ライフサイエンスコーパス: consciousness

1 odifications across systematic reductions in consciousness.

2 o our understanding of clinical disorders of consciousness.

3 graduate student got him interested in human consciousness.

4 ute myeloid leukaemia and depressed level of consciousness.

5 nnels (TREK-1) and reversibly induce loss of consciousness.

6 us to a place of truly new insight regarding consciousness.

7 ow that hASR predicts 6-month improvement of consciousness.

8 tunity to study the neurobiological basis of consciousness.

9 brain stimulation can alleviate disorders of consciousness.

10 mplications for ethics and for the nature of consciousness.

11 tion of the role of connectivity in level of consciousness.

12 )sleep, characterised by different levels of consciousness.

13 rkspace and integrated information theory of consciousness.

14 Psychedelics exert unique effects on human consciousness.

15 ion, and direction of change in the state of consciousness.

16 y MRI findings that best predicted the level consciousness.

17 networks in anesthetic effects on memory and consciousness.

18 hy (TMS-EEG), breaks down during the loss of consciousness.

19 etween reported unconsciousness and reported consciousness.

20 logical underpinnings of immersive states of consciousness.

21 e neurons should support a greater degree of consciousness.

22 l in relating body representations to bodily consciousness.

23 to resolve debates about the neural basis of consciousness.

24 ea or a combination thereof, without loss of consciousness.

25 se neurons during anesthetic-induced loss of consciousness.

26 ent pools of neurons behave as a function of consciousness.

27 idual cognition and a subsequent recovery of consciousness.

28 as been criticized for overintellectualizing consciousness.

29 y were implicated in studies of disorders of consciousness.

30 lated to movement disorders and disorders of consciousness.

31 of relevance for understanding mechanisms of consciousness.

32 lex locomotor actions in the absence of full consciousness.

33 different from that observed during loss of consciousness.

34 ized by frequent and transient impairment of consciousness.

35 gnosis of patients with chronic disorders of consciousness.

36 were clinically stable with no alteration in consciousness.

37 n interactions in patients with disorders of consciousness.

38 ress in detecting and predicting recovery of consciousness.

39 Responsiveness was used as a surrogate for consciousness.

40 sts a voluntary behavior with maintenance of consciousness.

41 racterized by motor difficulties and altered consciousness.

42 lded values exceeding those of normal waking consciousness.

43 vior in terms of cognition, rationality, and consciousness.

44 eveal visual mechanisms behind attention and consciousness.

45 nitive processing-the sole purview of waking consciousness.

46 ntral challenge in research on attention and consciousness.

47 at a time, integration across time, and self-consciousness.

48 standing interspecies variation in states of consciousness.

49 ght to be the building blocks of spontaneous consciousness.

50 mpening brain activity and promoting loss-of-consciousness.

51 t differ in several other respects than only consciousness.

52 vided reliable evidence of preserved minimal consciousness.

53 ed for new approaches to the neuroscience of consciousness.

54 an unreliable metric for arousal/recovery of consciousness.

55 the way for the current wave of research on consciousness.

56 neural networks and promote re-emergence of consciousness.

57 extraction activities should embrace climate consciousness.

58 n S1 and higher-order PMv prior to return of consciousness.

59 topological alterations observed in loss of consciousness.

60 than a subset of cells perfectly reflecting consciousness.

61 alongside old-growth forests, in the public consciousness.

62 been called upon to explain the emergence of consciousness.

63 rum was suggested to be critically linked to consciousness.

64 gestive of a direct causal effect of tDCS on consciousness.

65 , and angular gyri are fundamental for human consciousness.

66 ely limited to study of neural correlates of consciousness.

67 f response, this assured future regaining of consciousness.

68 ovide insight into object-specific access to consciousness?

69 functions that range from decision-making to consciousness(1).

70 neurologic manifestations were alteration of consciousness (27 of 37, 73%), abnormal wakefulness when

71 ere malaria; 421/2,208 (19.1%) with impaired consciousness, 665/2,240 (29.7%) with inability to drink

72 evere malaria: 421/2208 (19.1%) had impaired consciousness, 665/2240 (29.7%) had an inability to drin

73 hesized that it may serve as a biomarker for consciousness(7).

74 If so, the loss of consciousness, a feature of sleep, would be the conseque

75 Therefore, to isolate the neural basis of consciousness, a no-cognition paradigm is needed.

76 Raising consciousness about clinical significance should be an i

77 ehavioral arrest, moderate-to-severe loss of consciousness (absence), and distinct spike-wave dischar

78 th a two-level normalization model, in which consciousness affects only the first level and attention

79 ion and oxygen therapy, the patient regained consciousness after a few minutes.

80 Consciousness also depends on deep-layer neurons providi

81 cortex possesses a true neural correlate of consciousness and (2) this correlate consists of a popul

82 thus likely to participate in the control of consciousness and attention.

83 differences in brain dynamics between normal consciousness and both drug-states.

84 l dynamics is necessary for the emergence of consciousness and complex cognition, and that reduced or

85 Early detection of covert consciousness and cortical responses in the intensive ca

86 how the brain transitions between states of consciousness and drug-induced unconsciousness, or anest

87 ntions aimed at improving patients' level of consciousness and functional recovery were behavioural a

88 biological mechanisms underlying recovery of consciousness and have enabled the identification of pre

89 layer-specific thalamocortical correlates of consciousness and inform how targeted deep brain stimula

90 ected loss of heart function, breathing, and consciousness and is commonly the result of an electric

91 eveal the neural mechanisms underlying human consciousness and its disconnection from behavioral resp

92 erience, mediating both acute alterations in consciousness and long-term effects.

93 Anesthesia blocks consciousness and memory while sparing non-conscious bra

94 harges (SWDs) in the EEG and interruption of consciousness and ongoing behavior.

95 effects, in which individuals report altered consciousness and perceptions of themselves and their en

96 Together, these data show that access consciousness and perceptual integration can be dissocia

97 and provide an accessible tool that signals consciousness and recovery in patients with brain injuri

98 visual mismatch negativity independently of consciousness and task relevance.

99 ' respectively present one's self-protection consciousness and the ability of gaining information.

100 omputational mechanisms behind attention and consciousness and the perceptual consequences that they

101 ostic accuracy of patients with disorders of consciousness and to provide guidelines regarding the nu

102 aphy (EEG) signatures of transitions between consciousness and unconsciousness under anaesthesia have

103 ased beta connectivity was noted relative to consciousness and unconsciousness, again with increased

104 frontal and posterior cortices in mediating consciousness and unconsciousness.

105 d an acute-onset severe headache and loss of consciousness and was diagnosed with a Hunt and Hess gra

106 f clinically apparent seizures with improved consciousness and without additional antiseizure medicat

107 the cerebral cortex (for amnesia and loss of consciousness) and to the spinal cord (for atonia and an

108 movement disorders, 22 treated disorders of consciousness, and 14 treated other neurologic condition

109 "unresponsiveness" and internally generated consciousness, and by comparing brain activity levels ac

110 pressure, lower central temperature, altered consciousness, and decreased urine output was independen

111 e validity of the proposed EEG signatures of consciousness, and is suggestive of a direct causal effe

112 may help reveal brain mechanisms underlying consciousness, and minimize POCD in the choice and devel

113 Longer duration of illness, depressed consciousness, and peripheral blood eosinophilia were as

114 es (SWDs), behavioral arrest, and diminished consciousness are cardinal signs of seizures in human ab

115 t be based on a careful consideration of how consciousness arises in the only physical system that un

116 that most proponents of HOT do not stipulate consciousness as equivalent to metacognition or confiden

117 sical hand position, but also on bodily self-consciousness as quantified through illusory hand owners

118 enomenology constitutes an elevated level of consciousness - as measured by neural signal diversity.

119 and alter the time to loss and resumption of consciousness associated with isoflurane, a potent halog

120 epilepticus and improvement in the level of consciousness at 60 minutes occurred in 68 patients assi

121 Without behavioural evidence of consciousness at the bedside, clinicians may render an i

122 Is consciousness based in prefrontal circuits involved in c

123 te severe traumatic brain injury may recover consciousness before self-expression.

124 Among those with impaired consciousness (Blantyre Coma Score <=4), transfusion was

125 Many small molecules are used to alter human consciousness, but the repertoire of underlying molecula

126 oss of pain) independent of inducing loss of consciousness, but the underlying mechanisms remain uncl

127 ent seizures and improvement in the level of consciousness by 60 minutes after the start of drug infu

128 s from propofol-induced unconsciousness into consciousness by directly recording local field potentia

129 Unconscious patients predicted to recover consciousness by ICU discharge had better long-term func

130 of MRI and half of these patients recovered consciousness by ICU discharge.

131 y a more widespread role in the "piercing of consciousness" by non-conscious thought processes.

132 activity taking place below the threshold of consciousness, by design.

133 We conclude that the level of consciousness can be dissociated from cortical connectiv

134 These results demonstrate that attention and consciousness can effectively show different gain functi

135 ansitions in and out of the altered state of consciousness caused by intravenous (IV) N,N-Dimethyltry

136 pidly induce an extremely immersive state of consciousness characterized by vivid and elaborate visua

137 a bands were also significantly lower during consciousness compared to unconsciousness, with differen

138 ose who reported >=1 hit followed by loss of consciousness, compared to those who did not, also exhib

139 We suggest that the word "consciousness" conflates two different types of informat

140 ] and increased focal seizures and decreased consciousness considered to be medically significant [a

141 The two leading cognitive accounts of consciousness currently available concern global workspa

142 I and electrophysiology studies suggest that consciousness depends on large-scale thalamocortical and

143 ensive care unit (ICU) and found that covert consciousness detected by EEG is associated with better

144 displayed a response-gain function, whereas consciousness displayed a contrast-gain function.

145 in brain state that disrupt the contents of consciousness distinct from arousal and awareness of tho

146 Disorders of consciousness (DOC) are a common consequence of severe b

147 consciousness in patients with disorders of consciousness (DoC) caused by severe brain injuries.

148 The management of patients with disorders of consciousness (DOC) constitutes a challenge for clinicia

149 juries can lead to long-lasting disorders of consciousness (DoC) such as vegetative state/unresponsiv

150 urrent taxonomy of postcomatose disorders of consciousness (DoC), and it provides guidelines for how

151 rsus unresponsive and disconnected states of consciousness during constant anesthetic exposure reveal

152 changes in EEG connectivity associated with consciousness during non-rapid eye movement (NREM) sleep

153 low frequencies, is a potential indicator of consciousness during sleep.

154 networks are especially affected by loss of consciousness during temporal states of high integration

155 ing, for instance in diagnosing disorders of consciousness (e.g., coma, vegetative-state, locked-in s

156 cal brain structures are integral to motion, consciousness, emotions and learning.

157 Prominent theories of consciousness emphasise different aspects of neurobiolog

158 Study 1 analyzes stream-of-consciousness essays by 1,567 college students.

159 conditions in which brain activity supports consciousness even when that activity is fully causally

160 STATEMENT A number of prominent theories of consciousness exist, and a number of these share strong

161 How consciousness (experience) arises from and relates to ma

162 Investigation of consciousness (experience, mind, awareness, subjectivity

163 addition to previously validated markers of consciousness extracted from electroencephalograms (EEG)

164 43.7% and strongly associated with decreased consciousness, fever, and focal neurological signs.

165 of deep structural lesions for impairment of consciousness following hemorrhagic stroke and recovery

166 nts remained in a prolonged state of altered consciousness for a median of 2 days (interquartile rang

167 nal connectivity patterns that differentiate consciousness from unconsciousness remain unclear.

168 The higher-order theory (HOT) of consciousness has often been misunderstood by critics.

169 acteristics, different behaviours and health consciousness have an impact on the occupational health

170 aging studies of humans in altered states of consciousness have prompted the suggestion that maintena

171 scale (HR: 1.7; 95% CI: 1.1, 2.6), impaired consciousness (HR: 16.7; 95% CI: 3.1, 90.4), and a capil

172 egions was related to increased frequency of consciousness-impairing seizures (p<0.01, Pearson's corr

173 uggested as the mechanism underlying loss of consciousness in anesthesia.

174 of studies that argue for no causal role for consciousness in decision-making to real-life decisions.

175 w this as evidence against a causal role for consciousness in human decision-making and thus against

176 The loss of consciousness in non-REM (NREM) sleep or to GAs is chara

177 ate of up to 40% in determining the state of consciousness in patients with brain injuries(4,5).

178 own as the sniff response(8-11) to determine consciousness in patients with brain injuries.

179 ecting, predicting and promoting recovery of consciousness in patients with disorders of consciousnes

180 werful tool to study the functional bases of consciousness in physiological and pathological conditio

181 She lost consciousness in shock and sustained life-threatening in

182 nature of temporal experience or the role of consciousness in temporal cognition.

183 ephalography techniques have revealed covert consciousness in the chronic setting, but these techniqu

184 ly available for computation and report (C1, consciousness in the first sense), and the self-monitori

185 was accompanied by (i) neural signatures of consciousness in the form of a sustained desynchronizati

186 lography (EEG) in patients with disorders of consciousness in the intensive care unit (ICU) and found

187 subjective sense of certainty or error (C2, consciousness in the second sense).

188 We manipulated consciousness in two experiments in a group of healthy m

189 d volunteers, and patients with disorders of consciousness, in order to identify consciousness-specif

190 th an enhancement of putative EEG markers of consciousness: in comparison with non-responders, respon

191 waking state and (ii) in an altered state of consciousness induced by ingestion of Ayahuasca.

192 signals from humans during altered states of consciousness induced by three psychedelic substances: p

193 es can be catastrophic, resulting in loss of consciousness, injury and even death.

194 te model of memory as a way of fractionating consciousness into components that account for wide rang

195 e that one element of expanding a science of consciousness is appreciation of the interdependent co-c

196 of the theory that propofol-induced loss of consciousness is associated with disrupted thalamocortic

197 ul paradigm to identify neural correlates of consciousness is binocular rivalry, wherein a constant v

198 Consciousness is currently a thriving area of research i

199 to understand the biological basis of human consciousness is currently one of the greatest challenge

200 during anesthetic-induced altered states of consciousness is not completely understood.

201 the actual dynamics change during return of consciousness is not simply an inverse of loss of consci

202 of propofol, supporting the hypothesis that consciousness is related to complexity - independent of

203 research, it is not known whether access to consciousness is required to complete perceptual integra

204 EMENT The relationship between attention and consciousness is still debated.

205 thermore, an important issue in the study of consciousness is the prevalent confound of conscious per

206 he operational way to assess wakefulness and consciousness is through responsiveness.

207 n, and of human patients to gain clues about consciousness itself.

208 elected due to their differential effects on consciousness (ketamine, but not propofol, is known to i

209 Exclusion criteria were disorders of consciousness lasting more than 30 days and focal brain

210 rement, oxygen saturation, respiratory rate, consciousness level, and other evidence of clinical dete

211 ical layers are most sensitive to changes in consciousness level, consistent across different anesthe

212 rd, we obtained duration of hospitalization, consciousness level, disease severity, medical cost, and

213 ular effects, how anesthesia induces loss of consciousness (LOC) and affects sensory processing remai

214 story of traumatic brain injury with loss of consciousness (LOC) was reported in one CTE and one AD s

215 ronal dynamics during transitions of loss of consciousness (LOC) with the alpha2-adrenergic agonist d

216 by TBI severity (no TBI, TBI without loss of consciousness [LOC], and TBI with LOC).

217 Major theories of consciousness make distinct predictions about the role o

218 itself as a response-gain function, whereas consciousness manifests itself as a contrast-gain functi

219 cognition, and that reduced or disorganized consciousness may be associated with deviations from cri

220 at some patients with prolonged disorders of consciousness might benefit from therapeutic interventio

221 d 17 patients revealing signs of fluctuating consciousness (Minimally Conscious State).

222 t neurons more readily exhibit properties of consciousness (neural complexity and noise correlation)

223 Consciousness never fades during waking.

224 t can be difficult to determine the state of consciousness of a patient, to determine whether the pat

225 This expansion of researchers' consciousness of bias could inform the management of apo

226 What is the level of consciousness of the psychedelic state?

227 of a stimulus is separable from the "access consciousness" of its reportability.

228 y: the degree to which the "phenomenological consciousness" of the experience of a stimulus is separa

229 of cardiac activity associated with loss of consciousness, of spontaneous breathing, and of circulat

230 en positive, is used to infer restoration of consciousness, often without further behavioral corrobor

231 Here, the influence of both attention and consciousness on these functions were measured and they

232 travel strongly rely, at different levels of consciousness, on past and ongoing sensory input, bodily

233 ), rash (two), hyperglycaemia (one), loss of consciousness (one), sepsis (one), and vomiting (one).

234 It is not yet known whether attention and consciousness operate through similar or largely differe

235 ble for patients with prolonged disorders of consciousness, optimised stimulation parameters, alterna

236 aseline in concussed athletes with a loss of consciousness or amnesia.

237 Among those with impaired consciousness or hyperlactataemia, transfusion was assoc

238 Emerging evidence suggests that covert consciousness, or cognitive motor dissociation (CMD), is

239 s unexplained altered mental status, loss of consciousness, or poor arousal and responsiveness.

240 Emotional states of consciousness, or what are typically called emotional fe

241 as model systems in experimental studies on consciousness, previous research results have been confo

242 s against each dimension, we can construct a consciousness profile for that species.

243 Rather, each species has its own distinctive consciousness profile.

244 quences developing a better understanding of consciousness promises to bring, for instance in diagnos

245 First, attention lowered CRFs, whereas consciousness raised them.

246 re brain injuries and prolonged disorders of consciousness raises important issues particularly with

247 as well as its important prognostic value on consciousness recovery.

248 While the loss and return of consciousness regulated by anesthetic drugs and physiolo

249 for the cardiac cycle modulations and other consciousness-related EEG markers were combined, single

250 These results show that human consciousness relies on spatio-temporal interactions bet

251 The specific contents of human consciousness rely on the activity of specialized neuron

252 The role of the frontal cortex in consciousness remains a matter of debate.

253 How general anesthesia (GA) induces loss of consciousness remains unclear, and whether diverse anest

254 nation for how these changes lead to loss of consciousness remains unclear.

255 ding objective characterization of states of consciousness, repeated assessments of network metrics c

256 Similar to loss of consciousness, return of consciousness was identified wi

257 nergic agonist dexmedetomidine and return of consciousness (ROC) in a functionally interconnecting so

258 provides an important experimental tool for consciousness science and psychiatry.

259 Traversing visual neuroscience, consciousness science, genetics, chronobiology, and biol

260 ck and Koch (1998) claimed that a science of consciousness should first search for its neural correla

261 entral core brain network critical for human consciousness.SIGNIFICANCE STATEMENT Trying to understan

262 d volume were related to higher frequency of consciousness-sparing seizures (p < 0.02, Spearman's rho

263 rders of consciousness, in order to identify consciousness-specific patterns of brain function.

264 Loss of consciousness, status epilepticus classification, or age

265 o events that took place in the early 1990s, consciousness studies today are a continuation of resear

266 ions associated with changes in the level of consciousness, such as following severe brain injury or

267 Altered states of consciousness, such as psychotic or pharmacologically-in

268 reated as different from cognitive states of consciousness, such as those related to the perception o

269 .SIGNIFICANCE STATEMENT Numerous theories of consciousness suggest that functional connectivity acros

270 iousness is not simply an inverse of loss of consciousness, suggesting a unique process.

271 brain dynamics of patients with disorders of consciousness systematically change between day and nigh

272 on) and are more impacted during the loss of consciousness than integrative neurons.

273 ular interest to neuroscience is the loss of consciousness that accompanies both states.

274 ve, brain-based measures of the capacity for consciousness that are independent of sensory processing

275 Here, he tells us what is on his mind about consciousness these days.

276 s constitute the fundamental currency of our consciousness: they are the things that we perceive, rem

277 We used a visual masking paradigm to measure consciousness threshold, and diffusion MRI tractography

278 h structural connectivity is correlated with consciousness threshold, particularly in psychosis.

279 , as compared to a rather consistent loss of consciousness time.

280 ngle macaque as the animal transitioned from consciousness to unconsciousness under different anaesth

281 l substrates involved in the transition from consciousness to unconsciousness.

282 tures (e.g., respiratory distress or reduced consciousness) to receive immediate blood transfusion wi

283 s predicted both, impairment and recovery of consciousness, together with established measures of mas

284 sible delirium, headache, decreased level of consciousness, tremor, and seizures were most commonly o

285 EEG signatures for monitoring the levels of consciousness under sedation.

286 y changes were consistent with the fading of consciousness using its surrogate responsiveness.

287 gate this question, we manipulated access to consciousness using the attentional blink.

288 We assessed delirium and level of consciousness using the Confusion Assessment Method-ICU

289 crucial for adaptive behaviour yet access to consciousness varies for different types of objects.

290 How does consciousness vary across the animal kingdom?

291 phalopathy (CTE) has recently entered public consciousness via media reports and even a Hollywood mov

292 indow to evaluate patients with disorders of consciousness via the embodied paradigm, according to wh

293 The return of consciousness was distinguishable by a distinctive retur

294 Similar to loss of consciousness, return of consciousness was identified with an abrupt shift of dyn

295 Analogous findings were obtained when consciousness was regulated by physiological sleep.

296 To understand visual consciousness, we must understand how the brain represen

297 bs of connectivity discriminated behavioural consciousness with accuracy comparable to that achieved

298 and 15, suggesting that clinicians confused consciousness with decision-making capacity.

299 present a generalisable biomarker of loss of consciousness, with potential relevance for clinical pra

300 erved in humans, self-awareness and internal consciousness would be impaired if not abolished.