ライフサイエンスコーパス: contractile

1 g models predominantly predict that they are contractile.

2 of hypoxic pASCs demonstrated acquisition of contractile abilities in vitro.

3 of myosin energy-conserving states promotes contractile abnormalities, morphological and metabolic r

4 Eukaryotic cells have diverse protrusive and contractile actin filament structures, which compete wit

5 Leaks are prevented by contractile actin filaments surrounding the diapedesis p

6 ovulation failure by severely affecting the contractile actin networks in the myoepithelial sheath o

7 necessary for the assembly of NMII RLC into contractile actin networks.

8 ASTL increased cell spreading while reducing contractile actin stress fibers in normal and breast can

9 is executed in fungal and animal cells by a contractile actin- and myosin-based ring (CAR).

10 mmetric radial coordination of expansive and contractile activities contributes to epithelial replace

11 d to divergent adhesion phenotypes and NMIIA contractile activities depending on the mutation.

12 n-thin filaments are associated with altered contractile activity and lethal myopathies.

13 By varying the intensity of the contractile activity and of an externally imposed shear

14 a crucial role in regulating lens epithelial contractile activity and provide supporting evidence tha

15 nd how these adaptations influence lymphatic contractile activity are unknown.

16 vator, CDN 1163 partially restored lymphatic contractile activity in MetSyn lymphatic vessel by incre

17 Contractile activity in the lymphatic vasculature is ess

18 Diminished lymphatic contractile activity in the vessels from the MetSyn anim

19 The intrinsic lymphatic contractile activity is necessary for proper lymph trans

20 cal state of cardiomyocytes, and that cyclic contractile activity of cardiomyocytes accelerates TT di

21 that RBC biconcave shape also depends on the contractile activity of nonmuscle myosin IIA (NMIIA) mot

22 stributions along the membrane and mimic the contractile activity of sparsely distributed NMIIA filam

23 vitro model system to examine the effects of contractile activity on muscle clock phase.

24 g skeletal muscle increases in parallel with contractile activity such that oxygen delivery is suffic

25 ssels, whereas, the reduced MetSyn lymphatic contractile activity was not further diminished by thaps

26 Membrane potential and contractile activity was partially restored by the K(ATP

27 magnitude of vasodilatation to the degree of contractile activity.

28 ization) causing altered Ca(2+) dynamics and contractile activity.

29 xhibited impairments in its intrinsic phasic contractile activity; however, the molecular mechanisms

30 t Tmods are essential for the maintenance of contractile actomyosin bundles and that Tmod-dependent c

31 The primary force generator in contractile actomyosin networks is nonmuscle myosin II (

32 kinesis in many eukaryotes is dependent on a contractile actomyosin ring (AMR), composed of F-actin,

33 kinase Pak1 colocalizes with the assembling contractile actomyosin ring (CAR) and remains at the div

34 cytokinesis, where it helps to organize the contractile actomyosin ring at the equator of dividing c

35 ctivates the small GTPase RhoA to assemble a contractile actomyosin ring.

36 ed for the sustained stabilization of highly contractile actomyosin structures.

37 istamine, carbachol, and leukotriene D(4) as contractile agonists.

38 phatic pumping activity by regulating phasic contractile amplitude and frequency, but not the lymphat

39 showed that the contractile metrics such as contractile amplitude, frequency, ejection fraction, and

40 s, we demonstrated that uterine PVAT had pro-contractile and anti-dilatory effects on rat uterine art

41 oterenol stimulation reversed the depressive contractile and Ca(2+)-kinetic parameters.

42 enrichment for cardiac muscle developmental/contractile and cytoskeletal genes, highlighting key reg

43 hich arises from the cooperative work of the contractile and elastic elements within a myofibril.

44 ty of oncological drugs that may manifest as contractile and electrophysiological dysfunction, as wel

45 microdomains in VSMC ROS production and pro-contractile and growth signaling.

46 stics of right ventricular function - namely contractile and lusitropic reserve, as well as ventricul

47 exercise by accessing an enormous amount of contractile and lusitropic reserve, ensuring that VA cou

48 es within cell monolayers assume homogeneous contractile and mechanical cellular properties; however,

49 ted by computational models when homogeneous contractile and mechanical properties are assumed.

50 investigate the resistance exercise-induced contractile and metabolic adaptations.

51 We compare biventricular contractile and metabolic parameters measured during ESH

52 herapeutic restabilization corrects cellular contractile and metabolic phenotypes and may limit these

53 invasive and noninvasive (NI) biventricular contractile, and metabolic assessments were performed.

54 rk shows that these epithelial cells present contractile apical-medial MyosinII meshworks, which cont

55 K) motifs and is required for maintenance of contractile apparatuses in muscle cells.

56 The materials' humidity-responsive contractile behavior, a unique property of spider silks

57 at simplify motor ensembles result in global contractile behaviors, it remains unclear which strategi

58 ential to unmask the effects of mutations on contractile behaviour in vitro, providing new insights i

59 iverse intracellular structures ranging from contractile bundles to the mitotic spindle.

60 11 expression were remodeled and had reduced contractile but increased matrix and inflammatory genes

61 s may depolarise the monolayer, whereas less contractile cells can form swirling movement.

62 x can regulate the migration modes: strongly contractile cells may depolarise the monolayer, whereas

63 cle [Ca(2+)](i) levels, thereby relaxing the contractile cells to increase local blood flow and deliv

64 ced fibroblast differentiation into a highly contractile, collagen producing myofibroblast phenotype.

65 inferior oblique muscles had no significant contractile contribution, although the hypotropic SO rel

66 substantial maturation, particularly of the contractile cytoskeleton.

67 ect whereby cMyBP-C dephosphorylation causes contractile defects, which then lead to calcium-cycling

68 positive cardiac inotropic drug, rescued the contractile deficit in AAA cardiomyocytes, but not the c

69 We conclude that improvement of contractile deficits alone without improving calcium han

70 iated virus serotype 9 encoding PDE4B slowed contractile deterioration, attenuated hypertrophy and lu

71 intrinsic focal adhesion assembly as well as contractile differences that resulted from differential

72 ositive-displacement pumps, each linked to a contractile ductal network, milk begins its passage towa

73 w exoskeleton stiffness alters soleus muscle contractile dynamics and shapes the user's metabolic rat

74 p' exoskeleton controllers designed to steer contractile dynamics toward more economical force produc

75 (GoF) subunits results in profound lymphatic contractile dysfunction and LSM hyperpolarization that i

76 sclerosis, cardiac hypertrophy, arrhythmias, contractile dysfunction and the underlying alterations i

77 dial necrosis and fibrosis, left ventricular contractile dysfunction, electrocardiographic abnormalit

78 When the active component is contractile (e.g., an actomyosin solution), moderate act

79 nvective O(2) delivery, muscle force, muscle contractile economy and mitochondrial respiration were n

80 keletal muscle mitochondrial respiration and contractile economy in an isolated muscle preparation du

81 malized' per unit of developed force (muscle contractile economy).

82 ion affects neither muscle force, nor muscle contractile economy.

83 nstriction, mitotic entry in an artificially contractile ectoderm induced ectopic tissue invagination

84 onvoluted intercalated disc regions, loss of contractile elements with disrupted and haphazardly arra

85 , as is the case in eukaryotes, and that two contractile ESCRT-III polymers perform distinct roles to

86 d in scaffolds with thicker fibers were more contractile, expressed myofibroblast markers, and deposi

87 In health, PVAT secretes anti-contractile factors that relax the underlying artery.

88 tion, whereas responses to other relaxant or contractile factors were normal.

89 se results show that, even in the absence of contractile failure, diabetic heart exhibits a decreased

90 d may be more poised to redifferentiate into contractile fibroblasts in 3D-collagen matrix.

91 l displacements of their substrate, allowing contractile fibroblasts to attract M over distances that

92 f quantifying tissue-level functions such as contractile force and be amenable to standard multiwell-

93 The mylpfa mutant had reduced trunk contractile force and complete pectoral fin paralysis, d

94 filament stiffness and ultimately depressing contractile force and relaxation rate.

95 ave immediate, significant effects on muscle contractile force and suggest that forces transmitted to

96 onal analysis indicated considerably reduced contractile force and synchrony in SOD1 myotubes.

97 engineered heart tissue results in impaired contractile force development.

98 The contractile force exerted by the CaMiRi is measured and

99 drogels (Matrigel) that allows us to measure contractile force from the shape of the relaxed and cont

100 e changes and cell movements, powered by the contractile force generated by actin and myosin linked t

101 rs have previously shown that dATP increases contractile force in normal hearts and models of depress

102 but not other beta-blockers, indeed enhances contractile force in skeletal muscle and this is mediate

103 3D-print-molded multiwell plates capable of contractile force measurement.

104 We validated the contractile force response of CaMiRi using selected card

105 This platform represents an open-source contractile force screening system useful for drug scree

106 but fail to separate, indicating a temporal contractile force threshold for detachment.

107 n, and analysis to enable the measurement of contractile force with increased throughput.

108 ofibrotic functions, including myofibroblast contractile force, extracellular matrix (ECM) production

109 een three mechanical parameters-the cortex's contractile force, nuclear elasticity, and ECM rigidity-

110 mbling the fetal state, with a lower maximum contractile force, slower upstroke velocity, and immatur

111 g, skeletal muscles become atrophic and lose contractile force.

112 h intramuscular pressure directly influences contractile force.

113 nique for simultaneous quantification of the contractile forces and cytosolic calcium dynamics of mus

114 cally simple high-speed method for measuring contractile forces and cytosolic calcium dynamics of sin

115 The contractile forces generated by these networks are harne

116 es reveal a critical role for NMIIA-mediated contractile forces in maintaining multicellularity durin

117 ycycline-inducible MyoD, generate detectable contractile forces in response to electrical stimuli upo

118 Contractile forces of FDB fibers increase in response to

119 Posteriorly positioned myosin-dependent contractile forces pull on cell-cell contacts until cell

120 We describe a method for quantifying the contractile forces that tumor spheroids collectively exe

121 a Notch inhibitor, leads to further enhanced contractile forces.

122 rgin, significantly reduced lymphatic phasic contractile frequency and amplitude in control vessels,

123 phatic vessel displayed increasing intrinsic contractile frequency, force generation and vessel compl

124 MetSyn lymphatic vessel by increasing phasic contractile frequency.

125 rah in mice shows better recovery of cardiac contractile function after AMI compared to control mice.

126 tabolic inflexibility and stimulated cardiac contractile function and adrenergic responsiveness by en

127 (2+)) plays a central role in mediating both contractile function and hypertrophic signaling in ventr

128 ar integrity is concomitant with compromised contractile function and may contribute to the pathophys

129 otinic acid using cardiac MRI to demonstrate contractile function and Phosphorus-31 ((31) P) magnetic

130 Cardiac mitochondria are essential for contractile function and regulation of cell viability, w

131 MRI assessed ventricular geometry and contractile function at 2 and 8 d after TAC.

132 er, females experienced lesser reductions in contractile function at task failure (P <= 0.020), and g

133 Circumferential stretch is known to regulate contractile function in collecting lymphatic vessels; ho

134 As loss of contractile function in heart disease could often be mit

135 etween myocardial energetics and measures of contractile function in the mouse heart.

136 ning impacts the pASC proteome signature and contractile function in vitro and hence, they might be c

137 TNNT2 variant-dependent changes in sarcomere contractile function induced graded regulation of 101 ge

138 Heart failure (HF) with reduced contractile function is a common and lethal syndrome in

139 eloped less ventricular hypertrophy and that contractile function is better preserved.

140 essity of cMyBP-C phosphorylation for proper contractile function is well-established, but the physio

141 5 min, P < 0.001) during the +10% trial, and contractile function recovered faster post-exercise (P =

142 Contractile function was similarly impaired (ejection fr

143 mice leads to acute deterioration of cardiac contractile function with mutant animals demonstrating a

144 In cardiac gene therapy to improve contractile function, achieving gene expression in the m

145 phology, mitochondrial respiratory capacity, contractile function, and applied physical function (e.g

146 perienced lesser reductions in knee-extensor contractile function, and following heavy intensity exer

147 including mitochondrial energy transduction, contractile function, and ion transport.

148 bnormal electrocardiograms despite preserved contractile function, reduced total Cx43, and reduced ga

149 e significance of axial stretch in lymphatic contractile function, suggest that axial stretch may pla

150 pid changes in left ventricular geometry and contractile function, with a parallel modest infiltratio

151 tion and effectively maintain mechanical and contractile function.

152 roduction and contribute to deterioration of contractile function.

153 ed the strongest inhibition on cardiomyocyte contractile function.

154 UPR(mt), mitochondrial function, and cardiac contractile function.

155 MyBP-C and myosin may be targeted to improve contractile function.

156 ardiac atrophy and exhibited no reduction in contractile function.

157 I, consistent with its depressive effects on contractile function.

158 1 GoF has essentially no effect on lymphatic contractile function.

159 proliferative and motile circular shape to a contractile fusiform shape show changes in the location

160 let containing an isotropic and compressible contractile gel, representing a cell extract containing

161 tivity and were required for maintaining the contractile gene expression in human VSMCs.

162 ons in modulating the growth, metabolic, and contractile gene program in disease, and reveals a molec

163 e genes in the brain endothelium and cardiac contractile genes in the heart endothelium.

164 The severity of contractile impairment was proportional to histology-def

165 the Na(+) /Ca(2+) exchange that limits early contractile impairment.

166 ependent phenotypic switch from synthetic to contractile in pulmonary VSMCs.

167 andscape that, in muscle, result in aberrant contractile inhibition and excessive force.

168 pliance, as well as decreasing flow-mediated contractile inhibition via the enzyme endothelial nitric

169 Contractile injection systems are sophisticated multipro

170 te that the delivery of protein effectors by contractile injection systems may orchestrate microbe-an

171 ommonly describe the actin cytoskeleton as a contractile isotropic incompressible material.

172 Contractile kinetics were slowed in HF, with dramaticall

173 l capsid surrounded by head fibers and a non-contractile long tail.

174 d niche relocation through the smooth muscle contractile machinery that generates centripetal constri

175 s, we show here that ERK also signals to the contractile machinery through its substrate, p90 ribosom

176 enotype as siRNA knockdown of Nox5 increased contractile marker expression and decreased calcificatio

177 tion, while overexpression of Nox5 decreased contractile marker expression.

178 shown to be upregulated and mediate the VSMC contractile marker gene and PDGFRbeta expression in diff

179 man SMCs in vitro leads to downregulation of contractile markers and increase in MMP2 expression.

180 to PDGFB, mechanistically via modulation of contractile markers and MMP14 activation.

181 nthetic VSMCs showed decreased expression of contractile markers CNN-1 (calponin 1), alpha-SMA (alpha

182 By altering the contractile mechanics of the cardiomyocyte, myosin inhib

183 ity - emerge from first principles of muscle contractile mechanics.

184 lial to mesenchymal transition (EMT) to form contractile membranes within the eye.

185 We quantified contractile, metabolic, and electrophysiological propert

186 t tail collecting lymphatics showed that the contractile metrics such as contractile amplitude, frequ

187 ness of the tractions' spatial distribution, contractile moment of the cell pair, intercellular force

188 The sphincters are encircled by contractile mural cells, which are capable of bidirectio

189 d an inflammatory-like CAF (iCAF) subtype or contractile myCAFs, respectively.

190 Apical constriction is associated with contractile myosin pulses and involves RhoGEF3 and down-

191 R-type bacteriocins are minimal contractile nanomachines that hold promise as precision

192 as unique properties created by its emerging contractile nature; similarly, ECM lining blood vessels

193 ly, resulting in slower contractile rates of contractile networks.

194 NMII filaments can play contractile or scaffolding roles determined by their pos

195 enotypic plasticity, allowing acquisition of contractile or synthetic states, but critical informatio

196 d (p)-rC0C7-sc was less effective at damping contractile oscillations, results suggest that spontaneo

197 t these conformations are essential to adapt contractile output for energy conservation and that path

198 -C dephosphorylation is sufficient to reduce contractile parameters and calcium kinetics associated w

199 Kir6.1(-/-) ) or SUR2 (SUR2[STOP]) subunits, contractile parameters were not significantly different

200 hanisms underlying the accompanying improved contractile performance have been largely ignored.

201 rk through gap junctions, where it regulates contractile pericytes and smooth muscle cells and thus b

202 We further found that these contractile pericytes are capable of receiving propagati

203 By controlling blood flow at junctions, contractile pericytes within a functionally distinct pos

204 illary-enwrapping projections of junctional, contractile pericytes within a postarteriole transitiona

205 n the endogenous expression of PDGFRbeta and contractile phenotype of human VSMCs.

206 he normal arterial media continually express contractile phenotypic markers which are reduced dramati

207 onse and observed that relationships between contractile physiology and dynamic complexity were uniqu

208 c framework and combined with data on muscle contractile physiology and neural control.

209 the face of evolutionarily conserved muscle contractile physiology.

210 e of a passive isotropic fluid and an active contractile polar gel, in the presence of a surfactant t

211 racteristics of cell shape (e.g., expansive, contractile, polarized, etc.) and that shape heterogenei

212 Furthermore, the confluence of muscle contractile properties, hydrodynamics, and the high spee

213 metabolism, such as fibre type composition, contractile properties, substrate utilisation and blood

214 nic (MyHC-emb) is a skeletal muscle-specific contractile protein expressed during muscle development.

215 acidic isoform of calponin, an actin binding contractile protein, is expressed preferentially and abu

216 Phenotypic switching denotes a loss of contractile proteins and an increase in migration and pr

217 y obstruction by enhancing the expression of contractile proteins and their localisation to stress fi

218 VSMC and mouse aorta express high levels of contractile proteins and, more significantly, these cell

219 but high-resolution structures of fruit fly contractile proteins have not been determined.

220 and function: (1) Gene expression changes of contractile proteins such as higher atrial gene expressi

221 to specialized domains, while others (e.g., contractile proteins) do not show spatial confinement.

222 a hyperplasia of mural cells expressing more contractile proteins, whereas the upstream arteriole exh

223 late format based on spatially heterogeneous contractile, protrusive, and circumferential tractions.

224 d regulated, and how they act via individual contractile pulses and/or the formation of supracellular

225 s involved in activating TRPC1-based SOCs in contractile rat mesenteric artery VSMCs.

226 but unbound frequently, resulting in slower contractile rates of contractile networks.

227 , P<0.001) and a concomitant reduction in LV contractile recovery (1.6-fold, P<0.001), which was prev

228 ions to induce sarcomere re-organization and contractile recovery in DCM.

229 herefore, highlight TNT1's essential role in contractile regulation by diminishing its tropomyosin-an

230 eature's role in F-actin-Tm interactions and contractile regulation.

231 e 8-fold change in expression of the cardiac contractile regulatory gene cmlc2 was also seen in ventr

232 dehydrogenase kinase inhibition improves the contractile reserve and decreases hypertrophy by augment

233 y of GRK2 and GRK5 contribute to the loss of contractile reserve in the stressed and failing heart, i

234 carbohydrate metabolic reserve improves the contractile reserve, a group of animals were fed dichlor

235 rates that that the right heart has enormous contractile reserve, with a three- or fourfold increase

236 We established that the tailored contractile response constitutes a nuclear ruler-based s

237 ls treated with dichloroacetate had a larger contractile response to dobutamine stress than non-treat

238 Ultrafast measurements of the contractile response using line-field phase-resolved opt

239 units results in severely impaired lymphatic contractile responses to pinacidil.

240 0 ng/mL of IL-4, IL-5, IL-13, or IL-17A, and contractile responses, Ca(2+) mobilization, and receptor

241 t with the downstream production of cAMP and contractile responses.

242 ofilaments, which forms the scaffold for the contractile ring (Z-ring) to achieve bacterial cell divi

243 obe formation is driven by constriction of a contractile ring and requires the RhoGEF ECT-2, a RhoA a

244 al protein whose localization depends on the contractile ring and the secretory pathway.

245 ngs reveal how components of the cytokinetic contractile ring are reemployed during interphase to cre

246 esulting in decreased cell height and larger contractile ring area in cellularization similar to that

247 that these calcium transients could trigger contractile ring constriction.

248 We propose that lobe contractile ring formation is locally inhibited by the P

249 ndlin activates ECT-2 to promote cytokinetic contractile ring formation, we show that the ECT-2 regul

250 cytokinesis commonly relies on an actomyosin contractile ring that drives equatorial furrowing and se

251 uce force to assemble and then constrict the contractile ring to form a cleavage furrow.

252 s in the spatial cues that dictate where the contractile ring will form.

253 report evidence of an as yet unknown type of contractile ring-independent cytokinesis that we termed

254 However, also contractile ring-independent forms of cell division are

255 was reported to arrest with an unconstricted contractile ring.

256 We discovered that contractile rings in cps1-191 cells constrict slowly and

257 computational model of a chain of lymphatic contractile segments incorporating these adaptations pre

258 uses a collar to bridge a hollow tube with a contractile sheath loaded in a metastable state by a bas

259 opy reveals that they assemble and fire T6SS contractile sheaths at ~6% of the frequency of rhs (+) c

260 We consider a cell as an elastic, contractile shell surrounding a liquid incompressible cy

261 versus control mice revealed suppression of contractile SMC markers, extracellular matrix remodeling

262 ted with transdifferentiation of a subset of contractile SMCs into an MSC-like intermediate state tha

263 rease substrate contacts, others are broadly contractile, some polarize to facilitate migration, and

264 shortening velocity, and capture the extreme contractile speeds required to swim with tail-beat frequ

265 of a wide range of volatile odorants on the contractile state of airway smooth muscle (ASM) and unco

266 s and a global change from a remodeling to a contractile state of the acto-myosin network.

267 VSMCs for induction and maintenance of their contractile state.

268 rons which are critical for the relay of the contractile status of muscles back to the central nerve

269 Contractile stimulation causes the polymerization of NM

270 tion of S100A4 with NM myosin in response to contractile stimulation is activated by RhoA GTPase.

271 as rescued only in slow-twitch muscle, while contractile strength was improved only in fast-twitch mu

272 , and does not exert a strong influence over contractile strength.

273 forms, Tmod1 and Tmod3, as key components of contractile stress fibers in non-muscle cells.

274 We also modeled contractile stress fibers that bind the discrete adhesio

275 onventional myosin, as a stable component of contractile stress fibers.

276 these results suggest that mdivi-1 increases contractile stress generation, which may be caused by an

277 Although contractile stress is relatively low, myotomal muscles d

278 ergenic paper can generate a cyclically high contractile stress upon water absorption and desorption,

279 oral metamorphosis; Metamorphosis-Associated Contractile structures (MACs) and tetrabromopyrrole (TBP

280 proteins that form the rigid inner tubes of contractile tail phages, such as T4, and its C-terminal

281 Rounding is driven by contractile tension generated by myosin motors in the su

282 id (hCO) platform, which provides functional contractile tissue with biological properties similar to

283 gnaling modulates RHO-1/Rho activity in this contractile tissue.

284 tions, as well as the formation of localized contractile tractions with elongated cluster morphologie

285 e non-periodic tessellations of pre-stressed contractile unit cells that soften in water at rates pre

286 The smallest contractile unit in striated muscles is the sarcomere.

287 ction is the result of sarcomeres, the basic contractile unit, shortening because of hydrolysis of ad

288 are key components of sarcomeres, the basic contractile units of skeletal muscle myofibrils.

289 their upstream arterioles, into independent contractile units that were predominantly closed at rest

290 intimately linked to their functionality as contractile units.

291 len and rounded in shape, with hypertrophied contractile vacuoles and intense cytoplasmic vacuolizati

292 n of TRPML1 channels in fully differentiated contractile vascular smooth muscle cells (SMCs).

293 dult mice dramatically enhanced formation of contractile VSMCs and increased systemic blood pressure

294 We show here that contractile VSMCs are resistant to calcification and ide

295 als, promoting formation, and maintenance of contractile VSMCs in vivo.

296 injury' and 'vulnerable plaque' hypotheses, contractile VSMCs recruited from the media undergo pheno

297 00 calcium binding protein A4) compared with contractile VSMCs.

298 BMP9 and BMP10 for controlling formation of contractile VSMCs.

299 N'-terminal domains to damp sarcomere-driven contractile waves (so-called spontaneous oscillatory con

300 ibre recruitment was manipulated while total contractile work was held constant via reciprocal change