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1 teps of an induced immune response to become constitutive.
2 (day 7) ATDC5, and in RCS cells where it was constitutive.
3 onally regulated; however, HO2 expression is constitutive.
8 retion was necessary for GLEI formation, and constitutive activation of beta-catenin in young mice in
10 ts within the TSC1 or TSC2 genes, leading to constitutive activation of mechanistic target of rapamyc
11 reactive oxygen species (ROS), arising from constitutive activation of NOX2 oxidase, occurs in >60%
12 ted the nuclear accumulation of NRF2, led to constitutive activation of NRF2 signaling, and conferred
14 protein subunit alpha 13), resulting in the constitutive activation of RhoA (ras homolog family memb
15 eveloped a zebrafish melanoma model in which constitutive activation of ribosomal protein S6 kinase A
16 nding site or the ARM-TIR interaction caused constitutive activation of SARM1 and thereby led to axon
23 mutation resembles active LysRS and causes a constitutive activation of the microphthalmia transcript
24 ibition or specific Ship2 inhibition reduced constitutive activation of the mTORC1/ribosomal protein
25 We address this paradox by identifying the constitutive activation of the NRF2 master antioxidant r
26 glutamate receptor-like proteins (GLRs), or constitutive activation of the P-type H(+)-ATPase AHA1.
27 sistance mechanism to anti-HER2 therapies is constitutive activation of the phosphoinositide 3-kinase
29 own of ABCC4 expression markedly blunted the constitutive activation of the SHH pathway secondary to
31 when grown in Fe-sufficient condition, and a constitutive activation of the Strategy I Fe uptake gene
34 lpha-dependent, but mutations usually confer constitutive activation to the hormone receptor, renderi
35 is essential for effective innate immunity, constitutive activation typically causes harmful autoimm
36 etailed phenotypic and molecular analysis of constitutive activator and repressor HY5 fusion proteins
38 TIVE PARTNER b (RIPb; synonym: INTERACTOR OF CONSTITUTIVE ACTIVE ROP b) directly interacts with RACB
42 examined to better understand the origin of constitutive activity and the potential for retinal dege
43 ctively targeting GHSR and reducing its high constitutive activity appears to be a good candidate for
44 ugh the ERK cascade and mutations leading to constitutive activity are key drivers of human tumors, a
47 ck-Hall operational model, we quantified the constitutive activity for both pathways and conclude tha
48 The promoter of SfHsp70D showed the high constitutive activity in cell line and embryos, while th
49 LCgamma(2) variants typically do not exhibit constitutive activity in cell-free systems, leading to t
50 contrast between the low levels of beta(2)AR constitutive activity in cells and the high constitutive
51 constitutive activity in cells and the high constitutive activity observed in an isolated phospholip
53 e B-cell lymphoma (PMBL) cells depend on the constitutive activity of NF-kappaB and STAT transcriptio
54 s in the ENaC M2 helix may contribute to the constitutive activity of these channels at a resting pH.
55 ns and highly selective to Ca(2+) ; it shows constitutive activity regulated negatively by Ca(2+) and
56 2 altered GHSR1a signaling by inhibiting its constitutive activity, as well as by enhancing its G pro
57 rmation has been hypothesized to result from constitutive activity, but how the receptor could escape
58 o specific values, e.g., epsilon(R0) = 0: no constitutive activity, gamma = 1: no amplification (E(ma
64 or-bearing Smo/Smo medulloblastoma mice with constitutive actvation of the Smoothened (Smo) receptor
69 confirm the EP3gamma splice variant has both constitutive and agonist-sensitive activity to inhibit c
72 ere we employ a series of mouse mutants with constitutive and conditional Sox10 deficiencies to show
73 xpressing BvLz under the control of multiple constitutive and culm-regulated promoters on separate ex
78 resources, via the complementary pairing of constitutive and regulated promoters that vary in streng
80 becomes possible to visualize sorting to the constitutive and regulated secretory pathways in real ti
81 temperature sensitive variant that exhibits constitutive and stress-induced autophagic defects at pe
82 d and fail to innervate the striatum in both constitutive and striatal-specific Nolz1 mutant embryos.
83 velopment have mostly used mouse models with constitutive and tissue-specific homozygous knockout of
84 nter to the canonical view of prenylation as constitutive, and strikingly, in a manner dependent on a
85 at phage K1F is phagocytosed and degraded by constitutive- and PAMP-dependent LC3-assisted phagocytos
86 ine 100-phosphorylated RORalpha orchestrates constitutive androstane receptor (CAR) and hepatocyte nu
87 by xenobiotics, including phenobarbital via constitutive androstane receptor (CAR) and hepatocyte nu
88 otic receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are activated by
89 yl)oxime (CITCO) is a dual agonist for human constitutive androstane receptor (hCAR) and human pregna
90 ity of the upstream DNA sequences to recruit constitutive androstane receptor-retinoid X receptor het
91 ly produced by endothelial cells, disrupting constitutive ANGPT1-TIE2 signaling to destabilize the mi
95 N193189, a drug under development to inhibit constitutive BMP signaling during heterotopic ossificati
96 f Gpr81 suppresses breast cancer growth in a constitutive breast cancer mouse model (MMTV-PyMT-Tg).
101 nhancers: the proximal enhancer mediates the constitutive CCL5 expression during the steady state, wh
103 Importantly, EECM-BMEC-like cells exhibited constitutive cell surface expression of ICAM-1, ICAM-2,
106 thologic and molecular findings mimicked the constitutive Cfl2-knockout (KO) mice described previousl
107 se abnormalities are attributable neither to constitutive changes in gene expression nor to alteratio
108 normal wing morphology, when supplemented by constitutive Ci repressor, showing that Hh can signal no
109 ts indicate that cell-surface EMCN undergoes constitutive cleavage and that TNF-alpha treatment drama
110 We show that Rbm24-targeted deletion using a constitutive CMV-driven Cre in mouse, and rbm24a-CRISPR/
111 primary role of DMSP in high producers is a constitutive compatible solute; and (2) DMSP production
112 scriptomes of 16 mammalian tissues defines a constitutive "core" set of TOP mRNAs, but also identifie
113 driven by genetic alterations that activate constitutive cytokine receptor and kinase signaling, and
115 autophagy in Ho_CS epithelial cells, with a constitutive deficiency in autophagosome formation as de
118 el of fragile X (FX) suggests that increased constitutive dendritic protein synthesis yields exaggera
119 This opens the way to more physically based constitutive descriptions for the glasses allowing desig
120 heral blood monocytes, inhibit an apparently constitutive Dicer proteolysis, allowing for increased f
122 dge by using Arabidopsis thaliana lines with constitutive ectopic overexpression of the AtNBR1 gene (
123 e and the NAD(+)/NADH ratio, indicating that constitutive endoplasmic reticulum (ER)-to-mitochondria
126 emonstrate that the loss of NAA50 results in constitutive ER stress signaling, indicating that NAA50
129 over, regulated exons are often shorter than constitutive exons but are flanked by longer intron sequ
133 id (Macrosiphum euphorbiae) and has elevated constitutive expression levels in suppressor of prosyste
135 constitutively overexpressing BdRAM1 showed constitutive expression of AM-inducible genes even in th
137 elated to genotypic variation among samples, constitutive expression of dehydration-associated transc
138 tress response was present, we also observed constitutive expression of genes encoding proteins known
139 ides a framework for the cell type-specific, constitutive expression of IFN-kappa and its modulation
140 cronutrient balance on the regulation of the constitutive expression of innate immune genes, as a low
143 bosomal protein S6 pathway and downregulated constitutive expression of the antiapoptotic protein Mcl
145 which is spatially inverse to ventrolateral constitutive expression of the retinoic acid-synthesizin
146 of FA patients worldwide, is associated with constitutive expression of the transcription factor micr
153 ed cell death in response to interruption of constitutive flux of Ca(2+) from ER to mitochondria.
158 CDI is mediated by calmodulin binding to the constitutive GluN1 subunit, prior studies suggest that G
159 ), but not the histone modifications marking constitutive (H3K9(me3)) or facultative (H3K27(me3)) het
160 cells possess uracil in the late replicating constitutive heterochromatic regions, while drug treatme
161 mportance for the restricted transmission of constitutive heterochromatin during reprogramming and a
162 ochromatin in differentiated cell types, how constitutive heterochromatin is assembled de novo during
167 n development is the dramatic remodelling of constitutive heterochromatin, although the functional re
168 ametrical separation between facultative and constitutive heterochromatin, and the organization of RN
169 his irregularity is particularly striking in constitutive heterochromatin, which has typically been v
170 ding protein 2 (MeCP2) is a key component of constitutive heterochromatin, which is crucial for chrom
171 gns expressed in Escherichia coli, 65 formed constitutive heterodimers, and the crystal structures of
176 ite line that contains Nanoluc driven by the constitutive hsp70 promoter, as well as firefly lucifera
180 virus hosting capacities, including uniquely constitutive immune pathways, on cellular-scale viral dy
181 ays on bat cell lines expressing induced and constitutive immune phenotypes, then developed a theoret
183 the dynamic change in mechanical stress, the constitutive individual proteins need to reversibly stre
184 its affinity for beta subunits and relieves constitutive inhibition of Ca(V)1.2, observed as an incr
186 the P2 cytoplasmic tail domain mediated the constitutive interaction between STAT2 and IFNAR2 in res
187 tion by a variety of cells and its uptake by constitutive internalization and recycling of CCR2.
192 Itk and Btk to the cell membrane and induces constitutive kinase activation in transfected 293T cells
195 bryonic nervous system development, study of constitutive knockout (KO) of EphA4 in mice is limited d
196 In addition to the conditional alleles, constitutive knockout alleles were also obtained as bypr
197 liferation in nonmammalian utricles, whereas constitutive LATS1/2 kinase activity suppresses YAP-TEAD
198 orial softening damage model whose vectorial constitutive law captures oriented mesoscale frictional
199 molecular structure of spectrin networks and constitutive laws and also defines a new picture of a mu
200 t crystal dispersion demonstrated that local constitutive laws can be assessed by rheo-microMRI at a
201 hs) from BAFF-RFP mice expressed the highest constitutive levels of BAFF; other myeloid subsets, incl
202 d levels of Nrf2 to test the hypothesis that constitutive levels of Nrf2 in the premature lung are in
203 in tumor cell lines and BTICs expressed high constitutive levels of PD-L1 and PD-L2 and that PD-L2 ov
204 ve previously shown that SERKs can also form constitutive, ligand-independent complexes with the LRR
205 phosphorylate IFITM3 at Tyr20, which causes constitutive localization of this protein at the plasma
207 pidermis-specific expression of PIF4 induces constitutive long hypocotyls, while vasculature-specific
210 on from HSCs in response to stress, and that constitutive low Notch and high Wnt activity in leukemic
214 own, we demonstrate that, in contrast to the constitutive LPCAT1, LPCAT2 is required for macrophage c
216 SW480 colorectal cancer cells displayed constitutive macropinocytosis and increased extracellula
219 e examples of ISG hyperactivation, including constitutive MDA5 activation, they lack autoinflammatory
220 utside the viral context (RdRP mice) exhibit constitutive, MDA5-dependent, and quantitatively dramati
221 n reporter allele (Abcb1aAME), we found that constitutive MDR1 expression among hematopoietic cells w
226 d to strengthen classical crystal plasticity constitutive models to make predictions linked to the ef
228 l inhibition normalizes stimulus-induced and constitutive mRNA translation rate, decreases lactate an
232 the repression of NRF2 by KEAP1, leading to constitutive NRF2 activity and decreased oxidative stres
233 to negative Hippo pathway regulation due to constitutive nuclear localization and resistance to degr
239 age A resistant E. grandis genotype showed a constitutive overexpression of genes related to resistan
241 tomes infected by A. psidii and it reveals a constitutive overexpression of several resistance-relate
243 strains overexpressing CfrA from either the constitutive P (trc) promoter (Ptrc-cfrA) or the arsenit
246 we explored the cell-intrinsic mechanisms of constitutive PD-L1 and PD-L2 expression in brain tumors.
247 itory receptors, associated with an elevated constitutive phosphorylation of proximal signaling molec
250 thesis genes upregulated under low N include CONSTITUTIVE PHOTOMORPHOGENIC DWARF, DWF4, and BRASSINOS
251 -ideal plasmas), which is a weak link in the constitutive physics informing the structure and evoluti
252 o tumor cell-intrinsic mechanisms that cause constitutive PI3K/AKT/MTOR pathway activation, secreted
255 t on the agr-independent mgrA P2 reporter (a constitutive promoter from the mgrA two-component system
256 ous transgenic expression of the TFs under a constitutive promoter in the orange carrot cultivar 'Dan
257 sion activity of over 675,000 sequences in a constitutive promoter library and over 327,000 sequences
259 eta5i inhibitors, whose activity against the constitutive proteasome (c-20S) is cumulative with the t
260 Our findings demonstrate that ATRX forms a constitutive protein complex with FANCD2 and protects FA
263 obligate requirement for IL-11 signaling via constitutive pS-STAT3 in Helicobacter-induced gastric ca
267 ion of multi-experiment analysis to identify constitutive QTLs and candidate genes associated with th
273 r dynamics (MD) simulations to elucidate the constitutive relationship of calcium-silicate-hydrate (C
275 We observed that precancerous cells with constitutive Rheb activation through loss of tuberous sc
277 polarized vesicles that, while distinct from constitutive secretory vesicles, are dependent on actin
279 mall subset of phenotypes seen previously in constitutive Shank3 knockout mice, including increased a
281 ond germline and somatic mutations promoting constitutive SHH signaling, driver alterations affect a
285 ad to deregulated activation of formin and a constitutive stress response in cultured cells, primary
286 ependent even when transcription is rendered constitutive, suggesting additional posttranscriptional
290 r mutations and 7 novel mutations that cause constitutive TpoR activation, and a much larger number o
291 An upstream promoter, P (oah) , controls the constitutive transcription of the entire operon and a se
292 en receptor (ER) alpha-gene (ESR1) result in constitutive transcriptional activity in the absence of
293 tified a novel role for CPEB1 in maintaining constitutive translation of a large group of maternal mR
294 mic reticulum (ER); a protein kinase, called constitutive triple response 1 (CTR1); an ER-localized t
298 The AtNFS1 overexpression line exhibited constitutive upregulation of several defense-related gen