ライフサイエンスコーパス: connexin 36

1 red the presence of the gap junction protein connexin 36.

2 Our data shows that connexin 36, a gap junction protein specific to neurons,

3 ression of the neuronal gap junction protein connexin-36 among inhibitory interneurons and found a re

4 The selective delta cell knockout of connexin 36 confirmed the involvement of gap junctions.

5 which appear to be electrically coupled via connexin 36 containing gap junctions to the vertically o

6 on of heart rate and blood pressure involves connexin 36-containing gap junctions.

7 bility, and we here report that, indeed, the connexin-36-containing glutamatergic mossy fiber synapse

8 Gap-junction coupling of beta-cells by connexin-36 coordinates intracellular free calcium oscil

9 onal gap junction coupling and expression of connexin 36 (Cx36) (neuronal gap junction protein), and

10 During development, two connexin isoforms, connexin 36 (Cx36) and Cx45, are expressed in bipolar ce

11 channels formed by two homologs of mammalian connexin 36 (Cx36) and that, while Cx35 is restricted to

12 We have found variable connexin 36 (cx36) expression in different types of ON c

13 In the retina, connexin 36 (Cx36) gap junctions couple AII amacrine cel

14 at forms an electrically coupled network via connexin 36 (Cx36) gap junctions.

15 ce lacking the neuronal gap junction protein connexin 36 (Cx36) have nearly normal firing patterns at

16 In this study, we studied the expression of connexin 36 (Cx36) in the olfactory epithelium and olfac

17 nd in vitro is associated with a decrease in connexin 36 (Cx36) protein expression.

18 kade of gap junctions or genetic ablation of connexin 36 (Cx36) subunits eliminates the long-range co

19 gical blockade of GJs or genetic ablation of connexin 36 (Cx36) subunits, which are highly expressed

20 e contribution of the gap junctional protein connexin 36 (Cx36) to the regulation of sympathetic acti

21 For connexin 36 (Cx36), the major neuronal connexin, it has

22 ession of the neuronal gap junction protein, connexin 36 (Cx36), transiently increase during early po

23 OB) engage in strong electrical coupling via connexin 36 (Cx36)-mediated gap junctions.

24 ytosolic pores formed by the neuron-specific connexin 36 (Cx36).

25 s well as gap junctions that are mediated by connexin 36 (Cx36).

26 onal gap junction coupling and expression of connexin 36 (Cx36; neuronal gap junction protein) are re

27 beta-cells are electrically coupled via connexin-36 (Cx36) gap junction channels, which coordina

28 Connexin-36 (Cx36) gap junction permeability and associa

29 , hypothalamus, and thalamus of rats express connexin-36 (Cx36) gap junctions (GJs) and couple electr

30 Connexin-36 (Cx36) gap junctions also regulate islet ele

31 f stimulation intensities, primarily through connexin-36-dependent rod pathways.

32 pressed key intercellular junction proteins (connexin-36, E-cadherin, and occludin) at different leve

33 ell strains lacking the gap junction protein connexin-36 exhibited nonnegligible ice propagation rate

34 or incorporating the neuronal promoter human connexin 36 (hCx36) transduced ganglion cells within a d

35 show that, in rabbit retina, an antibody to connexin 36 heavily labels processes of AII amacrine cel

36 immunogold labeling revealed that 70-76% of connexin-36-immunolabeled particles were localized at fo

37 Expression of connexin-36 immunoreactivity is widespread in the forebr

38 unctions be demonstrated in association with connexin-36 immunoreactivity.

39 Connexin-36 is a neuronally specific protein associated

40 ctron microscopy, and electrophysiology that Connexin-36 is necessary for functional gap junctions (G

41 It is known that the gap junction protein connexin-36 is widely expressed in the sexually dimorphi

42 ctional coupling, and was still prevalent in connexin 36 knock-out animals.

43 The recent generation of the connexin-36 knock-out (Cx36 KO) mouse has offered a uniq

44 Utilizing islets from a gap junction protein connexin 36 knockout mouse model together with chemical

45 We characterized the connexin-36 knockout (Cx36(-/-)) mouse phenotype and per

46 recordings in bulb slices from wild-type and connexin 36-knockout (KO) mice.

47 ssion between AII cells and OFF cone BCs and connexin 36-labeled gap junctions between AII cells and

48 Connexin-36 localization was studied in the mouse somato

49 direct OSN inputs are drastically shunted by connexin 36-mediated gap junctions on MCs, but not tufte

50 tial association between GluN2B subunits and connexin 36 on AII amacrines, suggesting that NMDA recep

51 expression of the electrical synapse-forming connexin-36 protein.

52 read distribution of focal concentrations of connexin-36 subunits could provide a basis for the elect

53 g among these interneurons and expression of connexin 36 suggested that they form electrically couple

54 cate an energetic failure; and (2) a loss of connexin 36, suggesting alterations in the AII coupling

55 with myopia is near the GJD2 gene, encoding connexin-36, which forms retinal gap junctions.