ライフサイエンスコーパス: connexin 43

1 shed by gap junctions (GJ) composed of Cx43 (connexin 43).

2 dependent internalization and degradation of connexin 43.

3 the dephosphorylation and internalization of connexin 43.

4 re associated with a significant increase of connexin 43.

5 and profound disturbances in connexin 40 and connexin 43.

6 f Wnt10B, SFRP1, cyclin D1, FzD2, WISP2, and connexin 43.

7 ated with increased expression of myocardial connexin 43.

8 rated lowered expression of the gap junction connexin 43.

9 sperse with elongated macrophages expressing connexin 43.

10 conduction velocity due to downregulation of Connexin 43.

11 s on localization of desmosomal proteins and connexin 43.

12 ion of desmoplakin, plectin, N-cadherin, and connexin-43.

13 ponin I, troponin T, myosin heavy chain, and connexin-43.

14 in plakoglobin, and the gap-junction protein connexin-43.

15 pression of integrin alpha1, PDGF-R1beta and connexin-43.

16 a 53% reduction in the gap junction protein connexin-43.

17 n close association with both N-cadherin and connexin-43.

18 ofibroblast contact dynamism is modulated by connexin-43.

19 ild inflammation and increased expression of connexin 43, a gap junction protein involved with labor.

20 In contrast, connexin-43 abundance was higher (P<0.05) in cerebral co

21 torative effect and a stronger expression of connexin 43, alpha-sarcomeric actin, and major histocomp

22 Hearts were harvested for histology (connexin 43, alpha-sarcomeric actin, CD3, CD11c, major h

23 Connexin-43 also plays an essential role in facilitating

24 ibited hypertrophy and an increased level of connexin 43, an astroglial gap junction protein.

25 bFGF), NPCs express the gap junction protein connexin 43 and are dye-coupled.

26 ion also induced tyrosine phosphorylation of connexin 43 and association with c-Src, events linked to

27 Abundant connexin 43 and cadherin 11 in pellets demonstrated cell

28 This was accompanied by an increase in connexin 43 and connexin 40 expression levels, suggestin

29 diomyocytes >5-fold as reflected by elevated connexin 43 and consortin transcripts.

30 of A(L) cells that are dominant negative for connexin 43 and lack gap junction formation produced a c

31 Connexin 43 and N-cadherin were also present.

32 BMCs and myocytes express at their interface connexin 43 and N-cadherin, and this interaction may be

33 Thus, gap junction channels comprised of connexin 43 and other connexins in airway cells provide

34 hese findings suggest that crosstalk between connexin 43 and purinergic signaling contributes to podo

35 e kinase, resulting in the downregulation of connexin 43 and subsequent electric abnormalities.

36 icant decrease in the gap junction proteins, connexin-43 and connexin-40, was observed in N-cadherin-

37 ers of cellular injury and stress, including connexin-43 and kidney-injury-molecule-1 (Kim-1), were u

38 rogestin-sensitive genes (oxytocin receptor, connexin 43, and cyclooxygenase-2) and prolactins are do

39 cellular levels of E-cadherin, connexin 26, connexin 43, and gap junction.

40 Connexin 26, connexin 43, and gap-junction activity were also increas

41 esultant HCECs were immunostained with ZO-1, connexin 43, and Ki67.

42 ion, that IFN impairs migration by impairing connexin 43, and that impaired healing during NEC is ass

43 tion-associated genes, oxytocin receptor and connexin-43, and block oxytocin-induced contractility in

44 ssion and repressed E-cadherin, connexin-26, connexin-43, and gap junction levels in CRC cells.

45 n cardiac endothelial nitric oxide synthase, connexin-43, and markers of hypertrophy and fibrosis, in

46 unostaining for myosin heavy chain, actinin, connexin-43, and von Willebrand factor VIII showed exten

47 er ID proteins like N-cadherin, desmoplakin, connexin-43, and ZO-1 was significantly perturbed upon p

48 Connexin-32 and connexin-43 are among the most abundant connexins in bra

49 ESCs expressed connexin 43 at intercellular contact sites.

50 cta, and a larger fraction of phosphorylated connexin 43 at serine 368.

51 ibodies to detect total and dephosphorylated connexin-43 at various time points.

52 fic Connexin-43 deletion and pharmacological Connexin-43 blockade were associated with reduced cytoki

53 selective hemichannel blocker) and selective connexin-43 blockers (connexin-43 mimetic peptides (43)G

54 actor (NF)-kappaBeta and upregulated that of connexin 43, both of which sensitized cancer cells to Ta

55 YO5B in the surface trafficking of Kv1.5 and connexin-43 but not potassium voltage-gated channel, sub

56 tokeratin-19, OV-1 antigen, a6 integrin, and connexin 43), cell surface markers recently identified b

57 uired cell-cell contact and the formation of connexin 43-containing gap junctions between monocytes a

58 d PKCgamma was targeted into caveolin-1- and connexin 43-containing lipid rafts, and the PKCgamma pho

59 to spontaneously beating cardiomyocytes via connexin-43-containing gap junctions, cardiac macrophage

60 protein expression of CMC-specific markers, Connexin-43, CTI, CTT, Mef2c, Tbx5, Nkx2.5, GATA-4, and

61 ctional intracellular communication molecule connexin 43 (Cx-43), known to be involved in tumor cell

62 We report that elevated connexin-43 (Cx-43) in stem cells preconditioned with in

63 Gap junctions (connexin-43 [CX-43]) were formed between BCCs and BM str

64 A library clone with disrupted expression of connexin 43 (Cx43) (also known as gap junction protein a

65 e coupled via gap junctions (GJs) comprising connexin 43 (Cx43) (Gja1) and Cx30 (Gjb6), which facilit

66 GJ proteins, connexin 43 (Cx43) and connexin 47 (Cx47), play a crucia

67 Using short hairpin RNA knockdown of Connexin 43 (Cx43) and Cx26 together with rescue experim

68 f cells with dominant-negative constructs of connexin 43 (Cx43) and Cx43-specific antisense oligodeox

69 ecent study showed that gap junction protein connexin 43 (Cx43) and desmosome protein plakophilin-2 a

70 s transported to acidified endolysosomes via connexin 43 (Cx43) and gated by cAMP-EPAC-RAP1-PP2A sign

71 olar again, is associated with expression of connexin 43 (Cx43) and, that knockdown of Cx43 retards,

72 gap junction subunits connexin 26 (Cx26) and connexin 43 (Cx43) are expressed at the contact points b

73 ked by (1) antagonists of connexin channels, connexin 43 (Cx43) blocking peptide Gap26, or Cx43 gene

74 Phosphorylation of connexin 43 (Cx43) by PKC abolishes the permeability of

75 The gap junction protein Connexin 43 (Cx43) contributes to cell fate decisions th

76 Connexin 43 (Cx43) downregulation is associated with nor

77 Conduction slowing was likely due to connexin 43 (Cx43) downregulation, decreased colocalizat

78 nd control uninfected individuals to examine connexin 43 (Cx43) expression and distribution and HIV-a

79 e whether high glucose-induced inhibition of connexin 43 (Cx43) expression and reduced gap junction i

80 stigated and the model displayed predominant connexin 43 (Cx43) expression in basal proliferating cel

81 soluble Si on osteogenic differentiation and connexin 43 (CX43) gap junction communication in culture

82 The pore-forming gap junctional protein connexin 43 (Cx43) has a short (1-3 h) half-life in cell

83 (MAPK) phosphorylation of proteins including connexin 43 (Cx43) has been associated with VSMC prolife

84 function of astroglial gap junction protein connexin 43 (Cx43) has increasingly been associated to n

85 The connexin 43 (Cx43) hemichannel (HC) in the mechanosensor

86 have recently reported an important role of Connexin 43 (Cx43) hemichannels in the pathogenesis of l

87 This study shows that opening of connexin 43 (Cx43) hemichannels leading to the release o

88 Previous studies have implicated connexin 43 (Cx43) in ATP release, but definitive proof

89 Postnatal endothelial-specific deletion of connexin 43 (Cx43) in connexin 37 null (Cx37(-/-) ) mice

90 (+) (mitoK(ATP)) channels, and mitochondrial connexin 43 (Cx43) in cytoprotection, it is not clear ho

91 We investigated the role of connexin 43 (Cx43) in maintaining the integrity of mitoc

92 ia on the expression and channel activity of connexin 43 (Cx43) in melanoma cells and its impact on t

93 , we effectively abolished the expression of connexin 43 (Cx43) in OECs in both juvenile and adult mi

94 Connexin 43 (Cx43) is a gap junction (GJ) protein widely

95 Connexin 43 (Cx43) is expressed in the embryonic heart,

96 The phosphoprotein connexin 43 (Cx43) is the major constituent of gap junct

97 Connexin 43 (Cx43) is the major protein component of gap

98 In mammalian tissues, connexin 43 (Cx43) is the most prominent member of the c

99 Connexin 43 (Cx43) is the most ubiquitous connexin in va

100 we measured accumulation of dephosphorylated Connexin 43 (Cx43) isoform P0 and AMP kinase activation

101 al pharmacological inhibitors, including the connexin 43 (Cx43) mimetic peptide Gap26, carbenoxolone,

102 eceptor agonist; EC50 0.1 microM) stimulated connexin 43 (Cx43) mRNA and protein expression within 1-

103 2) (PGE(2)) had a stimulatory effect on both connexin 43 (Cx43) mRNA and protein expression.

104 tein alpha1 gene (Gja1), resulting in a G60S connexin 43 (Cx43) mutant protein that is dominant negat

105 tion of the ventricular gap junction protein connexin 43 (Cx43) occurs in epicardial border zone myoc

106 Here we show that connexin 43 (Cx43) plays a key role in protection afford

107 udies indicate that the gap junction protein connexin 43 (Cx43) renders GBM cells resistant to TMZ th

108 Overexpression of connexin 43 (Cx43) via transduction of BMSCs with a lent

109 These genes include GJA1 (encoding connexin 43 (Cx43)) and TWIST1, which are highly upregul

110 Herein, we demonstrate that connexin 43 (Cx43), a gap junction integral membrane pro

111 rate that one of these regulating factors is Connexin 43 (Cx43), a gap junction protein highly expres

112 Here, we report that the expression of connexin 43 (Cx43), a major gap junction protein, is mar

113 munoblotting to ZO-1, cytokeratin K12 (K12), connexin 43 (Cx43), cytokeratin K10 (K10), and involucri

114 ns, which differs from another gap junction, connexin 43 (Cx43), during skin wound healing.

115 We have found that connexin 43 (Cx43), expressed by thymic T(R) cells proge

116 expression, turnover and phosphorylation of connexin 43 (Cx43), one of the major proteins of gap jun

117 s evident in mouse lungs lacking endothelial connexin 43 (Cx43), or in rat lungs in which we pretreat

118 Previously, we showed that connexin 43 (Cx43), the main GJ protein in the immune sy

119 Using human and mouse models, we show that connexin 43 (Cx43), the main GJ protein in the immune sy

120 GJA1 encodes connexin 43 (Cx43), the most widely expressed gap juncti

121 the abundance of the gap junctional protein, connexin 43 (CX43), which is highly expressed in astrocy

122 ntrol mice, Abeta25-35 peptide promoted both connexin 43 (Cx43)- and Panx1 HC-dependent MC dye uptake

123 studies have illustrated the significance of connexin 43 (Cx43)-based gap junction in maintaining the

124 et of AMs attached to the alveolar wall form connexin 43 (Cx43)-containing gap junction channels with

125 ical studies revealed that the mBMSCs formed connexin 43 (Cx43)-containing gap junctional channels (G

126 through astrocyte gap junctions composed of connexin 43 (Cx43).

127 nexins, of which the best-studied isoform is connexin 43 (Cx43).

128 ncides with the reduced expression levels of connexin 43 (Cx43).

129 ll to cell through gap junctions composed of connexin 43 (Cx43).

130 ct with the C-terminal cytoplasmic region of connexin 43 (Cx43).

131 ated discs and binds to gap junction protein connexin 43 (Cx43).

132 arcinoma-astrocyte gap junctions composed of connexin 43 (Cx43).

133 rescent dye calcein; (ii) immunostaining for connexin 43 (Cx43); and (iii) measurement of intracellul

134 c kidney 293 (HEK293) cell expressing either connexin-43 (Cx43 HEK) or inward rectifier potassium cha

135 lia-specific disruption of the gene encoding connexin-43 (Cx43) (hGFAP::CreER(T2+/-)/Cx43(f/f) mice).

136 The disease was accompanied by connexin-43 (Cx43) aberrantly enhanced in both cardiac a

137 lated with decreased protein accumulation of connexin-43 (Cx43) and N-cadherin, whereas at later stag

138 Decreasing the amount of functional connexin-43 (Cx43) at the membrane through Cx43 silencin

139 Mutations in the gene encoding connexin-43 (Cx43) cause the human development disorder

140 Connexin-43 (Cx43) gap junctions provide intercellular c

141 pression of the cardiac gap junction protein connexin-43 (Cx43) has been suggested as playing a role

142 il cluster in a contact-dependent manner via connexin-43 (Cx43) hemichannels, which are mediators of

143 stresses within the tissues and depended on connexin-43 (Cx43) hemichannels, which opened preferenti

144 test whether c-Src tyrosine kinase mediates connexin-43 (Cx43) reduction and sudden cardiac death in

145 Connexin-43 (Cx43), a connexin constituent of gap juncti

146 Connexin-43 (Cx43), a gap junction protein involved in c

147 Coupling correlated with levels of connexin-43 (Cx43), a protein previously linked to late-

148 molecules, such as the gap junction protein connexin-43 (Cx43), also influence proliferation.

149 n expression and subcellular localization of connexin-43 (Cx43), the major ventricular gap junction p

150 ancer cells express the gap junction protein connexin-43 (Cx43), yet whether Cx43 regulates collectiv

151 cell-contact dependent and mediated by HSPC connexin-43 (Cx43).

152 e (P4) is known to inhibit the expression of connexin-43 (Cx43, major component of GJs) and GJ format

153 cs, and integral gap junction proteins Cx43 (connexin 43), Cx45 (connexin 45), and ZO-1 (zonula occlu

154 phosphorylation of the gap junction protein connexin 43, decreases gap junction communication, and i

155 Both macrophage-specific Connexin-43 deletion and pharmacological Connexin-43 blo

156 urance-trained R735X-infected mice displayed connexin 43 delocalization at intercardiomyocyte gap jun

157 The connexin 43 density was significantly increased in the m

158 In conclusion, inhibition of autocrine Connexin-43-dependent ATP signalling on macrophages impr

159 During early reperfusion, slow recovery from connexin-43 dephosphorylation leads to persistent CV slo

160 CV slowing was accompanied by connexin-43 dephosphorylation.

161 Direct binding of MMP-7 to connexin-43, determined by surface plasmon resonance tec

162 ibrosis, and conduction defects with altered connexin 43 distribution.

163 tomorphometry of myocardial architecture and connexin 43 distribution.

164 portantly, the activities of stromal AE2 and connexin-43 do not place an energetic burden on cancer c

165 To examine whether diabetes-induced connexin 43 downregulation promotes retinal vascular les

166 Pharmacological inhibition of cSrc mitigates connexin 43 downregulation, slowed conduction, and arrhy

167 Connexin 43/ERK-mediated anti-apoptosis induced by bisph

168 ique pattern of change with development, (3) connexin-43 exhibited ontogenic increases in protein abu

169 the development of NEC, and showed restored connexin 43 expression and intestinal restitution.

170 es a strong correlation between the sites of connexin 43 expression and the clinical phenotype displa

171 d enhanced sarcomere alignment and increased connexin 43 expression at 220 days after transplantation

172 Connexin 43 expression, trafficking, and localization we

173 ated with IFN release and loss of enterocyte connexin 43 expression.

174 TNF-alpha also increased connexin-43 expression and hemichannel activity, but not

175 munoblot was used to measure connexin-32 and connexin-43 expression in cerebral cortices of fetuses a

176 onitis/sepsis model, we identified increased Connexin-43 expression in peritoneal and hepatic macroph

177 mpaired gap junctions (particularly, loss of connexin-43 expression) following stiffening.

178 tenin Tyr142-phosphorylation was mediated by connexin 43/Fer and that the beta-catenin Ser45/Thr41-ph

179 This resulted in disassembly of connexin 43 gap junction plaques and decreased gap junct

180 function and increased strong expressions of connexin 43 gap junction protein in heart and lung speci

181 d rafts, and the PKCgamma phosphorylated the connexin 43 gap junction proteins on Ser-368.

182 Inhibiting connexin 43 gap junctions abolished network activity, su

183 Connexin 43 (gap junction protein) is expressed in pigme

184 um, mice with a heterozygous deletion of the connexin 43 gene (connexin 43+/-) had proteinuria, BUN,

185 was identified that included Nanog, GTCM-1, connexin 43 (GJA1), oct-4, and TDGF1 (cripto).

186 (endothelial nitric oxide synthase), glial (connexin-43, glial fibrillary acidic protein, CD11b), an

187 terozygous deletion of the connexin 43 gene (connexin 43+/-) had proteinuria, BUN, and serum creatini

188 ls such as mitochondrial K(ATP) channels and connexin-43 have now been implicated as critical regulat

189 Our results show that in the olfactory bulb, connexin 43 hemichannel function is promoted by neuronal

190 he osteocyte's response was observed through connexin 43 hemichannel opening.

191 This screen identified Cx43 (connexin 43) hemichannel blockade as a robust suppressor

192 that release further ATP; by 7 h treatment, connexin 43 hemichannels (Cx43 HCs) are also opened.

193 We infused a mimetic peptide that blocks connexin 43 hemichannels into the lateral ventricle of c

194 s, we showed that the activity of astroglial connexin 43 hemichannels, opened in an activity-dependen

195 P is released by efflux through gap junction connexin 43 hemichannels, the opening of which is evoked

196 n receptor, bisphosphonates do so by opening connexin 43 hemichannels.

197 ith the observation that ATP is released via connexin 43 hemichannels.

198 LR-2 and -4 agonists trigger ATP-release via Connexin-43 hemichannels in macrophages leading to poor

199 crossing into a cardiomyocyte-specific Cx43 (connexin 43) heterozygous background.

200 e purity of the SAN protein was confirmed by Connexin 43 immunoblot.

201 Intercalated disk morphology and connexin 43 immunolabelling were not different in hypert

202 ) mice were developed to specifically assess Connexin-43 impact in macrophages.

203 ow that knockout of the gap junction subunit connexin 43 in astrocytes throughout the brain causes ex

204 g Wnt10B, SFRP1, cyclin D1, FzD2, WISP2, and connexin 43 in both genotypes; however, there was a furt

205 mmunoreactive cells and gap junction protein connexin 43 in both small intestine and colon.

206 mmunostaining revealed de novo expression of connexin 43 in damaged glomeruli in patients with glomer

207 studies, ZO-1 colocalized with cadherins and connexin 43 in intercellular junctions.

208 conduction, whereas conditional deletion of connexin 43 in macrophages and congenital lack of macrop

209 ic glia, either reducing glial expression of connexin 43 in Sox10::CreER(T2+/-) /Cx43(f/f) mice or ac

210 ori the transcription factors GATA4 and SRF, connexin 43 in the cell membrane, and myoinositol 1,4,5-

211 cardiac output and decreased expressions of connexin 43 in the heart and lungs.

212 fect localization of desmosomal proteins and connexin 43 in the skin, and result in desmosome aggrega

213 Enterocytes expressed connexin 43 in vitro and in vivo, and exchanged fluoresc

214 N-cadherin and connexin-43 in adherens junction and gap junction betwee

215 expressed primarily in oligodendrocytes and connexin-43 in astrocytes in adult brain.

216 an inward-rectifying potassium channel, and connexin-43 in primary human fibroblasts from the heart,

217 injury elicited a persistent upregulation of connexin-43 in spinal astrocytes for >3 weeks.

218 olangiocyte differentiation (cytokeratin 19, connexin 43, integrin beta4, and gamma-glutamyltranspept

219 ted upregulation of contractile proteins and connexin 43 is a critical step in myometrial activation,

220 ted upregulation of contractile proteins and connexin 43 is a critical step in myometrial activation,

221 n post-MI remodeling and to demonstrate that connexin-43 is a novel MMP-7 substrate.

222 educed gap junctional coupling in areas with Connexin 43 isoform P0 accumulation.

223 ps at baseline, but regional accumulation of Connexin 43 isoform P0 occurred within minutes in all Ca

224 Connexin 43 knockout (Cx43 KO) mice exhibit conotruncal

225 Connexin 43 knockout (Cx43alpha1KO) mice exhibit germ ce

226 Connexin 43 knockout (Cx43alpha1KO) mice have conotrunca

227 -cell impulse transmission (24% reduction in Connexin-43 levels).

228 Connexin 43 loss may provide insights into the developme

229 ced in individuals with glomerular diseases, connexin 43 may be a novel target for therapeutic treatm

230 These findings suggest that connexin 43-mediated communication between the retina an

231 ay require interenterocyte communication via connexin 43-mediated gap junctions.

232 Additionally, the connexin 43+/- mice showed less crescent formation, tubu

233 blocker) and selective connexin-43 blockers (connexin-43 mimetic peptides (43)Gap26 and (37,43)Gap27)

234 acted hypertrophic cardiomyocyte growth, and connexin 43 mislocalization caused by cnNfat3 expression

235 degrees C), followed by analysis of CE cell connexin-43 mRNA and protein by semiquantitative RT-PCR

236 Oxytocin receptor and connexin-43 mRNA expression were reduced in the myometri

237 CE cell connexin-43 mRNA levels in CNTF-treated and (rhCNTFRalph

238 of VIP protein and mRNA, N-cadherin (but not connexin-43) mRNA and protein, and the antiapoptotic Bcl

239 robust expression of cardiac alpha-actinin, connexin 43, myosin light chain 2a, alpha/beta-myosin he

240 e ZO-1-associated proteins such as vinculin, connexin 43, N-cadherin, and alpha-catenin showed no sig

241 We found that pYbeta1 colocalized with connexin-43, N-cadherin, and Nav1.5 at intercalated disk

242 ic compact region around the SAN artery with Connexin 43-negative pacemaker cardiomyocytes visualized

243 Astrocytic connexin-43 (now known as GJ1) has been implicated in ga

244 epithelial junction proteins (ss-catenin and connexin 43), of stromal keratocytes (CD34), of apoptosi

245 the MAP kinase-dependent phosphorylation of connexin 43 on serines 255, 262 and 279/282.

246 gap junction coupling with dominant negative connexin 43 or by disrupting lactate efflux was sufficie

247 lloproteinase-9, collagen I/III, and reduced connexin 43 phosphorylation (P<0.05 versus WKY).

248 As connexin-43 phosphorylation recovered in the reperfused

249 ns of reports indicate that dysregulation of connexin 43 plays an important role in bladder overactiv

250 Connexin-43 processing by MMP-7 was confirmed by in sili

251 that JNK activation led to specific loss of connexin 43 protein and gap junctions without affecting

252 Connexin 43 protein in HCSC and MCSC was examined using

253 d the effects of ontogeny on connexin-32 and connexin-43 protein abundance in cerebral cortices of sh

254 We conclude that (1) connexin-32 and connexin-43 protein are expressed early in fetal life an

255 t at E15.5 albino RPE cells have fewer small connexin 43 puncta, and a larger fraction of phosphoryla

256 markers for astrocytic cells and fibers and connexin 43 puncta.

257 Connexin 43 reboots meiosis and reseals blood-testis bar

258 haT-catenin in mice reduces plakophilin2 and connexin 43 recruitment to the ICD.

259 cardiomyocytes showed sarcolemmal damage and connexin 43 redistribution/internalization.

260 ion at Cys(156), leading to cSrc activation, connexin 43 reduction, impaired gap junction function, a

261 In addition, while levels of connexin 43 remained unchanged, its relocalization from

262 hort hairpin RNA-mediated knockdown of Cx43 (connexin 43) retards the apically directed interkinetic

263 y also express cardiac gap-junction protein, connexin-43, similar to CMs and synchronized spontaneous

264 essed using live microscopy with oleamide or connexin 43 siRNA.

265 agonist, and pretreatment of astrocytes with connexin-43 small interfering RNA.

266 s blocked by carbenoxolone, Gap26/Gap27, and connexin-43 small interfering RNA.

267 nally, therapeutic treatment of GN mice with connexin 43-specific antisense oligodeoxynucleotide impr

268 Treatment of cultured podocytes with connexin 43-specific blocking peptides attenuated TGF-be

269 undergone by the fraction of plasma membrane connexin 43 targeted for macroautophagy and the sequence

270 RATIONALE: Downregulation of Cx43 (connexin 43), the major cardiac gap junction protein, is

271 lated disks, identified by immunostaining of connexin 43, the major protein of cardiac gap junctions.

272 actile proteins and the gap junction protein connexin 43 through cAMP/PKA signaling in human myometri

273 actile proteins and the gap junction protein connexin 43 through cAMP/PKA signaling in human myometri

274 demonstrate a novel mechanism of astrocytic connexin-43 to enhance spinal cord synaptic transmission

275 trol subjects and revealed redistribution of connexin-43 to lateral membranes in sepsis (P < 0.020).

276 igated whether nerve injury could upregulate connexin-43 to sustain late-phase neuropathic pain by re

277 RATIONALE: Delivery of Cx43 (connexin 43) to the intercalated disc is a continuous an

278 were subjected to immunostaining with ZO-1, connexin 43, type IV collagen, laminin-5, and perlecan,

279 GJA1, which encodes the gap junction protein connexin 43, underlie oculodentodigital syndrome.

280 Ralpha) and CNTF (0.83 nM) responsiveness in connexin 43 upregulation were monitored (Western blot an

281 n be counteracted by forced up-regulation of connexin 43, via either gene transfer or proteasome inhi

282 the presence of c-Kit, CD34, Ano1, NTPDase2, connexin 43, vimentin, desmin, PDGFbeta receptor and mer

283 n analyses performed at 24, 72, and 144 hpi, connexin 43 was efficiently downregulated during HCMV in

284 Connexin 43 was expressed at this site from E15 onward,

285 n were reduced, and the gap junction protein connexin 43 was mislocalized to the lateral myocyte bord

286 increased atrial interstitial fibrosis, but connexin 43 was not affected.

287 The transmural distribution of connexin 43 was quantified with immunohistochemistry.

288 F stimulation leading to the upregulation of connexin-43 was demonstrated, and the effectiveness of r

289 ctural remodeling was prominent at 10 weeks: connexin-43 was downregulated and redistributed to later

290 In humans, Connexin-43 was upregulated on macrophages isolated from

291 redox-sensitive gap junctional protein Cx43 (Connexin 43) was reduced in the peri-infarct area of wil

292 ficant decrease in the gap junction protein, connexin 43, was observed in the N-cadherin-depleted hea

293 ern and function of the gap junction protein connexin 43 were examined in vivo in the rat at the inte

294 nd the gap junction proteins connexin 40 and connexin 43 were misexpressed and/or mislocalized in Lmn

295 Expression and distribution of connexin 43 were unaffected, but CAR(+)/(-) hearts displ

296 unction of the beta-catenin signaling target connexin-43 were down-regulated by FH535, and functional

297 eta-catenin and its effectors, cyclin D1 and connexin 43, were up-regulated in TSC-related angiomyoli

298 lated expression of the gap junction protein connexin 43, which has been observed in the progression

299 y, they show convincing co-localization with connexin 43, which was not present in smooth muscle.

300 by gap junctions formed by proteins such as connexin-43, which allows the absorbed acid load to be t