ライフサイエンスコーパス: constant domain

1 ed beyond antigen binding by the heavy-chain constant domain.

2 ional changes occur in a loop in the H chain constant domain.

3 ntracellular interactions has focused on the constant domain.

4 A for the variable domain and 0.7 A for the constant domain.

5 in variable domain linked to the kappa-chain constant domain.

6 mains and remain wild-type in their antibody constant domains.

7 bs) to the IgG3 subclass by exchanging their constant domains.

8 immunoglobulin-like variable domain and two constant domains.

9 the bending angles between the variable and constant domains.

10 le (VH)-encoded "elbow" between variable and constant domains.

11 at several positions, including variable and constant domains.

12 one antigen-binding domain, the VHH, and two constant domains.

13 the H and L chains in both the variable and constant domains.

14 e unpaired cysteine residues commonly in the constant domains.

15 ntibody was engineered to contain human IgG1 constant domains.

16 local dyad axis, exact only with respect to constant domains.

17 te consequence of deletion of the CH1 and CL constant domains.

18 the Cys at the N terminus of the heavy chain constant domain 1 (C(H)1) (Kabat position 127) to a Ser

19 ive expression of T cell receptor beta-chain constant domains 1 and 2 (TRBC1 and TRBC2).

20 HuCC49 deltaCH2 is a heavy chain constant domain 2 domain-deleted antibody under developm

21 ingle N-linked oligomannose structure in the constant domain 3 (Cepsilon3) of IgE, at asparagine-394

22 boundary region between the second and third constant domains--a site analogous to that recognized by

23 nization: a membrane-proximal immunoglobulin constant domain and a membrane-distal immunoglobulin var

24 L) chains owing to the deletion of the first constant domain and a reshaped surface at the VHH side,

25 the atomic resolution structure of the IgNAR constant domains and a structural model of this heavy ch

26 ing a stabilizing disulfide bond between the constant domains and disrupting predicted glycosylation

27 s of E559 were replaced with human IgG1kappa constant domains and the resulting chimeric mouse-human

28 the elbow angle between the variable and the constant domains, and it is significantly larger for bin

29 strategy to prevent TCR mispairing: swapping constant domains between the alpha and beta chains of a

30 d upon removal of the BiP-sequestering first constant domain (C(H)1) from u(s).

31 position 442 (EU/OU numbering) in the third constant domain (C(H)3) of the heavy chain of several Ig

32 ural isoforms are defined by the light chain constant domain (C(L)) and the heavy chain C(H)1 domain

33 We identified two constant domains, C1 and C3, that act as dimerization mo

34 We found that folding of the TCR alpha chain constant domain Calpha is dependent on alphabeta heterod

35 ar modeling to identify mutations in the TCR constant domains (Calpha/Cbeta) that increase the unfold

36 nstant domain, hinge region, and heavy-chain constant domains CH1 and CH2 are observed, leaving glyco

37 ain synthesis, BiP binds stably to the first constant domain (CH1) of the heavy chain, causing it to

38 y chain (HC) bearing a deletion of the first constant domain (CH1).

39 both chains, the region between heavy-chain constant domains CH2 and CH3, and the disulfide bond (S-

40 TCR signaling domains +/- an IgG heavy chain constant domain (CH2CH3) to create a series of vector co

41 the disulfide bond (S-S)-linked heavy-chain constant domain CH3.

42 plus up to approximately 60 residues of the constant domain (CL).

43 ir of Fab arms results from asymmetry in the constant domain (Cmu3) at the IgM subunit interacting mo

44 The TCRbeta chain constant domain contains an unusually elongated, solvent

45 Two modifications to the constant domain control antibody activity: theirreversib

46 production in both the antibody variable and constant domain create further complexity and can modula

47 alian IgG has three rather than the four IgM constant domains; deletion of the ancestral IgM C2 domai

48 , the first constant domain of mu, and seven constant domains encoded by a delta gene homolog.

49 the splice donor site at the end of the last constant domain exon (D7) is ignored and transcription c

50 h could be broadly implemented across the Ig constant domain family.

51 tralizing activity and induction of antibody constant domain (Fc)-mediated innate immune effector fun

52 d in vitro folding studies revealed that the constant domain folds rapidly and stably even in the abs

53 Noteworthy, the fibril harbours an extended constant domain fragment, thus ruling out the variable d

54 e soluble human insulin receptor (HIRs) with constant domains from immunoglobulin Fc and lambda subun

55 few cleavages in the S-S-linked light-chain constant domain, hinge region, and heavy-chain constant

56 ns of the N-terminal variable domain and the constant domains, however, greatly affected receptor act

57 gned the neutralization epitope to the third constant domain, immediately C terminal to the V3 loop.

58 disulfide bridge that links the variable and constant domains in addition to the two intrachain disul

59 Constant domains in antibody molecules at the level of t

60 respective regions between the variable and constant domains in both chains, the region between heav

61 The constant domain influences antigen recognition through e

62 Although other heavy chain-constant domains interact transiently with BiP, in the a

63 vely, these results verify the importance of constant domain interactions in antibody variable domain

64 n of one CD3epsilon subunit within the rigid constant domain module has implications for the mechanis

65 localized site is embedded within the rigid constant domain module has implications for the mechanis

66 eric D10 TCR suggesting that neither the TCR constant domains nor potential N- or O-linked carbohydra

67 e single-chain TCR genetically linked to the constant domain of an IgG1 H chain.

68 ng is a recombination event that changes the constant domain of antibody genes and is catalyzed by ac

69 s are more involved in this process than the constant domain of Apo(a).

70 monstrate that N-linked glycosylation in the constant domain of human IgA1 plays an important role in

71 ning the extracellular domain of ILA and the constant domain of human IgG (ILA-IgG) also inhibited ly

72 n-consensus asparaginyl residue in the C(H)1 constant domain of IgG1 and IgG2 antibodies.

73 were created by exchanging each variable and constant domain of JR-CSF gp120 with that of JR-FL or wi

74 ains a rearranged variable domain, the first constant domain of mu, and seven constant domains encode

75 One epitope mapped to the constant domain of RAP-1 (amino acids [aa] 144 to 187),

76 ely map the T-cell epitope identified in the constant domain of RAP-1 to aa 159 to 187 (FVVSLLKKNVVRD

77 e linker region between the variable and the constant domain of the IGLV3-21 light chains, previously

78 rmational changes in the native state to the constant domain of the light chain (C(L)).

79 ant effects were conferred by changes in the constant domain of the light chain.

80 lutamine-to-proline change within the second constant domain of the surface protein (SU); a threonine

81 The constant domains of antibodies are important for effecto

82 The constant domains of D-alphaPD-1 were derived from mouse

83 n the interfacial region of the variable and constant domains of different murine antibody antigen-bi

84 The murine constant domains of E559 were replaced with human IgG1ka

85 or extracellular domain with hinge and C2/C3 constant domains of human IgG1 or IgG3 heavy chains were

86 racellular domain of B7.2, and the hinge and constant domains of murine IgG2a.

87 of the elbow angle between the variable and constant domains of the Fab.

88 In GBid, the constant domains of the Fabs are located in the backbone

89 cats, cloned and sequenced the variable and constant domains of the feline heavy chains of IgG1a (IG

90 coded beads having capture sequences for the constant domains of the T-cell receptor alpha and beta c

91 regions between the variable domains and the constant domains of these antibodies.

92 nterface exchange between the TCR alpha/beta constant domain pair and the IgG1 CH3 homodimer was evid

93 erfaces of two different immunoglobulin (Ig) constant domain pairs are exchanged in part or fully to

94 ceptor (TCR) alpha/beta, and TCR gamma/delta constant domain pairs, and we found that they successful

95 nclusion of the Cgamma2 and Cgamma3 -encoded constant domains perturbed cellular activation whilst ma

96 ibody, when engineered to contain human IgG1 constant domains, possesses effector cell-mediated antit

97 tching," intramolecular interactions between constant domains promote homophilic binding.

98 ion via their variable domains, the antibody constant domain provides a functional link between innat

99 ngineer a monoclonal IgE antibody with human constant domains recognizing CSPG4 to target melanoma.

100 es in the orientations of their variable and constant domains, reflected by a 32 degrees difference i

101 Different constant domain residues in solanezumab/crenezumab/chime

102 to and activate lymphoid cells, perhaps via constant domains, resulting in protection of CS effector

103 d light chain V domains expressed in the IgM constant domain scaffold compared with the IgG scaffold.

104 ndicate a favorable effect of the remote IgM constant domain scaffold on the integrity of the V-domai

105 th of which are present in the IgG1 and IgG2 constant domain sequences, and Asn-35, which was present

106 ody was constructed such that the IgG1 C(H)3 constant domain serves as the oligomerization domain and

107 binding arms that engage CD3 and EpCAM and a constant domain that recruits Fc receptor-bearing cells,

108 ns of communication between the variable and constant domains that affects the overall antibody struc

109 nges in the loop region of the heavy chain's constant domain; this corresponds well with expected all

110 N-linked glycosylation sites in the antibody constant domain to achieve specific conjugation to the a

111 s many V, J and D segments that combine with constant domains to produce either an alpha or a delta c

112 ession of T cell antigen receptor beta-chain constant domain (TRBC) 1 and 2.

113 Rituximab) is a chimeric mAb with human IgG1 constant domains used in the therapy of non-Hodgkin's B

114 relationships, whereas no alteration of the constant domains was found.

115 of (auto)antibodies are determined by their constant domain, which defines the antibody isotype and

116 gn of therapeutics are antibody variable and constant domains, which are responsible for antigen bind