ライフサイエンスコーパス: conserve

1 emble of conformations are more likely to be conserved.

2 ins, whereas a suite of regulatory genes are conserved.

3 tions of some rare codons are evolutionarily conserved.

4 le of CL in iron-sulfur biogenesis is highly conserved.

5 eactivity to social threat was likely highly conserved.

6 predicted enhancer loops outputs were highly conserved.

7 mer and nonamer sequences flanking less well-conserved 12- or 23-bp spacers.

8 DNA substrate for the unessential but highly conserved A* protein.

9 glutamate (Glu130) of alphaC helix, which is conserved across all kinases.

10 on by PRO heterotetramer formation, which is conserved across all kinetoplastids, and describe a chap

11 animals; however, the enzyme appears broadly conserved across all kingdoms of life, which suggests th

12 ified an insertion of eight residues that is conserved across arrestin-2 homologs, but absent in arre

13 o confirmed that residues in sequence motifs conserved across bacterial and eukaryotic orthologs modu

14 nriched in classical boundary marks and more conserved across cell lines and tissues.

15 h the activities of the viral protein kinase conserved across herpesviruses and two cellular proteins

16 rating that the overall AHAS architecture is conserved across kingdoms.

17 This activity is conserved across most C. auris clades, with the exceptio

18 chain fatty acid metabolism as a key element conserved across multiple host genotypes.

19 assification of TIMCs into subtypes that are conserved across patients and across species.

20 a cytosolic sulfotransferase that is highly conserved across species and extensively expressed in th

21 xpressed in the studied tissues is generally conserved across species, but the precise developmental

22 bonding interactions of Glu200 with residues conserved across the Dio family anchor the loop's N-term

23 in their vacuolar sequestration, a function conserved across the flowering plants.

24 ar receptor (NR) transcription factors use a conserved activation function-2 (AF-2) helix 12 mechanis

25 The unfolded protein response (UPR) is a conserved adaptive signaling pathway that governs protei

26 will be necessary to combat poaching and to conserve African elephants.

27 sHSPs comprise a conserved alpha-crystallin domain flanked by variable N-

28 hat human JPX and mouse Jpx are functionally conserved although they have low similarity in the prima

29 The Thr518Met mutation altered a highly conserved amino acid in the MYRF protein and three of fo

30 sperms, and to which extent PT functions are conserved among angiosperms.

31 These residues are highly conserved among EEEV strains, and therefore a change in

32 over previously uncharacterized CIF peptides conserved among higher plants.

33 the NA active site, engaging residues highly conserved among IBV NAs.

34 covered that long and short RPT isoforms are conserved among members of this phylogenetic group.

35 e Orc6 subunit is the smallest and the least conserved among ORC subunits.

36 ed by transmembrane helices 1, 6, and 10 and conserved among SLC7 transporters.

37 demonstrate that H3.3K27M and mIDH1 hijack a conserved and critical metabolic pathway in opposing way

38 Jellyfish genomes reveal a mosaic of conserved and divergent genomic characters evolved from

39 other known fucosyltransferases to identify conserved and divergent structural features for donor an

40 by regulating the biogenesis of lipid A, the conserved and essential anchor of LPS.

41 nhibited plant drought tolerance, indicating conserved and positive roles of PTPN in plant drought to

42 20K), conditioning on a broad set of coding, conserved and regulatory annotations.

43 IAVs, three N-linked glycosylation sites are conserved and that a fourth site is conserved in H3N2 IA

44 core UV-B stress signaling pathway genes are conserved and upregulated in response to UV-B irradiatio

45 Conserved antibody variable gene expression indicates th

46 se designs include a point mutation in a key conserved antigenic site to stabilize its conformation,

47 be important climate adaptation tactics for conserving aquatic biodiversity.

48 The Src homology 2 (SH2) domain has a highly conserved architecture that recognizes linear phosphotyr

49 The structure reveals that cGAS uses two conserved arginines to anchor to the nucleosome acidic p

50 that some conserved epitopes, including two conserved arginines, are shared by the class 5 adhesins.

51 becomes autoacylated at a site defined by a conserved Asp-His-His-Cys motif.

52 These findings highlight both conserved aspects and plasticity among arrestin-receptor

53 These findings establish conserved aspects of sex-biased brain development in hum

54 One example is the conserved bacterial ribosome silencing factor (RsfS) tha

55 Absence of a conserved basic residue and presence of acidic residues

56 Previous studies have implicated conserved basic residues in the cytosolic portions of be

57 de regulating endoreplication progression is conserved between insects and mammalian cells.

58 me composition and functional potential were conserved between PM(2.5) and PM(10), although considera

59 he crosstalk between osteocalcin and IL-6 is conserved between rodents and humans.

60 CDK19 is conserved between vertebrate and invertebrate model orga

61 le SAS subfamilies are encoded in widespread conserved bicistronic operon architectures that are remi

62 The conserved binding mode of the guests permits deciphering

63 et viruses overlapped spatially, revealing a conserved binding site in the central cavity of the vira

64 goal-directed behavior involves evolutionary conserved brain structures like the striatum and optic t

65 We report that a conserved bromo-adjacent homology (BAH) module of BAHCC1

66 oops that enclose substrates in the PHDs are conserved, but the C-terminal helix of the PHDs is strik

67 Irbp18, an evolutionarily conserved bZIP gene, heterodimerizes with Xrp1 and with

68 nt (Srp), in vivo and in vitro through their conserved C-zinc finger domains.

69 These similarities represent conserved, canonical properties of the functional circui

70 raction of distinct regulatory subunits with conserved catalytic subunits in holoenzyme complexes.

71 Apoptosis is an ancient and evolutionarily conserved cell suicide program.

72 rsity in the molecular mechanisms underlying conserved cellular functions, such as DNA replication an

73 the colitis response and shows how a highly conserved chromatin remodeling factor has a distinct rol

74 heath (AMsh) glia as a model and show that a conserved cis-Golgi membrane protein eas-1/GOLT1B negati

75 res of a previously unrecognized, but widely conserved class of prokaryotic sensory system that we re

76 Acyl carrier protein (ACP) is a highly conserved cofactor protein that is required by Type II f

77 itecture of the T4aPM and the location of 10 conserved core proteins within this architecture have be

78 y by inhibition of RHO-1, which depends on a conserved cysteine in its nucleotide binding site (C20).

79 evis egg extracts and mammalian cells that a conserved cysteine residue within the Aurora A activatio

80 We discuss the idea that oxidation of conserved cysteine residues and partial unfolding of its

81 trate reduction, which is then resolved by a conserved cysteine, Cys-66, or by the nonconserved resid

82 Moreover, these benefits are conserved despite appreciable corticospinal conduction d

83 this opinion article, we propose that highly conserved DNA methyltransferases (MTases) represent a un

84 Ultimately, we discuss how some highly conserved DNA MTases may emerge as promising targets for

85 gs show that small changes outside of highly conserved DNA-binding regions can lead to profound chang

86 Antibodies targeting the RSV G central conserved domain are protective in both prophylactic and

87 ntibodies, especially binding to the central conserved domain.

88 Egr2 induction is evolutionarily conserved during alternative polarization of mouse and h

89 lytical approaches have explored this highly conserved, dynamic period across numerous model organism

90 scription through direct Twist1 binding to a conserved E-box element at the IL-6 promoter.

91 ancient and diverse clade of animals, with a conserved early developmental program but diverse larval

92 se data suggest that PI3K inactivation has a conserved effect of upregulating mitochondrial metabolis

93 is the largest subunit of the evolutionarily conserved Elongator complex, which catalyses translation

94 old and suppresses thermogenesis in order to conserve energy reserves.

95 st-transcriptional processes enable cells to conserve energy, prepare for prolonged stress and accele

96 suspended when they are not needed, thereby conserving energy for growth and development.

97 medial habenula (MHb) is a phylogenetically-conserved epithalamic structure that is a powerful modul

98 -wide cross-reactivity, suggesting that some conserved epitopes, including two conserved arginines, a

99 bility, allowing for adaption to imperfectly conserved epitopes.

100 lopmentally modulated, we studied the highly conserved, essential transcription factor Grainy head (G

101 d Pv-M17 bind metal ions and substrates in a conserved fashion, although Pv-M17 forms the active hexa

102 ted to coordinate multicellular movements, a conserved feature in twitching bacteria.

103 This is likely a conserved feature of the metazoan SAC, since the relevan

104 svirus entry into cells, clarifying both the conserved features and the unique features.

105 tems biology approaches has revealed new and conserved features in the genome of human herpesvirus 6.

106 RV), Mayaro, or chikungunya viruses reveal a conserved footprint of the broadly neutralizing mAb RRV-

107 show that an ancient hydrophobic interface, conserved for hundreds of millions of years, is entrench

108 ACBP is a topologically simple and highly conserved four-alpha-helix bundle protein that acts as a

109 XPB is conserved from archaea to human.

110 ernate exosome formation mechanism, which is conserved from fly to human, is described here, with exo

111 mer consisting of alpha and beta heterodimer conserved from yeast to human.

112 revent blood loss in response to injury is a conserved function of all vertebrates.

113 , our results show that loss of an otherwise conserved function of Nef has a positive effect on HIV-1

114 hip, and the encoded proteins exhibit highly conserved G-protein activities while showing expression

115 ge-like THP-1 cells (THP1-MPhi) have largely conserved gene expression patterns.

116 Borrelia burgdorferi conserved gene products BB0406 and BB0405, members of a

117 , a powerful genetic system that shares many conserved genes and pathways with humans.

118 y mass spectrometry in strains with the most conserved genes of each step deleted, but also additiona

119 Targeting highly conserved genomic regions make pan-family assays robust

120 ctions with Bub3, which are mediated through conserved GLEBS domains in both Bub1 and BubR1.

121 The conserved Gsx homeodomain proteins regulate specific asp

122 ticle coating with a rationally designed and conserved guiding peptide targets their delivery to chlo

123 ing factors, Ddi1 and its homologs contain a conserved helical domain (helical domain of Ddi1, HDD) a

124 results indicate that nidoviruses contain a conserved helicase core domain and key amino acid sites

125 a inviability is reversed by deletion of the conserved helicase PIF1 and/or DNA damage checkpoint-med

126 bination signal sequences (RSSs) composed of conserved heptamer and nonamer sequences flanking less w

127 Substitution of either conserved histidine compromised the ability of Sts-1 to

128 peline to define the in vivo function of non-conserved human lncRNAs.

129 The interface formed a conserved hydrophobic cavity suitable for targeted drug

130 loral repressor LF Our results establish the conserved importance of the CDK8 module in plants and pr

131 plying that this mechanism is evolutionarily conserved in amniotes.

132 This novel LOTUS domain-RNA interaction is conserved in bacteria, plants and animals, comprising th

133 the HSP70 gene family have largely remained conserved in canonical sequence motifs and copy numbers

134 A pair of histidine residues, which are conserved in coronavirus spike proteins, are predicted t

135 PTPN14 binds to a C-terminal arginine highly conserved in diverse HPV E7.

136 ites are conserved and that a fourth site is conserved in H3N2 IAVs.

137 orks and gene expression changes were mostly conserved in human brains.

138 Proton leak-mediated NGSIS is conserved in human islets and is stimulated by exposure

139 ck, suggesting that this oscillator might be conserved in humans(3).

140 As TSP-12 and TSP-14 are conserved in mammals, our findings suggest that the mamm

141 e and that this molecular function is likely conserved in other DUF328 family members.

142 yeast but was recently shown to be partially conserved in other eukaryotes, such as higher plants.

143 -AMP-specific phosphodiesterase that is also conserved in pathogens such as Streptococcus pneumoniae

144 endent predatory mechanism is evolutionarily conserved in Pristionchus pacificus, a nematode species

145 ified in essential germline proteins and are conserved in prokaryotes and eukaryotes.

146 PTS(Ntr) is widely conserved in proteobacteria, highlighting its global imp

147 d injury, we asked if the S1 CST response is conserved in rodents.

148 exposures from other mechanisms that may be conserved in TDS.

149 rranged and lost in most Mycena species, but conserved in the Armillaria lineage.

150 that the dual functions of EspE and EspF are conserved in the orthologous proteins from M. tuberculos

151 miR-451 is highly conserved in vertebrates and regulates erythrocyte matur

152 ional read-through across two evolutionarily conserved, in-frame stop codons of MTCH2 using luminesce

153 verexpression of an operon encoding a highly conserved inorganic phosphate importer, PstSCAB, increas

154 on, we designed GS-6207 to bind tightly at a conserved interface between capsid protein monomers, whe

155 east and human EMC cryo-EM structures reveal conserved intricate assemblies and human-specific featur

156 The evolutionarily conserved lethal-7 (let-7) microRNAs (miRNAs) are well-k

157 3A and TbArl3C, suggesting the presence of a conserved LIFT pathway in these protozoan parasites.

158 oderm and trophectoderm, and identify deeply conserved lineage-specific markers that pre-date the eut

159 omplexes (MTCs) are large (250 to >750 kDa), conserved macromolecular machines that are essential for

160 adult gliomas to characterize evolutionarily conserved mammalian mutational processes in gliomagenesi

161 Altogether, we uncover a conserved mechanism of paternal epigenetic information t

162 T. gondii) is a protozoan parasite that uses conserved mechanisms to infect rodents and human hosts.

163 ia and insulin resistance are evolutionarily conserved metabolic adaptations to severe injury includi

164 The evolutionarily conserved microtubule (MT)-severing AAA-ATPase enzyme Ka

165 dies thus indicate that while IgLONs share a conserved mode of interaction and are able to bind each

166 molecule binding to each ZF4 and ZF5, with a conserved mode of interaction.

167 protein complex folds into an evolutionarily conserved modular architecture.

168 Hsp90 is a highly conserved molecular chaperone important for the activity

169 of 70 kDa (Hsp70s) are ubiquitous and highly conserved molecular chaperones.

170 The conserved molecular hallmark of heterochromatin is the H

171 For example, conserved molecular thermosensors, including thermosensi

172 , we report that males lacking piRNAs from a conserved mouse pachytene piRNA locus on chromosome 6 (p

173 A conserved MT-associated protein complex, Augmin, recruit

174 RNase P and MRP are highly conserved, multi-protein/RNA complexes with essential ro

175 It is now believed that conserved multisubunit protein machines extract these li

176 ensitive to truncations and mutations in the conserved N terminus of the Rubisco large subunit.

177 Disease-mutations cluster within the conserved N-Lip and C-Lip regions that are separated by

178 ating that L-Phe binding and mutation of the conserved N-terminal Trp8 to Ala both promote an inward-

179 tity of both partially conserved (W) and non-conserved (N9) residues.

180 modomains through displacement of a normally conserved network of four water molecules.

181 ines and infections, we found mAbs targeting conserved neutralizing influenza virus hemagglutinin epi

182 process that competes with denitrification, conserves nitrogen, and minimizes nutrient loss in soils

183 ese polymorphisms alter function varies from conserving normal pyroptotic function to inhibiting casp

184 of a nuclear transport reporter, suggesting conserved NPC regulation by CN.

185 istone locus body (HLB) is an evolutionarily conserved nuclear body that regulates the transcription

186 al assays, and MS analyses, we show that the conserved nucleophilic residue Cys-122 is S-sulfenylated

187 Importantly, four motifs of conserved nucleotide sequences (CNSs) were also determin

188 Causal variants were enriched at conserved nucleotides, tended to have low derived allele

189 The mycobactin biosynthesis pathway, conserved only among the mycolata family of actinobacter

190 of acidic residues in the vestibule regions, conserved only in YfdC-alpha, were found to be responsib

191 also known as neuropsin or OPN5) is a highly conserved opsin that is sensitive to visible violet ligh

192 d identified previously unknown interactions conserved over 1.1 billion years of green plant evolutio

193 in the size of these cells and have remained conserved over 200 million years of mammalian evolution.

194 esence of acoustic communication is strongly conserved over time.

195 that the VEGF-C/NRP2/GLI axis is a novel and conserved paracrine means by which EMT cells enhance met

196 way has been implicated as an evolutionarily conserved pathway in mammals; however, how this pathway

197 s, which can synthesize it de novo through a conserved pathway.

198 in the function of the adult heart, identify conserved pathways that regulate structural complexity a

199 macaque and human brain tissue demonstrate a conserved pattern for PI5P4Kalpha and PI5P4Kbeta.

200 support policies geared toward managing and conserving peatlands in vulnerable regions, such as the

201 rophysiological measurements to identify two conserved phenylalanine residues that form an aromatic p

202 Wnt proteins are evolutionarily conserved polarity cues, yet Wnt mutants display variabl

203 iation to the peroxisome, while a stretch of conserved positive charges and a central pleckstrin homo

204 binding sites within each subunit: a highly conserved primary site in transmembrane domain (TMD) hou

205 g PE and PPE families of proteins, named for conserved Pro-Glu and Pro-Pro-Glu motifs in their N term

206 Autophagy is an evolutionarily conserved process that plays a key role in the maintenan

207 In bacteria, the best conserved promoter feature is the AT-rich -10 element; a

208 on, we have demonstrated that CAPG, a highly conserved protein in eutherian mammals, elicits a transc

209 Spn1/Iws1 is a conserved protein involved in transcription and chromati

210 P47Rec is a highly conserved protein with submicrovillar localization in mi

211 opment, a mechanism that may apply for these conserved proteins across species and for other TMO nano

212 al ribosome is recycled into subunits by two conserved proteins, elongation factor G (EF-G) and the r

213 e models, can support ballistic transport of conserved quantities including energy.

214 While most of its subunits are conserved, recent data have shown that the arrangement o

215 They co-occurred with a strictly conserved recombinase and transposon Tn3 family but with

216 g and ubiquitin-like domains, they contain a conserved region with similarity to retroviral proteases

217 fied three such epitopes derived from highly conserved regions within LASV proteins.

218 ggest that SCYL-1/SCYL1 is an evolutionarily conserved regulator of Slo2 channels.

219 e of the Mediator complex, which is a deeply conserved regulator of transcription in eukaryotes.

220 nd cell culture studies to identify a highly conserved regulatory mechanism linking anxiety and alcoh

221 Here, we identify the conserved ReoM protein as a novel PASTA-eSTK substrate i

222 ral studies, we hypothesized that Asn-169, a conserved residue in the AAG active-site pocket, contrib

223 SAR studies on conserved residues (Leu25, His26, Val29, Pro30, Phe31, P

224 ried in the cytosolic domain and chelated by conserved residues from CTD and the His-Cys-His (HCH) mo

225 A lipid binding groove and clusters of conserved residues highlight potential functional sites.

226 We show that conserved residues in site alpha influence enzyme proces

227 The conserved response revealed several regeneration-respons

228 Shutoff of global protein synthesis is a conserved response to cellular stresses.

229 ng a central sensory lesion, is a robust and conserved response.

230 ide insight into how cells and viruses use a conserved RNA phosphatase to regulate and respond to ppp

231 However, predicting a conserved RNA structure remains unreliable, even when us

232 alian cells, TALPID3 and ANKRD26 also play a conserved role in coordinating the recruitment of FBF1 t

233 OAP is a telomere-binding protein that has a conserved role in Drosophila, but it also needs to evolv

234 ety of embryological processes, and it has a conserved role in patterning the dorsal-ventral body axi

235 To determine whether Sting plays a conserved role in Pink1/parkin related pathology, we tes

236 and demonstrate that ESX-1 substrates have a conserved role in regulating gene expression.

237 anded CGG repeats and their translation play conserved roles in regulating fragile X protein (FMRP) s

238 Here, we uncover evolutionarily conserved rules of engagement between RNA helicases and

239 The conserved SAM domain was required for SAMD14 to increase

240 a-helical integral membrane proteins contain conserved sequence motifs that are known to be important

241 to a CRISPR-based gene drive inserted into a conserved sequence of the doublesex (dsx) gene.

242 nteractions with PTAP and LYPXnL, two highly conserved sequences named late (L) domains, which bind T

243 s KCC-mediated efflux via phosphorylation at conserved, shared motifs.

244 s genome flexibility occurs within a rigidly conserved shell, we determined the high-resolution cryo-

245 nd to two molecules of the phosphatase via a conserved short linear motif.

246 istic motifs (in the form of a collection of conserved short peptides) of each subfamily, and thus we

247 cyte maturation trajectories identify highly conserved signaling pathways, pharmacological targeting

248 The Hippo pathway is an evolutionarily conserved signalling pathway with key roles in organ dev

249 sensing of pathogens by macrophages engages conserved signalling pathways and transcription factors

250 WT HNF-1beta binds to two evolutionarily conserved sites located 94 and 30 kb from the mouse Lef1

251 The evolutionarily conserved Ski2-Ski3-Ski8 (Ski) complex containing the 3'

252 cal cell files), restrict uptake of water to conserve soil moisture (reduced hydraulic conductance, n

253 Although most effectors show conserved spatiotemporal expression profiles and likely

254 ted to a low-Na(+) freshwater environment to conserve sperm's ability to depolarize.

255 Destabilization of myosin energy-conserving states promotes contractile abnormalities, mo

256 Due to the conserved sterol biosynthesis between mice and humans, w

257 at similarities may identify convergent and conserved strategies and shed light on the promise they

258 Y (NPY) and NPY receptors represent a highly conserved, stress-activated system involved in diverse c

259 ged selected amino acid residues in a highly conserved stretch within the regulatory region of yeast

260 Class I adenylate-forming enzymes share a conserved structural fold but act on a wide range of sub

261 ch as architectures, folds and conformity to conserved structural motifs.

262 g additional evidence against their proposed conserved structures.

263 ribe patient-derived xenografts with species-conserved subtype-discriminating functional properties.

264 ted with inactivation of the gene SMARCB1, a conserved subunit of the chromatin remodeling BAF comple

265 The barely exergonic process that just conserves sufficient energy for a modest lifestyle invol

266 e interactions are largely mediated by three conserved, surface-exposed lysine residues (triK), which

267 were grossly examined at the time of breast conserving surgery from January 2014 to July 2020.

268 We introduced a mutation (S217A) in the conserved switch I region of the active site to examine

269 The strong conserved synteny between mouse chromosome 12aF1 and hum

270 We conclude that the abundance of conserved target sites in mosquito genomes and the inher

271 o fulfil this role they must be effective at conserving the ecosystems and species that occur within

272 Although evolutionally conserved, the mammalian ribosome assembly system is mor

273 One mechanism relies on the conserved THO complex in association with cotranscriptio

274 Phosphorylation of a conserved threonine motif (T788/T789) in the integrin be

275 Because ShK-like2 but not ShK-like1 is conserved throughout sea anemone phylogeny, we conclude

276 This universally conserved transcription elongation factor is known as Sp

277 Previous research has identified four conserved transcription factors, fos-1 (Fos), egl-43 (EV

278 ngi and animals are driven by a functionally conserved transcription-translation feedback loop.

279 Capicua (CIC) is a highly conserved transcriptional repressor that is differential

280 ial topoisomerase I structures showed that a conserved transesterification unit (N-terminal toroid st

281 hosphorylation of eIF2alpha (P-eIF2alpha), a conserved translation initiation factor, is clock contro

282 Nonsense-mediated mRNA decay (NMD) is a conserved translation-coupled quality control mechanism

283 The conserved transport protein particle (TRAPP) complexes r

284 We recently identified MmpL11 as a conserved transporter of mycolic acid-containing lipids

285 variants in which one or two of four highly conserved Trp residues in the binding tunnel had been re

286 ng the putative interaction between a highly conserved Trp/Glu residue pair in the lower pore is detr

287 Displacement of a conserved tryptophan (W571) from its typical pocket in t

288 Human telomerase assays determined a conserved tyrosine steric gate regulates ribonucleotide

289 orhabditis elegans, we found that the highly conserved UNC-119 protein provides a link between the me

290 in the understanding of the UPR, emphasizing conserved UPR elements between plants and metazoans and

291 s encouraged to aim at better discriminating conserved versus taxon-specific genetic elements underly

292 dependence on the identity of both partially conserved (W) and non-conserved (N9) residues.

293 g into the transient pocket and displacing a conserved water network.

294 ing and closing across the diel cycle, which conserves water and provides a means of maintaining grow

295 enetic analysis showed Asp t 36 to be highly conserved with close similarity to the triose-phosphate

296 Furthermore, XPG DNA binding elements conserved with FEN1 superfamily members enable insights

297 tty acid and TAG synthesis appear to be well conserved with plants, the pathways of TAG catabolism an

298 C so as to identify those molecules that are conserved with respect to modulation of expression.

299 processes involved in development are deeply conserved within the animal kingdom.

300 hint at additional functions, since the most conserved Y RNA contains a domain that is a close tRNA m