ライフサイエンスコーパス: contiguous

1 20 carbons are quaternary, and 7 of them are contiguous.

2 l communities to two types of HL: random and contiguous.

3 ae solely consists of trisaccharide units of contiguous (1 --> 4)-beta-linked glucose residues joined

4 infected tissue homogenates, we assembled a contiguous 174-kb genome sequence containing 128 unique

5 ame instruments were readministered at eight contiguous 2-year time periods.

6 t plant communities at meter scales across a contiguous 25,000 m(2) archaeological land surface at Ol

7 virtually the entire human proteome tiled in contiguous 49 amino acid sequences with 25 amino acid ov

8 es possess independently derived clusters of contiguous 5mC encompassing many genes.

9 In contrast, additional residues lining a contiguous adjacent surface on the C-terminal domain wer

10 ge-scale cooperation is required to maintain contiguous air contact across the posterior breathing sp

11 The four contiguous all-carbon quaternary centers of waihoensene,

12 It is even possible to install three contiguous all-carbon quaternary centers using this meth

13 alkenes, which furnishes products with three contiguous all-carbon secondary stereocenters.

14 gery (ie, surgery that involves the teeth or contiguous alveolar bone) during BMA treatment.

15 fibrosis spreads from affected alveoli into contiguous alveoli and leads to death by asphyxiation.

16 structed into short stretches of overlapping contiguous amino acids.

17 me assembly using CCS reads alone produced a contiguous and accurate genome with a contig N50 of >15

18 ity radiofrequency ablation strategy created contiguous and durable ablation lines in significantly l

19 This genome is more contiguous and more complete than GRCh38, the latest ver

20 g-read sequencing data into highly accurate, contiguous, and correctly phased diploid genomes.

21 ATWI was defined as T-wave inversion in >/=2 contiguous anterior leads (V1 to V4).

22 apillary density below 0.5 percentile over a contiguous area above 98.5 percentile of the normal refe

23 in the RetGC binding map to a localized and contiguous area on the structure, involving a loop betwe

24 fic NMR line-broadening effects mapping to a contiguous area on the surface of the protein.

25 Clusters were defined as the contiguous area served by a single community health work

26 A cost-effective strategy to generate highly contiguous assemblies with a very low overall error rate

27 ry best practices for obtaining accurate and contiguous assemblies, a 'missing manual' that guides ke

28 Using our highly contiguous assemblies, we characterize structural variat

29 in a plant sex chromosome, based on a highly contiguous assembly of the W chromosome of the dioecious

30 , where the relative stereochemistry at five contiguous asymmetric centers can be controlled through

31 been applied successfully to the assembly of contiguous bacterial isolate genomes, extraction of DNA

32 th alternating barbs and a uniform series of contiguous barbules, supporting the developmental hypoth

33 ation of a heteroduplex dsDNA that pairs >20 contiguous bases in the initiating strand with sequence

34 d are guided by contact with the wall to the contiguous branch channel independent of its width.

35 es specificity based on the use of spatially contiguous but distinct domains.

36 novel loci were observed when evaluating the contiguous but not the composite electrocardiographic tr

37 and C20 families depending on the number of contiguous carbon atoms that constitute their central fr

38 icyclic tropane skeletons, allowing for five contiguous carbon stereocenters to be set in a single ex

39 es by increasing interaction strength in the contiguous case.

40 This barrier function typically requires a contiguous cell layer but since teeth penetrate the oral

41 opy, and immunolabeling, we demonstrate that contiguous cell walls indeed exhibit hybrid mechanochemi

42 -biting, generalist tick were collected from contiguous chaparral and grassland habitats, and RNA fro

43 A variety of isoquinuclidines having five-contiguous chiral centers, including an all-carbon quate

44 architectures, with six fused rings and four contiguous chiral centers, is reported.

45 stituted thiolane ring leading to up to four contiguous chiral centers.

46 s, and changes in nucleosome phasing along a contiguous chromatin fiber.

47 encing with Hi-C scaffolding produces highly contiguous, chromosome-length scaffolds, and we identify

48 e below sea level along more than 15% of the contiguous coastline.

49 s created with the lattice catheter remained contiguous compared with only 14.3% lines created with a

50 e projects have a dual purpose: delivering a contiguous, complete genome assembly and creating a full

51 are accurate (quality value > 40) and highly contiguous (contig N50 > 23 Mbp) with low switch error r

52 atial patterns of measles vaccination in ten contiguous countries in the African Great Lakes region b

53 r, utilizing multiple embedded channels, non-contiguous crack control can be maintained at angles up

54 arises because transporting nutrients via a contiguous cytoplasm enables continued exploitation of r

55 ed us to image the soma and up to 300 mum of contiguous dendrite at 15 Hz, while resolving individual

56 This work presents the most contiguous diploid human genome assembly so far, with ex

57 bed de novo goat genome sequence is the most contiguous diploid vertebrate assembly generated thus fa

58 Anatomically, contiguous disease spread on MRI was not apparent in thi

59 Both interactions are directed by a contiguous DNA- and histone-binding domain (DHBD) harbor

60 t pathogenic mutations cluster in three semi-contiguous domains outside the kinase region of the prot

61 tized mice are synchronized within spatially contiguous domains spanning tens of micrometers at frequ

62 osition connects these chitin buds to form a contiguous duct that largely separates from the apical s

63 ls, the primary cilium insulates itself from contiguous dynamic membrane processes on the cell surfac

64 , have distinct assemblages and meet along a contiguous, east-west boundary.

65 -controlled microfluidic switchboard allowed contiguous electrochemical measurements of glucose and l

66 Hrr25 central domain and Mam1 form a novel, contiguous embellishment to the Hrr25 kinase domain that

67 lar linear ablation catheter safely delivers contiguous endocardial or epicardial lesions without gap

68 KRASG12D or BRAFV600E induced "zipper-like" contiguous expression of junctional proteins at sinusoid

69 invasion into the pelvicalyceal system with contiguous extension up to the urinary bladder.

70 hepatic veins (V) or portal bifurcation (P), contiguous extrahepatic tumour (E), multifocal tumour (F

71 hree new carbon nitrogen bonds are formed in contiguous fashion, involves in situ generation of enami

72 bonds and one ring in a single operation in contiguous fashion.

73 ould create >251,000 ha in total of restored contiguous forest and enhance species persistence by a f

74 Russian forests are the largest contiguous forest belt in the world that accounts for 17

75 impact and still constitute large tracts of contiguous forest interior.

76 ould create >316,000 ha in total of restored contiguous forest.

77 g implicit temporal information by combining contiguous frames also led to a significant increase in

78 In particular, those possessing numerous contiguous, fully substituted carbon atoms (i.e., tertia

79 topographic basis functions, rather than as contiguous functional areas.

80 ification, and lineage convergence, in which contiguous functionally related cell types are specified

81 bolic pathways that produce SMs are found in contiguous gene clusters in fungal genomes, an atypical

82 e severe renal manifestations of the TSC/PKD contiguous gene syndrome and open new perspectives for t

83 t expression of the paternal copy of several contiguous genes on chromosome 15q11-q13 and affects mul

84 s arise from altering the dosage of multiple contiguous genes.

85 ielded better repeat resolution and far more contiguous genome assemblies.

86 own to regulate genes over long distances, a contiguous genome assembly is crucial for predicting and

87 Accurate and contiguous genome assembly is key to a comprehensive und

88 Taken together, the highly contiguous genome assembly we present opens unexplored a

89 Using a highly contiguous genome assembly, we show that gene expression

90 Firstly, the analysis of contiguous genome segments across species, has highlight

91 on a subset of isolates and generated highly contiguous genomes.

92 The exceptions to the contiguous glycan shield include the conserved receptor

93 Both conservation of contiguous gp41 membrane-proximal external region (MPER)

94 er scaffold P4HB compared with a consecutive contiguous group treated with porcine cadaveric mesh for

95 g adenomas and PanINs, contrasting with more contiguous growth of advanced subclones.

96 erived from XBP1 pre-mRNA, that folds as two contiguous hairpins.

97 , assemble into antimicrobial pores and form contiguous helices that are biologically promiscuous and

98 backbone chemical shifts are indicative of a contiguous helix (residues 3-17) in the productive dimer

99 ssing strain produced an increased number of contiguous heterocysts but a decreased percentage of tot

100 -feeding trophic modes were more abundant in contiguous, high seagrass cover landscapes while suspens

101 rgent responses of communities to random and contiguous HL result from different constraints imposed

102 ncer and our toolkit, we assembled 11 highly contiguous human genomes de novo in 9 d.

103 nd green/UWF-AF images and the presence of a contiguous hyperAF ring varied with imaging modality.

104 The disordered regions are not contiguous in sequence to the site of mutation, and even

105 es spatially adjacent fragments that are not contiguous in sequence-a major bottleneck in structure p

106 ed covariates to inform predictions that are contiguous in space and time and global in extent.

107 Their highly convoluted contiguous inner membrane compartmentalizes the organell

108 inner boundary membrane, thereby ensuring a contiguous inner membrane.

109 trial fibrillation (AF) ablation is based on contiguous (intertag distance <=6 mm), optimized (Ablati

110 that they developed into preretinal NV with contiguous intraretinal components.

111 q11.2DS NAHR events demonstrating completely contiguous LCR22 structures surrounding and within delet

112 Yet, inclusion of contiguous, living muscle to support pump function has n

113 etions ranging from 350 bp to 6900 bp in non-contiguous loci on several chromosomes, most commonly in

114 ng using continuously driven domain walls in contiguous magnetic tracks is lacking.

115 gorithms have enabled the creation of highly contiguous mammalian genomes.

116 ked and eventually fusing to form the single contiguous MAT locus that is now extant in the pathogeni

117 stable if the particles are fused to form a contiguous matrix, thus creating a positional overlap at

118 edPipe (Neoantigen Prediction Pipeline) as a contiguous means of predicting putative neoantigens and

119 or neoantigen discovery NeoPredPipe offers a contiguous means of processing single and multi-region s

120 rately assessing structural variation across contiguous megabase DNA regions.

121 enables us to perform targeted isolation of contiguous megabase-sized segments of the genome.

122 ome but not all ERC vesicles are tethered by contiguous "membrane bridges." Furthermore, tubular recy

123 e observed connecting two distant cells with contiguous membranes, with the core infectious viral mac

124 Notably, in 5 contiguous Midwest states, nearly half of young women wi

125 orm for sensing systems for the detection of contiguous multi-sites of DNA methylation without extern

126 tion on the level of methylation at specific contiguous multi-sites, not to mention easy-to-use detec

127 ure multicellular host tissues into a single contiguous multinucleate cell.

128 These contiguous mutations in the CD site of ERK2 are both req

129 The frequency of contiguous mutations was analyzed using a novel computat

130 e bulk of Sso7d was undermethylated at three contiguous N-terminal lysine residues but not at central

131 ional connectivity within these anatomically contiguous networks in children with SCD compared with c

132 ent groups of nucleotides forming physically contiguous networks within the three-dimensional structu

133 F(65) inter-domain residues in recognizing a contiguous, nine-nucleotide Py tract.

134 anglion cells (RGCs) in response to a large, contiguous object, but not to disjointed objects.

135 the chromosome typically as a divergent but contiguous operon.

136 gether, this protocol can yield high-quality contiguous or circular bacterial genomes from a complex

137 Generating a contiguous, ordered reference sequence of a complex geno

138 s for large multifocal tumors or tumors with contiguous organ involvement remain to be defined.

139 mes for large multifocal ICCs or tumors with contiguous organ involvement.

140 SD were R2 resection, resection of 3 or more contiguous organs, and histologic type.

141 An immunotherapy formulation consisting of 3 contiguous overlapping peptides (COPs) derived from Bet

142 ng UV and blue cones typically converge into contiguous pairs, despite the regular spacing of their c

143 rs the protein conformation (to maximize the contiguous patch of the positive charge on the RBD surfa

144 s they facilitate the construction of highly contiguous physical genome maps obviating the need for l

145 ants (15% Black; 30% Hispanic/Latino) into 6 contiguous, physiologically distinct (P wave, PR segment

146 other approaches now aim to sequence longer contiguous pieces of DNA, which are essential for resolv

147 , migration, and eventual integration in the contiguous population.

148 ne forest species (seaweeds), which revealed contiguous populations extending from the Bering Sea to

149 to different durations are orderly mapped in contiguous portions of the cortical surface so as to for

150 rallel monomers or a 48 nt sequence with two contiguous quadruplexes), but did not avidly interact wi

151 ce coil MRI scans were obtained in multiple, contiguous, quasicoronal planes during monocular central

152 ned and highly substituted cyclobutenes with contiguous quaternary carbon centers can be synthesized

153 ts feature multiple stereocenters, including contiguous quaternary carbons.

154 lement sequencing data, leading to much more contiguous reconstructions of genomes than previously po

155 in monkeypox isolates circulating within the contiguous region of Bayelsa, Delta, and Rivers states,

156 x II of the DnaJ J-domain and a structurally contiguous region of DnaK, involving lobe IIA of the nuc

157 om 188 patients enabled us to assemble 7,190 contiguous regions (contigs) larger than 1 kbp, of which

158 lls allow calcium imaging from multiple, non-contiguous regions across the cortex.

159 allows the discovery of methylation 'loci'; contiguous regions of methylation consistently methylate

160 d region (DER) finder that seeks to identify contiguous regions of the genome showing differential ex

161 y Elements (HALPER), a tool for constructing contiguous regulatory element orthologs from the outputs

162 A median of 3 (range: 1-5) contiguous ribs were resected.

163 with each other, suggesting that they form a contiguous ring-like structure that wraps around two act

164 hourly water parcels were tracked along two contiguous river sections of different characteristics.

165 These R-lesions could be R-tracts, contiguous runs of >/=4 RNA nucleotides within DNA stran

166 Strands of DNA with four or more contiguous runs of 2'-deoxycytidine (dC) nucleotides hav

167 ations (CNAs), which delete or amplify large contiguous segments of the genome, are a common type of

168 sequence of deletions and amplifications of contiguous segments that transforms one profile into the

169 as enabled by digitally "stitching" together contiguous SEM images.

170 led to align, and assembled these reads into contiguous sequences (contigs).

171 helix binding is uniquely realized by short, contiguous sequences with reduced amino acid diversity,

172 ality draft genomes, containing 150 or fewer contiguous sequences, from disease isolate collections:

173 This resulted in four contiguous sequences: two large circular chromosomes and

174 Twelve contiguous short-axis sections and six four-chamber sect

175 um, by accumulating association signals from contiguous single markers.

176 wo forms of pairing: tight pairing, spanning contiguous small domains, and loose pairing, consisting

177 lfide-bonded knottin scaffold that creates a contiguous solvent-accessible surface.

178 generates products that contain up to three contiguous sp(3) stereocentres with a high stereoselecti

179 xanes consisting of a polyyne, with up to 24 contiguous sp-hybridized carbon atoms, threaded through

180 junctions that considerably deviate from the contiguous staining and straight contact phenotype seen

181 eriod from 2010 to 2012 were over 42% in the contiguous states of Nebraska, Missouri, Colorado, Iowa,

182 highly stereoselective formation of a third contiguous stereocenter making use of a diastereoselecti

183 ffective to secure the F-ring and the fourth contiguous stereocenter of (-)-deoxoapodine with complet

184 ng tricyclic scaffolds containing up to five contiguous stereocenters (including quaternary stereocen

185 , enantioenriched scaffolds with up to three contiguous stereocenters are rapidly delivered.

186 zed homopropargyl amines bearing up to three contiguous stereocenters can be prepared in a single ste

187 this intermediate affords lignans featuring contiguous stereocenters in a high diastereomeric purity

188 nalized perhydroquinoline core displays four contiguous stereocenters including an all-carbon quatern

189 ed pair of consecutive epimerizations at two contiguous stereocenters is observed on the basis of sin

190 ubstrate stereocontrol to establish the five contiguous stereocenters of (-)-bactobolin A.

191 d stereoselectively forming three of the ten contiguous stereocenters of chromodorolide B.

192 ex tetracyclic architectures containing five contiguous stereocenters with excellent diastereocontrol

193 reactions, was applied to install the three contiguous stereocenters with high enantio- and diastere

194 ured hydroxyisochromanone core bearing three contiguous stereocenters, a modular oxazole formation, a

195 These products contain up to four contiguous stereocenters, two of which may be tetrasubst

196 fully substituted glycolic esters with three contiguous stereocenters.

197 a ketone, to give products containing three contiguous stereocenters.

198 hly enantiomerically enriched amines bearing contiguous stereocenters.

199 olecular scaffolds which contain up to seven contiguous stereocenters.

200 of hydroxyl-isochromanones with up to three contiguous stereocenters.

201 homoallylic alcohols/amines with up to three contiguous stereocenters.

202 uantities of the tricyclic core bearing four contiguous stereocenters.

203 five-membered-ring scaffolds with up to five contiguous stereocenters.

204 eading to branched products with up to three contiguous stereocentres in a (syn, anti)-mode with exce

205 ers of an organic compound that has multiple contiguous stereocentres remains a challenge.

206 yclic carbon skeletons containing up to four contiguous stereocentres, all with high diastereoselecti

207 rs of novel tricyclic heterocycles with five contiguous stereocentres.

208 y active complex natural products containing contiguous stereogenic carbon centres.

209 tide with a carbon backbone containing eight contiguous stereogenic carbons in a C20 hexacyclic core.

210 our stereoisomers of the product bearing two contiguous stereogenic centers could be accessed by chan

211 of nucleophilic attack (C6-C7) on the three contiguous stereogenic centers in good to excellent yiel

212 e beta-hydroxyboronates containing up to two contiguous stereogenic centers in up to 99:1 e.r. and gr

213 Three contiguous stereogenic centers were formed with excellen

214 orks via creation of two new rings and three contiguous stereogenic centers with high diastereoselect

215 The products contain three new contiguous stereogenic centers, generated with a high le

216 The products bear up to three contiguous stereogenic centers, including quaternary cen

217 e 5-trifluoromethyl-2-oxazolines bearing two contiguous stereogenic centers, one of them being a quat

218 rmation of 3-acetoxyindanones possessing two contiguous stereogenic centers, one of which is an all-c

219 functionalized core, possessing a series of contiguous stereogenic centers.

220 cted natural products containing two or more contiguous stereogenic quaternary carbon atoms and key r

221 ex natural products that contain two or more contiguous stereogenic quaternary carbon atoms in their

222 ) are a class of single-stranded RNAs with a contiguous structure that have enhanced stability and a

223 nsmural lesions without collateral injury to contiguous structures.

224 as the normal features of the bowel wall and contiguous structures.

225 en balanced by treatment group in a selected contiguous study area were re-enrolled and 1613 (89%) pr

226 ral models reveal that these residues form a contiguous surface within a monomer and, interestingly,

227 determined using a segmentation technique on contiguous T1-weighted axial MRI slices from the level o

228 was developed, enabling construction of two contiguous tertiary stereocenters in a single step with

229 alpha-functionalized products containing two contiguous tertiary stereogenic centres in excellent yie

230 oblem of segment detection, which identifies contiguous time periods with consistent network structur

231 the mutants of a turn region (S6-S7) that is contiguous to a known aggregation-prone region (APR).

232 by inducing the degranulation of mast cells contiguous to such nociceptors, through the release of s

233 yostatin that span the arm region, the loops contiguous to the protease cleavage sites, and the laten

234 Current energies used to create contiguous, transmural, and durable atrial lesions can r

235 nerate substituted isocyanides incorporating contiguous tri- and tetra-substituted centers.

236 PNG) lies within one of the largest areas of contiguous tropical forest and is characterized by envir

237 A patient was diagnosed with a large semi-contiguous tumor by imaging, histologically composed of

238 as available to reproduce the models for the contiguous U.S.

239 ia concentrations in large reservoirs in the contiguous U.S.

240 p surface air HCHO concentrations across the contiguous U.S.

241 loading over the period 1987-2012 across the contiguous U.S. and attribute these trends to long-term

242 annual average NO2 measurements (1990-2012, contiguous U.S. EPA sites).

243 nterannual phenological variation across the contiguous United States (CONUS), we first detected the

244 is developed at the county level across the Contiguous United States (CONUS).

245 ass concentrations are decreasing across the contiguous United States (CONUS).

246 ality rates (CDC WONDER) for counties in the contiguous United States (n = 3,109) were investigated u

247 on data involving 100 million devices in the contiguous United States (plus Alaska and Hawaii) from F

248 ouseholds, we estimate these GHGs across the contiguous United States and clarify the respective infl

249 ant-Lepidoptera interactions from across the contiguous United States and demonstrate that among ecos

250 .5)-related emissions for each county in the contiguous United States and match location-specific emi

251 ssolved ions, for all stream segments in the contiguous United States at monthly time steps between t

252 of fair market value of private lands in the contiguous United States by training tree-based ensemble

253 The contiguous United States contains a disconnected patchwo

254 0y), and on life expectancy at birth, in the contiguous United States during 1980-2010.

255 In 2012, the contiguous United States experienced exceptionally warm

256 ricity consumption for every city across the contiguous United States for all assessed methods.

257 (region, state, county, urban area) for the contiguous United States in 2000 and 2010.

258 e the first large mammal extirpated from the contiguous United States in recent history.

259 s one of the few continental glaciers in the contiguous United States known to preserve environmental

260 olution noise and light data from across the contiguous United States to assess how these stimuli aff

261 urrence of subsequent precipitation over the contiguous United States using remotely sensed soil mois

262 the total annual premature mortality in the contiguous United States(1-3).

263 n environmental quality and mortality in the contiguous United States, 2000-2005.

264 tify the exchange of air pollution among the contiguous United States, and assess its impact on prema

265 occur first in eastern Beringia, next in the contiguous United States, and last in South America.

266 Across the contiguous United States, cities' hard infrastructures h

267 For the contiguous United States, extinction began at ca. 12,900

268 analyzing fragmentation patterns across the contiguous United States, we demonstrate that only 41% o

269 of the area of man-made water bodies in the contiguous United States, were identified as being suita

270 or the entire contemporary population of the contiguous United States.

271 h a sister with breast cancer) living in the contiguous United States.

272 abase of individual rain events spanning the contiguous United States.

273 rvey of students in secondary schools in the contiguous United States.

274 s to ambient ozone concentrations across the contiguous United States.

275 o climate change at the state level over the Contiguous United States.

276 ydrologic/water quality network model of the contiguous United States.

277 sions for cattle, swine, and poultry for the contiguous United States.

278 HATS comprised Medicare beneficiaries in the contiguous United States.

279 ivity - to human land development across the contiguous United States.

280 t PM2.5 during pregnancy and term LBW in the contiguous United States.

281 les from 49 wastewater facilities across the contiguous United States.

282 to guide improvements to air quality in the contiguous United States.

283 observations made since the year 2000 in the contiguous United States.

284 y margins of habitat suitability such as the contiguous United States.

285 nomic inequalities in noise pollution in the contiguous United States; and b) consider the modifying

286 s and chemical synthesis, which contains two contiguous unsaturated residues, Dha-(E)-Dhb.

287 Our assessments over contiguous US suggest consistent increase in water stres

288 for the 2010 Census in the 48 states of the contiguous US.

289 temperature over 38 years (1980-2017) in the contiguous USA and formulated a Bayesian spatio-temporal

290 ough New York City in 1999 and spread to the contiguous USA within three years while transitioning fr

291 h worker, and each cluster comprised several contiguous villages, contained roughly 4000 people, and

292 opposite chirality are incapable of forming contiguous Watson-Crick base pairs with each other-has e

293 The Everglades is a large contiguous wetland with geographically dispersed wading

294 Contiguous white matter fiber pathways linking these gra

295 e survey provided >31000 images and revealed contiguous, white-colored bacterial colonization coating

296 best pooled data assembly produced a highly contiguous wild-type C. elegans genome containing 48 con

297 across the landscape such that they were not contiguous with each other but separated by a surroundin

298 chorioretinal atrophy of the posterior pole contiguous with the disc in all but 1 patient that was a

299 y articulated to the thorax but also broadly contiguous with the notum anteriorly and posteriorly (de

300 Comparison of contiguous X and Y chromosome assemblies shows that hemi