two different 1,6-conjugate addition-initiated cyclization cascades.

91 lled fashion through application of a tandem conjugate addition-intramolecular cyclization method dev

92 cid which is advanced via a highly selective conjugate addition/intramolecular Friedel-Crafts acylati

93 rrolo[4,3,2-de]quinoline-4-carboxylate via a conjugate addition/intramolecular Ullman reaction sequen

94 iginal bifunctional platforms for the domino conjugate addition inverse-electron-demand hetero-Diels-

95 In triflic acid-promoted reactions, conjugate addition is observed with pyrazine-, 2-pyrimid

96 Our data indicates that oxa-conjugate addition is reversible and that the stereochem

97 tically active species from solution and the conjugate addition is turned OFF.

98 atalytic enantioselective aldol and boronate conjugate additions, is discussed and illustrated throug

99 ed on results from DBFOX/Ph-promoted radical conjugate additions, is in need of revision.

100 eptide mimics by means of an organocatalytic conjugate addition, leading to chiral cyclic hemiacetals

101 The stepwise trans pathway, beginning with a conjugate addition-like transition state, becomes increa

102 containing the key functional groups for oxa-conjugate addition-mediated dihydropyran formation.

103 l substrates in contrast to more traditional conjugate addition methods.

104 on of alcohols to ynones and promotes tandem conjugate addition/Michael cascade reactions.

105 We report an enantioselective conjugate addition nitro-Mannich reaction protocol which

106 Conjugate addition occurs selectively at the 3-position

107 Base-mediated double conjugate addition of 1,3-propane dithiol to various sil

108 A novel gamma-selective conjugate addition of 1-silyl-substituted dienol ethers

109 Under dinuclear catalysis, the direct conjugate addition of 2(5H)-furanone to nitroalkenes inv

110 The copper-catalyzed asymmetric conjugate addition of 2-oxazoline- and 2-thiazoline 4-ca

111 A convenient, mild and effective conjugate addition of 3-butyn-2-one to a variety of anil

112 (i) an asymmetric Reformatsky reaction; (ii) conjugate addition of a chiral vinyllithium reagent; (ii

113 nylene)-2-phenylallyl (BDPA) radical via the conjugate addition of a derivatized fluorene nucelophile

114 A metal-free method for enantioselective conjugate addition of a dimethylphenylsilyl group to alp

115 The key step involves intramolecular 1,4-conjugate addition of a hydroxymethyl radical generated

116 ished as turnover limiting followed by rapid conjugate addition of a nickel hydride and nonselective

117 which are united in the synthetic pathway by conjugate addition of a nucleophilic tertiary radical to

118 ne, was elaborated through an intramolecular conjugate addition of a phenol to create the dihydrofura

119 f the process is attributed to a cooperative conjugate addition of a thiourea-bound carbamate anion t

120 a-arylation of propargylic ether followed by conjugate addition of a vinyl palladium intermediate and

121 shown to very effectively promote asymmetric conjugate addition of acetylacetone to trans-beta-nitroo

122 itional type of adduct resulting from direct conjugate addition of Ade to AF followed by hydrolytic c

123 An efficient intermolecular conjugate addition of alcohols to activated alkenes cata

124 lyzed by diarylprolinol ether catalysts, the conjugate addition of aldehydes to nitro-olefins and the

125 ptoid hybrids was assessed in the asymmetric conjugate addition of aldehydes to nitroolefins, where m

126 es the facial bias of the rotaxane-catalyzed conjugate addition of aldehydes to vinyl sulfones.

127 rted zinc-copper matrix reagent promotes the conjugate addition of alkyl iodides to cyclic and acycli

128 Last, conjugate addition of alkyl iodides to Dha, promoted by

129 ny natural products and pharmaceuticals--via conjugate addition of alkylzirconium reagents to a terti

130 The enantioselective conjugate addition of alkynyl nucleophiles has been a lo

131 per(II) triflate catalyzed tandem asymmetric conjugate addition of AlMe3 to 2-methyl-2-cyclohexen-1-o

132 nsesterification, followed by intramolecular conjugate addition of alpha,beta-unsaturated esters to p

133 menaquinone (vitamin K(2)) is a Stetter-like conjugate addition of alpha-ketoglutarate with isochoris

134 synthase, or MenD, catalyze the Stetter-like conjugate addition of alpha-ketoglutarate with isochoris

135 Conjugate addition of alpha-nitrophosphonates to enones

136 The beta-aminoester, formed by the conjugate addition of ammonia on olefinic ester, undergo

137 ated in a highly stereocontrolled fashion by conjugate addition of an alkyllithium reagent to the s-c

138 processes constitute an uncommon instance of conjugate addition of an allyl moiety and afford the des

139 Nickel-(II)-catalyzed 1,4-conjugate addition of an alpha-alkylidene-beta-dicarbony

140 efficient route was developed that involved conjugate addition of an aryl Grignard reagent to a 2-ni

141 etoester starting materials and proceeds via conjugate addition of an in situ-generated palladium eno

142 catalyst and a syn-selective intramolecular-conjugate addition of an oxygen nucleophile to an alpha,

143 a alkaloid-derived urea-catalyzed asymmetric conjugate addition of aromatic thiols to cycloalkenones

144 l cinchona alkaloids catalyze the asymmetric conjugate addition of aromatic thiols to cycloalkenones

145 ickel catalyst and Cp2TiCl allows the direct conjugate addition of aryl and alkenyl iodides, bromides

146 The synthetic sequence begins with the conjugate addition of benzeneselenol to nitroalkenes (in

147 or the site-selective and diastereoselective conjugate addition of boron-stabilized allylic nucleophi

148 The substrate-controlled 1,3-stereoselective conjugate addition of boronic acids and potassium triflu

149 We have applied this new strategy to the conjugate addition of C-nucleophiles to enals via iminiu

150 th high levels of enantioselectivity via the conjugate addition of cyclic amines to unactivated alpha

151 utyrine (Dhb), respectively, followed by the conjugate addition of Cys residues to the Dha and Dhb re

152 ismuth-mediated two-component hemiacetal/oxa-conjugate addition of delta-trialkylsilyloxy and delta-h

153 The conjugate addition of dialkylzinc reagents to allyl fuma

154 y active (1 mol % cat. loading) promoters in conjugate addition of dibenzoylmethane to various trans-

155 An enantioselective copper-catalyzed conjugate addition of diethylzinc led to highly crystall

156 Copper-catalyzed conjugate addition of diorgano zinc reagents to nitroacr

157 Subsequent conjugate addition of either a PIII species or phosphoru

158 Conjugate addition of either lithium (R)-N-allyl-N-(alph

159 amidite ligand promotes the copper catalyzed conjugate addition of Et(2)Zn to a N-carbamoyl-4-pyridon

160 ion but also as a functional equivalent to a conjugate addition of fluoride, furnishing products in m

161 Copper catalysis in the conjugate addition of Grignard reagents affords modest y

162 TMSCl-mediated conjugate addition of Grignard reagents to 2-substituted

163 Sequential carbonyl addition-conjugate addition of Grignard reagents to 3-oxocyclohex

164 Sequential carbonyl addition-conjugate addition of Grignard reagents to cyclic 5-7-me

165 each elementary step of the copper-catalyzed conjugate addition of Grignard reagents to enamides, all

166 Enantioselective conjugate addition of Grignard reagents to enones, catal

167 Conjugate addition of guanidine to a bis enone followed

168 A silver-catalyzed cycloisomerization/1,6-conjugate addition of homopropargyl sulfonamides to p-qu

169 utes a new approach for the enantioselective conjugate addition of hydrazones to enals under metal-fr

170 ort chain reductase YwfH which catalyzes the conjugate addition of hydride at the C(4) olefinic termi

171 for carrying out the stereocontrolled formal conjugate addition of hydroxycarbonyl anion equivalents

172 iodoallenolate intermediate is generated via conjugate addition of iodide to an alkynone followed by

173 Conjugate addition of LDA/HMPA to an unsaturated ester p

174 Preparatively useful conjugate addition of lithiated methyl pyridines to cycl

175 The conjugate addition of lithium (R)-N-(3-chloropropyl)-N-(

176 The conjugate addition of lithium (R)-N-benzyl-N-(alpha-meth

177 These substrates are readily prepared via conjugate addition of lithium (S)-N-benzyl-N-(alpha-meth

178 been developed, using the diastereoselective conjugate addition of lithium (S)-N-benzyl-N-(alpha-meth

179 enantioselective copper-catalyzed asymmetric conjugate addition of Me2Zn to (Z)-nitroalkenes led to t

180 omponent diastereo- and enantioselective 1,6-conjugate addition of multifunctional allyl moieties to

181 The conjugate addition of N-formyl derivatives of 2-amino-3-

182 The 1,6-conjugate addition of nucleophiles to dienyl diketones p

183 d the first example of a catalytic reductive conjugate addition of organic halides that proceeds via

184 ing use of the regio- and diastereoselective conjugate addition of organolithium reagents to alpha,be

185 Kinetic studies of the conjugate addition of propanal to nitrostyrene catalyzed

186 Key steps include a stereoselective conjugate addition of pyrrolidino enedione 19 to afford

187 recedented highly enantioselective catalytic conjugate addition of simple alkyl thiols to alpha,beta-

188 Specifically, a Bronsted base catalyzed conjugate addition of substituted 2-cyanomethylpyridine

189 st-translationally modified proteins through conjugate addition of sulfur nucleophiles to dehydroalan

190 turated ester, and doubly diastereoselective conjugate addition of the antipodes of lithium N-benzyl-

191 exahydro-1H-indole-2-carboxylic acid) by the conjugate addition of the free amine to the cyclohexadie

192 ne 10 under acidic conditions led to net bis-conjugate addition of the latent diol to give the thermo

193 A regio- and diastereoselective conjugate addition of the lithium anion of N-allyl imine

194 Reversible conjugate addition of the nucleophile to the 4-position

195 bsequent aza-Wacker oxidative cyclization or conjugate addition of the olefinated intermediates provi

196 on of the bicyclic isoxazolidine arises from conjugate addition of the oxime onto the diene to afford

197 Subsequent conjugate addition of the requisite antipode of lithium

198 he installation of the C8-hydroxyl group via conjugate addition of water to a putative strained bridg

199 osphite 6b catalyzes highly enantioselective conjugate additions of acyl silanes to alpha,beta-unsatu

200 Finally, a GC2 base was found to catalyze conjugate additions of alpha-aryl ester pronucleophiles,

201 Enantioselective conjugate additions of arylboronic acids to beta-substit

202 development of a highly efficient method for conjugate additions of commercially available bis(pinaco

203 n a three-component (A(3)) condensation, and conjugate additions of Cu acetylides.

204 e substrates were readily prepared using the conjugate additions of lithium (R)-N-benzyl-N-(alpha-met

205 ) were achieved using the diastereoselective conjugate additions of lithium amide reagents in the key

206 The first examples of conjugate additions of N-tert-butanesulfinyl metalloenam

207 ssible organocopper catalyst can promote 1,6-conjugate additions of propargyl and 2-boryl-substituted

208 The highly diastereoselective 1,4-conjugate additions of several nitrogen nucleophiles to

209 The highly diastereoselective conjugate additions of the novel lithium amide reagents

210 mmetric alpha-alkylation of aldehydes by 1,6-conjugated addition of enamines to p-quinone methides is

211 rization of Michael acceptors, for which the conjugated addition of the Lewis base to the acid-activa

212 ng position of the vinyl substituent, either conjugate addition or Markovnikov addition occurs.

213 novel, one-step Diels-Alder/beta-elimination/conjugate addition organocascade sequence allowed rapid

214 ) as the allyl transfer reagent and promotes conjugate addition over 1,2-addition.

215 A merged conjugate addition/oxidative coupling sequence that repr

216 calculations and kinetics studies, support a conjugate addition pathway as more favorable energetical

217 lkenylboronate esters by a rhodium-catalyzed conjugate addition pathway is disclosed.

218 suggest that the reaction is proceeding by a conjugate addition pathway rather than by a pathway invo

219 yclic carbene (NHC)-mediated organocatalytic conjugate-addition polymerization of acrylic monomers.

220 nd the catalytic nature of this NHC-mediated conjugate-addition polymerization.

221 Cu-catalyzed enantioselective conjugate additions proceed to completion within only 2

222 A dynamic beta-elimination/conjugate addition process was strategically applied to

223 t the stereochemical outcome of organocopper conjugate addition processes focus on the nucleophilic a

224 ions, the model under went regiospecific oxa-conjugate addition producing a stable trans oxetane as t

225 ester, thioester, nitro moieties) within the conjugate addition products allowed for straightforward

226 as a selective coupling partner to generate conjugate addition products exclusively.

227 endo-8 from the respective syn-4 and anti-7 conjugate addition products in a one-pot tandem fashion.

228 formations, including allylic substitutions, conjugate additions, proto-boryl additions to alkenes, b

229 tion mixture allowed a one-pot methylenation/conjugate addition protocol to be developed, which great

230 ne intermediates, consisting of the proposed conjugate addition-proton transfer-NHC release fundament

231 a highly stereoselective heteroatom-directed conjugate addition reaction and cyclopentanone ring cycl

232 sted acid-catalyzed asymmetric guanidine aza-conjugate addition reaction has been developed.

233 talysts for the unreported, enantioselective conjugate addition reaction of the barbituric acid pharm

234 the oxidized Leu66 side chain, suggesting a conjugate addition reaction of the imidazole nitrogen to

235 These fragments were linked by a challenging conjugate addition reaction that also generated the C11

236 ulfonyl anion surrogate in the DBU-catalyzed conjugate addition reaction with enones and enals for th

237 es, which involved a 6-exo-trig free-radical conjugate addition reaction.

238 e recently introduced; these boryl and silyl conjugate addition reactions (BCA and SCA, respectively)

239 Copper-catalyzed asymmetric conjugate addition reactions are a very powerful and wid

240 The insights enabled conjugate addition reactions between aldehydes and nitro

241 atalyst loadings as low as 0.1 mol%, for the conjugate addition reactions of 1,3-dicarbonyl compounds

242 The conjugate addition reactions of trans-1,2-di(2-pyridyl)e

243 Conjugate addition reactions to enones can now be done i

244 The conjugate addition reactions used both acrylate and male

245 results of systematic studies of arylcuprate conjugate addition reactions with cis and trans gamma-al

246 N-carbamoyl-4-pyridones undergo conjugate addition reactions with organocuprates and org

247 Catalytic asymmetric conjugate addition reactions with organometallic reagent

248 sconnection that complements a wide range of conjugate addition reactions(1-5).

249 ligand for enantioselective nickel-catalyzed conjugate addition reactions.

250 odulate asymmetric quimioselective aldol and conjugate addition reactions.

251 ctive species in copper-catalyzed asymmetric conjugate addition reactions.

252 expand the classical reactivity pattern for conjugate addition reactions.

253 ously been used to guarantee good results in conjugate addition reactions.

254 H-Pro-Pro-Xaa-NH2-type peptidic catalysts in conjugate addition reactions.

255 s" expands the scope of potential donors for conjugate addition reactions.

256 density functional theory calculations, of a conjugate addition-rearrangement sequence that leads to

257 in good to excellent yields through a tandem conjugate addition/Smiles rearrangement involving aryl a

258 The conjugate addition step occurred in less than a minute a

259 tudy, we demonstrate that a transannular oxa-conjugate addition strategy is a viable approach to the

260 This oxa-conjugate addition strategy should provide a viable rout

261 of Michael acceptors is amenable to this new conjugate addition strategy.

262 olefin geometry was discovered using a silyl conjugate addition strategy: aldehydes and ketones were

263 The conjugate addition takes place smoothly in toluene at ro

264 s introduced by means of an enantioselective conjugate addition that forms an all-carbon quaternary c

265 exchange, thiolate-disulfide interchange and conjugate addition) that displays bistability and oscill

266 etone oxidation, aryl-halide activation, and conjugate addition through a single catalytic cycle.

267 ng an alternative disconnection, a hemiketal conjugate addition to a naphthaquinone electrophile was

268 relative stereochemistry; a malonate enolate conjugate addition to a nitrosoalkene in order to instal

269 enter and the a/d rings, 2) a malonate anion conjugate addition to a transient nitrosoalkene to insta

270 tereochemistry was established by asymmetric conjugate addition to an alpha,beta-unsaturated ester (6

271 photoredox-mediated decarboxylative radical conjugate addition to dehydroalanine derivatives is disc

272 ty and stereocontrol in catalytic asymmetric conjugate addition to enamides, the method is distinguis

273 strated in a Rh(I)-catalyzed decarboxylative conjugate addition to form a C-C bond at a meta position

274 ters that react constructively via thiol-ene conjugate addition to form sulfide functionalized copoly

275 n intermolecular ester enolate/nitrosoalkene conjugate addition to form the C-15/16 bond, followed by

276 a highly anti-diastereoselective arylcuprate conjugate addition to gamma-alkoxy-alpha,beta-enoates an

277 s, thiolate addition to PhOBtz resembles 1,6-conjugate addition to p-QMs which is accompanied by a la

278 1,6-conjugate addition to the quinone is favored over 1,4-co

279 ivatives are obtained in excellent yields by conjugate addition to tosylacetylene (ethynyl p-tolyl su

280 lex diazo-containing scaffolds are formed by conjugate addition to vinyl diazonium salts.

281 s a test-bed reaction, we monitored 48 thiol conjugate additions to a Meldrum's acid derivative (1) i

282 Conjugate additions to acyclic and cyclic 5-7-membered a

283 ted as promoters of enantioselective radical conjugate additions to alpha,beta-unsaturated alpha-nitr

284 Diastereoselective conjugate additions to alpha,beta-unsaturated sulfones h

285 rategy addresses the challenge of performing conjugate additions to disubstituted alkenenitriles and

286 nucleophiles in intramolecular Michael-type conjugate additions to in situ generated nitrosoalkenes

287 ered protic environment that readily undergo conjugate additions to substituted alpha,beta-unsaturate

288 reoselective, catalyst-controlled asymmetric conjugate additions to thioesters to set key stereocente

289 talyzed method for enantioselective boronate conjugate additions to trisubstituted alkenes of acyclic

290 enantioselective catalytic methods including conjugate addition under metal-free conditions with an N

291 ion (>4 A) and products that are reactive to conjugate additions under mild conditions.

292 ormed by an organocatalytic enantioselective conjugate addition using the respective trifluoroborate

293 exhibited by the metal-free approach (e.g., conjugate addition vs reaction with an alkyne, allene, o

294 adducts followed by catalyst-free indolizine conjugate addition was developed.

295 proceeds via sequential Michael and Mannich conjugate additions whereby the primary amine activates

296 his process merged an intramolecular radical conjugate addition with an enolate hydroxylation and cre

297 amides 1 were subjected to rhodium-catalyzed conjugate addition with arylboronic acids providing high

298 ydropyrrole intermediate in situ followed by conjugate addition with p-quinone methides.

299 ic applications of ynones will be focused on conjugate additions with boron-, carbon-, nitrogen-, oxy

300 s from amines, as well as cycloadditions and conjugate additions with unsaturated carboxylic acids.