ライフサイエンスコーパス: constraint

1 that it fails to constrain what counts as a constraint.

2 e criminal DNA database) subject to a budget constraint.

3 ility when releasing the external mechanical constraint.

4 f minimizing the loss subject to a unit norm constraint.

5 nerve tissue growth with minimal mechanical constraint.

6 iability is sensitive to changes in task and constraint.

7 ure against a moderate inspiratory threshold constraint.

8 ay take the structure too far away without a constraint.

9 ands toward oxygen and light via geometrical constraint.

10 overestimating loss to follow-up due to data constraints.

11 nsional loop that folds under its mechanical constraints.

12 king different three-dimensional (3D) tissue constraints.

13 tic trade-offs rather than specific nutrient constraints.

14 of STRs, including abundance and mutational constraints.

15 ary metabolites, independent of phylogenetic constraints.

16 mall animal models that begins to meet these constraints.

17 bility on human performance given biological constraints.

18 extracted from recent work that equates such constraints.

19 s have been employed to alleviate production constraints.

20 ulti-country power estimate, and operational constraints.

21 assays are nonspecific binding and diffusion constraints.

22 hedule predictions to accommodate real-world constraints.

23 ited by the requirement of material-specific constraints.

24 de-offs between competing biotic and abiotic constraints.

25 power series expansion, that satisfies these constraints.

26 incorporated phosphoinositides due to steric constraints.

27 y recognition to tackle these challenges and constraints.

28 a one-step approach by harnessing geometric constraints.

29 sed with water scarcity and natural resource constraints.

30 unaffected by correlations and phylogenetic constraints.

31 achytene piRNA genes are under few selective constraints.

32 with local socio-cultural opportunities and constraints.

33 nt policies is recommended to include market constraints.

34 oldest, but has hitherto lacked precise age constraints.

35 oteins evolve to satisfy multiple functional constraints?

36 ce of adaptation [1-4] versus organizational constraints [5-7] in shaping common macroevolutionary tr

37 nal inference and supports flexible sparsity constraints, allowing to jointly model variation across

38 This spatial emergent constraint allows us to halve the uncertainty in DeltaC(

39 requency modes and to relax some geometrical constraints along the predicted transitions.

40 generalization of ET shows that evolutionary constraints among sequence, structure, and function are

41 ytes, revealing ancient selection and recent constraint and drift on knee regulatory elements, which

42 enriched in genes with evidence of selective constraint and genes with disease-appropriate annotation

43 In the setting of severe resource constraint and high risk of infection to patients and cl

44 and in the setting of acute severe resource constraint and high risk of infection to patients and st

45 uses biomass composition as the main output constraint and ignores potential changes in cell volume.

46 and psychopathology that provides important constraints and alternative evidence-based conceptions.

47 ated by age and experience, where life stage constraints and competition for resources may also play

48 sments (LCAs) that do not account for market constraints and consider byproducts either available bur

49 etermine how animals work within attentional constraints and how environmental pressures may exploit

50 cell types, anatomical structures, metabolic constraints and immune environment, differs drastically

51 Due to financial constraints and low-quality forage, African livestock ar

52 protocols are mostly qualitative due to time constraints and motion sensitivity.

53 f suspension due to the severe health system constraints and physical distancing measures in place to

54 s-pre-M1 and S2-M4-work in concert to remove constraints and prime the channel for rapid opening, fac

55 the agent adjusts the penalty of unsatisfied constraints and re-casts the given problem to a new Isin

56 , which is inconsistent with memory capacity constraints and recency effects observed in human cognit

57 quantifying trait correlations, phylogenetic constraints and spatial variability at large scales by c

58 e discuss the structural origins of negative constraints, and potential general implications for the

59 human behaviour co-varies with the task-goal constraints, and that the patterning of the behavioural

60 ionality, cognitive architectures, cognitive constraints, and the scope or resource rational analysis

61 l resources, to understand hospital capacity constraints, and to determine when peak demand occurs.

62 d to parameterize the model using a multiple constraint approach.

63 rearrangement of nuclear positions, material constraints are lifted, thus providing a generic and ful

64 lize more easily in countries where economic constraints are more limited.

65 ng the stratosphere and suggest that further constraints are needed to fully resolve the issue.

66 species' poleward range boundaries, climatic constraints are often assigned greater importance than b

67 tricted within the hairpin, these structural constraints are relieved in the absence of RNA secondary

68 imentally measured contact count probability constraints are satisfied.

69 In the case of forensic science, some constraints are the strict requirements enforced in fore

70 l generic backbone-backbone hydrogen bonding constraints as a determining factor in governing this tr

71 vironmental predictability and physiological constraints as key factors shaping stress response evolu

72 Globally, no species is exempt from the constraints associated with limited available habitat or

73 Wireless alternatives eliminate constraints associated with optical fibers, but their us

74 e Processor (ESP) that overcomes some of the constraints associated with traditional sampling since i

75 answer relies on the notion of developmental constraints: at any stage of ontogenesis, morphogenetic

76 es (attention and expectations) and external constraints (available sensory and motor degrees of free

77 Annotations of evolutionary sequence constraint based on multi-species genome alignments and

78 squares (MCR-ALS) enhanced with signal shape constraints based on parametric functions.

79 mbles using experimental data, and extending constraint-based analyses to ensemble scale.

80 For example, users who do not have deep constraint-based metabolic model knowledge can just type

81 olbox, termed FastMM, to effectively conduct constraint-based metabolic modeling.

82 riendly toolbox for large-scale personalized constraint-based metabolic modeling.

83 The implementation of SAMMI with popular constraint-based modeling toolboxes also allows for effo

84 es random samples from convex and non-convex constraint-based models by targeting under-sampled regio

85 Medusa builds on the COBRApy package for constraint-based reconstruction and analysis by compress

86 In constraint-based reconstruction and analysis of metaboli

87 he theory is framed by fundamental geometric constraints between three structure descriptors-surface

88 However, a spatial constraint blocks this well-known reaction and enables a

89 However, beyond these constraints, both effects co-exist under similar conditi

90 ical response of DNA to bending and twisting constraints, both of which are important in defining the

91 erstand whether both predators and prey with constraint-breaking adaptations actually manifest compar

92 Constraint-breaking adaptations are evolutionary tools t

93 Both Mojave species hold constraint-breaking adaptations in relation to their cou

94 somatic alterations relieve baseline fitness constraints by normalizing the underlying germline defic

95 However, this geometric constraint can be relaxed in two-dimensional (2D) perovs

96 also shows, more broadly, how a nutritional constraint can drive predators towards omnivory.

97 These constraints can lead to long turnaround times for labora

98 ble to prioritize short genes, for which LOF constraint cannot be estimated with confidence(2).

99 aints (DARC) aids the visualization of these constraints, characterizes how they correlate with each

100 ropose that the release of axial respiratory constraints, combined with selection for novel mammalian

101 subject to stronger sequence and functional constraints compared to other CTCF sites.

102 ause of functional, developmental or genetic constraints, conforming to evolutionary modules.

103 s, it likely put the dentition under greater constraints, conserving the highly stereotyped nature of

104 nes also displayed a relaxation of selective constraints consistent with greater redundancy.

105 These structural constraints constitute hypotheses that can be tested exp

106 ble to the pathogen and not due to metabolic constraints, contrary to what ecological theory suggests

107 Such constraints could arise from our dependence on harmonic

108 Deep Analysis of Residue Constraints (DARC) aids the visualization of these const

109 e that antigen processing represents a major constraint determining immunodominance.

110 en attenuated at high elevations as land-use constraints diminished and topographic constraints incre

111 Saccharomyces cerevisiae colonies, metabolic constraints drive cells into groups exhibiting gluconeog

112 n humans, highlights their similar metabolic constraints during early life and excludes late weaning

113 s may not be the most stringent experimental constraint; e.g. the goal may instead be to minimize exp

114 g., coding, noncoding, level of evolutionary constraint), effect sizes, linkage disequilibrium with t

115 These constraints enable efficient extraction of band-edge pro

116 However, the impact of eco-geographical constraints faced by domesticated plants and crop wild r

117 uide RNAs (CRISPR-dCas9) to inform a Bt user constraint file (UCF) for Cello.

118 It has been a major constraint for higher productivity and has destroyed mil

119 Surface defects have been a key constraint for perovskite photovoltaics.

120 Salinity is a major abiotic constraint for rice farming.

121 This implied a functional constraint for sauropod species which evolved lower brow

122 Here, we describe a process to learn the constraints for specifying proteins purely from evolutio

123 48 +/- 0.15 (2sigma) Ma) with no similar age constraints for the overlying biozone.

124 the d(CGA) triplet repeat motif and provides constraints for using this pH-adaptive structural motif

125 atory test modalities, and laboratory report constraints, further complicated by infrequently collect

126 However, the forces and constraints governing the evolution of sex-biased genes

127 This constraint has left gaps in how radiation impacts intrat

128 However, the causes of evolutionary constraint have remained elusive due to a poor mechanist

129 These constraints have led to systems that are often expensive

130 occal epidemiology and clinical trial design constraints hinder the enrollment of those populations a

131 Removing the constraints imposed by having to maintain cell viability

132 ice was sufficient to overcome the metabolic constraints imposed by plasmablasts and enhanced parasit

133 However, metabolic constraints imposed by the tumor microenvironment (TME)

134 s colonization and extinction depends on the constraints imposed by trophic, service, and engineering

135 lived for their body size, we find increased constraint in inflammation, DNA repair, and NFKB-related

136 nd immunity are under increased evolutionary constraint in large and long-lived mammals.

137 Loss of developmental stage-specific constraint in macrometastases triggered by natural kille

138 and thus would be expected to show decreased constraint in our analysis.

139 Health-care resource constraints in low-income and middle-income countries ne

140 Drought is one of the main constraints in peanut production in West Texas and easte

141 model-free iteration process under a set of constraints in real and reciprocal spaces.

142 s, highlighting the critical role of genetic constraints in shaping the shorter term (experimental ev

143 Our model, originally shaped by detailed constraints in the spatial literature, successfully char

144 These results suggest that the impact of constraints in vaccine supply on the public health impac

145 serves features that hint at miniaturization constraints, including a unique pattern of cranial fusio

146 d-use constraints diminished and topographic constraints increased.

147 related with scores of the personality trait constraint independent of sex or age.

148 anscripts, genome-wide analysis of selective constraints indicates that most of the produced RNA are

149 Based on the spatial and temporal constraints inherent to our experimental design, we posi

150 ween laboratory conditions and environmental constraints is an enigma known as "the phosphate problem

151 Practical and ethical constraints limit our ability to experimentally test soc

152 show that, although in practice experimental constraints limit our scheme, the TBP can be arbitrarily

153 t different life-history stages, with energy constraints limiting the onset of male reproduction but

154 ind that vp1 evolution is subject to tighter constraints, limiting its ability to evade vaccine-induc

155 gorithm is based on the observation that the constraint matrix of the underlying optimization problem

156 -but complementary-to loss-of-function (LOF) constraint metrics(2).

157 disease genes(5), that outperforms missense constraint metrics(3) and that is comparable-but complem

158 of Na(V)1.9, although hampered by technical constraints, might also be moving ahead.

159 Performing analysis on non-coding constraint mutations and their position relative to near

160 find a significant enrichment of non-coding constraint mutations in the neighborhood of 78 genes tha

161 ify 1776 other genes enriched for non-coding constraint mutations with likely regulatory potential, p

162 explained by performance- or resource-based constraints, nor by the authors' brief discussion of ref

163 ,000 deaths (95% CrI 7,000-23,000) at a dose constraint of 20 million, and increases to 6.6 million c

164 000 deaths (95% CrI 18,000-61,000) at a dose constraint of 60 million.

165 ) sulfides in this study allows for a better constraint of Co biogeochemistry in various natural and

166 ation of FMD under normal conditions through constraint of endothelium-dependent NO-mediated vasodila

167 ese hierarchies arise due to the operational constraint of the networks and whether they impose limit

168 heir configuration space, without the strict constraints of a well-defined crystalline symmetry and l

169 in another, indicating that the evolutionary constraints of antigenic site B have changed over time.

170 le NTW avoids thermal limits and may relieve constraints of cooler night-time temperatures; a nuance

171 visual processing to simultaneously satisfy constraints of efficiency and stability.

172 often have low signal to noise ratio due to constraints of experiment facilities and availability of

173 ver, are severely limited by the fundamental constraints of lightwave diffraction.

174 orming the maximum amount of work within the constraints of locally available energy, water, and nutr

175 ll, we show that NetPAS can take topological constraints of molecular networks into account and offer

176 approach to implement these tools within the constraints of the current knowledge base, addressing se

177 d the optimum design that balances practical constraints of working with animals versus sensitivity a

178 ing to light the dimensionality, as a hidden constraint on carrier dynamics, and identify the diffusi

179 , indicating that high temperatures may be a constraint on child nutrition.

180 hese lifespan traits affect the evolutionary constraint on hundreds of genes.

181 A constraint on information loss determines the size of th

182 und that a reduction in MKRN3 alleviated the constraint on kisspeptin-expressing neurons to allow pub

183 l process models cannot capture an important constraint on resource allocation, which is competition

184 n-atmosphere CO(2) flux provide an important constraint on the global carbon budget.

185 eawater acidity alone provides an incomplete constraint on the nature and source of carbon release.

186 n recent years, cobalt has become a critical constraint on the supply chain of the Li-ion battery ind

187 A major constraint on the wider adoption of biopesticides is the

188 f connectivity degree distributions based on constraints on a neuron's total synaptic weight.

189 ables the model to capture effects of memory constraints on auditory pattern detection.

190 Such constraints on behavioral flexibility have been studied

191 tic tree allometries, incorporates hydraulic constraints on biomass accumulation, and features a new

192 e of normal liver cell transcription through constraints on cell cycle re-entry of quiescent hepatocy

193 nomy of drinking water provision reveals the constraints on community water systems that affect their

194 Here, we investigate constraints on correlations in networks under the natura

195 age-insensitive gene groups, suggesting that constraints on dosage balance operate immediately follow

196 ive rearrangements to relieve all inhibitory constraints on enzyme catalysis.

197 flationary CD8(+) T cells, despite intrinsic constraints on epitope display at individual sites of in

198 be random or to an extent explainable, given constraints on fault/shear-zone interaction and the buil

199 females is common and often driven by social constraints on female mate choice.

200 water treatment costs, compounding existing constraints on groundwater resources.

201 e putative DNA-binding domain imposed strong constraints on how TerS(P76-26) can bind DNA.

202 This work identifies molecular constraints on immune receptor function and activation.

203 Our results provide key constraints on inner core age that could be older than t

204 ms of sensory selection and places important constraints on its implementation.SIGNIFICANCE STATEMENT

205 ic and chemical approach places quantitative constraints on mush pile thicknesses.

206 the importance of physical and physiological constraints on oxygen supply affecting aerobic metabolis

207 es released eukaryotes from the bioenergetic constraints on prokaryotes, facilitating the evolution o

208 These results can explain observed constraints on rabies virus host shifts, describe a prev

209 We quantitatively analyze the topological constraints on RNA 3D conformational space, in particula

210 contacts can cause much stronger topological constraints on RNA global fold than non-cross-linked bas

211 cording to this distribution revealed strong constraints on short-term plasticity; particularly facil

212 spotic species, dominance might impose fewer constraints on social choices, tolerance is greater than

213 educed from net primary productivity provide constraints on soil bacterial abundance independent from

214 e beneath the southern Lau basin, adding new constraints on the displacement process of the Pacific m

215 , and the present result thus introduces new constraints on the dynamics of the sub-cloud atmosphere.

216 Here we present directly measured constraints on the f-mode frequencies of the companions

217 tudies of cell populations provide essential constraints on the global mechanisms that coordinate cel

218 herefore can impose temporary stress-induced constraints on the growth-promoting gene networks under

219 The results highlight the need for improved constraints on the identities, properties, and concentra

220 dimentary sinks provides uncertainty-bounded constraints on the intensity of Hirnantian-Rhuddanian eu

221 These data therefore relax previous constraints on the late veneer and are consistent with v

222 -biased decision-making and put experimental constraints on the neural implementation of accumulation

223 rigin of pathogen recognition and the common constraints on the plant immune system.

224 Our observations provide high-resolution constraints on the processes by which swarms initiate, g

225 and bonobos (Pan paniscus), exhibit notable constraints on the proclivity to engage in such food tra

226 These measurements provide quantitative constraints on the role of dilution-driven evaporation o

227 ar magnetic resonance and SAXS data provided constraints on the solution structure of the aptamer and

228 RCK leverages evolutionary constraints on the somatic mutational process in cancer

229 gases in Earth's mantle can provide crucial constraints on the source and timing of volatile (C, N,

230 d method does not impose additional locality constraints on the spectral features and therefore helps

231 The past quantum state yields tighter constraints on the spin component than those obtained by

232 reliability of the measure by investigating constraints on the timescale over which blink rate patte

233 A-bridging proteins must exert rather strong constraints on their binding sites; they must block the

234 -to-dimer conversion of TrkA and the loss of constraints on TrkH are required for channel gating.

235 mers in the presence of ATP and releases the constraints on TrkH, resulting in an open channel confor

236 Rather than compounding functional constraints on variation, metamorphosis seems to have pr

237 We suggest that the distinct ecological constraints on vision and hearing can explain this diffe

238 lt-affected watersheds, imposing significant constraints on water availability and enhancing aridity.

239 roviding supplies, but neglected the quality constraints on water usability.

240 d ultrathin structures that meet aerodynamic constraints on wing weight and thickness.

241 In particular, the geometrical constraints, photoisomerization rates, and electronic st

242 To investigate the constraints posed by the limited access to biodiversity

243 All these fundamental constraints preclude the continual reduction of pixel di

244 erial endosymbiont transformed the selective constraints present at the origin of eukaryotes.

245 on divergence driven by changes of selective constraint probably plays a big role in the long-term di

246 th conservation priorities and institutional constraints remains poorly understood.

247 Dutch eating habits, satisfying optimization constraints required a shift away from beef, cheese, but

248 ven in conserved motifs, but reveal inherent constraints restricting tolerated substitutions due to e

249 for solving an integer linear program, or a constraint satisfaction program, which, although guarant

250 eukaryotic proteomes, and that bioenergetic constraints selected for temporal organisation that prom

251 They did so within the environmental constraint set by the physics of water surface tension.

252 considering other factors such as logistical constraints, staff shortages, and reallocation of resour

253 using different combinations of evolutionary constraints such as gene gain, gene loss and mutation ra

254 xpression evolves under greater evolutionary constraint than mRNA levels, and translation efficiency

255 provides significantly stronger eccentricity constraints than currently achievable through either rad

256 ant cell fate reverts towards homeostasis, a constraint that explains how selection operates in norma

257 Photothermal heating represents a major constraint that limits the performance of many nanoscale

258 ions interact with ecological and logistical constraints that are magnified in wildlife, such as poor

259 dom (DOF), wrapping over complex geometrical constraints that change its moment arms and lead to comp

260 The architectural constraints that dictate the formation of polyMOFs were

261 to resolve a variety of plant physiological constraints that occur within hydroponic systems.

262 he flat state due to geometric compatibility constraints that prohibit finite Gaussian curvature.

263 that the H1N1 HA is under other biophysical constraints that result in compensatory decreases in cha

264 underlie episodic memory respond to vascular constraints that ultimately give rise to amnesia.

265 Because of the land constraint, the intrinsically low yields of energy per u

266 Given biological constraints, the ideal optimally uses the statistics rel

267 es-can mitigate some of these transportation constraints, their cost-effectiveness compared with land

268 out inherent physical or chemical meaning or constraints, they are prone to biased interpretation.

269 Depending on local constraints, this fragment variably formed new domains,

270 A major constraint to current RTB breeding programmes is limited

271 is strategy removes ventilation as the major constraint to exercise capacity in COPD, allowing maxima

272 This provides an observational constraint to future studies of the geodynamo and palaeo

273 rgely determines host range and is the major constraint to interspecies transmission.

274 The evaluation of the mid-Pliocene adds a constraint to possible future warmer scenarios associate

275 These efforts are critical constraints to atmospheric assessment of anthropogenic f

276 at the brain is able to use these contextual constraints to predict the animacy of upcoming words dur

277 ess impact and find that adding water-stress constraints to productivity-based ranking of suitable si

278 Regulatory constraints to which this industry is bound will be outl

279 rational agents routinely deal with resource constraints together, offers a natural laboratory to tes

280 plore a range of ecological and evolutionary constraints under which stability of a population may be

281 problem, acknowledging the many operational constraints under which surveillance systems operate, th

282 As a result, constraints used in different cognitive domains often ha

283 Observational constraints using sea surface temperature patterns reduc

284 os (A1B and A2) while implementing dispersal constraints using the cellular automation model MigClim.

285 on forms tertiary amines, without structural constraint, via the coupling of aldehydes and secondary

286 The release of dynamic constraint was evident by an increase in the radius of c

287 To remove this constraint, we engineered variants of Streptococcus pyog

288 To overcome these constraints, we compiled diet (stable isotopes) data and

289 Using geochemical constraints, we examine an extensive compilation of date

290 To provide these observational constraints, we measured the contribution of BC to INP c

291 To circumvent these constraints, we realize a paradigm of phonon trapping us

292 Structural models with different geometric constraints were considered in the GA calculations, with

293 Across all countries, financial constraints were identified as the main challenges in ad

294 matrix that has no running water; ecosystem constraints were then considered in relation to those of

295 determining the AQY-M of samples and provide constraints when modeling photobleaching rates in natura

296 DIP/Dpr subgroups is controlled by "negative constraints", which interfere with binding.

297 nd data interpretation methods to avoid this constraint, which resulted in chemical fingerprinting sy

298 direct collocation tool to handle kinematic constraints, which enable modeling of kinematic loops (e

299 degree of generalism) and contemporary local constraints (winds experienced at the strait and climati

300 esults reveal the fundamental mechanisms and constraints with which convergence enables stereotypy in