ライフサイエンスコーパス: connexin

1 ells expressing connexin36, a major neuronal connexin.

2 e way Cx26 interacts with other co-expressed connexins.

3 istribution patterns of three major vascular connexins.

4 ion and disruption of gap junction proteins, connexins.

5 se via canalostomy in adult mice with floxed connexin 26 (Cx26) alleles promoted Cre/LoxP recombinati

6 the genes encoding for gap junction proteins connexin 26 (Cx26) and connexin 30 (Cx30) have been link

7 the genes encoding for gap junction proteins connexin 26 (Cx26) and connexin 30 (Cx30) have been link

8 We found that connexin 26 (Cx26) and Cx30 GJs readily diffuse within t

9 (PCs), coupled by gap-junctions composed of connexin 26 (Cx26) and Cx30.

10 Because in the human skin connexin 26 (Cx26) is co-expressed with other connexins,

11 are knock-outs for the gap-junction channels connexin 26 and connexin 30 genes, we show that defects

12 are knockouts for the gap-junction channels connexin 26 and connexin 30 genes, we show that defects

13 progression of deafness for a boy with GJB2 (CONNEXIN 26) mutations.

14 GJB2 encodes connexin 26, a gap junction protein, which permits inter

15 e adult CC was paralleled by upregulation of connexin 26, which correlated with the resumption of pro

16 gap junction proteins connexin 26 (Cx26) and connexin 30 (Cx30) have been linked to syndromic and non

17 gap junction proteins connexin 26 (Cx26) and connexin 30 (Cx30) have been linked to syndromic and non

18 gged Cx30 via canalostomy in P4 mice lacking connexin 30 (Cx30) promoted formation of Cx30 gap juncti

19 or the gap-junction channels connexin 26 and connexin 30 genes, we show that defects in non-sensory c

20 or the gap-junction channels connexin 26 and connexin 30 genes, we show that defects in nonsensory ce

21 regions of the DG, such as PARK7, RACK1, and connexin 31/gap junction.

22 Mutations in connexin-31 (Cx31) are associated with multiple human di

23 We identified connexin 32 (Cx32), the predominant hepatic gap junction

24 kade of gap junctions or genetic ablation of connexin 36 (Cx36) subunits eliminates the long-range co

25 gical blockade of GJs or genetic ablation of connexin 36 (Cx36) subunits, which are highly expressed

26 e contribution of the gap junctional protein connexin 36 (Cx36) to the regulation of sympathetic acti

27 ctional coupling, and was still prevalent in connexin 36 knock-out animals.

28 tial association between GluN2B subunits and connexin 36 on AII amacrines, suggesting that NMDA recep

29 cate an energetic failure; and (2) a loss of connexin 36, suggesting alterations in the AII coupling

30 on of heart rate and blood pressure involves connexin 36-containing gap junctions.

31 recordings in bulb slices from wild-type and connexin 36-knockout (KO) mice.

32 It is known that the gap junction protein connexin-36 is widely expressed in the sexually dimorphi

33 bility, and we here report that, indeed, the connexin-36-containing glutamatergic mossy fiber synapse

34 f stimulation intensities, primarily through connexin-36-dependent rod pathways.

35 l-specific deletion of connexin 43 (Cx43) in connexin 37 null (Cx37(-/-) ) mice results in rapid regr

36 ccompanied by an increase in connexin 43 and connexin 40 expression levels, suggesting their role in

37 , aldo-keto reductase family 1, member 7 and connexin 40) and by the appearance of markers of fibrobl

38 nd this correlated with restoration of Gja5 (connexin 40) expression in the heart.

39 velocity, including Scn5a (Nav1.5) and Gja5 (connexin 40), are persistently downregulated long after

40 AV nodes showed that ZO-1 loss decreased Cx (connexin) 40 expression and intercalated disc localizati

41 bundle, but has no significant effect on the connexin-40-positive bundle branches.

42 ession of the arterial markers ephrin-B2 and Connexin-40.

43 ibrosis, and lateralization of cardiomyocyte connexin-40.

44 GJ proteins, connexin 43 (Cx43) and connexin 47 (Cx47), play a crucia

45 s transported to acidified endolysosomes via connexin 43 (Cx43) and gated by cAMP-EPAC-RAP1-PP2A sign

46 ked by (1) antagonists of connexin channels, connexin 43 (Cx43) blocking peptide Gap26, or Cx43 gene

47 The gap junction protein Connexin 43 (Cx43) contributes to cell fate decisions th

48 nd control uninfected individuals to examine connexin 43 (Cx43) expression and distribution and HIV-a

49 soluble Si on osteogenic differentiation and connexin 43 (CX43) gap junction communication in culture

50 function of astroglial gap junction protein connexin 43 (Cx43) has increasingly been associated to n

51 have recently reported an important role of Connexin 43 (Cx43) hemichannels in the pathogenesis of l

52 This study shows that opening of connexin 43 (Cx43) hemichannels leading to the release o

53 Postnatal endothelial-specific deletion of connexin 43 (Cx43) in connexin 37 null (Cx37(-/-) ) mice

54 We investigated the role of connexin 43 (Cx43) in maintaining the integrity of mitoc

55 , we effectively abolished the expression of connexin 43 (Cx43) in OECs in both juvenile and adult mi

56 Connexin 43 (Cx43) is the most ubiquitous connexin in va

57 tein alpha1 gene (Gja1), resulting in a G60S connexin 43 (Cx43) mutant protein that is dominant negat

58 udies indicate that the gap junction protein connexin 43 (Cx43) renders GBM cells resistant to TMZ th

59 rate that one of these regulating factors is Connexin 43 (Cx43), a gap junction protein highly expres

60 ns, which differs from another gap junction, connexin 43 (Cx43), during skin wound healing.

61 expression, turnover and phosphorylation of connexin 43 (Cx43), one of the major proteins of gap jun

62 GJA1 encodes connexin 43 (Cx43), the most widely expressed gap juncti

63 ntrol mice, Abeta25-35 peptide promoted both connexin 43 (Cx43)- and Panx1 HC-dependent MC dye uptake

64 studies have illustrated the significance of connexin 43 (Cx43)-based gap junction in maintaining the

65 through astrocyte gap junctions composed of connexin 43 (Cx43).

66 ated discs and binds to gap junction protein connexin 43 (Cx43).

67 arcinoma-astrocyte gap junctions composed of connexin 43 (Cx43).

68 Connexin 43 (gap junction protein) is expressed in pigme

69 This was accompanied by an increase in connexin 43 and connexin 40 expression levels, suggestin

70 diomyocytes >5-fold as reflected by elevated connexin 43 and consortin transcripts.

71 hese findings suggest that crosstalk between connexin 43 and purinergic signaling contributes to podo

72 cta, and a larger fraction of phosphorylated connexin 43 at serine 368.

73 urance-trained R735X-infected mice displayed connexin 43 delocalization at intercardiomyocyte gap jun

74 d enhanced sarcomere alignment and increased connexin 43 expression at 220 days after transplantation

75 um, mice with a heterozygous deletion of the connexin 43 gene (connexin 43+/-) had proteinuria, BUN,

76 Our results show that in the olfactory bulb, connexin 43 hemichannel function is promoted by neuronal

77 that release further ATP; by 7 h treatment, connexin 43 hemichannels (Cx43 HCs) are also opened.

78 s, we showed that the activity of astroglial connexin 43 hemichannels, opened in an activity-dependen

79 ith the observation that ATP is released via connexin 43 hemichannels.

80 e purity of the SAN protein was confirmed by Connexin 43 immunoblot.

81 ow that knockout of the gap junction subunit connexin 43 in astrocytes throughout the brain causes ex

82 mmunostaining revealed de novo expression of connexin 43 in damaged glomeruli in patients with glomer

83 conduction, whereas conditional deletion of connexin 43 in macrophages and congenital lack of macrop

84 ic glia, either reducing glial expression of connexin 43 in Sox10::CreER(T2+/-) /Cx43(f/f) mice or ac

85 fect localization of desmosomal proteins and connexin 43 in the skin, and result in desmosome aggrega

86 ced in individuals with glomerular diseases, connexin 43 may be a novel target for therapeutic treatm

87 gap junction coupling with dominant negative connexin 43 or by disrupting lactate efflux was sufficie

88 Connexin 43 protein in HCSC and MCSC was examined using

89 t at E15.5 albino RPE cells have fewer small connexin 43 puncta, and a larger fraction of phosphoryla

90 markers for astrocytic cells and fibers and connexin 43 puncta.

91 Connexin 43 reboots meiosis and reseals blood-testis bar

92 haT-catenin in mice reduces plakophilin2 and connexin 43 recruitment to the ICD.

93 cardiomyocytes showed sarcolemmal damage and connexin 43 redistribution/internalization.

94 This screen identified Cx43 (connexin 43) hemichannel blockade as a robust suppressor

95 crossing into a cardiomyocyte-specific Cx43 (connexin 43) heterozygous background.

96 RATIONALE: Delivery of Cx43 (connexin 43) to the intercalated disc is a continuous an

97 redox-sensitive gap junctional protein Cx43 (Connexin 43) was reduced in the peri-infarct area of wil

98 cs, and integral gap junction proteins Cx43 (connexin 43), Cx45 (connexin 45), and ZO-1 (zonula occlu

99 RATIONALE: Downregulation of Cx43 (connexin 43), the major cardiac gap junction protein, is

100 shed by gap junctions (GJ) composed of Cx43 (connexin 43).

101 Additionally, the connexin 43+/- mice showed less crescent formation, tubu

102 terozygous deletion of the connexin 43 gene (connexin 43+/-) had proteinuria, BUN, and serum creatini

103 ild inflammation and increased expression of connexin 43, a gap junction protein involved with labor.

104 actor (NF)-kappaBeta and upregulated that of connexin 43, both of which sensitized cancer cells to Ta

105 olangiocyte differentiation (cytokeratin 19, connexin 43, integrin beta4, and gamma-glutamyltranspept

106 e ZO-1-associated proteins such as vinculin, connexin 43, N-cadherin, and alpha-catenin showed no sig

107 lated expression of the gap junction protein connexin 43, which has been observed in the progression

108 uired cell-cell contact and the formation of connexin 43-containing gap junctions between monocytes a

109 ic compact region around the SAN artery with Connexin 43-negative pacemaker cardiomyocytes visualized

110 nally, therapeutic treatment of GN mice with connexin 43-specific antisense oligodeoxynucleotide impr

111 Treatment of cultured podocytes with connexin 43-specific blocking peptides attenuated TGF-be

112 ated with increased expression of myocardial connexin 43.

113 rated lowered expression of the gap junction connexin 43.

114 sperse with elongated macrophages expressing connexin 43.

115 conduction velocity due to downregulation of Connexin 43.

116 s on localization of desmosomal proteins and connexin 43.

117 The disease was accompanied by connexin-43 (Cx43) aberrantly enhanced in both cardiac a

118 Decreasing the amount of functional connexin-43 (Cx43) at the membrane through Cx43 silencin

119 Connexin-43 (Cx43) gap junctions provide intercellular c

120 pression of the cardiac gap junction protein connexin-43 (Cx43) has been suggested as playing a role

121 il cluster in a contact-dependent manner via connexin-43 (Cx43) hemichannels, which are mediators of

122 stresses within the tissues and depended on connexin-43 (Cx43) hemichannels, which opened preferenti

123 Coupling correlated with levels of connexin-43 (Cx43), a protein previously linked to late-

124 n expression and subcellular localization of connexin-43 (Cx43), the major ventricular gap junction p

125 ancer cells express the gap junction protein connexin-43 (Cx43), yet whether Cx43 regulates collectiv

126 cell-contact dependent and mediated by HSPC connexin-43 (Cx43).

127 e (P4) is known to inhibit the expression of connexin-43 (Cx43, major component of GJs) and GJ format

128 fic Connexin-43 deletion and pharmacological Connexin-43 blockade were associated with reduced cytoki

129 Both macrophage-specific Connexin-43 deletion and pharmacological Connexin-43 blo

130 portantly, the activities of stromal AE2 and connexin-43 do not place an energetic burden on cancer c

131 onitis/sepsis model, we identified increased Connexin-43 expression in peritoneal and hepatic macroph

132 mpaired gap junctions (particularly, loss of connexin-43 expression) following stiffening.

133 LR-2 and -4 agonists trigger ATP-release via Connexin-43 hemichannels in macrophages leading to poor

134 ) mice were developed to specifically assess Connexin-43 impact in macrophages.

135 N-cadherin and connexin-43 in adherens junction and gap junction betwee

136 an inward-rectifying potassium channel, and connexin-43 in primary human fibroblasts from the heart,

137 Oxytocin receptor and connexin-43 mRNA expression were reduced in the myometri

138 ctural remodeling was prominent at 10 weeks: connexin-43 was downregulated and redistributed to later

139 In humans, Connexin-43 was upregulated on macrophages isolated from

140 er ID proteins like N-cadherin, desmoplakin, connexin-43, and ZO-1 was significantly perturbed upon p

141 (endothelial nitric oxide synthase), glial (connexin-43, glial fibrillary acidic protein, CD11b), an

142 by gap junctions formed by proteins such as connexin-43, which allows the absorbed acid load to be t

143 to spontaneously beating cardiomyocytes via connexin-43-containing gap junctions, cardiac macrophage

144 In conclusion, inhibition of autocrine Connexin-43-dependent ATP signalling on macrophages impr

145 ofibroblast contact dynamism is modulated by connexin-43.

146 ion of desmoplakin, plectin, N-cadherin, and connexin-43.

147 pression of integrin alpha1, PDGF-R1beta and connexin-43.

148 ional gap junctions partially contributed by Connexin 45 (CX45).

149 junction proteins Cx43 (connexin 43), Cx45 (connexin 45), and ZO-1 (zonula occludens-1) were identif

150 no significant change with the loss of ZO-1, Connexin-45 and Coxsackie-adenovirus (CAR) proteins were

151 Here, we incorporate native connexin-46/50 (Cx46/50) intercellular channels into a d

152 GJ proteins, connexin 43 (Cx43) and connexin 47 (Cx47), play a crucial role in production an

153 n L-type Ca(2+) channel) and the HC-specific connexin-55.5 promoter to express AMPApHluorin (pHluorin

154 Connexins and connexin channels play important roles in

155 iew the current understanding of the role of connexins and gap junctions in cancer, with particular f

156 This combinatorial analysis of vascular connexins and identification of the vascular relay regio

157 e protein with shared structural features to connexins and pannexins, has been implicated in ATP rele

158 Alterations in connexins and specifically in 43 isoform (Cx43) in the h

159 Our findings suggest that connexins are involved in the early reaction of ependyma

160 Connexins, as members of gap junctions, are important in

161 We investigated connexin-assembled gap junctions as an alternative route

162 Phosphorylation is integral to regulating connexin assembly, degradation, and electrical and metab

163 s SnapShot highlights mutations in different connexins associated with human pathologies and how they

164 may be in addition to previously discovered connexins at sites of myocyte-nonmyocyte contact in the

165 aper gives an overview of the involvement of connexin-based and pannexin-based channels in noncancero

166 Connexin-based channels exhibit two distinct voltage-dep

167 rol electrical synchronization in the heart, connexin-based hemichannels must be correctly targeted t

168 Connexin blockade reduced the injury-induced proliferati

169 cell membrane, are topologically similar to connexins, but do not form cell-to-cell gap junction cha

170 , intercellular channels composed of subunit connexins, can play a major role in secondary cell death

171 xhibiting no aberrant effects on coexpressed connexins cause only hearing loss.

172 m) or PPADS (50 mum) but were blocked by the connexin channel blockers octanol (1 mm) and carbenoxolo

173 Different connexin channels have distinct molecular selectivities

174 pansion of hemichannel activity, mediated by connexin channels in a nonjunctional configuration.

175 ed oxidative stress regulates the opening of connexin channels in a system mediated by phosphoinositi

176 f alternative therapeutic strategy targeting connexin channels in AD.

177 A signal property of connexin channels is the ability to mediate selective di

178 Connexins and connexin channels play important roles in cell growth/di

179 Some cancers express connexin channels that allow solute exchange between cel

180 In the absence of connexin channels, Ca(2+) waves are impaired, leading to

181 brainstem were blocked by (1) antagonists of connexin channels, connexin 43 (Cx43) blocking peptide G

182 e was mediated by Ca(2+)-dependent, pannexin/connexin-conductive pathway involving protein tyrosine k

183 base balance of cells at the hypoxic core of connexin-coupled tumor growths.

184 With intact connexin-coupling, acid retention at the core increased

185 Investigation of GJB2 encoding connexin (Cx) 26 revealed heterozygosity for the recurre

186 inst breast cancer cells: a critical role of connexin (Cx) 43 hemichannels in osteocytes in the suppr

187 Our data show that connexin (Cx) 50 regulated lens cell-cycle progression a

188 By using the connexin (Cx) channel inhibitor Gap27 (0.1 mg/kg, IC50 a

189 atodermia variabilis, caused by mutations in connexin (Cx) genes.

190 GJ channels are composed of Connexin (Cx) hexamers paired across extracellular space

191 Expressed adenosine receptor subtypes and connexin (Cx) isoforms were identified by RT-PCR.

192 In the heart, three major connexin (Cx) isoforms, Cx40, Cx43, and Cx45, form GJ ch

193 Connexin (Cx) protein forms hemichannels and gap junctio

194 Mutations of these connexin (Cx) proteins cause dysmyelinating diseases in

195 Gap-junction (GJ) channels formed from connexin (Cx) proteins provide direct pathways for elect

196 Gap junction (GJ) channels, formed of connexin (Cx) proteins, provide a direct pathway for met

197 A connexin (Cx) traverses the membrane four times and has

198 ntercellular communication, specifically via connexin (Cx)-mediated gap junctions (GJs), play a key r

199 Mutations in GJB2 (connexin [Cx]26) cause either deafness or deafness assoc

200 ve function was not observed with other lens connexins, Cx43 and Cx46.

201 3) and Ca(2+) through channels made from two connexins, Cx43 and Cx50, that are highly expressed in v

202 Connexins (Cxs) are a family of membrane-spanning protei

203 The hemichannel configuration of connexins (Cxs) displays isoform-specific permeability p

204 gap junction families: pannexins (Panxs) and connexins (Cxs).

205 In connexin-decoupled spheroids, 4,4'-diisothiocyano-2,2'-s

206 upling in cochlear organotypic cultures from connexin-deficient mice that are models DFNB1 nonsyndrom

207 Separate connexin domains partake in proposed gating mechanisms o

208 ecular bases underlying the dysregulation of connexins during cancer development, offers novel opport

209 s and other extra-cardiomyocyte alterations, connexin dysregulation and Na(+)-channel dysfunction), e

210 eno-associated viral (BAAV) vectors restores connexin expression and rescues gap junction coupling in

211 s of this study were to manipulate inner ear connexin expression in vivo using BAAV vectors, and to i

212 We also found that connexin expression is key to IHC functional maturation.

213 tion, alters their automaticity and enhances connexin expression.

214 The connexin family of membrane proteins enable gap junction

215 ed by gap junctions formed by members of the connexin family.

216 anio rerio, require two gap-junction-forming Connexins for formation and function.

217 a typically astrocytic connexin, is the main connexin forming functional channels in OECs.

218 normalities may involve different aspects of connexin function.

219 We find that one Connexin functions presynaptically while the other funct

220 e than 50 years, deciphering the links among connexins, gap junctions and cancer, researchers are now

221 mouse model to selectively delete candidate connexin genes with temporal control from OECs and addre

222 identified atrial-specific mutations within connexin genes, suggesting that somatic mutations may ac

223 ways in the lens including lens crystallins, connexins, growth factors, membrane proteins, intermedia

224 Gap junction channels made of different connexins have distinct permeability to second messenger

225 sumption of proliferation and a reduction of connexin hemichannel activity.

226 mechanism for Ca(2+) gating among different connexin hemichannel isoforms.

227 bral perfusion, supporting the hypothesis of connexin hemichannel-mediated release of signaling molec

228 In the last decade, it has become clear that connexin hemichannels also provide a pathway for cellula

229 ction in the olfactory bulb, where astrocyte connexin hemichannels are both targets and modulators of

230 Gap junctions and connexin hemichannels are key regulators of the biology

231 nAChRs and connexin hemichannels are potential molecular targets fo

232 Aberrant opening of nonjunctional connexin hemichannels at the plasma membrane is associat

233 In contrast to gap junctions, connexin hemichannels become particularly active in live

234 Moreover, defect of connexin hemichannels by deletion of connexin26 (Cx26) a

235 The release of ATP from connexin hemichannels in cochlear non-sensory cells has

236 The release of ATP from connexin hemichannels in cochlear nonsensory cells has b

237 s to photoreceptors, potentially mediated by connexin hemichannels, appeared unaffected.

238 mediated gating and permeability features of connexin hemichannels, we heterologously expressed Cx30

239 Connexin36 (Cx36) is the most abundant connexin in central nervous system neurons.

240 results point to the expression of a second connexin in mouse horizontal cells.

241 Connexin43 (Cx43), the predominate connexin in the myocardium and epithelial tissues, is ph

242 to intercalated discs, Cx43 being the major connexin in the working myocytes.

243 Connexin 43 (Cx43) is the most ubiquitous connexin in various cells, and presents as hemichannels

244 Our findings suggest that connexins in ependymal cells are potential targets to im

245 eath or exert transdominant effects on other connexins in keratinocytes will lead to skin diseases an

246 Therefore, this study identifies a role for connexins in regulating cell-cycle modulators and, conse

247 Thus, we hypothesized that communication via connexins in the CC is developmentally regulated and may

248 cells with immunohistochemistry for various connexins in the neonatal and the adult (P > 90) normal

249 tive effect when co-expressed with wild-type connexins, including Cx26 and Cx43.

250 Examples include connexin, innexin and pannexin, which form gap junctions

251 er channels with a similar topology, such as connexins, innexins and volume-regulated anion channels(

252 th other large-pore forming proteins such as connexins, innexins, and LRRC8, pannexins have minimal s

253 Stability of the arrangement of connexins is thought to regulate intercellular communica

254 indicates that Cx43, a typically astrocytic connexin, is the main connexin forming functional channe

255 Depending on the connexin isoform, the cluster of channels (the gap junct

256 transfected with connexin45, which is among connexin isoforms expressed in neurons.

257 However, different connexin isoforms have diverse channel-dependent and -in

258 xin26 (Cx26) and Cx30, which are predominant connexin isoforms in the cochlea, did not reduce ATP rel

259 differences in the gating mechanisms between connexin isoforms.

260 Using connexin knock-out mice, we show that IHCs fire spontane

261 In connexin knock-outs, inner hair cells remained stuck at

262 Using connexin knockout mice, we show that IHCs fire spontaneo

263 In connexin knockouts, IHCs remained stuck at a pre-hearing

264 onnexin 26 (Cx26) is co-expressed with other connexins, like Cx43 and Cx30, and as the KID syndrome i

265 llular channels composed of pannexins, being connexin-like proteins recently identified in the liver

266 While the stability of connexin localization in GJ plaques has been studied, mo

267 cological and genetic interventions to block connexin-mediated hemichannel activity specifically in a

268 All connexin mutants were translated into stable, full-lengt

269 ial treatment strategies involving fibrates, connexins, neuroprotectants, photobiomodulation, and ant

270 s, at the N terminus segment of Cx26, change connexin oligomerization compatibility, allowing aberran

271 In contrast, inhibition of connexins, P2Y12, P2Y1 or thromboxane formation had no e

272 To investigate whether connexin phosphorylation regulates the known role of zon

273 Connexins play essential roles in lens homeostasis and d

274 works near the extracellular entrance of the connexin pore, a region thought to be involved in gating

275 Finally, we show that connexin protein expression in cardiac lymphatics is con

276 with increased GJ plaque size and increased connexin protein half-life, while maintaining GJ channel

277 ructures, consisting of gap junction-forming connexin proteins and also multiple scaffolding and regu

278 e arrays of intercellular channels formed by connexin proteins and provide for the direct communicati

279 Connexin proteins are the building blocks of hemichannel

280 analysis to identify the residues within the connexin proteins that determine gap junction plaque sta

281 Connexin-purinergic signaling in enteric glia mediates t

282 chlea provided that the expression of either connexin reaches a threshold level.

283 chlea provided that the expression of either connexin reaches a threshold level.

284 As such, connexins regulate one of the most crucial functional re

285 various inherited skin disorders, but not in connexin-related disease.

286 No indices of electrical, profibrotic, or connexin remodeling were noted in POAF, but Ca(2+)-trans

287 We find here that connexin signaling in the ependyma changes after injury

288 ical coupling mediated by other unidentified connexin subtypes.

289 The emergence of new strategies for connexin targeting, combined with an improved understand

290 , they form selective networks, however, the connexins that support OEC connectivity in vivo have not

291 Connexins, the constituent proteins of gap junctions, ar

292 astrocytes is their high expression level of connexins, the molecular constituents of gap junction ch

293 Connexins, the proteins that form gap junctions in verte

294 ot extrapolate the effect of a kinase on one connexin to another.

295 pendent changes in 29 of 63 ion channel/pump/connexin transcripts, indicating a pleiotropic effect on

296 cellular contact sites composed of clustered connexin transmembrane proteins that act in dual capacit

297 Here, we report the discovery that some connexin types form plaque structures with strikingly di

298 organization of plaques composed of multiple connexin types.

299 ng OP treatment, while the expression of key connexins was unaffected.

300 nsively connected by gap junctions formed of connexins, which also exist as functional hemichannels a