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1 populations and the cytokines they expressed constitutively.
2 mice lacking CB(2) in neurons, monocytes or constitutively.
4 lying that changes in expression result from constitutively accessible promoters under the influence
6 e, we report that TALI (a) is predisposed to constitutively activate GPHR, (b) can by itself rearrang
9 ations of the transcription factor NTL8 that constitutively activate VIN3 expression and alter the sl
10 and TACSTD2(low) luminal cells transduced by constitutively activated AKT1 (caAKT1), and c-Myc can fo
12 d the MIN7 vesicle-trafficking pathway, or a constitutively activated cell death1 (cad1) mutant, carr
13 tion (GOF) transgenic mouse, which expresses constitutively activated FGFR3 (FGFR3(K650E)) in postmit
14 rleukin-13 (IL-13) and IL-4 signaling and is constitutively activated in malignant lymphocytes from S
16 e embryo defects can be partially rescued by constitutively activated mitogen-activated protein kinas
22 V600E mutation of BRAF (BRAF(V600E)), which constitutively activates the ERK/MAPK signaling pathway,
27 yeloma cell lines expressing wild-type (WT), constitutively active (CA) (G12V/G13D/Q61H), or dominant
29 o BRAF/MEK inhibitors, whereas expression of constitutively active ABL1/2 is sufficient to promote re
31 d, administration of oleate, while mimicking constitutively active Acc1 in WT cells, alleviates the v
33 ctivity for sodium over potassium, ENaCs are constitutively active and display a remarkably high degr
34 ation in rhodopsin causes the receptor to be constitutively active and leads to congenital stationary
36 rast, in cancer cells, we found that AMPK is constitutively active and that archazolid does not affec
37 Liquid biopsies have demonstrated that the constitutively active androgen receptor splice variant-7
41 Chronic myeloid leukemia (CML), caused by constitutively active BCR-ABL1 fusion tyrosine kinase, h
42 gs indicate that whereas LBR tends to be the constitutively active C14-sterol reductase, DHCR14 level
44 we generated and analyzed mice expressing a constitutively active CD30 receptor in B lymphocytes.
45 Our results show that the V60L mutant forms constitutively active channels that are insensitive to A
46 ), we analyzed the conditional expression of constitutively active CPK1 in conjunction with in vivo p
49 utants and fusions signal as RAS-independent constitutively active dimers with the exception of BRAF
52 ine-controlled transactivator (tTA) from the constitutively active Eef1a1 locus in a Cre recombinase-
53 he results showed that NSCLC cell lines with constitutively active EGFR mutations tend to have very o
57 that are silenced by histone methylation in constitutively active EZH2((Y641)) mutant melanoma and a
58 rahepatic cholangiocarcinomas (ICCs) express constitutively active fibroblast growth factor receptor
60 roscopy, we determine the structures of this constitutively active form (Mec1(F2244L)-Ddc2) at 2.8 an
61 ed oxidative injury causes upregulation of a constitutively active form of acetylcholine-dependent K(
62 the MAPK pathway through overexpression of a constitutively active form of c-Raf (ca-Raf) inhibits pr
64 2/STAT5 signaling, while overexpression of a constitutively active form of STAT5 partially ameliorate
65 carried out in villin-TLR4 mice, carrying a constitutively active form of TLR4, their littermates, a
66 the wave landscape using TIRF microscopy and constitutively active formin constructs tagged with fluo
71 Furthermore, liver-specific expression of constitutively active FoxO1 in transgenic mice induced a
72 tates present in the membrane containing the constitutively active G90D rhodopsin mutant or apoprotei
75 (RNAPII) with, and diminished expression of, constitutively active genes and the inducible CUP1 gene.
78 lyze GTP, keeping this molecular switch in a constitutively active GTP-bound form that drives, unchec
79 gain-of-function mutation that results in a constitutively active H(+) pump partially suppressed SAU
80 lacentogenesis, we determined the effects of constitutively active Hif-1alpha, specifically in tropho
83 e either prone for decommissioning or remain constitutively active in epiblast stem cells (EpiSCs), a
85 tor (BCR) signaling, MYD88/IRAK signaling is constitutively active in PEL, but that under cell cultur
89 cogenic mutations occur in exons 2 or 3, two constitutively active KRAS proteins-each capable of tran
91 analyses demonstrated that the expression of constitutively active MKK4, MKK5, or YDA driven by the R
93 omal content during chronically inhibited or constitutively active mTORC1 signaling, respectively, an
95 A) allele consists in a transgene encoding a constitutively active mutant form of TGFbeta (TGFbeta(CA
97 suggest that compound-directed conversion of constitutively active mutant Ras into functionally inact
100 S101A/S241A, a phosphorylation-deficient and constitutively active mutant, prevents hypoxia-induced b
101 stepwise N-terminal truncations, 3) distinct constitutively active mutations distributed across the h
103 rescued by conditional overexpression of the constitutively active NOTCH intracellular domain in CD11
104 ated orphan receptor-gammat (RORgammat) is a constitutively active NR that positively regulates the e
106 induced changes occur to some extent even in constitutively active or inactive mutants, showing that
108 Adeno-associated viral (AAV) delivery of constitutively active Pfn1 to rodents promoted axonal re
109 on and suggest that AAV-mediated delivery of constitutively active Pfn1, together with the identifica
110 examining the genetic interaction between a constitutively active phyB(Y276H)-YFP allele (YHB-YFP) a
111 Ai screen in Drosophila for suppressors of a constitutively active Polo mutant, we identified a stron
113 disruption of these interactions resulted in constitutively active proteins, freed from autoinhibitio
116 ent on its GAP activity as overexpression of constitutively active Rabs inactivated by RN-tre failed
120 tations W515L/K/R/A or S505N, which generate constitutively active receptors and consequent loss of T
121 cells by immunostaining, while expression of constitutively active Rho or Rho-kinase (Rok) rescues th
122 udies with pseudohyperphosphorylated tau and constitutively active RhoA revealed that LM11A-31 likely
135 helia, while conditional overexpression of a constitutively active version of Yap, Yap5SA, is suffici
136 participate in amelioration of tauopathy by constitutively active XBP-1, possibly through endoplasmi
137 an effect partially rescued by expression of constitutively active YAP (S127A), suggesting the effect
138 oe et al. (2019) show that the expression of constitutively active YAP induces a remarkable degree of
139 ic kidney (HEK)-293 cells transfected with a constitutively active YAP mutant, and the conditioned me
140 ed in the tail, whereas cells overexpressing constitutively active YAP were able to travel through th
141 mary villous cytotrophoblasts overexpressing constitutively active YAP-5SA with YAP KO cells and sync
142 cells to trametinib, while overexpression of constitutively active YAP1 protein induced trametinib re
143 cking out Depdc5 in muscle would make mTORC1 constitutively active, causing hypertrophy and improving
145 RNA-seq data revealed enriched expression of constitutively active, treatment-refractory AR splice va
147 osphopeptide complex, from which we design a constitutively-active mutant (confirmed via enzyme assay
149 ylinositol 4,5-bisphosphate (PIP(2)) or that constitutively adopt a closed conformation, we confirmed
151 Mtr10 mediates retrograde import of tRNAPhe, constitutively and in response to amino acid deprivation
152 u-microtubule binding, as substitutions with constitutively and positively charged nonaromatic lysine
153 rees C; in each ryp mutant, the fungus grows constitutively as hyphae regardless of temperature, and
156 cromolar [Ca(2+) ] activates the channel via constitutively-bound calmodulin, whereas higher [Ca(2+)
159 e than 100 trillion symbiotic microorganisms constitutively colonize throughout the human body, inclu
162 n mobile genetic elements (MGEs), where they constitutively defend against invaders or are induced to
166 ed in cell wall and cuticle biosynthesis are constitutively down-regulated in ccc1 mutants, and the c
170 ased levels of B2 RNA processing, leading to constitutively elevated B2 RNA target gene expression an
172 Rad26 does not directly displace RNAPII but constitutively evicts Spt5, a key transcription elongati
174 The results obtained indicate that hAEC constitutively express a unique combination of functiona
179 tilized transgenic mouse strains that either constitutively express only FN containing the EDA isofor
180 we engineered tumor-targeted CAR T cells to constitutively express the immune-stimulatory molecule C
181 , we employed murine GBM cells engineered to constitutively express the type I Herpes Simplex Virus (
182 ersatile genetic tool that can be applied to constitutively express transgenes in specific cell types
183 al, there are 2 classes of reporter systems: constitutively expressed (always-on) reporter constructs
185 gand or B cell-activating factor, which were constitutively expressed and upregulated during inflamma
186 ponse that was specifically directed against constitutively expressed antigens of microvascular glome
187 Beyond its role in inflammation, CCL22 is constitutively expressed at high levels in lymphoid orga
189 Dependency Map, we observe that half of all constitutively expressed genes are never detected in any
192 ing, we discovered that NHR-23/NR1F1 is also constitutively expressed in developing primary spermatoc
194 al infection, and DNA damage, but it is also constitutively expressed in many types of cancer, althou
195 er in the caspase family of proteases and is constitutively expressed in most cell types including ne
196 TSG-6 and heavy-chain protein-hyaluronan are constitutively expressed in normal skin and increase pos
197 is an inositol-1,4,5-trisphosphate receptor constitutively expressed in stem cells of the adjacent r
198 that ARID1, a transcription factor which is constitutively expressed in the vegetative nucleus but d
200 ce and patients with gastritis, pS-STAT3 was constitutively expressed irrespective of Helicobacter in
201 onRII, the low-affinity receptor for IgE, is constitutively expressed on B cells and has been shown t
203 tudies in stably transfected HeLa cells that constitutively expressed PDZK1 showed that coexpression
204 ated early-stage antiviral factor; RPRD2), a constitutively expressed protein that potently restricts
207 last stem cells (EpiSCs), and identified the constitutively expressed zinc finger transcription facto
209 derable controversy regarding whether PRF is constitutively expressed, rapidly increased similarly to
211 signaling are attenuated in transgenic mice constitutively expressing adropin and in fasting mice tr
216 CSF-1 and IL-34 were expressed and secreted constitutively from GF, with comparable levels in GF fro
217 Several thousand residues of 8-oxodG are constitutively generated in the genome of mammalian cell
218 et al. indicate that oncoproteins that drive constitutively high cAMP signaling pathway output in sus
221 ity is thought to be negatively regulated by constitutively high ciliary cAMP maintained by the Galph
224 diates an early step in D1 assembly, exhibit constitutively high psbA ribosome occupancy in the dark
225 ncluding 3D and PDX models, we discover that constitutively high SOX6 expression promotes elevated le
227 hat root cortical aerenchyma (RCA) is formed constitutively in OsEPF1OE lines regardless of tissue ag
228 oxypeptidase (Vasohibins-SVBP) activities to constitutively increase alpha-tubulin detyrosination nea
230 at the IRAK pathway induced cellular signals constitutively, independent of IL-1beta stimulation, whi
233 otif for endogenous Src tyrosine kinase that constitutively inhibits I(Kv1.5) Disrupting the Src-bind
234 rved that the EphB1 receptor tyrosine kinase constitutively interacts with caveolin-1 (Cav-1), the ke
237 ent model of CAR activation, ectopic CAR1 is constitutively localized in the nucleus and is loaded on
238 proportion of naked mole-rat p53 protein is constitutively localized in the nucleus prior to DNA dam
239 trast to the other class IIa HDACs, HDAC7 is constitutively localized to the cardiomyocyte cytoplasm,
240 compared to the day in WT cones but remained constitutively low in mutant cones both day and night.
241 3(tm1.1Hwrt) hypomorphic mice, which express constitutively low levels of alpha3* nAChRs, self-admini
242 ere cell expansion defects and corresponding constitutively low levels of PM H(+)-ATPase phosphorylat
244 e we show that ESCs with three epitypes, WT, constitutively methylated, or hypomethylated, all underg
245 that PI4KIIIbeta1 and PI4KIIIbeta2 activity constitutively negatively regulates LR primordium format
246 rs murine chondrocyte proliferation, whereas constitutively nuclear nls-YAP5SA accelerates proliferat
247 ivity or ligand-dependent activation but are constitutively open at physiological membrane potentials
251 ory variants controlling the gene expression constitutively or drought-dynamically are unraveled.
252 Resonance energy transfer can be used to constitutively or dynamically modulate actuation sensiti
253 evelopment in B. distachyon Transgenic lines constitutively overexpressing BdRAM1 showed constitutive
254 high-temperature specialists of F. thermalis constitutively overproduce glycolipid isomers associated
256 gulated by transient phosphorylation, PKC is constitutively phosphorylated following biosynthesis to
262 t abundant circulating antibody class but is constitutively present in healthy tissues bound to resid
265 ericryptal Ptgs2-expressing fibroblasts that constitutively process arachidonic acid into highly labi
266 s, half of the mRNA splice forms of Opa1 are constitutively processed to yield exclusively s-OPA1.
268 the expression of CX3CL1, a unique chemokine constitutively produced by neurons to suppress microglia
270 In Mdr2(-/-) mice, hepatic B lymphocytes constitutively produced IgG during fibrosis progression,
271 th high levels of SLC7A11 (SLC7A11(high)) to constitutively reduce cystine to the more soluble cystei
272 ynaptic interaction between Elfn1 and mGluR7 constitutively reduces initial release probability onto
276 Here we demonstrate that AMs, but not ECs, constitutively secrete paracrine activity localized to E
277 early secretory pathway more slowly than the constitutively secreted GLUT1 transporter and localize C
278 of molecular tools, we found that VPA0226, a constitutively secreted lipase, is required for escape o
280 lls, and expression of a 4E-BP1 variant that constitutively sequesters eIF4E promoted reporter activi
281 absorption cross section of PSII suggested a constitutively small light-harvesting antenna size relat
282 n ago4-1 but also in plants overexpressing a constitutively stable version of the oxygen sensor RELAT
284 ate for AMP-activated protein kinase (AMPK), constitutively suppresses this central metabolic sensor.
285 10069 bacteria harboring the pYA5199 plasmid constitutively synthesized the YopE(Nt138)-LcrV fusion p
286 e of P. falciparum (PfGCaMP3) that expresses constitutively the genetically encoded Ca(2+) indicator
287 interface enables this interaction to occur constitutively throughout the cell cycle and regardless
289 sis thaliana), although GAMYB-like genes are constitutively transcribed during vegetative growth, the
293 d cells suggests that they could be produced constitutively under stress conditions in anticipation o
294 oeae, the sole causative agent of gonorrhea, constitutively undergoes diversification of the Type IV
295 e majority of distal regulatory elements are constitutively unmethylated throughout T cell differenti
299 SA exhibited higher amounts of flavan-3-ols constitutively via the same transcriptional activation m
300 ng a cytomegalovirus (CMV)-cre strain, Wasf3 constitutively was inactivated, which led to viable mice