ライフサイエンスコーパス: conserved sequence

1 terminally adjacent to this phylogenetically conserved sequence.

2 as dominant between G and A in the GAAC/GTTC conserved sequence.

3 amino acids at position 201 in the otherwise conserved sequence.

4 hly variable blocks punctuated by regions of conserved sequence.

5 led LAZY gene includes five short regions of conserved sequence.

6 egions in proteins are often flanked by very conserved sequences.

7 t they consist of clustered blocks of highly conserved sequences.

8 and comparable breadth of responses against conserved sequences.

9 Fezf2-bound fragments were enriched for conserved sequences.

10 -gene reporter construct that includes these conserved sequences.

11 s across gene bodies, coinciding with highly conserved sequences.

12 verse group of agents displays six blocks of conserved sequences.

13 ead species-specific responses of genes with conserved sequences.

14 ough these repeats were nestled among highly conserved sequences.

15 by computational tools based on their highly conserved sequences.

16 ied three disordered loops in TP with highly conserved sequences.

17 microRNAs in the same family or with highly conserved sequences.

18 orter indicated that all four motifs and the conserved sequence 2 (CS2) element within the 3'-DB are

19 We also identified a highly conserved sequence 21 kilobase 5' of BP4 that we called

20 A-binding module, since it includes a poorly conserved sequence, a solvent-exposed and somewhat unsta

21 Many methods have been developed to identify conserved sequences across species; however, existing me

22 tified 964 copy number differences (CNDs) of conserved sequences across three primate species and exa

23 mammalian HEK293T cells, the 5' part of this conserved sequence acts at the nascent peptide level to

24 The only universally conserved sequence among all influenza A viral neuramini

25 , with conspicuous 20-kb stretches of highly conserved sequences among the four arms that show eviden

26 The conserved sequence and distinct secondary structures of

27 rmation, whereas regional centromeres lack a conserved sequence and instead are epigenetically inheri

28 ng bioinformatics algorithms that search for conserved sequence and structural features located in in

29 The large datasets obtained further provide conserved sequence and structure motifs that may be used

30 kinesin-5 inhibitor, consistent with the non-conserved sequence and structure of its loop5 insertion.

31 Homologous protein families share highly conserved sequence and structure regions that are freque

32 NA template-containing promoters composed of conserved sequences and a 3-base loop-5-base pair stem h

33 ns of L1- and L2-dsRNA/SsMBV1 share strictly conserved sequences and form stable stem-loop structures

34 e U2, U4, U5, and U6 snRNAs contain expected conserved sequences and have the ability to adopt second

35 transfer RNAs (tRNAs) contain evolutionarily conserved sequences and modifications that ensure unifor

36 egions, (2) rapid extraction and curation of conserved sequences, and (3) for bacteria, identifies un

37 ulose synthesis, other domains such as plant-conserved sequences, and class-specific regions that are

38 ies reveal that all the five residues in the conserved sequence are required for binding to Nedd8.

39 were able to bind hemin, suggesting that the conserved sequences are responsible for the hemin bindin

40 The dsDMRs contain evolutionarily conserved sequences, are associated with developmental g

41 x grass species made it possible to identify conserved sequences as short as 9 bp with false discover

42 that provides a single uninterrupted view of conserved sequences as they appear in a species of inter

43 ring membrane fusion may lie in part in this conserved sequence associated with the gp41 loop region.

44 orylating caspase-2 within an evolutionarily conserved sequence at Ser 340.

45 Although conserved sequence at the 3' end is not required, 2' hyd

46 An evolutionarily conserved sequence at the 5' terminus of hantaviral geno

47 We then identified a short conserved sequence at the C terminus of the Acm1 D-box t

48 the influenza A virus (IAV) genome contains conserved sequences at the 5'- and 3'-terminal ends, whi

49 wo different modes and provide evidence that conserved sequence B helps ensure release of APC from Ax

50 for new partners--20-amino-acid repeat 2 and conserved sequence B--in destruction complex action.

51 Conserved sequences between CFH and CFHR3 mean that the

52 The guanine (G)-tract of conserved sequence block 2 (CSB 2) in human mitochondria

53 Its location within conserved sequence block 3 (CSBIII), just upstream of th

54 Regions of 100% homology were found for Conserved Sequence Block I, Conserved Sequence Block III

55 The latter position is the 5'-nucleotide of conserved sequence block II and is critical to replicati

56 These mutations are found within conserved sequence block II, a critical regulatory eleme

57 y were found for Conserved Sequence Block I, Conserved Sequence Block III and the L-strand origin of

58 The conserved sequence block that includes rs55705857 is con

59 e analysis found one repetitive unit between conserved sequence blocks (CSB)-1 and CSB-2 for L. hubba

60 t within these genomic expanses, clusters of conserved sequence blocks (CSBs) are positioned once eve

61 evealed that they contain clusters of highly conserved sequence blocks (CSBs) made up of shorter shar

62 regulatory regions identified evolutionarily conserved sequence blocks (CSBs) with similarities to ne

63 We identify a polymorphism within the conserved sequence box II region of the D-loop as a plau

64 is mediated by the X domain of P (XD) and a conserved sequence (Box-2) within the C-terminal domain

65 sms in this common subspace, genes of highly conserved sequences but significantly different cell-cyc

66 ts (TMS) with a pair of oppositely oriented, conserved sequences called the alpha-repeats that are im

67 o short, partially complementary, and highly conserved sequences can form a stable RNA duplex at phys

68 t the C. glabrata Ure2p, which does have the conserved sequence, cannot form [URE3] as judged by its

69 rienced intensified selective pressure, with conserved sequence changes in Antarctic species suggesti

70 We report that GC skew is a conserved sequence characteristic of the CGI promoter cl

71 ch hypervariable region followed by a highly conserved sequence comprising two potential HXH metal-bi

72 xidine dihydrochloride, suggesting that this conserved sequence confers uncoupling potential to V(1)V

73 microscopy observations, we propose that the conserved sequence connecting the MPER with the N-termin

74 We further show that these evolutionarily conserved sequences contain clusters of transcription bi

75 tion is confined to 255 bp of evolutionarily conserved sequence containing functional transcription f

76 2 binding sites that are highly enriched for conserved sequences corresponding to abundant brain miRN

77 We also demonstrated, for Pfim3, that the conserved sequence corresponds to BvgA binding sites.

78 ed short direct repeats (DRs), also known as conserved sequences (CS) and repeated conserved sequence

79 A conserved sequence, derived from the deleted region, enh

80 a transcriptional activator that binds to a conserved sequence (designated as AW box) boxes in the p

81 upon IRP1 binding and illustrate how small, conserved, sequence differences among IRE-mRNAs selectiv

82 In murine cytomegalovirus, poorly conserved sequences distal to the pac2 motif up to 150 b

83 cent structural studies revealed that highly conserved sequences downstream of the phosphorylation si

84 Deletion of one of these conserved sequences (ECR2) from a BAC transgene revealed

85 Here, we report that deletion of the conserved sequence EDTEE, which is located within a cyto

86 amer can form a base-paired structure with a conserved sequence element (alpha) located near a 5' spl

87 A cross-species analysis identifies a highly conserved sequence element in LINC-PINT that is essentia

88 promoter was dependent on the action(s) of a conserved sequence element mapping to a chromatin DNase

89 ted by trans-acting factors that recognize a conserved sequence element termed the primer binding sit

90 e function is less closely associated with a conserved sequence element than previously believed.

91 n (MSD) of the HIV-1 glycoprotein gp41 bears conserved sequence elements crucial to the biological fu

92 B sites of the LTR are among the most highly conserved sequence elements of the HIV-1 genome.

93 Mutations in conserved sequence elements of the sRNA, which allow sRN

94 5.8S rRNA is guided by snoRNA snR43 by using conserved sequence elements that also function to guide

95 These proteins have highly conserved sequence elements that are contained within tw

96 quences in the Theileria genome and identify conserved sequence elements that may be involved in gene

97 Conserved sequence elements upstream of individual other

98 rlaps the tRNA primer binding site, a highly conserved sequence essential for virus replication and d

99 Remarkably, we find that even highly conserved sequences exhibit more functional differences

100 of viral nucleocapsid protein (N) with this conserved sequence facilitates mRNA translation by a uni

101 Whereas this evolutionarily conserved sequence facilitates virus replication with th

102 proved the display of functional data and of conserved sequence features associated with FunFams with

103 Conserved sequence features corresponding to iHMR transc

104 Based on the conserved sequence features we predict that this domain

105 menclature for AT structural, functional and conserved sequence features, based on explicit criteria.

106 recognize the same pMHC epitope often share conserved sequence features, suggesting that it may be p

107 To clarify the potential role of conserved sequence features, we predicted the structures

108 with a set of distinctive and evolutionarily conserved sequence features, which can be utilized to di

109 GC content regions but lack repeats or other conserved sequence features.

110 We postulate that CNDs of these conserved sequences fine-tune developmental pathways by

111 On the basis of conserved sequence fingerprints within paralogues, we pr

112 analysis to establish the importance of this conserved sequence for integration and characterize the

113 A highly-conserved sequence from retroviral transmembrane (TM) pr

114 We explore how conserved sequences from both NBDs form ATP-binding site

115 volves proteolytic removal of inhibitory and conserved sequences from the large central B domain whic

116 The larger conserved sequences from the Vista enhancer browser (VEB

117 The conserved-sequence genome confirms outbreak samples with

118 ium samples, ROC curves demonstrate that the conserved-sequence genome disambiguates same-patient sam

119 The conserved-sequence genome is sample set-independent, whi

120 the gp120 trimer, the inaccessibility of the conserved sequences, highly variable protein sequences,

121 gonists of the MC4R are characterized by the conserved sequence His(6)-Phe(7)-Arg(8)-Trp(9), which is

122 We investigated whether a conserved sequence-HRVW(279)QNRR--in delta subunit contr

123 Indeed, conserved sequences immediately upstream and downstream

124 Here we find that a conserved sequence in EZHIP is necessary and sufficient

125 1783-1795) report that a highly conserved sequence in intron 5 of Tcf7l2 conceals an int

126 We identified a conserved sequence in the C-terminal moiety of pUL56 (67

127 We show that a peptide (p10) derived from a conserved sequence in the C-terminal part of the extrace

128 We identified a short conserved sequence in the center of the RAVE subunit Rav

129 by ubiquitination is controlled by a highly conserved sequence in the CTR to affect cellular localiz

130 ediated delivery of siRNA targeting a highly conserved sequence in the dengue virus envelope gene (si

131 its duplicated methyltransferase domain and conserved sequence in the double E loop, appears to have

132 nase Greatwall (Gwl), which phosphorylates a conserved sequence in the effector Endosulfine (Endos).

133 otes an intramolecular association between a conserved sequence in the flexible pocket linker and the

134 (mouse K310) located within an evolutionary conserved sequence in the human GR N-terminal domain all

135 inducer IRF3 by binding to an evolutionarily conserved sequence in the IFNB1 enhanceosome that overla

136 Finally, NKX2.1 protein binds a highly conserved sequence in the Lhx6 promoter, and this sequen

137 Furthermore, SCL33 protein bound to a conserved sequence in this intron, indicating auto-regul

138 nd antibodies induced by vaccines containing conserved sequences in HA1 of wild-type influenza A(H5N1

139 We noted that conserved sequences in HSURs 1 and 2 constitute potentia

140 Here, we developed shRNAs targeting conserved sequences in human HD and mouse HD homolog (HD

141 rectly interacts with DNA via evolutionarily conserved sequences in its C-terminus.

142 ng and stress response systems by binding to conserved sequences in its target mRNAs and altering the

143 yeast box C/D snoRNAs identified additional conserved sequences in many snoRNAs that are complementa

144 Our bioinformatic analysis of conserved sequences in promoters of microRNAs, previousl

145 arcin-ricin loop (SRL) is one of the longest conserved sequences in the 23S ribosomal RNA.

146 We used computational algorithms to find conserved sequences in the 3' untranslated region (UTR)

147 We identify conserved sequences in the 3'UTR of NSF as miR-33 respon

148 tuf gene that identify Staphylococcus genus, conserved sequences in the femB gene that specifically d

149 Twenty-five of the 27 Anopheles miRNAs had conserved sequences in the genome of a divergent relativ

150 genesis approach, we targeted evolutionarily conserved sequences in the intron of the Antirrhinum PLE

151 ant RNA to the X chromosome, suggesting that conserved sequences in the inverted region are important

152 find that mir-125a-5p targets evolutionarily conserved sequences in the Lfng 3' UTR and that preventi

153 Here we confirm that conserved sequences in the N and C termini of the Mfa1 f

154 presses transcription by directly binding to conserved sequences in the promoters of its target genes

155 pose a novel core genome method that selects conserved sequences in the reference genome by comparing

156 By analyzing point mutations in conserved sequences in the T-box DNA-binding domain, we

157 ich permits rapid and sensitive detection of conserved sequences in the tuf gene that identify Staphy

158 Using primers developed from conserved sequences in the Wm82 Rpp4 candidate genes, we

159 es and extends these findings and identifies conserved sequences in zebrafish and human, suggesting f

160 Several families lack this short conserved sequence, including the Brassicaceae, and we p

161 between both RNAs corresponds to a very-well-conserved sequence, it is plausible to admit that this r

162 RGLU1 contains a long, highly evolutionarily conserved sequence known as an Ultraconserved Element (U

163 ne C-terminal-most residues of SSB, a highly conserved sequence known as the SSB-Ct element.

164 Here we show that a conserved sequence located immediately upstream of the C

165 ption by binding to the syp enhancer (SE), a conserved sequence located upstream of four syp promoter

166 l wound enhancers all contain evolutionarily conserved sequences matching binding sites for JUN/FOS a

167 hromosome on a mouse background where highly conserved sequences may confound the analysis.

168 introns and endonucleases, the targeting of conserved sequences, may provide the impetus for the evo

169 he immediate promoter region and an upstream conserved sequence module were each found to contain a C

170 nce and function, and contain several highly conserved sequence modules that are likely involved in r

171 acid substitutions in a region of the highly conserved sequence motif B in the fingers domain on repl

172 Transfer RNAs (tRNAs) require the absolutely conserved sequence motif CCA at their 3'-ends, represent

173 Pf1 residues within a highly conserved sequence motif immediately C-terminal to SID1

174 miR-155 targeted a conserved sequence motif in the 3'UTR of TRF1, resulting

175 sequence and an Arg residue within a highly conserved sequence motif in the channel leading to the R

176 e, a 60-90-residue globular prodomain with a conserved sequence motif including a cysteine engaged in

177 hat one of these glycans is located within a conserved sequence motif of the receptor-binding region,

178 carrying a missense mutation that disrupts a conserved sequence motif of the small GTPase, RAS GENES

179 A highly conserved sequence motif on helix I contributes to posit

180 Plant HSFs of subgroup B lack a conserved sequence motif present in the transcriptional

181 omains, but contains in its helical domain a conserved sequence motif termed COS-box that has been sp

182 However, a conserved sequence motif was identified on both negative

183 A conserved sequence motif was identified that contains se

184 Together, these results define a conserved sequence motif within an otherwise poorly defi

185 f the phenotype of a mutant missing a highly conserved sequence motif within the catalytic domain of

186 s has pointed toward involvement of a highly conserved sequence motif, E1XXE2RFXYY (from here on refe

187 The aptamer, which does not contain the conserved sequence motif, is specific for the rRNA bindi

188 odule, a repressor helix built from a family conserved sequence motif, PCFXXLP.

189 Biotin synthase contains a highly conserved sequence motif, YNHNLD, in which Asn153 and As

190 tes are not detected but can be induced-at a conserved sequence motif-via the ectopic overexpression

191 larger cytoplasmic domains contains a highly conserved sequence motif.

192 TOST-1 interact directly with ERH-2 using a conserved sequence motif.

193 promoter to be the (approximate) start of a conserved sequence motif; and (ii) we developed a highly

194 cytochrome P450 (CYP) family 2 sequences, 20 conserved sequence motifs (CSMs) were identified with th

195 In addition, it utilizes two conserved sequence motifs [Thr-h-Gly-Phe-(Asn/Asp)-Glu-X

196 divides CPNs into two groups that share many conserved sequence motifs but differ in both structure a

197 million years of evolution, with one of the conserved sequence motifs encompassing the yar promoter.

198 Conserved sequence motifs guide the rational design of l

199 Considerations of conserved sequence motifs in other such molecules sugges

200 l approach, we identified two evolutionarily conserved sequence motifs in the CC subfamilies: a drast

201 y important regions include those containing conserved sequence motifs involved in ATP and RNA bindin

202 Using the conserved sequence motifs of BAHD members, we searched t

203 alternatively spliced exons and a family of conserved sequence motifs overlapping branchpoints we te

204 the first gene of each TU tend to have more conserved sequence motifs than those of the other genes

205 a-helical integral membrane proteins contain conserved sequence motifs that are known to be important

206 The N terminus of eRF1 contains highly conserved sequence motifs that couple stop codon recogni

207 rize the contribution of this and additional conserved sequence motifs to the regulation of specific

208 ng site estimation suite of tools, BEST, 407 conserved sequence motifs were identified in promoter re

209 8.1, 8.2, and 8.3, and that the TRB CDR3 had conserved sequence motifs which were shared across diffe

210 op GTPases, MAPGAPS correctly aligned weakly conserved sequence motifs within 33 distantly related GT

211 Conserved sequence motifs within the TMD were replaced w

212 cription factor (TF) binding, evolutionarily conserved sequence motifs, gene expression, and chromati

213 even transmembrane helices that contain well-conserved sequence motifs, indicating that they are prob

214 This feature, together with other conserved sequence motifs, place AaSDR-1 into the "class

215 res of Spc97 and Spc98 suggest functions for conserved sequence motifs, with implications for the gam

216 ears nuclear localization signals and highly conserved sequence motifs.

217 conserved RNA folding motifs rather than the conserved sequence motifs.

218 in TERT, which includes three evolutionarily conserved sequence motifs: CP2, CP, and T.

219 r G protein activators is characterized by a conserved sequence named the Galpha-binding and activati

220 nteractions with PTAP and LYPXnL, two highly conserved sequences named late (L) domains, which bind T

221 ys, phosphorylation of a serine present in a conserved sequence near the amino terminus of GSK-3 gene

222 Some of the most highly conserved sequences occur in genes encoding RNA binding

223 -Arnt-Sim (PAS) domain that is preceded by a conserved sequence of 25-27 amino acids known as the PAS

224 The most conserved sequence of MFPs is located in their distal C-

225 ylation sites, which are located in a highly conserved sequence of occludin, YETDYTT; Tyr-398 and Tyr

226 observations that: (i) it contains the most conserved sequence of SH2 domains, GSFLVR; (ii) it binds

227 y recognizing its target located in a highly conserved sequence of the 3'-untranslated region (3'-UTR

228 to a CRISPR-based gene drive inserted into a conserved sequence of the doublesex (dsx) gene.

229 he potential for microRNA binding sites in a conserved sequence of the Nef-3'-LTR, several host micro

230 In contrast with the highly conserved sequence of the protease catalytic domain, the

231 the H2-H3 domain indicating that the highly conserved sequence of the terminal part of H2 is not cri

232 This coil to helix transition involves the conserved sequence of Thr(16)-Pro(17)-Arg(18) (Ser(16)-P

233 ology 2 (SH2) domains are composed of weakly conserved sequences of approximately 100 aa that bind ph

234 sage for all species tested, we predict that conserved sequences of IhtA are necessary for function a

235 fy a nine amino acid motif within the highly conserved sequences of the exon 2b encoded domain that m

236 ative DBD of NRs, sequences of LBD were less conserved: Sequences of THRs, RARs and RXRs were >/=90%

237 Conserved sequences on the 3' and 5' ends of the crRNA a

238 nd in only one species, hundreds have either conserved sequence or position within Saccharomyces uORF

239 identified in sequenced Lytechinus BACs, as conserved sequence patches in similar regions of the res

240 They share a conserved sequence pattern and catalyse the displacement

241 lix, containing a hydrophobic surface with a conserved sequence pattern that interacts with key hydro

242 erant 'reading head' in C4BP, which detected conserved sequence patterns hidden within hypervariabili

243 ns involved in pathway interactions revealed conserved sequence patterns that enabled us to unambiguo

244 Late (L) domains containing the highly conserved sequence PPXY were first described for retrovi

245 iate adjacent bases, allowing us to define a conserved sequence preference for the mammalian DNA meth

246 This is the report where conserved sequences present in all the serotypes of Deng

247 ith corneal infection, revealed areas of non-conserved sequence principally in genes for the virus fi

248 ies of teleosts we identified a small highly conserved sequence (R2) located 1.7 kb upstream of the p

249 own as conserved sequences (CS) and repeated conserved sequences (RCS), have been identified as being

250 We observed that a weakly conserved sequence region (the variable region), located

251 We show that one of the conserved sequence regions in the C-terminal domain of P

252 JAZ proteins contain two highly conserved sequence regions: the Jas domain that interact

253 Primary sigma factors share four regions of conserved sequence, regions 1-4, which have been further

254 scattering analyses reinforce and extend the conserved sequence relationships of group 4 enzymes and

255 The second stem-loop contains conserved sequences required for base pairing with the m

256 Mutation of conserved sequences revealed that putative transcription

257 alled the YARHG domain after the most highly conserved sequence-segment.

258 G1 proteins are composed of two stretches of conserved sequences separated by a variable linker seque

259 ues that include the DFGWG motif, the single conserved sequence signature of BAHD super-family member

260 omic sequences enables the identification of conserved sequence signatures and can enrich for coding

261 evels of primary transcripts, are encoded by conserved sequences similar to those found at canonical

262 RNA genes and a novel assay that amplifies a conserved sequence specific for the sicavar gene family

263 st activator Gcn4 functions through a short, conserved sequence-specific motif.

264 lincRNAs can recognize protein targets in a conserved, sequence-specific manner in order to affect c

265 m many two-component systems has established conserved sequence, structural, and mechanistic features

266 ch is crucial for selective amplification of conserved sequences such as rRNA genes.

267 Here we found a highly conserved sequence (termed "ISLAD") that is associated w

268 Two intron 4 deletions occur in a highly conserved sequence that is part of the 3' untranslated r

269 e GPR158 C terminus additionally contained a conserved sequence that was capable of enhancing RGS7 GT

270 rs, EvoPrinterHD facilitates the analysis of conserved sequences that are essential for coordinate ge

271 d alignment programs, to characterize highly conserved sequences that are shared among co-regulating

272 erences profile is also generated to portray conserved sequences that are uniquely lost in any one of

273 'universal' overgo-hybridization probes from conserved sequences that can be used to efficiently scre

274 ased experiments have identified 5'-flanking conserved sequences that control pancreatic and beta-cel

275 Since exon 4 cluster introns lack conserved sequences that could mediate robust long-range

276 lar and leafy spurge have identified several conserved sequences that may be important for their expr

277 vidence of RNA secondary structures or other conserved sequences that might directly control elongati

278 In the HAmg vaccine, highly conserved sequences that were originally covered by glyc

279 ing the Cdc34(tm) mutation, which alters the conserved sequence, the cyclin-dependent protein kinase

280 th short (<200 bp) islands of evolutionarily conserved sequences, the function of most of these unann

281 When flanked by conserved sequences, the self-complementary diSSR (AT)n

282 lncRNA expression, we find that lncRNAs with conserved sequence undergo similar changes in expression

283 evolve separately to target the same highly conserved sequences, uniting afterwards to create a comp

284 nstrate that Pbx1 and Emx2 bind in vivo to a conserved sequence upstream of Alx1 and cooperatively ac

285 B1 plus both the proximal part of B1 and non-conserved sequence upstream of B1.

286 on bioinformatic analyses of evolutionarily conserved sequences, we predicted another peptide hormon

287 motifs and two additional mutations, in less conserved sequences, which also affect splicing.

288 n signal (NLS) was mapped to a short, highly conserved sequence whose activity was compromised by poi

289 A molecule recognizes a short, approximately conserved sequence within a gene's promoter region and,

290 Tra2beta binds to a highly conserved sequence within E23 and transactivates its spl

291 rs55705857 maps to a highly evolutionarily conserved sequence within the long non-coding RNA CCDC26

292 We identified a conserved sequence within the Muscle creatine kinase (MC

293 high cleavage activity and specificity for a conserved sequence within the ribosomal rDNA repeats, lo

294 The presence of highly conserved sequences within cis-regulatory regions can se

295 The new program also identifies conserved sequences within rearranged DNA, highlights re

296 ce conservation and enables the discovery of conserved sequences within rearranged DNA.

297 s occur throughout TFAP2A, but mostly within conserved sequences within the DNA contact domain of AP-

298 with physiological outcomes usually rely on conserved sequences within the RNA element.

299 gh mutational analysis of the evolutionarily conserved sequences within this enhancer, we identify tw

300 ns, and it is unclear whether including only conserved sequences would yield sufficient cellular immu