ライフサイエンスコーパス: contractile function

1 1 GoF has essentially no effect on lymphatic contractile function.

2 stress modulates trabeculation to influence contractile function.

3 comere shortening and reduced in vivo atrial contractile function.

4 ly significant parasympathetic control of LV contractile function.

5 in the heart directly correlate with cardiac contractile function.

6 ormationally sensitive regions that underlie contractile function.

7 nergetics to cardiac myocyte and whole-heart contractile function.

8 role of oxygen in the regulation of cardiac contractile function.

9 tion and effectively maintain mechanical and contractile function.

10 han wild-type mice but unexpectedly enhanced contractile function.

11 sulting in subsequent improvement of cardiac contractile function.

12 al stress throughout life to maintain proper contractile function.

13 ons of NO exert purely inhibitory effects on contractile function.

14 in modulations of myocardial energetics and contractile function.

15 iling heart to revive the myocardium and its contractile function.

16 pathways important for energy metabolism and contractile function.

17 LM, and correlates with impaired post-anoxia contractile function.

18 roduction then inhibits all other aspects of contractile function.

19 tes sarcomere assembly, and promotes cardiac contractile function.

20 e and lipid metabolism, energy transfer, and contractile function.

21 ascular load than IPAH and leads to worse RV contractile function.

22 ee of pathological remodeling, and preserves contractile function.

23 roduction and contribute to deterioration of contractile function.

24 acellular cAMP but minimally affects cardiac contractile function.

25 d cytoskeletal dynamics in the regulation of contractile function.

26 soforms that is essential for tuning cardiac contractile function.

27 ed the strongest inhibition on cardiomyocyte contractile function.

28 g to balance myocardial substrate supply and contractile function.

29 ophy, left ventricular dilation, and reduced contractile function.

30 umption was proportionate to the increase in contractile function.

31 ncreasing SERCA activity results in enhanced contractile function.

32 essential for normal cardiac respiratory and contractile function.

33 (LDH) release and infarct size and improved contractile function.

34 y effects of genetic manipulation on cardiac contractile function.

35 mide does not limit left ventricular chamber contractile function.

36 of genetic and extrinsic factors to maintain contractile function.

37 cription, signaling, growth, metabolism, and contractile function.

38 (d) improved myocyte calcium transients and contractile function.

39 AP-targeted PKA in control of heart rate and contractile function.

40 remodeling, as well as greater depression of contractile function.

41 UPR(mt), mitochondrial function, and cardiac contractile function.

42 MyBP-C and myosin may be targeted to improve contractile function.

43 ardiac atrophy and exhibited no reduction in contractile function.

44 I, consistent with its depressive effects on contractile function.

45 cardiomyocyte-specific knockout mice reduces contractile function.

46 us and Ca(2+) handling, both of which impact contractile function.

47 sing m6A in RNA and decreasing cardiomyocyte contractile function.

48 lymerization in both cardiac development and contractile function.

49 load and afterload) as well as its intrinsic contractile function.

50 e monophosphate (cAMP) levels and myocardial contractile function.

51 ) uptake impair mitochondrial energetics and contractile function.

52 he upregulation of genes related with muscle contractile function.

53 y that is independent of obesity and cardiac contractile function.

54 uced increase in m6A and decrease in cardiac contractile function.

55 rgy in the form of ATP to support persistent contractile function.

56 y role in the regulation of normal PVAT anti-contractile function.

57 es in energy production, and improvements in contractile function.

58 , maintaining ventricular wall thickness and contractile function.

59 ceptor signalling and the impacts on cardiac contractile function.

60 anoids, thereby restoring ENS cell types and contractile function.

61 nner consistent with impaired relaxation and contractile function.

62 etrimental effects on cardiac electrical and contractile functions.

63 of interdependency that regulate the cardiac contractile functions.

64 ses revealed improvement in left ventricular contractile function 2 weeks after transplant (hCPC vers

65 In cardiac gene therapy to improve contractile function, achieving gene expression in the m

66 rah in mice shows better recovery of cardiac contractile function after AMI compared to control mice.

67 rdiomyocytes offers the potential to restore contractile function after myocardial injury.

68 by an absence of muscle pathology, restored contractile function and a reduction in serum creatine k

69 tabolic inflexibility and stimulated cardiac contractile function and adrenergic responsiveness by en

70 MRI revealed preservation of contractile function and an improved ejection fraction 1

71 h in turn resulted in marked increases in BZ contractile function and ATP turnover rate.

72 ct heart can improve myofilament and in vivo contractile function and attenuate maladaptive remodelin

73 , VEGF-B167 markedly preserved diastolic and contractile function and attenuated ventricular chamber

74 develop cardiac dilation and showed improved contractile function and blunted adverse remodeling.

75 nvestigate protein localization and evaluate contractile function and Ca(2+) transients, compared wit

76 haq mice had marked abnormalities of myocyte contractile function and calcium transients.

77 Surprisingly, however, cardiac contractile function and cardiac compliance were unimpro

78 onclude that neuronostatin regulates cardiac contractile function and cardiomyocyte survival.

79 ha-actinin associated with severely impaired contractile function and cardiomyopathy in vivo.

80 This perturbation has been shown to impair contractile function and cause muscle fatigue in dystrop

81 ink in the myocyte, influencing both cardiac contractile function and cell metabolism and survival an

82 myocyte architecture, calcium handling, and contractile function and compared our results vs. severa

83 and NO generation with increased recovery of contractile function and decreased infarction in the pos

84 Contractile function and dynamic force-length measuremen

85 nases inhibitor, was reported to improve the contractile function and elastic fiber structure and org

86 PDPN receptor CLEC-2, PDPN endowed FRCs with contractile function and exerted tension within the reti

87 ects that these roles may have on myocardial contractile function and HF development.

88 (2+)) plays a central role in mediating both contractile function and hypertrophic signaling in ventr

89 MIF depresses human myocardial contractile function and impairs mitochondrial respirati

90 for ROS-induced SrcFK activity in normal VSM contractile function and in vascular remodelling in card

91 Specialized contractile function and increased mitochondrial number

92 usion injury, evidenced by lower recovery of contractile function and increased necrosis and apoptosi

93 s with type 2 diabetes mellitus (DM2) affect contractile function and insulin action in cardiomyocyte

94 Contractile function and insulin action were analyzed in

95 ar integrity is concomitant with compromised contractile function and may contribute to the pathophys

96 l resting SR Ca(2+) leak resulted in reduced contractile function and muscle fiber atrophy for longer

97 nt (3E10Fv-MTM1) in Mtm1delta4 mice improved contractile function and muscle pathology.

98 baseline (pH 7.4) indicated similar cellular contractile function and myofilament calcium sensitivity

99 with diminished IGF contents but with normal contractile function and no apparent endoplasmic reticul

100 he main contributor to depressed ventricular contractile function and occurrence of arrhythmia in hea

101 otinic acid using cardiac MRI to demonstrate contractile function and Phosphorus-31 ((31) P) magnetic

102 g complete SERCA inhibition eventually limit contractile function and precipitate LV pump failure.

103 ue by combining experimental measurements of contractile function and pressure generation with a prev

104 on (MI) is associated with depressed cardiac contractile function and progression to heart failure.

105 Preservation of contractile function and protection against adverse chan

106 fer revealed improved systolic and diastolic contractile function and reductions in left ventricular

107 Cardiac mitochondria are essential for contractile function and regulation of cell viability, w

108 rare variant in MYH11, R247C, alters myosin contractile function and SMC phenotype, leading to incre

109 The contractile function and the CSA of LV cardiomyocytes is

110 Ventricular contractile function and the VCS fate map remained uncha

111 streptozotocin (STZ) treatment, and bladder contractile function and TLR4 pathway expression were ev

112 The preserved contractile function and translocation responses to PHE

113 ating peptide preserved the left ventricular contractile function and was accompanied by increased le

114 of nitric oxide (NO) in regulating lymphatic contractile function and, consequently, lymph flow has b

115 h wild type, suggesting a greater reserve of contractile function and/or recruitment of compensatory

116 Myofibroblasts develop contractile functions and secrete the extracellular matr

117 6a3(+/d16) mice displayed compromised muscle contractile functions and thereby provide an essential p

118 phology, mitochondrial respiratory capacity, contractile function, and applied physical function (e.g

119 perienced lesser reductions in knee-extensor contractile function, and following heavy intensity exer

120 ained, can induce changes in cell structure, contractile function, and gene expression.

121 more left ventricle (LV) dilation, worse LV contractile function, and higher LV end-diastolic pressu

122 ransforming growth factor betabeta1, reduced contractile function, and inhibited mRNA expression of a

123 including mitochondrial energy transduction, contractile function, and ion transport.

124 ATP is required for normal cardiac contractile function, and it has long been hypothesized

125 requires a constant flux of ATP to maintain contractile function, and there is increasing evidence t

126 Omecamtiv mecarbil increased atrial contractile function, and there were no clinically relev

127 components including left ventricular size, contractile function, and VA coupling.

128 of ejection fraction (EF)-ventricular size, contractile function, and ventricular-arterial (VA) inte

129 Left ventricular structure, diastolic and contractile function, and ventricular-arterial coupling

130 observation that myosin II organization and contractile function are optimally matched to the load c

131 r mechanisms by which vascular smooth muscle contractile functions are regulated are not completely e

132 ter TAC resulted in a significant decline in contractile function as compared with animals in which C

133 HF myocardium exhibited impaired contractile function as evidenced by reduced maximal for

134 s, acting to regulate cardiac metabolism and contractile function, as well as promoting anticontracti

135 lt heart elicited significant enhancement of contractile function, associated with preferential phosp

136 MRI assessed ventricular geometry and contractile function at 2 and 8 d after TAC.

137 It also led to significantly increased contractile function at baseline and during adrenergic s

138 peptide 1 (GLP-1) therapies improve cardiac contractile function at rest and in response to adrenerg

139 er, females experienced lesser reductions in contractile function at task failure (P <= 0.020), and g

140 uce CEPT1, which remodels the SR to preserve contractile function at the expense of insulin sensitivi

141 of mutations in cMyBPC that lead to abnormal contractile function at the myofilament level, thereby c

142 nsfer in the failing heart not only improves contractile function but also directly restores electric

143 RB3 were generated and they exhibited normal contractile function but altered cardiac signal transduc

144 n A and angiopoietin-2 reduced cardiomyocyte contractile function, but only activin A reduced the exp

145 pharmacological agent that augments cardiac contractile function by enhancing myofilament Ca(2+) sen

146 light chain 4 (MYL4), which is important for contractile functions by increasing force production.

147 Failure to induce critical genes involved in contractile function, calcium handling and energy metabo

148 he proximal C-terminal domain causes reduced contractile function, cardiac hypertrophy, and heart fai

149 lts align with the hypothesis that defective contractile function contributes to the pathogenesis of

150 Assessment of cardiac contractile function, coronary arterial flow reserve, is

151 igh-fat diet, with the result that [ATP] and contractile function decreased significantly.

152 Diminished contractile function develops in response to low dose ph

153 elimb grip strength, ex vivo measurements of contractile function) did not improve.

154 tes cTnI at Ser-150 in vivo to alter cardiac contractile function directly at the level of the myofil

155 so it is unclear whether these cells improve contractile function directly through addition of new fo

156 TP-generating processes may therefore affect contractile function directly.

157 SOCE to optimize Ca(2+) dynamics and muscle contractile function during acute exercise.

158 emethylase, plays a critical role in cardiac contractile function during homeostasis, remodeling, and

159 stigate the effects of cardiomyocyte Nox2 on contractile function during increased Ang II activation.

160 nd most significantly increased intact heart contractile function (echocardiography) compared to vehi

161 nderstand the mechanisms underlying impaired contractile function, electrophysiological studies were

162 nhanced cytosolic Ca(2+) handling, increased contractile function, elevated sarcoplasmic/endoplasmic

163 All measures of systolic contractile function fell during HD and HDF, with partia

164 12-hour controlled mechanical ventilation on contractile function, fiber dimension, cytokine producti

165 thods to preserve cardiac cell viability and contractile function following ischemia are limited in t

166 oponin I cleavage in rat hearts and improved contractile function following ischemia-reperfusion.

167 baseline mitochondrial function and cardiac contractile function following pressure overload hypertr

168 the cardiomyocyte would be unable to recover contractile function following the simulated conditions

169 othelin-1 is critical for maintaining normal contractile function, for controlling superoxide and Mmp

170 occur within the heart with age to maintain contractile function from the maladaptive responses asso

171 ventricular ejection fraction (a measure of contractile function), from 44,959 patients at the Mayo

172 rary to our hypothesis, neither physical nor contractile function improved.

173 is function of the right ventricle show that contractile function improvement precedes right ventricu

174 It normalized the contractile function in 2 patients.

175 t of agonist-induced PKCbetaII activation on contractile function in adult cardiac myocytes.

176 PERK regulates skeletal muscle mass and contractile function in adult mice.

177 hereby enhancing angiogenesis and preserving contractile function in an animal AMI model.

178 th gata1 MO rescued trabeculation to restore contractile function in association with upregulation of

179 alogues significantly increased intact heart contractile function in calsequestrin-overexpressing mic

180 TMEM51 was associated with contractile function in cardiomyocytes.

181 Circumferential stretch is known to regulate contractile function in collecting lymphatic vessels; ho

182 regression of acute individual measures with contractile function in corresponding areas at day 21 de

183 Thus, short-term Akt activation improves contractile function in failing hearts.

184 y by short-term Akt activation might improve contractile function in failing hearts.

185 thermia (33.0 degrees C) on left ventricular contractile function in healthy pigs and compared them w

186 As loss of contractile function in heart disease could often be mit

187 novel cell-based therapies that can restore contractile function in heart disease.

188 e a novel therapeutic strategy for improving contractile function in heart failure.

189 paired CK-related energy metabolism improves contractile function in HF.

190 Regional myocardial blood flow and contractile function in ischemic myocardium are well mat

191 mulation impairs beta-adrenergically induced contractile function in isolated cardiomyocytes and Lang

192 aphy, and 40% reduction in right ventricular contractile function in isolated perfused hearts.

193 The E2-treatment led to impaired contractile function in male CMs only, which was charact

194 between humans and mice, and that E2 impairs contractile function in male CMs only.

195 ct of restoring sarcolemmal nNOSmu on muscle contractile function in mdx mice.

196 ochondrial gene regulatory derangements, and contractile function in MHC-PPARalpha mice.

197 In conclusion, EMEPO improved contractile function in myocytes experiencing an imbalan

198 We hypothesized that EMEPO would improve contractile function in myocytes with altered nitroso-re

199 ugh CK ex vivo and in vivo but did not alter contractile function in normal mice.

200 Remarkably, in the context of well preserved contractile function in perfused hearts, we observed dec

201 one had little effect on the acceleration of contractile function in response to dobutamine.

202 ed hearts indicated exacerbated postischemic contractile function in Sestrin2 KO hearts compared with

203 Maternal obesity impairs fetal cardiomyocyte contractile function in sheep.

204 receptor gamma axis in endothelial cells and contractile function in smooth muscle cells.

205 phosphorylation is a key aspect of impaired contractile function in the diseased myocardium.

206 re consequences for the energetic support of contractile function in the heart and is implicated in t

207 eversing concentric remodeling and improving contractile function in the hearts of patients with diab

208 etween myocardial energetics and measures of contractile function in the mouse heart.

209 Acute Ang II treatment also enhanced contractile function in transgenic hearts in vivo and tr

210 ning impacts the pASC proteome signature and contractile function in vitro and hence, they might be c

211 efficient in triggering obesity and impaired contractile function in vitro; however, no cardiac dysfu

212 Quantification of cardiomyocyte contractile function in vivo opens many possibilities fo

213 , and is essential for maintenance of normal contractile function in vivo.

214 hy and showed ventricular dilation, impaired contractile function, increased myocyte length and accum

215 phy, indicating that Akt activation improves contractile function independently of its growth-promoti

216 TNNT2 variant-dependent changes in sarcomere contractile function induced graded regulation of 101 ge

217 25 in vivo resulted in a significant loss of contractile function, injection of an antisense oligonuc

218 Heart failure (HF) with reduced contractile function is a common and lethal syndrome in

219 eloped less ventricular hypertrophy and that contractile function is better preserved.

220 se provides further evidence that proper SMC contractile function is critical for maintaining the int

221 likely due to altered muscle metabolism, as contractile function is normal.

222 essity of cMyBP-C phosphorylation for proper contractile function is well-established, but the physio

223 LAS, as a marker for longitudinal contractile function, is an independent parameter for ou

224 LA contractile function (LA negative peak strain), conduit

225 However, right ventricular contractile function may improve following CRT independe

226 ve of human engineered cardiac tissue (hECT) contractile function measurements under matched experime

227 In addition to contractile function measurements, dynamic features of R

228 , cardiomyocyte hypertrophy, and enhanced LA contractile function (median active emptying fraction 16

229 ex, stroke volume index, global and regional contractile function (myocardial strain), coronary arter

230 er mutations in the kinase that controls SMC contractile function (myosin light chain kinase [MYLK])

231 stolic calcium, consistent with the observed contractile function observed in experimental PV measure

232 pothesized that diminished LA compliance and contractile function occur early during the development

233 profound implications for understanding the contractile function of actomyosin, as needed in therape

234 anner, with significant implications for the contractile function of actomyosin.

235 maturation, but its specific effects on the contractile function of aneural engineered muscle remain

236 vivo, neural agrin can directly promote the contractile function of aneural engineered muscle via me

237 Contractile function of cardiac cells is driven by the s

238 intracellular calcium, [Ca2+]i, regulate the contractile function of cardiac muscle cells.

239 Moreover, MRTF-A improves contractile function of chronic hibernating myocardium o

240 tructural organization, vascularization, and contractile function of fully differentiated vs. undiffe

241 tes glomerular filtration rate (GFR) and the contractile function of glomerular mesangial cells (MCs)

242 CPB decreases myogenic contractile function of human peripheral arterioles in r

243 ty has emerged as a novel therapy to restore contractile function of injured failing myocardium.

244 Contractile function of intact extensor digitorum longus

245 GATA-6 deregulates CPI-17 expression and the contractile function of smooth muscle.

246 ave been identified in genes that govern the contractile function of the cardiomyocytes.

247 BVR and HO-2 levels, myocyte apoptosis, and contractile function of the heart can be modulated by sm

248 ndan improves neuromechanical efficiency and contractile function of the human diaphragm.

249 type-specific expression of Cxs for optimal contractile function of the mammary myoepithelium.

250 ment patterns are not reliable indicators of contractile function of the SO muscle.

251 the downstream consequences of the earliest contractile function on cardiac differentiation and morp

252 all amounts of myotubularin, showed impaired contractile function only in EDL muscles.

253 idant exposure that do not result in loss of contractile function or gross oxidative stress.

254 alone had no effect on left ventricular (LV) contractile function or on isoprenaline- or preload-indu

255 e-cigarettes has no acute effect on cardiac contractile function or tissue fibrosis, but it increase

256 myofibril organization, and skeletal muscle contractile function owing to compensatory upregulation

257 t of energy significantly impaired postshock contractile function (p < .05), whereas the change of en

258 the failing heart improved left ventricular contractile function (P<0.01), suppressed cardiac altern

259 diac regeneration and contributes to loss of contractile function, pathological remodelling and susce

260 s essential throughout vSMC life to maintain contractile function, prevent vSMC reprogramming, and pr

261 5 min, P < 0.001) during the +10% trial, and contractile function recovered faster post-exercise (P =

262 bnormal electrocardiograms despite preserved contractile function, reduced total Cx43, and reduced ga

263 rt, yet their functional roles in modulating contractile function remain incompletely understood.

264 d yet the role of this isoform in modulating contractile function remains controversial.

265 tionship between cardiomyocyte shape and the contractile function remains unclear.

266 sue properties can be evaluated by measuring contractile function, responsiveness to electrical stimu

267 F, we show that tadalafil treatment improves contractile function, reverses transverse tubule loss, r

268 Myocardial contractile function significantly improved after resver

269 p(-/-) mice manifested a severe reduction of contractile function, signs of heart failure, and increa

270 Besides hampering contractile function, smoking may have immediate benefic

271 e significance of axial stretch in lymphatic contractile function, suggest that axial stretch may pla

272 ocardium can improve myofilament and in vivo contractile function, suggesting that cMyBPC gene therap

273 : cardiac size (end-diastolic volume [EDV]); contractile function (the end-systolic pressure volume r

274 that TRPC6 may regulate GFR by modulating MC contractile function through multiple Ca(2+) signaling p

275 modulates cardiomyocyte SR Ca(2+) uptake and contractile function through redox-regulated changes in

276 s (KATP channels) in cardiac myocytes adjust contractile function to compensate for the level of avai

277 reconcile observed cellular and organ level contractile function using a cardiac multiscale model.

278 We tested the hypothesis that contractile function using speckle-tracking echocardiogr

279 IS200D were protected, recovering 88+/-8% of contractile function versus 35+/-15% in littermate contr

280 in the central region of Tm modifies cardiac contractile function via its effect on the overlapping e

281 Although OB fetal hearts exhibited a normal contractile function vs. CON fetal hearts during basal p

282 splantation and to compare regional MBF with contractile function (wall motion) and microvascular den

283 Contractile function was also equally impaired in Cont a

284 Contractile function was also preserved in colon ascende

285 /kg intraperitoneally), and left ventricular contractile function was assessed 5 days later using bot

286 Decreased contractile function was associated with attenuated TGF-

287 Small artery contractile function was examined in vitro with wire myo

288 Also, the oxygen cost of the contractile function was increased by 63% and 46% in hea

289 abbreviation of systolic ejection, although contractile function was largely preserved.

290 re housed in hypoxia for 3 wk before in vivo contractile function was measured using cine MRI.

291 Contractile function was rescued by replacing oleate wit

292 Contractile function was similarly impaired (ejection fr

293 Extracellular matrix protein levels and contractile function were also impaired.

294 Cardiac remodeling and contractile function were assessed extensively at the wh

295 These effects of ANP and BNP on contractile function were examined further by using an i

296 for all of the cardiomyocytes that recovered contractile function, whereas the absence of Mb(III) ban

297 mphatic vasculature, NO production depresses contractile function, which influences lymph flow needed

298 Determining whether the increase in contractile function will translate into improved clinic

299 mice leads to acute deterioration of cardiac contractile function with mutant animals demonstrating a

300 pid changes in left ventricular geometry and contractile function, with a parallel modest infiltratio