ライフサイエンスコーパス: constraint imposed by

1 uding man), one cause of these failures is a constraint imposed by a small minority of females in the

2 ical model, which predicts that the entropic constraint imposed by a thin periplasm is sufficient to

3 Demographic stochasticity and the constraints imposed by a finite lattice size appear to p

4 r recycling technologies and to the systemic constraints imposed by a global economy.

5 CAR for cell entry because of the geometric constraints imposed by a rigid fiber.

6 This order, combined with the constraints imposed by a strong negative selection, was

7 The geometric constraints imposed by a tetradentate P4N2 ligand play a

8 ine is only partially determined by physical constraints imposed by adjacent organs; its sex-specific

9 evolved: they would have had to overcome the constraints imposed by an endogenous system operating to

10 energetic modelling approach to explore the constraints imposed by an obligate scavenging lifestyle,

11 g sequence of HAV, consistent with noncoding constraints imposed by an underlying RNA secondary struc

12 pel transdisciplinary research targeting the constraints imposed by and compensatory adaptations invo

13 of >10(12 )independent sequences without the constraints imposed by any in vivo step.

14 le, where neurons and synapses operate under constraints imposed by behavior, cognition, and neural a

15 cognate guard protein, as well as functional constraints imposed by biochemical activities or interac

16 It is proposed that developmental constraints imposed by both this retinally driven mechan

17 in antibody responses may reflect structural constraints imposed by C region on V region binding.

18 ase, where s is determined only by geometric constraints imposed by c(0), a c(0) > 0 will impede such

19 ssor by preventing release of cells from the constraints imposed by cadherin-mediated cell-cell adhes

20 its original state, indicating evolutionary constraints imposed by catalytic requirements.

21 dsorption is highly sensitive to topological constraints imposed by CBN surface structure; in particu

22 l genetic-epigenetic interaction, and reveal constraints imposed by chromatin structure.

23 We propose that topological constraints imposed by chromosome length and perinuclear

24 es could reflect an adaptive response to the constraint imposed by chronic restraint stress on mitoch

25 ric peptides overcome the intrinsic sequence constraints imposed by class A and class B GPCR divergen

26 se encoding SRs, but also that the selective constraints imposed by codon bias sustain this reduced o

27 Constraints imposed by comorbidities (notably cardiovasc

28 of Aux/IAA duplication include evolutionary constraints imposed by complex interactions among protei

29 e we directly address whether conformational constraints imposed by cotranslational folding affect th

30 as essentially the same geometry despite the constraints imposed by covalent linkage of the cysteine

31 The constraints, imposed by cyclization, confer CCPTs with t

32 Altogether, this work highlights the constraints imposed by development on an organism's resp

33 of low and slow diffusion, likely because of constraints imposed by differences in culture, geography

34 capes also identify differential specificity constraints imposed by diverse structural folds of natur

35 Constraints imposed by earlier studies and the experimen

36 chieve their proper localizations within the constraints imposed by embryonic development.

37 , and oxides) is challenging due to activity constraints imposed by energy scaling relationships.

38 The relative importance of intrinsic constraints imposed by evolved physiological trade-offs

39 energy per unit time) as possible, given the constraints imposed by external conditions and other org

40 linkage disequilibrium (LD) patterns and the constraints imposed by family structure when assigning i

41 ogical pattern covariations, the role of the constraints imposed by finite resource supply, and a com

42 l disparity in spite of strong biomechanical constraints imposed by flight.

43 studies often do not consider the geometric constraints imposed by folded peptide secondary structur

44 vation of ubiquitin is assumed to arise from constraints imposed by folding, stability, and interacti

45 Despite the constraints imposed by four disulfides, this "straitjack

46 a function of the strength of selection and constraints imposed by genetic architecture.

47 ve developed under the conditions of spatial constraints imposed by green belts and hard urban bounda

48 Removing the constraints imposed by having to maintain cell viability

49 ustrates both their intrinsic plasticity and constraints imposed by hexamer assembly.

50 reases the ECE by effectively overcoming the constraints imposed by highly ordered, polar-correlated

51 formulations alleviate the nonphysiological constraints imposed by historic media, and lead to cell

52 We demonstrate functional constraints imposed by HIV clade relating to the residue

53 parasites harm their hosts, and suggest that constraints imposed by host ecology can lead to populati

54 tial for adaptive trait combinations and the constraints imposed by hybrid fitness loss during incipi

55 fied genomic regions between strains without constraints imposed by in vitro manipulations.

56 drug applications while recognizing the time constraints imposed by infection(s).

57 Constraints imposed by integrating regulatory data have

58 ible conformers are presumably disallowed by constraints imposed by inter-ring contacts.

59 bound conformation accompanying loss of the constraint imposed by interactions of the alpha-domain.

60 not sampled by OX-GG adducts because of the constraints imposed by its cyclohexane ring, which may e

61 2 side chain residues on Ab affinity and the constraints imposed by L chain mutations in maintaining

62 Steric constraints imposed by L(2) prevent the large BF4(-) ani

63 espite a surge in interest and activity, the constraints imposed by large-scale computational resourc

64 vely long distances, because the biophysical constraints imposed by liquid transport in hyphae and in

65 ic igneous rocks appears to be prohibited by constraints imposed by liquidus phase-equilibria on evol

66 matrices as well as considering the physical constraints imposed by local structure.

67 studies 'in the wild', i.e., outside of the constraints imposed by marker-based motion capture.

68 However, there may be situations where constraints imposed by market institutions dominate stra

69 By removing the constraints imposed by mechanical clamping from the subs

70 These results indicate that constraints imposed by metal coordination spheres on RNA

71 way to elucidate the evolutionary mechanical constraints imposed by nature upon individual subcellula

72 heir vascular walls are thinner owing to the constraints imposed by neighboring bone spicules, which

73 In these cases, the mechanical constraints imposed by neighboring cells triggered this

74 key determinant of H1 CTD structure and that constraints imposed by neighboring nucleosomes cause lin

75 on individual wall properties, as mechanical constraints imposed by neighbors appear to be important.

76 This is in the context of constraints imposed by networks of cell walls that both

77 l manner to maximize performance, within the constraints imposed by neural noise.

78 h synaptic connections are formed within the constraints imposed by neuron morphology, we compared th

79 tissue culture.(15) In addition, mechanical constraints imposed by nuclear crowding and spatial conf

80 re clusters) on the basis of the geometrical constraints imposed by nuclear size and shape.

81 The structural constraints imposed by on-surface bottom-up GNR synthesi

82 cient translocation in vivo despite temporal constraints imposed by ongoing translation and a crowded

83 tubules for adequate function and geometric constraints imposed by organ size.

84 3 domain is regulated both by conformational constraints imposed by other domains and by plasmin- med

85 hain to study its innate kinetics, free from constraints imposed by other regions of the molecule.

86 tible with Na+ binding in trypsin because of constraints imposed by P225 on the protein backbone.

87 r diversity and pattern; however, structural constraints imposed by plant cell walls and the absence

88 ice was sufficient to overcome the metabolic constraints imposed by plasmablasts and enhanced parasit

89 -ATPase functions to overcome conformational constraints imposed by PLB on the N-domain of the Ca-ATP

90 comparable loop structure, PIE cannot due to constraints imposed by production of immune cells.

91 for these groups, in contrast to the steric constraints imposed by propeller loops in human telomeri

92 These results indicate that the structural constraints imposed by protein architecture play a domin

93 First, we can rationalize them in terms of constraints imposed by protein structure: We find that p

94 ating eddy feedbacks on upwelling within the constraints imposed by reconstructions of winds and Anta

95 urons and modular control, together with the constraints imposed by recruitment order.

96 f larger subpopulations due to local circuit constraints imposed by recurrent inhibition.

97 e physical requirements that arise under the constraints imposed by river dynamics--every spanning tr

98 not from evolutionary optimization but from constraints imposed by rules intrinsic to RNA polymer fo

99 a1 transcripts may reflect certain molecular constraints imposed by scid on the resolution of Vlambda

100 midpoint attractor interacts with geometric constraints imposed by sea level and the mountaintop to

101 n can arise inadvertently as a by-product of constraints imposed by selection on different traits.

102 ssembly reflect the interplay between steric constraints imposed by short linkers and the bulk of the

103 rimental data that allow us to determine the constraints imposed by signaling specificity on these pa

104 onal change is suggested without geometrical constraints imposed by small cavitands.

105 However, that is rarely feasible due to the constraints imposed by standardized measures of reading

106 es, taxonomic categories and habitats, using constraints imposed by static state variables.

107 apt to create a decision surface without the constraints imposed by statistical classifiers.

108 Finally, we find that the constraint imposed by stickiness on protein divergence i

109 h sequence conservation as expected from the constraints imposed by structure.

110 In practice, the physicochemical constraints imposed by surfactant molecules limit the ac

111 ge and breeding phenology respond jointly to constraints imposed by temperature and resource phenolog

112 g selection pressures beyond the biophysical constraints imposed by TF-DNA interactions.

113 anges in distance by available FRET pairs (a constraint imposed by the dimensions of the enzyme), a D

114 The observation can be explained by the constraint imposed by the fundamental feedback structure

115 ration, phytoplankton overcame the metabolic constraint imposed by the greater temperature sensitivit

116 cies glochidial size in Unio as reflecting a constraint imposed by the likelihood of successful trans

117 Removal of the conformational constraint imposed by the proline ring likely raises the

118 tion of the 3-4 amide and the conformational constraint imposed by the seven-membered ring, both of w

119 A maximum speed constraint imposed by the use of RSPs would indicate a p

120 This unusual scenario likely arises from the constraints imposed by the 222 symmetry of the enzyme.

121 by utilizing an excitonic coupling model and constraints imposed by the 3JCalphaHNH coupling constant

122 could not be explained in terms of possible constraints imposed by the 5-fluoroorotate selection.

123 terest for protein engineering, the sequence constraints imposed by the adjoining SECIS element sever

124 sexes to one of combined sexes must overcome constraints imposed by the advantages of sexual dimorphi

125 Shifting focus to the constraints imposed by the allocation of protein synthes

126 Using constraints imposed by the amino acid residues identifie

127 on processing dynamics, and suggest that the constraints imposed by the ascending arousal system cons

128 the feasibility of growth trajectories under constraints imposed by the associated storage resource a

129 set of HEL determinants owing to processing constraints imposed by the background genes?

130 cts from the protein but likely results from constraints imposed by the bicyclo[3.1.0]hexane scaffold

131 systems during the fabrication process, the constraints imposed by the biomolecules due to the limit

132 ons-is attributed primarily to the geometric constraints imposed by the bismacyclic scaffold.

133 their global tendency to align and the local constraints imposed by the boundary conditions.

134 relative to dG:dC as a result of structural constraints imposed by the C-nucleotide character of CdG

135 les is determined, in part, by the geometric constraints imposed by the catalytic sites.

136 ude of biochemical activities and by spatial constraints imposed by the cell boundary.

137 The nonrandom spindle positioning is due to constraints imposed by the cell cortex in flat cells tha

138 of nutrients by the fungus was restricted by constraints imposed by the cellular structure of the dif

139 Structural constraints imposed by the chemical modifications drive

140 Understanding the specific constraints imposed by the CNS on local T cell activity

141 rences in specific DNA contacts but from the constraints imposed by the configuration of the componen

142 l properties of the protein polymers and the constraints imposed by the curved cell membrane.

143 ased on these results, we postulate that the constraints imposed by the cyclohexane ring of OX affect

144 d on the overall objective of the study, and constraints imposed by the data, to define the appropria

145 e as an immobilized competitor that overcame constraints imposed by the deep binding cleft and struct

146 It was found that constraints imposed by the disulfide bond confer an unex

147 t thymines in double helical DNA, due to the constraints imposed by the DNA structure; the 5S configu

148 ence that these are in part a consequence of constraints imposed by the dosage compensation mechanism

149 evaluating their actions in relation to the constraints imposed by the environment.

150 uals interact while adhering to the dynamics constraints imposed by the environment.

151 ent developmental program and the mechanical constraints imposed by the environment.

152 g place in enzymatic sites, where structural constraints imposed by the enzyme cavity can impart ster

153 tivity appears to be a direct consequence of constraints imposed by the enzyme on the orientation of

154 Apparently, the quaternary constraints imposed by the fimbrial shaft on the adhesin

155 ate are avoided by the strict stereochemical constraints imposed by the folate-binding funnel.

156 We propose that constraints imposed by the follicle BM influence NC and

157 of the A-DNA stems to B-DNA stems within the constraints imposed by the four-base loop that caps the

158 tion of free-oscillation data and additional constraints imposed by the free-air gravity anomaly, lat

159 te of 0.15 degrees per year--consistent with constraints imposed by the free-oscillation data.

160 symmetry considerations and by the geometric constraints imposed by the frozen matrix.

161 rate our understanding of attention from the constraints imposed by the gate metaphor.

162 induced unfolding was hindered by the steric constraints imposed by the gel pores such that more dena

163 ntitative genetic approach to understand the constraints imposed by the genetic architecture of trait

164 This methodology not only removes the constraints imposed by the genetic code on our ability t

165 y phase of observed genotypes conditional on constraints imposed by the genotypes of other pedigree m

166 lar cortical neurons that reflects the tight constraints imposed by the geometry of 3D vision.

167 between local chiral interactions and global constraints imposed by the geometry of the self-assemble

168 locity and curvature likely results from the constraints imposed by the grain boundary network and im

169 alpha(IIb)beta(3) molecule and disruption of constraints imposed by the heteromeric association of th

170 volved and refined to be compatible with the constraints imposed by the host endogenous macromolecula

171 Because of highly restrictive constraints imposed by the host, it is more likely that

172 quasispecies virus population and the immune constraints imposed by the host.

173 e LOS of mutant 559 may be due to structural constraints imposed by the incomplete biosynthesis of th

174 sumably through the alleviation of migratory constraints imposed by the interaction of leukocytes wit

175 elated patterns of sequence evolution due to constraints imposed by the interaction, and molecular ar

176 embrane-proximal level may reflect proximity constraints imposed by the intracellular domains for sig

177 row more slowly than heterotrophs because of constraints imposed by the intracellular production of r

178 eA-catalyzed reaction is consistent with the constraints imposed by the kinetic mechanism determined

179 Due to experimental constraints imposed by the lack of genetic tools and the

180 NA is reduced and presumably reflects steric constraints imposed by the large size of the polycyclic

181 xes and consequent inability to overcome the constraints imposed by the lattice contacts.

182 nanostructure designs, most notably the size constraints imposed by the length of available scaffold

183 Therefore, regulation must be coupled to constraints imposed by the level of energy metabolism.

184 ciency is attributed here to the anisotropic constraints imposed by the membrane, which are not incor

185 e a challenge to the negotiation of physical constraints imposed by the microenvironment and tissue s

186 ibutions, combined with backbone topological constraints imposed by the model pore, result in milesto

187 driven by cell pressurization and mechanical constraints imposed by the nanoscale architecture of the

188 d state that is proposed to exist because of constraints imposed by the nature of the CO/CO2 reaction

189 It is useful to begin by considering constraints imposed by the nature of the protein synthet

190 they are to the varied, sometimes stringent, constraints imposed by the need for real-world precision

191 ntrol information flow, our results identify constraints imposed by the need to avoid interference be

192 physiological impact of gene sharing and the constraints imposed by the need to maintain the original

193 at species evolve longer lifespans under the constraints imposed by the need to reduce cancer risk.

194 ewest possible stem divisions subject to the constraints imposed by the need to renew the tissue.

195 Physical constraints imposed by the needle's linear geometry intr

196 g of enzyme levels in E. coli to respect the constraints imposed by the network structure at steady s

197 fficking of stem cells allows them to escape constraints imposed by the niche, enabling self-preserva

198 In face of the structural constraints imposed by the nucleosomal structure, integr

199 preciated aspect of tumorigenesis may be the constraints imposed by the organism's developmental prog

200 The latter adaptations are constraints imposed by the overriding requirement for ex

201 Physical and chemical constraints imposed by the periinfarct glial scar may co

202 wn to 0.055 K, suggesting that the geometric constraints imposed by the perovskite framework and the

203 o the commensurate nature of the geometrical constraints imposed by the pi-pi interactions and only t

204 otor increased by 500% due to the mechanical constraints imposed by the polymer chains on its conjuga

205 dynamics to explore the temporal and spatial constraints imposed by the primary cilium on Hedgehog si

206 However, the constraints imposed by the prior distributions in CoGAPS

207 ld-type peroxo intermediate models including constraints imposed by the protein also identify the cis

208 The structural constraints imposed by the protein host on the di-Fe cor

209 In particular, the 50 degrees kinks are constraints imposed by the protein rather than a feature

210 Within the constraints imposed by the protein subunits, the DNA can

211 v spike configuration and by avoiding steric constraints imposed by the quaternary structure of the f

212 in drug design, and show their basis in the constraints imposed by the range of allowable mutation i

213 e dosage constraints, such that the relative constraints imposed by the recent WGD are still being re

214 fragment (deltaKD) freed from autoinhibitory constraints imposed by the regulatory domain is catalyti

215 rthermore, the elimination of the structural constraints imposed by the regulatory subunits within th

216 the helical conformations formed result from constraints imposed by the relatively rigid and sterical

217 e sulfuryl-group transfer mechanism, and (3) constraints imposed by the residues lining the substrate

218 We suggest that geometric constraints imposed by the reverse micelles need to be c

219 during synthesis and is mediated by spatial constraints imposed by the ribosomal exit tunnel as well

220 the SecM protein evolved as a consequence of constraints imposed by the ribosome and the Sec machiner

221 ed fundamental physics, owing to performance constraints imposed by the rigours of space operation(7)

222 Steric constraints imposed by the ring predict that modified nu

223 in the organism does not depend on physical constraints imposed by the shape or size of specific org

224 They also emphasize how constraints imposed by the signalling environment can jo

225 Constraints imposed by the specific function of CYP51 ha

226 Using constraints imposed by the spin-spin interactions, a pac

227 Considering constraints imposed by the structural data, we suggest a

228 Here, we explore constraints imposed by the structure of the microenviron

229 otides that are energy-minimized, subject to constraints imposed by the sugar-phosphate backbone segm

230 By using a virtual bond to model the constraints imposed by the sugar-phosphate backbone, twi

231 Based on the constraints imposed by the suggested integral control, w

232 liminating mechanical and geometrical design constraints imposed by the supporting semiconductor wafe

233 18 rearrangement is explained through steric constraints imposed by the surrounding hemicarcerand on

234 However, there are constraints imposed by the three-dimensional protein str

235 and incorrect nucleotides by using geometric constraints imposed by the tight fit of the active site

236 Our results, together with constraints imposed by the time scales of development, s

237 bearing the brunt of funding cuts and other constraints imposed by the Trump administration.

238 However, metabolic constraints imposed by the tumor microenvironment (TME)

239 the first and third levels and highlighting constraints imposed by the two-qubit representation.

240 The intrinsic manifold presumably reflects constraints imposed by the underlying neural circuitry.

241 ignatures of perovskites--owing to geometric constraints imposed by the underlying substrate.

242 tract cortical functions within quantifiable constraints imposed by the underlying synaptic architect

243 te vaccine molecules for P. vivax, given the constraints imposed by the use of primate models and the

244 s problem which ensures that several lineage constraints imposed by the use of variant allele frequen

245 The steric constraints, imposed by the substitution mode of the 1,5

246 m pole-to-pole despite the potential spatial constraints imposed by their extensive thylakoid network

247 y and this is likely to be determined by the constraints imposed by their position within the CSC rat

248 Distance constraints imposed by these cross-links provide experim

249 Lifting the constraints imposed by this principle could circumvent d

250 ee to advocate for their patients within the constraints imposed by this public process.

251 d unfolding may be due in part to the steric constraints imposed by this structural element, together

252 ry theory, we demonstrate that the stringent constraints imposed by traditional scaling laws can be r

253 spatial segregation in cities by considering constraints imposed by transportation networks.

254 s colonization and extinction depends on the constraints imposed by trophic, service, and engineering

255 ls of F-actin-tropomyosin filaments, free of constraints imposed by troponin or other actin-binding p

256 These deviations reflect constraints imposed by tumor fitness selection pressures

257 nd steer the reaction trajectories away from constraints imposed by typical excited state dynamics.

258 nalysis, being less dependent on the spatial constraints imposed by underlying vasculature.

259 atural instability of retroviral repeats and constraints imposed by virion packaging limits.

260 Microbes drive ecosystems under constraints imposed by viruses.

261 empirical results suggest that computational constraints imposed by visual system architecture limit