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2 group IVa cytosolic phospholipase A(2) with consequent AA release for synthesis of all eicosanoids,
3 loss is linked to malignant degeneration via consequent aberrant DNA methylation, and possibly to car
4 to tau-mediated relaxation of chromatin and consequent aberrant expression of multiple biotin-relate
5 design and assessment are possible, and the consequent ability to precisely abrogate specific MMP ac
6 pening of the tight junctions in vitro and a consequent about 3-fold improvement in paracellular tran
7 ons in homogentisate 1,2-dioxygenasegene and consequent accumulation of homogentisic acid (HGA), caus
8 ein confinement at the connecting cilium and consequent accumulation of inner segment membrane protei
10 rotein precursor ions in a single window and consequent acquisition of composite tandem mass spectra
13 -time analyses of GPCR ligand engagement and consequent activation, measured as receptor internalizat
17 uppresses sensitization to aeroallergens and consequent allergic lung inflammation in a murine model
18 sults show that alternative core packing and consequent allosteric modulation of binding interfaces c
23 novel role for MALAT1 dysregulation and the consequent AS alteration in MS pathogenesis, based on an
24 s ILC2s chronically for IL-13 production and consequent asthma-like disease traits that peak and last
29 esistance, which provoked carbapenem use and consequent carbapenem resistance and finally increased c
30 wever, the contribution of vascular leak and consequent cardiac edema to the genesis of atrial arrhyt
32 f androgen to enhance androgen signaling and consequent cell proliferation, leading to castration-res
33 evolution is necessarily constrained by the consequent challenge to protein folding and function.
37 endent aberrant DNA methylation of NR3C1 and consequent changes in other stress-related genes might b
39 marked by two global glaciations with strong consequent changes in the amount of available marine ben
40 C)n trinucleotide repeats (n = 1, 4) and the consequent changes in the overall structure of the RNA a
41 olae can enrich specific lipid species, with consequent changes in their localization upon caveolar f
42 e extracellular environment through MSCs and consequent changes to histone modification state and chr
43 nt through mechanosensitive ion channels and consequent changes to histone modification state and chr
46 finity to Hsc70, CHIP protein half-life, and consequent clearance of stress-induced ubiquitinated-ins
47 g the successive somatic genetic changes and consequent clonal expansions that lead to cancer(1).
53 ) inhibition of mitochondrial Complex 1 with consequent compromised ATP and AMP homeostasis or 2) inh
54 drial electrogenic transport mechanisms with consequent compromised malate-aspartate shuttle and chan
55 ate-containing 2-oxoacid dehydrogenases with consequent control over glycolysis and mitochondrial res
58 osphoinositide 3-kinase (PI3K) pathway, with consequent CREB-dependent transcription of antiinflammat
61 an increase in the net phosphorylation and a consequent decrease in catalytic activity of sperm GSK3.
62 nspiration, mainly driven by snow loss and a consequent decrease in reflection of solar radiation.
64 reduced thermodynamic activity of KTP, and a consequent decrease in the maximum achievable aqueous ph
66 eletion of the X-linked gene, Cosmc, and the consequent decrease of protein O-glycosylation, induces
67 RC1 signaling and increased autophagy with a consequent decreased myotube diameter to a greater exten
69 able to reductions in primary production and consequent degradation of ecosystem services as climate
70 te understanding of the role of IDO1 and the consequent degradation of tryptophan in mRNA translation
71 nd LIKE HETERCHROMATIN PROTEIN 1 (LHP1), for consequent deposition of H3K27me3 marks, leading to repr
73 In addition, hepatocyte ATX ablation and the consequent deregulation of lipid homeostasis was also sh
75 enhancement of volatile GeO(x) formation and consequent desorption from the SiGe with ozone insertion
77 lar signal-regulated kinase 5) signaling and consequent detrimental overexpression of KLF (Kruppel-li
78 tion of pancreatic stellate cells (PSCs) and consequent development of dense stroma are prominent fea
79 ienced by the TCs within a few weeks and the consequent differences in their organization of vortex-s
81 s most free iodide ions, thus preventing the consequent dissolution of the cathode-plated iodine as t
82 ts in its nuclear export for degradation and consequent down-regulation of FOXO3a-target autophagy-re
83 rrect selection of polo poly(A) signals with consequent downregulation of Polo expression levels and
84 ing of information across data sites, with a consequent drastic reduction in estimation uncertainty;
85 achieve receptor saturation, but also on the consequent drug release rate being tuned to ensure prolo
88 des litter particle size and shape and their consequent effect on fuel bed structure, ventilation and
89 nanoparticle systems, their formulations and consequent effect on pharmacokinetic distribution of del
90 ng individual CTCF insulators and evaluating consequent effects on genome topology and transcription.
91 the tumour microenvironment, as well as the consequent effects on liver tumorigenesis, are not compl
93 rsity, such as dispersal limitation, and the consequent effects on productivity is less well known.
94 rication properties of the platform, and the consequent effects on tissue function, were demonstrated
95 monstrate that hepatic AR up-regulation, and consequent elevation in fructose, sorbitol and/or uric a
101 ding to parasite sequestration in organs and consequent excessive inflammatory responses and endothel
104 local maximum of the phytohormone auxin, and consequent expression of CLASS III HOMEODOMAIN-LEUCINE Z
106 in improved multi-level signal detection and consequent extraction of reliable information about topo
109 tional phases of hypoemia and hypermia, with consequent fluctuations in shear rate, occuring during r
110 in China, where rapid population growth and consequent food demand must be balanced against potentia
113 sulted in its increased degradation with the consequent formation of volatile sulfur compounds, namel
115 egenerative macrophage polarization with the consequent functional recovery of endothelial cells.
121 role of LA metrics in evaluation of LVDD and consequent heart failure with preserved ejection fractio
123 ed reductions in gross CO(2) emissions, with consequent high risk of overshooting global temperature
124 r comparatively rapid evolutionary rates and consequent high taxonomic resolution, mitochondrial sequ
125 hat higher initial BSA concentration and the consequent higher BSA surface loading enhanced BSA adsor
129 ling is elevated in Rab23(-/-)sutures with a consequent imbalance in MAPK, Hedgehog signaling and RUN
132 ulating adipocyte inflammatory potential and consequent impact of such inflammation in disease pathog
133 ormal fluid flow intensity and pattern, with consequent impact on dand5 expression pattern and left-r
134 te proliferation on lipid metabolism and the consequent impact on whole-body physiology, we performed
137 malization of endogenous D-serine levels and consequent improvement of nigrostriatal hypoglutamatergi
139 that SidJ polyglutamylation of SidE, and the consequent inactivation of Ub ligase activity, is requir
140 include elevated tissue transglutaminase and consequent inactivation through C-terminal cross-linking
141 ds to increased levels of FSP1 protein and a consequent increase in the levels of coenzyme Q(10), an
143 1, resulting in elevation of PYCR1 level and consequent increase of proline synthesis and cell prolif
145 gregates and dysfunctional mitochondria, the consequent increased production of reactive oxygen speci
147 smotic pressure gradients between cells with consequent increases in cellular ion concentrations driv
149 arco-trafficking of heroin and fentanyl with consequent increases in opioid overdose mortality As inj
150 ncreased uplift and erosion of mountains and consequent increases in silicate weathering, which remov
151 creased in microglia at 24 h after SAH, with consequent increases in the downstream molecules myeloid
153 panded energy and resource utilization, with consequent influence on global processes much greater th
154 , the prevalence, optimal treatment, and the consequent influence on mortality, morbidity, and graft
155 sociated increment of oxidative damage, with consequent inhibition of cell activation and eventual ce
156 ossmann fold closes the catalytic cleft with consequent inhibition of the deamination process. In sil
157 in the mechanisms of infection, spread, and consequent inhibition of the viral lifecycles by neutral
158 ith this may reduce their systemic entry and consequent injury during cholestasis, such as from bilia
159 the initial steps of viral infection and the consequent innate immune responses within the natural co
160 ensatory increase in beta-cell mass, and the consequent insulin secretion, can effectively cope with
161 to the integrin beta cytoplasmic domain and consequent integrin activation, platelet aggregation, an
166 tracellularly via electron shuttles, and the consequent ion migration led to high anode salinities an
169 t is due to mutations in the DMD gene with a consequent lack of dystrophin protein that leads to dete
170 ity and complexity of human brain tissue and consequent lack of insight into disease mechanisms.
171 its virtual absence of bioinclusions and the consequent lack of palaeontological information, which i
172 nd Prevention for transmission to NCHS, with consequent lag in capturing the total number of deaths c
175 om endothelial-to-mesenchymal transition and consequent liver fibrosis in mice via a SMAD3-dependent
177 linker region in the PCBP2/SLIVm complex and consequent loss of affinity of PCBP2 for the SLIVm upon
178 metals to reduction and aggregation and the consequent loss of catalytic activity and selectivity li
179 otic-mediated microbiota destruction and the consequent loss of colonization resistance can result in
180 tant CSPalpha causes its mislocalization and consequent loss of its synaptic SNARE-chaperoning functi
184 ate that down-regulation of GDPGP1/mcp-1 and consequent loss of neuronal glycogen is a maladaptive re
185 d Frenkel/mixed-Frenkel-CT character and the consequent loss of null exciton/monomer-like properties.
186 eins and highlight low kappaB-Ras levels and consequent loss of Ral control as risk factors, thus emp
187 The breakdown of the epidermal barrier and consequent loss of skin hydration is a feature of skin a
188 f particularly radiosensitive cell types and consequent loss of specific cellular functions, the loca
191 Intervertebral disc (IVD) degeneration and consequent low back pain (LBP) are common and costly pat
194 nce on chemical-bonding interactions, and on consequent material properties, of chalcogenides has not
195 > 1000, 524 and 82 kDa respectively) with 3 consequent meals on oat-derived phenolic compounds in ur
196 icipants who had engaged in NSSH reported no consequent medical or psychological service contact, com
199 e speed of pCPI-17 dephosphorylation and the consequent MLCP activation during muscle relaxation.
200 unterclockwise to clockwise rotation, with a consequent modulation of the bacterial swimming behavior
202 inhibiting c-Maf in myeloid progenitors, and consequent myeloid-lineage cells, including TAMs, delaye
204 stoma due to MYCN oncogene amplification and consequent N-Myc oncoprotein over-expression die of the
205 ation as a key mediator of neuroinvasion and consequent neuroinflammatory processes, as observed in p
206 relative to functional mitochondria and the consequent neuronal injury are determined by Fis1-mediat
208 ergy-dense foods, particularly fructose, and consequent obesity and insulin resistance (metabolic syn
209 cause of the elevated outflow resistance and consequent ocular hypertension characteristic of glaucom
210 (PE) is characterized by poor placentation, consequent on aberrant extravillous trophoblast (EVT) ce
212 ined by the presence of systemic hypoxia and consequent on disordered neutrophilic inflammation.
214 on that critical telomere shortening and the consequent onset of telomeric DNA damage and cellular se
216 ecular basis of HI/HA dominant mutations and consequent over-activity of GDH through alteration of th
217 fluenced chloroplast electron transport with consequent overreduction of plastoquinone and donor-side
218 ate cancer has resulted in overdiagnosis and consequent overtreatment as well as underdiagnosis and m
219 ulation of reactive oxygen species (ROS) and consequent oxidative stress, specifically in the gut.
220 a decrease in mitochondrial translation and consequent OXPHOS deficiency, without affecting mitochon
222 al cells by controlling Wnt4 expression with consequent paracrine canonical Wnt signaling activation.
224 s in rVRG axon damage, PhMN denervation, and consequent partial-to-complete paralysis of hemidiaphrag
227 tion of the podocin-encoding gene Nphs2, the consequent podocyte damage and proteinuria rendered the
229 promoted recruitment of splicing factors and consequent pre-mRNA structural remodeling, leading up to
230 with distinct electronic configurations and consequent prediction of unique reactivity and magnetic
233 PTX3 to the phagocytosis of MSU crystals and consequent production of IL-1beta occurred through a mec
234 ce that lack ANT1 show blunted mitophagy and consequent profound accumulation of aberrant mitochondri
235 y restoration of steady-state RNA levels and consequent rebalancing of translational homeostasis.
238 utic drugs promotes NF-kappaB activity, with consequent recruitment of NF-kappaB to the A3B gene prom
239 e liver promotes an AGER1/RAGE imbalance and consequent redox, inflammatory, and fibrogenic activity
240 acerbation episodes per patient-year, with a consequent reduction in additional courses of antibiotic
243 e-mediated HIF-1alpha activation, imposing a consequent reduction of LPS-induced Il1b expression.
246 vention of its interaction with VKORC1v2 and consequent rescue from degradation represent newly recog
249 rmalizes the platelet proteomic profile with consequent restoration of platelet ultrastructure and ph
250 ansion of varzea and terra firme forests and consequent retraction of igapo forests, with a millennia
251 f life due to the high respiratory rate, and consequent ripening, which limits the marketing period i
252 iuresis with a reduction in plasma volume, a consequent rise in haematocrit, improved vascular functi
254 ve effect of hepatic COX-2 induction and the consequent rise of derived prostaglandins against IRI.
255 ivity leads to expression of 2A protease and consequent robust CVB3 IRES-mediated translation by the
257 ers activation of the NLRP3 inflammasome and consequent secretion of interleukin 1beta (IL-1beta).
258 g NOD2-dependent activation of NF-kappaB and consequent secretion of pro-inflammatory chemokine, CXCL
259 G protein alpha-subunit activating CFTR with consequent secretory diarrhea, the AC isoform(s) involve
260 er, the mechanisms underlying expression and consequent selection and fixation of the prokaryotic gen
262 e loss alters metabolic gene expression with consequent serine and glycine elevation in the brain.
267 ins (RAPs), with a particular focus on their consequent specialized translational control in stem cel
269 e regulates 15-lipoxygenase-1 expression and consequent SPM biosynthesis involving ERK-1/2 during M2
270 d the premature expression of Cdkn2a and the consequent stabilization of p53, an effector of the pre-
271 that serve as discriminative stimuli and/or consequent stimuli, making it nearly impossible to disen
274 Epitaxial growth of Pt clusters and the consequent strong metal-support interaction between Pt a
275 ERAD) of nascent pro-cathepsin D (pCatD) and consequent suppression of lysosome-localized proapoptoti
276 to functional portal desensitization with a consequent suppression of vagal sensitivity to portal gl
278 Under the extreme energy deposition and consequent thermal energy dissipation induced by energet
279 te in the pathogenesis of plaque rupture and consequent thrombosis, but polymorphonuclear leukocytes
281 erythematosus and type 1 diabetes patients, consequent to aberrant regulation by miRNA-7 and 155.
282 amental injury wave produced by shear forces consequent to blast shock waves passing through density
283 ients is an outcome of beta-cell dysfunction consequent to GIP resistance and hyperglucagonemia.
284 o target therapeutically) or merely develops consequent to inflammatory injury (in which case efforts
288 1-13) our findings suggest that this was not consequent to regional decimation of savanna elephants f
289 -gated K(+) (K(Ca)) channels, likely KCa3.1, consequent to spike Ca(2+) influx (the K(Ca)-sAHP compon
293 xposure, such as packaging and handling with consequent transference and adherence to the tissues, ar
294 xcessive calcium loading of mitochondria and consequent triggering of the mitochondrial permeability
295 the rapid accrual of cytotoxic T cells, with consequent tumor clearance potentiated by PD-L1 blockade
297 wo epitopes was variable between donors with consequent variable prevention of adenoviral disseminati
298 th melanoma commonly avoid sun exposure, and consequent vitamin D deficiency might worsen outcomes, w
299 e over a 27-year period (1990-2016), and the consequent weakening of vertical mixing in the upper oce
300 jury relate to diffuse axonal injury and the consequent widespread disruption of brain connectivity.