ライフサイエンスコーパス: constitutively active

1 arious signaling pathways and is known to be constitutively active.

2 Conversely, the p.Tyr64Asp substitution is constitutively active.

3 weight AR species were nuclear localized and constitutively active.

4 We hypothesized that expression of constitutively active 4E-BP1 constructs (4E-BP1F113A and

5 o BRAF/MEK inhibitors, whereas expression of constitutively active ABL1/2 is sufficient to promote re

6 Constitutively active Acc1 (acc1(S/A) ) or a deletion of

7 d, administration of oleate, while mimicking constitutively active Acc1 in WT cells, alleviates the v

8 thin this surface renders cGAS massively and constitutively active against self-DNA.

9 cells is stimulated by myristoylated (i.e., constitutively active) Akt and reduced by the Akt-specif

10 ndrial Akt in ESCs, a mitochondria-targeting constitutively active Akt1 (Mito-Akt1) was expressed in

11 ts in CAPE-treated embryos are suppressed by constitutively active Akt1.

12 n treatment and adenoviral overexpression of constitutively active AMPK downregulated mitochondrial s

13 Using mice expressing dominant negative and constitutively active Ampk in skeletal muscle, we demons

14 Unlike its constitutively active ancestor trypsin, FVIIa is alloste

15 ctivity for sodium over potassium, ENaCs are constitutively active and display a remarkably high degr

16 ation in rhodopsin causes the receptor to be constitutively active and leads to congenital stationary

17 ever, in tumorigenesis, STAT proteins become constitutively active and promote the expression of prog

18 xhaustion, or oncogene activation, mTORC1 is constitutively active and resistant to serum and amino a

19 The short isoform TAK1DeltaE12 is constitutively active and supports TGF-beta-induced EMT

20 rast, in cancer cells, we found that AMPK is constitutively active and that archazolid does not affec

21 TRPV6 channels are constitutively active and their open probability depends

22 e the canonical effectors, BOK appears to be constitutively active and unresponsive to antagonistic e

23 Liquid biopsies have demonstrated that the constitutively active androgen receptor splice variant-7

24 Treatment-refractory, constitutively active androgen receptor splice variants

25 pecifically, the expression of truncated and constitutively active AR variant 7 (AR-V7).

26 f mechanisms, including the emergence of the constitutively active AR variant V7 (AR-V7).

27 raint from un-liganded LBD as exemplified by constitutively active AR variants (AR-Vs), which are ass

28 and miR-361-3p modulation altered levels of constitutively active AR variants, and inhibited variant

29 PEG10 is expressed by prostate cancer with constitutively active AR-splice variants that can be exp

30 0 was also expressed in prostate cancer with constitutively active AR-splice variants.

31 Our findings identify a novel constitutively active AR-V, ARv5es and establish a metho

32 ments that allosterically suppress otherwise constitutively active AR-Vs; one in exon 5 for v6es and

33 Finally, expression of constitutively active ARF1 in fibroblasts induced format

34 This phenotype is suppressed by constitutively active arl-8 or unc-104 mutants.

35 A UgpB mutant unable to bind G3P is constitutively active as a chaperone, and its crystal st

36 ids of the endogenous TTP protein renders it constitutively active as an mRNA-destabilizing factor.

37 Conversely, overexpressing constitutively active Atg7, which forces autophagy and r

38 whether the EBV LMP2A protein, which mimics constitutively active B cell receptor signaling, is requ

39 Chronic myeloid leukemia (CML), caused by constitutively active BCR-ABL1 fusion tyrosine kinase, h

40 Finally, we found that a constitutively active beta-catenin could only partially

41 Both constructs were constitutively active but were monomeric as determined b

42 ed guanine nucleotide-exchange factors or of constitutively active (but not wild-type) forms of these

43 Conversely, overexpression of constitutively active c-Abl in hA53Talpha-syn mice accel

44 gs indicate that whereas LBR tends to be the constitutively active C14-sterol reductase, DHCR14 level

45 yeloma cell lines expressing wild-type (WT), constitutively active (CA) (G12V/G13D/Q61H), or dominant

46 e investigated the responses controlled by a constitutively active (CA) MPK3 in Arabidopsis thalianaC

47 Renal expression of the constitutively active (CA)-SPAK mutant was specifically

48 dual neurons using dominant-negative (dn) or constitutively-active (ca) forms of nuclear-localized Ca

49 substitutions of F518 and Y563 even lead to constitutively active CaPLSases that bypass Ca(2+)-depen

50 cking out Depdc5 in muscle would make mTORC1 constitutively active, causing hypertrophy and improving

51 We report that a constitutively active CB(2) variant has higher thermosta

52 we generated and analyzed mice expressing a constitutively active CD30 receptor in B lymphocytes.

53 Here, the effects of constitutively active CD40 in DCs on atherosclerosis wer

54 Additional BCR stimulation of these constitutively active cells, however, led to reduced act

55 Our results show that the V60L mutant forms constitutively active channels that are insensitive to A

56 nase dead) and GRK2-S670A (unphosphorylated, constitutively active) conferred protection from cisplat

57 n homology) domains, revealing that it has a constitutively active conformation.

58 ), we analyzed the conditional expression of constitutively active CPK1 in conjunction with in vivo p

59 eserpine (VMAT inhibitor), and VP16-XlCreb1 (constitutively active CREB) would break the all-or-none

60 ly mimicked in WT neurons upon expression of constitutively active CRMP2 (CRMP2(T/A)).

61 Constitutively active D13K-Y106W CheY has been an import

62 Autophagy is a constitutively active degradation pathway that promotes

63 ng a possible therapeutic strategy where the constitutively active dimer conformer of PDK1 may be ren

64 constraints on the activation loop yielded a constitutively active dimer, providing clues regarding h

65 ignal either as active monomers (class 1) or constitutively active dimers (class 2).

66 utants and fusions signal as RAS-independent constitutively active dimers with the exception of BRAF

67 Constitutively active EDA caused elevated IOP starting a

68 7BL/6J mice and further amplified the IOP in constitutively active EDA mice.

69 ine-controlled transactivator (tTA) from the constitutively active Eef1a1 locus in a Cre recombinase-

70 In mice with constitutively active EGFR [EGFR(DSK5) mice], we find th

71 mall cell lung cancer xenograft expressing a constitutively active EGFR conformational mutant exhibit

72 NSCLC patients with constitutively active EGFR mutations eventually develop

73 he results showed that NSCLC cell lines with constitutively active EGFR mutations tend to have very o

74 Furthermore, in knock-in mice harboring constitutively active eNOS, elevated CRP did not invoke

75 h this substitution converts the enzyme to a constitutively active enzyme, it results in PKU because

76 We demonstrate conversion of constitutively active enzymes into peptide-operated synt

77 Ks)) of the cardiac action potential or as a constitutively active epithelial leak current.

78 ible transgenic line to induce expression of constitutively active ErbB2 (caErbB2) selectively in SCs

79 therapy-resistant tumors driven by different constitutively active ERs.

80 d D538G ERs, the two most commonly occurring constitutively active ERs.

81 The second mechanism requires constitutively active expression of LGP2 and HDAC4.IMPOR

82 that are silenced by histone methylation in constitutively active EZH2((Y641)) mutant melanoma and a

83 rahepatic cholangiocarcinomas (ICCs) express constitutively active fibroblast growth factor receptor

84 ress the AMPylation activity mediated by the constitutively active Fic(E247G) mutant in Drosophila S2

85 Here, we show that excessive AMPylation by a constitutively active Fic(E247G) mutant is lethal in Dro

86 In contrast, Ypt7-tm is constitutively active for HOPS-dependent fusion, indepen

87 overed by MTORC1 inhibition or expression of constitutively active forkhead box protein O1 (FoxO1).

88 roscopy, we determine the structures of this constitutively active form (Mec1(F2244L)-Ddc2) at 2.8 an

89 ed oxidative injury causes upregulation of a constitutively active form of acetylcholine-dependent K(

90 the MAPK pathway through overexpression of a constitutively active form of c-Raf (ca-Raf) inhibits pr

91 t cancer cell lines expressing an inducible, constitutively active form of IkappaB kinase beta (CA-IK

92 hageal epithelia, leading to expression of a constitutively active form of IKKbeta (IKKbetaca) in epi

93 By contrast, the constitutively active form of Mek1 stimulated Erk1 even

94 Co-electroporation with a constitutively active form of PI3K rescued migration.

95 e show that B cell-intrinsic expression of a constitutively active form of PI3K-P110alpha by high-avi

96 s EGFR-dependent and may be initiated by the constitutively active form of RAS.

97 A constitutively active form of SRF/Mkl1 was not sufficien

98 ed STAT3 activation or overexpression of the constitutively active form of STAT3 decreased SOX11 expr

99 tiate leukemia, we crossed mice expressing a constitutively active form of STAT5 (Stat5b-CA) with mic

100 2/STAT5 signaling, while overexpression of a constitutively active form of STAT5 partially ameliorate

101 AURs was also enhanced in lines expressing a constitutively active form of the BR signaling component

102 carried out in villin-TLR4 mice, carrying a constitutively active form of TLR4, their littermates, a

103 ected liver tissues from mice that express a constitutively active form of YAP (YAP(S127A)) and analy

104 tive to changes in free Ca2+, resulting in a constitutively active form under physiological Ca2+-conc

105 the wave landscape using TIRF microscopy and constitutively active formin constructs tagged with fluo

106 Moreover, expression of constitutively active forms of Akt1 and Akt2 restores th

107 In prostate cancer, generation of constitutively active forms of androgen receptor (AR) va

108 We overexpressed FAK alone, constitutively active forms of beta-catenin (CAT) alone,

109 Furthermore, constitutively active forms of Yap or Taz were sufficien

110 Targeting of a constitutively active FoxM1 construct or the activation

111 Recruiting a constitutively active FoxM1 construct or the activation

112 However, adenoviral expression of WT or constitutively active FoxO1 and insulin treatment are su

113 Furthermore, liver-specific expression of constitutively active FoxO1 in transgenic mice induced a

114 Mechanistically, constitutively active FOXO3 conferred cytoprotection by

115 Coexpression of a constitutively active G (alphaq) protein that does not c

116 rmal growth factor-like growth factor) and a constitutively active G protein-coupled receptor (US28)

117 We focused on the constitutively active G12V K-Ras and two of its variants

118 fused with a fluorescent protein label, the constitutively active G12V mutant H-Ras.

119 tates present in the membrane containing the constitutively active G90D rhodopsin mutant or apoprotei

120 sing a forward genetic approach, we isolated constitutively active gain-of-function variants of the A

121 This pathway was stimulated by constitutively active Galpha(s) (Galpha(s)Q227L), which

122 Further, over-expression of a constitutively active Galpha, lacking the GTPase activit

123 Co-expression of Gbetagamma, but not constitutively active Galphai or Galphao, inhibited TRPM

124 tion of adhesion, we analyzed the effects of constitutively active Galphai1(Q204L) expression on adhe

125 (RNAPII) with, and diminished expression of, constitutively active genes and the inducible CUP1 gene.

126 nables BRD4 recruitment for transcription of constitutively active genes.

127 ion, whereas the expression of Gli2DeltaN, a constitutively active Gli2, restored Hh pathway activati

128 stration is disrupted in EHEC that expresses constitutively active GrlA mutants.

129 lyze GTP, keeping this molecular switch in a constitutively active GTP-bound form that drives, unchec

130 ant negative (GDP-bound) versus wild-type or constitutively active (GTP-bound) RAB-A2a variants discr

131 We found that, in planta, the constitutively active, GTP-bound AtGPA1(Q222L) mutant an

132 In Saccharomyces cerevisiae pho84 mutants, constitutively active Gtr1 suppresses a TORC1 signaling

133 Overexpression of Gtr1 and a constitutively active Gtr1(Q67L) mutant suppresses TORC1

134 gain-of-function mutation that results in a constitutively active H(+) pump partially suppressed SAU

135 Here, we demonstrate that constitutively active Hedgehog signaling in murine inter

136 lacentogenesis, we determined the effects of constitutively active Hif-1alpha, specifically in tropho

137 ic ERBB2 isoform (ERBB2DeltaEx16) that forms constitutively active homodimers.

138 mysterious methylation is also common within constitutively active housekeeping genes.

139 ble for Tr1 cell induction, as expression of constitutively active HRas rescues IRF4 expression and T

140 ing the putative substrate-binding site in a constitutively active Hsp104 variant impairs the recover

141 we report that Igfbp7-deficient mice exhibit constitutively active IGF signaling, presenting with pro

142 In contrast, flies with a constitutively active immune system had microbiota readi

143 Our data show that, in Drosophila, constitutively active immunity shapes the structure and

144 egetative development in Arabidopsis, but is constitutively active in anthers of unstressed plants.

145 e either prone for decommissioning or remain constitutively active in epiblast stem cells (EpiSCs), a

146 Once expressed, HRI is constitutively active in neurons because endogenous heme

147 tor (BCR) signaling, MYD88/IRAK signaling is constitutively active in PEL, but that under cell cultur

148 iptional mediator of oncogenic signaling, is constitutively active in ~70% of human cancers.

149 enchymal Twist2-Cre to drive expression of a constitutively active inhibitor of NF-kappaB kinase subu

150 hosphatase-1 through the overexpression of a constitutively active inhibitor-1 (I-1c) has been shown

151 Here, we report that expression of the constitutively active intracellular domain of Notch4 (N4

152 nsformation from a proton-activated toward a constitutively-active ion channel.

153 ore, which widen it, cause the channel to be constitutively active, irrespective of Ca(2+).

154 g kinase, cyclin H-CDK7-Mat1 (CAK), which is constitutively active, is responsible for the activating

155 Forced expression of a constitutively active isoform of MBNL1 inhibited GSC sel

156 We show that different PKMs, the constitutively active isoforms of PKCs generated by calp

157 loss is not fully rescued by expression of a constitutively active Jak2 allele.

158 n of spindle orientation in combination with constitutively active K-Ras resulted in massive tissue o

159 Here, we chose constitutively active K-Ras4B as our control and two dou

160 ycogen synthase kinase 3beta (GSK3beta) is a constitutively active kinase known to promote cell death

161 c mutations in the MPS1 T-loop to generate a constitutively active kinase results in a prolonged mito

162 Using zapalog, we tether mitochondria to constitutively active kinesin motors, forcing them down

163 Mice carrying a conditional constitutively active KRas (caKRas) allele and the CD4Cr

164 cogenic mutations occur in exons 2 or 3, two constitutively active KRAS proteins-each capable of tran

165 Overproduction of wild-type or constitutively active Lyn inhibited production of TNF-al

166 Moreover, by generating constitutively active MALT1 mutants that overcome the ne

167 Expression of a constitutively active Mek1 (Mek1(DD)), the known ERK act

168 d virus serotype 9 carrying cardiac-specific constitutively active MEK1 (TnT-MEK1-CA) was administrat

169 l-like ovarian cancer cells by co-expressing constitutively active MEK1 and Src rather than either al

170 d skin tumorigenesis, in which expression of constitutively active MEK1 in differentiating epidermal

171 analyses demonstrated that the expression of constitutively active MKK4, MKK5, or YDA driven by the R

172 We generated MNK1 knockout (KO) or constitutively active MNK1 (caMNK1)-expressing human MCF

173 First, we transiently expressed a constitutively active (MPK4(CA)) and an inactive (MPK4(I

174 betic mice with transgenic mice expressing a constitutively active mTOR (mTORca) or kinase-dead mTOR

175 Conversely, constitutively active mTORC1 led to DZ enrichment but lo

176 omal content during chronically inhibited or constitutively active mTORC1 signaling, respectively, an

177 Unlike the NLRC4-H443P mutant, another constitutively active mutant (NLRC4-V341A) associated wi

178 A constitutively active mutant form of FGFR3 decreased BPV

179 A) allele consists in a transgene encoding a constitutively active mutant form of TGFbeta (TGFbeta(CA

180 expression of the wild-type receptor and its constitutively active mutant form, EGFRvIII, limits sens

181 get of personalized treatment for NSCLC with constitutively active mutant forms of EGFR and constitut

182 We also observed expression of constitutively active mutant MAP2K1 (p.K57E) in erlotini

183 ted by mutant LRRK2, whereas expression of a constitutively active mutant of NCLX that enhances calci

184 Overexpression of a FAK phosphomimetic and constitutively active mutant p-FAK-Y407E in these cells

185 Mice expressing a constitutively active mutant PTH1R exhibited a dramatic

186 suggest that compound-directed conversion of constitutively active mutant Ras into functionally inact

187 driver oncogene that encodes a highly biased constitutively active mutant receptor.

188 We show that CysLTR2-L129Q is a constitutively active mutant that strongly drives Gq/11

189 S101A/S241A, a phosphorylation-deficient and constitutively active mutant, prevents hypoxia-induced b

190 osphopeptide complex, from which we design a constitutively-active mutant (confirmed via enzyme assay

191 as how pathologically overexpressed EGFR or constitutively active mutants, leads to oncogenic pathwa

192 stepwise N-terminal truncations, 3) distinct constitutively active mutations distributed across the h

193 Expression of constitutively active myristoylated Akt reversed the siP

194 The constitutively active Nlrp3(A350V) mutation abolished th

195 rescued by conditional overexpression of the constitutively active NOTCH intracellular domain in CD11

196 se hematopoietic progenitors transduced with constitutively active Notch1 failed to generate leukemia

197 ated orphan receptor-gammat (RORgammat) is a constitutively active NR that positively regulates the e

198 In contrast, constitutively active NRAS expression induced ETS1 and C

199 In contrast, the introduction of a constitutively active oncogenic KRas mutation inhibited

200 own previously for rod cells, attenuation of constitutively active opsin can be achieved with the unb

201 1-cis-retinal and the accumulation of toxic, constitutively active opsin.

202 Further investigations using constitutively active or dominant-negative forms of Rab

203 induced changes occur to some extent even in constitutively active or inactive mutants, showing that

204 Here, we discovered several constitutively active Orai1 and Orai3 mutants, containin

205 Previous studies using constitutively active Orai1 mutants gave rise to, but di

206 Adeno-associated viral (AAV) delivery of constitutively active Pfn1 to rodents promoted axonal re

207 on and suggest that AAV-mediated delivery of constitutively active Pfn1, together with the identifica

208 examining the genetic interaction between a constitutively active phyB(Y276H)-YFP allele (YHB-YFP) a

209 e because PTEN deficiency or expression of a constitutively active PI3K rescued function of B cells i

210 by activating PP2A(Cdc55) We discovered that constitutively active Pkc1 can drive cells through a mit

211 nstitutively active mutant forms of EGFR and constitutively active PKCalpha.

212 c neurons throughout the brain expressed the constitutively active PKM1 isoform, while neural progeni

213 A)-mediated knockdown, and overexpression of constitutively active PLK1 (PLK1(CA) ).

214 Ai screen in Drosophila for suppressors of a constitutively active Polo mutant, we identified a stron

215 wth and metastasis, which was rescued by the constitutively active PPP1R1A.

216 programmable transcriptional regulators are constitutively active, precise temporal and spatial cont

217 acrophages; while rLm30 expressing r30 via a constitutively active prfA* regulon (rLmIII/a30) express

218 Assembly of the endocytic machinery is a constitutively active process that is important for the

219 CK2 is a constitutively active protein kinase overexpressed in nu

220 Here we show that CK2, a ubiquitous and constitutively active protein kinase, phosphorylates HSJ

221 disruption of these interactions resulted in constitutively active proteins, freed from autoinhibitio

222 Inhibition of Akt activity by constitutively active PTEN similarly decreases crestin e

223 f synaptic vesicles, which can be rescued by constitutively active Rab26.

224 22N variant rather than with WT Rab4 or with constitutively active Rab4Q67L proteins.

225 nd Mon1A/B-deficient cells and restored by a constitutively active Rab7.

226 ent on its GAP activity as overexpression of constitutively active Rabs inactivated by RN-tre failed

227 ansgenic mice with cardiac overexpression of constitutively active Rac1 (RacET) develop an age-depend

228 Re-expression of constitutively active RAC1 in G9a-deficient tumor cells

229 ike ovarian cancer cells, whereas expressing constitutively active Rac1 leads to EMT in epithelial-li

230 Finally, constitutively active Rac1 rescued the PCP defects in Pa

231 Src are higher in ovarian cancer cells with constitutively active Rac1, we conclude that Rac1 sustai

232 1/2 (MEK1/2) and Src inhibitors can abolish constitutively active Rac1-led EMT and mesenchymal trait

233 matrix degradation by invadopodia, whereas a constitutively active Rac3 can rescue the deficits in in

234 This was suppressed by constitutively active RagB, an activator of mTOR.

235 To optimally deliver constitutively active Rap1a (CARap1a) into the RPE of wi

236 hai1(Q204L) expression on adhesion driven by constitutively active Rap1a(G12V) or its downstream effe

237 is and leading to high expression of ERAS, a constitutively active RAS protein normally expressed onl

238 full activation of signalling downstream of constitutively active RAS with which it interacts in a B

239 revealed R371Q:ALK6 is a previously unknown constitutively active receptor.

240 gnaling driven by TGFbeta ligand Activin and constitutively active receptors Alk4 and Alk2 remain int

241 tations W515L/K/R/A or S505N, which generate constitutively active receptors and consequent loss of T

242 Constitutively active Rheb (Rheb(CA)), the canonical act

243 cells by immunostaining, while expression of constitutively active Rho or Rho-kinase (Rok) rescues th

244 y a dominant-negative PLCdelta1 mutant and a constitutively active RhoA mutant.

245 udies with pseudohyperphosphorylated tau and constitutively active RhoA revealed that LM11A-31 likely

246 Constitutively active ROCK enhanced ARM and impaired PSD

247 e Rho of plants (ROP) effector interactor of constitutively active ROP (ICR1).

248 s of active ROP2, including those expressing constitutively active ROP2 (CA-ROP2), contain high level

249 genesis of the allosteric site, which led to constitutively active SARM1.

250 CYTOKININ INDEPENDENT1 (CKI1), encoding the constitutively active sensor His kinase that activates M

251 Pim kinases are a family of constitutively active serine/threonine kinases that are

252 dministration and transgenic mice carrying a constitutively active SHP2 mutation.

253 Overexpression of constitutively active SHP2 reduced the responsiveness of

254 Instead constitutively active signal peptidase cleaves RsiV at s

255 M also suppressed the constitutively active simian virus 40 (SV40) promoter an

256 as free from HSP90, exclusively nuclear, and constitutively active similarly as previously reported f

257 Here, we show that expression of constitutively active SMAD2/3 significantly improves the

258 Here by inducing expression of constitutively active Smoothened (SmoM2) or Gli2 (DeltaN

259 Reconstituted SNAREs are constitutively active, so a major focus has been to iden

260 Moreover, overexpression of wild-type and constitutively active SOD2 similarly blunted inflammasom

261 The constitutively active species responsible for the night

262 M2 isoform of pyruvate kinase (PK) over its constitutively active splice variant M1 isoform is consi

263 Transgenic tomato overexpressing constitutively active stable DELLA proteins (S-della) di

264 This study, along with other studies of constitutively active STAT mutants, provides insight int

265 reast cancer, MCF-7 cells that do not harbor constitutively active STAT3.

266 We establish that KirBac1.1 is in a constitutively active state in POPC:POPG bilayers throug

267 carboxamide (AICAR) or adenovirus expressing constitutively active subunits of AMPK decreased cue-ind

268 LRT persistence even when BvgAS is rendered constitutively active, suggesting the presence of BvgAS-

269 Conversely, a strain containing a constitutively active SurR variant displays a growth phe

270 strains with altered GAL1 promoter dynamics (constitutively active, synthetic with nucleosome-disfavo

271 ivity is counteracted by the expression of a constitutively active TAZ mutant.

272 Consistently, expression of constitutively active TEL-SYK counteracted the apoptotic

273 Moreover, constitutively active transcription factor Hac1p restore

274 splice variants including AR-V7 function as constitutively active transcription factors in CRPC cell

275 roteins that function as ligand-independent, constitutively active transcription factors.

276 RNA-seq data revealed enriched expression of constitutively active, treatment-refractory AR splice va

277 he link between GRHL2 and AR also applied to constitutively active truncated AR variants (ARV), as GR

278 tumorigenic MI line harbored membrane-bound, constitutively active, truncated EGFR.

279 through adeno-associated virus expressing a constitutively active type I receptor significantly redu

280 Many Ab strains harbor a constitutively active type VI secretion system (T6SS) th

281 neoplasia characterized by expression of the constitutively active tyrosine kinase BCR/Abl.

282 The NPM-ALK fusion protein is a constitutively-active tyrosine kinase, and plays a major

283 Glycogen synthase kinase-3 (GSK-3) is a constitutively active, ubiquitously expressed protein ki

284 ; its disruptive effects can be rescued by a constitutively active UNC-9::GFP protein, demonstrating

285 GluD1(R)-channels are constitutively active under basal conditions carrying to

286 In this work, we expressed the constitutively active UPR(ER) transcription factor, XBP-

287 silencing and forced expression of wild-type/constitutively active variants, we provide evidence that

288 helia, while conditional overexpression of a constitutively active version of Yap, Yap5SA, is suffici

289 ly progressed to cancer upon introduction of constitutively active versions of either HRAS or BRAF.

290 Ser133 and Ser204 sites, PAK1S133A mutant is constitutively active, whereas, PAK1S204A is not activat

291 Deubiquitinases are commonly regarded as constitutively active, with limited regulatory and targe

292 participate in amelioration of tauopathy by constitutively active XBP-1, possibly through endoplasmi

293 an effect partially rescued by expression of constitutively active YAP (S127A), suggesting the effect

294 oe et al. (2019) show that the expression of constitutively active YAP induces a remarkable degree of

295 In vivo, constitutively active YAP lowers plasma glucose levels a

296 ic kidney (HEK)-293 cells transfected with a constitutively active YAP mutant, and the conditioned me

297 ponse to glucagon and dexamethasone, whereas constitutively active YAP suppresses it.

298 ed in the tail, whereas cells overexpressing constitutively active YAP were able to travel through th

299 mary villous cytotrophoblasts overexpressing constitutively active YAP-5SA with YAP KO cells and sync

300 cells to trametinib, while overexpression of constitutively active YAP1 protein induced trametinib re