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1 n the genus Conus (known as "conotoxins" or "conopeptides").
2 which together define a new P-superfamily of conopeptides.
3 notably different from other Gla-containing conopeptides.
4 onses to hydroxylated versus nonhydroxylated conopeptides and the relative susceptibility of proteins
8 (V)1.2 and that further engineering of micro-conopeptides belonging to the KIIIA group may provide su
14 somally expressed polypeptide chains of four conopeptides from the venoms of Conus gladiator and Conu
17 because (i) they are not constrained as most conopeptides, (ii) they are extremely short in length, (
19 at are functionally linked to the targets of conopeptides) is another determinant of the elicited beh
22 selection; the magnitude depends on which A-conopeptide lineage and amino-acid locus is analyzed.
23 ustelinus, conolysin-Mt, we expand the known conopeptide mechanisms to include association with and d
24 inding site for the N-channel-specific omega-conopeptide MVIIA, but also a distinct high-affinity sit
25 istinct high-affinity site for another omega-conopeptide (MVIIC), which affects both N- and P/Q-chann
28 o-conotoxin KIIIA is representative of micro-conopeptides previously characterized as inhibitors of t
31 esponses to the K-channel antagonist, kappaM-conopeptide RIIIJ (RIIIJ), reliably identified six discr
35 he venom of Conus purpurascens, is the first conopeptide shown to inhibit the Shaker K(+) channel.
36 C-PrXA is strikingly different from the many conopeptides shown to be nicotinic antagonists; it is mo
38 s might help improve the design of analgesic conopeptides that selectively "avoid" nAChR receptors wh
40 to help identify the allosteric site for rho-conopeptide TIA, an inverse agonist at this receptor.
43 ypeptides stabilized by disulfide bonds, and conopeptides, which have no or only one disulfide bond.
44 we have identified a unique single-disulfide conopeptide with a noncompetitive, potentially allosteri
47 rmatic tools, we found the highest number of conopeptides yet discovered in a single Conus specimen,