ライフサイエンスコーパス: contractile response

1 this compound caused, at least in part, the contractile response.

2 23/Ser24 clusters to the endothelin-mediated contractile response.

3 ignificantly phosphorylated during the acute contractile response.

4 a constant level to ensure constancy of the contractile response.

5 st or antagonist in a P2Y6 receptor-mediated contractile response.

6 ment fully revives the diminished beta(1)-AR contractile response.

7 desensitization, permitting agonist-induced contractile response.

8 ty and, surprisingly, restore the beta(1)-AR contractile response.

9 ndent activation of AC and induce a positive contractile response.

10 d the beta(2)-AR but not beta(1)-AR-mediated contractile response.

11 ure overload hypertrophy and beta-adrenergic contractile response.

12 nockdown of I-mfa significantly enhanced the contractile response.

13 M) and GSK-269962 (50 nM) both abrogated the contractile response.

14 n are associated with the LY379196-sensitive contractile response.

15 A nor soluble guanylate cyclase altered this contractile response.

16 d by activated mast cells that may promote a contractile response.

17 yometrial activation, allowing for a maximal contractile response.

18 yometrial activation, allowing for a maximal contractile response.

19 NA interference significantly attenuated the contractile response.

20 changes contribute to age-related changes in contractile responses.

21 activity (23%) and impaired beta-adrenergic contractile responses.

22 microM) caused a complete restoration of the contractile responses.

23 l cues, while myofibroblasts showed enhanced contractile responses.

24 t express PARs and the mechanisms leading to contractile responses.

25 t with the downstream production of cAMP and contractile responses.

26 whereby mast cells may modulate HASM-driven contractile responses.

27 tein levels resulting in higher 5-HT-induced contractile responses.

28 Increased phenylephrine-induced contractile response after treatment with dextrin was re

29 )-AR-mediated negative modulation on myocyte contractile response and [Ca(2+)](i) regulation.

30 of protein kinase, blocked the increases in contractile response and Ca2+ currents to ISO in WT and

31 f cyclooxygenase-derived prostanoids in this contractile response and determined whether there were a

32 elated with a prevention of the hyperdynamic contractile response and enhanced myocardial protection,

33 re in Pkd2(+/-) mice exhibits an exaggerated contractile response and increased sensitivity to PE.

34 proteins responsible for alpha 1-AR-mediated contractile response and inositol phosphate accumulation

35 odeled (32% longer and 18% wider), but their contractile response and intracellular calcium kinetics

36 s Ca(2+) release at baseline, as well as the contractile response and the incidence of arrhythmias in

37 n may enable Piezo1 to coordinate both acute contractile responses and long-term adaptive processes,

38 tion of esophagogastric junction opening and contractile response, and motility classification scheme

39 fic IKK2-deficient mice had decreased aortic contractile responses, and reduced hypertensive response

40 The oral contractile responses, and the anal relaxation and contr

41 Both oxygen sensing and the contractile response are thought to be intrinsic to pulm

42 nally considered cardiodepressant mediators, contractile responses are complex and bimodal, with an e

43 OA-NO(2) significantly inhibits Ang II contractile response as compared to oleic acid (OA) in m

44 M by 27%) and anal (LM by 36% and CM by 36%) contractile responses as well as the anal relaxation res

45 ed decreases in both KCl- and u46619-induced contractile responses at both time points.

46 with isoproterenol resulted only in a modest contractile response but caused significant mortality in

47 from alpha(1)3.2-null arteries showed normal contractile responses, but reduced relaxation in respons

48 0 ng/mL of IL-4, IL-5, IL-13, or IL-17A, and contractile responses, Ca(2+) mobilization, and receptor

49 The altered contractile responses coincided with a down-regulation o

50 PKA-) and DBL(PKA-) mice displayed a blunted contractile response compared to wild-type and TnI(PKA-)

51 We established that the tailored contractile response constitutes a nuclear ruler-based s

52 Maximum contractile response decreased significantly in the RESU

53 Basal contractile activity and maximum contractile response did not change significantly in the

54 nels in PDGFRalpha(+) cells and may increase contractile responses due to increased Ca(2+) sensitizat

55 h sensitivity in homeostasis and exacerbated contractile responses during colitis.

56 tration needed to produce 50% of the maximal contractile response (EC50).

57 gnificantly attenuated both phasic and tonic contractile responses elicited by phenylephrine, angiote

58 e decreased (efficacy as measured by maximum contractile response, Emax: 3.0 +/- 0.3 vs. 4.7 +/- 0.2

59 of the frequency causing 50% of the maximal contractile response (ES50).

60 To evaluate neurally mediated contractile responses, frequency-response curves to elec

61 nhibition of PI3K enhances forskolin-induced contractile response in a betaARK-ct sensitive manner.

62 nfusion was associated with a more robust LV contractile response in AC(VI) mice (P < 0.05).

63 on attenuates the adrenergic-induced cardiac contractile response in animal hearts.

64 ignificantly suppressed tetrodotoxin-induced contractile response in mouse colon, which suggests that

65 AT1b receptor is a major mediator for Ang II contractile response in mouse vessels, such as abdominal

66 results suggest that alpha 1-ARs mediate the contractile response in rat aorta by coupling to both Gq

67 on segments produced up to a 10-fold greater contractile response in Smn deficient tissues.

68 g by fenoterol restores the blunted beta2-AR contractile response in the failing heart.

69 f beta2-AR/G(s) by ligands restores beta2-AR contractile response in the failing heart.

70 rs after lipopolysaccharide, despite reduced contractile responses in aortic rings and the lack of ef

71 ufficient for robust RLC phosphorylation and contractile responses in bladder smooth muscle.

72 s leukotriene (LT)D4 receptor expression and contractile responses in cultured human airway smooth mu

73 ced PKA phosphorylation of phospholamban and contractile responses in myocytes.

74 R, PKA phosphorylation of phospholamban, and contractile responses in PGE2-pretreated myocytes.

75 ae infection can directly alter the vascular contractile responses in porcine coronary arteries, prov

76 ssociated with recovery of betaAR-stimulated contractile responses in rescued cardiomyocytes.

77 ure-evoked elevation of cytosolic Ca(2+) and contractile responses in SMCs were dependent on voltage-

78 roglitazone decreases norepinephrine-induced contractile responses in the rat tail artery, an effect

79 rophic signals and the regulation of myocyte contractile responses in the setting of heart failure.

80 OVA failed to elicit histamine release or contractile responses in trachea isolated from sensitize

81 sine attenuates the myocardial metabolic and contractile responses induced by ss-adrenergic stimulati

82 The "rescued" contractile response is completely reversed by a beta(1)

83 The contractile response is variable and depends on actomyos

84 Despite a similar contractile response, M/MtCK-/- hearts increased [ADP] b

85 lation with isoproterenol but attenuated the contractile response (maximal cell shortening, 15.5 +/-

86 ontractile activity, maximum agonist-induced contractile response (measured as total force generation

87 panel of beta2-AR ligands revealed that the contractile response mediated by most beta2-AR agonists,

88 n and myosin light chain), regulators of the contractile response (myosin light chain kinase, myosin

89 pendent on H(2)O(2), whereas beta-adrenergic contractile responses occur independently of H(2)O(2) si

90 of PKG KT 5823 (1 micromol/L); the positive contractile response of 1 micromol/L SNAP persisted, des

91 The negative contractile response of 100 micromol/L SNAP was complete

92 hrine release simultaneously with the evoked contractile response of a mesenteric artery from a healt

93 By studying the contractile response of cells to dynamic stiffness condi

94 that disrupts the final 51 aa increases the contractile response of cultured cardiac cells to cholin

95 fects of cardiopulmonary bypass (CPB) on the contractile response of human peripheral microvasculatur

96 The contractile response of isolated afferent arterioles to

97 (all after topical 2.5% phenylephrine), and contractile response of isolated CM strips, obtained <1

98 The post-CPB contractile response of peripheral arterioles to ET-1 wa

99 The Ca2+-activated contractile response of permeabilized bronchial smooth m

100 Functionally, the contractile response of pressurized thoracodorsal resist

101 isoproterenol (ISO) resulted in an impaired contractile response of TG hearts.

102 The anal contractile response of the CM was unaffected by L-NA.

103 er or stimulation chamber decreased the oral contractile response of the LM and CM (by about 30-40 %)

104 arginine (L-NA; 100 microM) reduced the oral contractile response of the LM and CM by 50%, the anal c

105 e response of the LM and CM by 50%, the anal contractile response of the LM by 30%, and the anal rela

106 ceptor subtypes, is then able to enhance the contractile response of the myometrium.

107 A substantial component of the contractile response of the vas deferens to sympathetic

108 alcium entry via VDCCs serves to enhance the contractile response of these cells.

109 , airway responsiveness was monitored by the contractile response of tracheal smooth muscle to electr

110 effect of insulin to attenuate the Ca2+ and contractile response of vascular smooth muscle to a numb

111 ndothelium-derived NO and thereby reduce the contractile response of vascular smooth muscle.

112 The enhanced contractile responses of airways from the SO2-exposed ne

113 hyperresponsive to vasopressin; in contrast, contractile responses of collaterals to endothelin are a

114 Contractile responses of coronary arteries to cumulative

115 The maximal contractile responses of femoral arterial rings to the s

116 asthma exacerbations by directly modulating contractile responses of HASM.

117 Additionally, we observed altered contractile responses of isolated arteries from SMTNL1 K

118 in coronary artery disease, we compared the contractile responses of leukotriene C4 (LTC4) and leuko

119 l of key regulatory proteins is required for contractile responses of mature VSM.

120 dine attenuated the graded carbachol-induced contractile responses of mouse bronchial rings and calci

121 ty of tasks and to illustrate the individual contractile responses of MUs whose collective action det

122 Contractile responses of normal LV rings were measured i

123 Contractile responses of the carotid artery were enhance

124 drenergic receptor kinase 1 in mediating the contractile responses of the heart to beta-adrenergic st

125 ls but they do not always accurately predict contractile responses of the human heart.

126 thonium (300 microM) almost blocked the oral contractile responses of the LM and CM but had no affect

127 ctile responses, and the anal relaxation and contractile responses of the LM and CM produced by L-NA

128 microM) in the recording chamber reduced the contractile responses of the LM and CM.

129 The contractile responses of the renal arterial rings to tra

130 In addition, contractile responses of TSM to methacholine (MCh) were

131 atively important mechanisms involved in the contractile responses of vascular tissues to pH change a

132 embrane (ERM) formation, a proliferative and contractile response on the retinal surface.

133 We conclude that the higher 5-HT-induced contractile response results from a higher density of 5-

134 During recovery the contractile response returned to 51% of control, indicat

135 ut significant, increase in the component of contractile responses sensitive to Rho-kinase antagonism

136 ding of the functional effects of non-linear contractile responses, slow muscle relaxation, and neuro

137 acellular calcium during metaphase induced a contractile response, suggesting that calcium transients

138 enhancement of vasopressin-mediated Ca2+ and contractile responses suggests increases in vasopressin

139 ch P3 regenerative cells are shown to lack a contractile response that is seen in other fibroblast cu

140 onditions but after CP-Rep elicited a potent contractile response that was inhibited in the presence

141 (MAs) from RGS2(-/-) mice showed an elevated contractile response to 5 nM angiotensin II and a loss o

142 e sensitivity in that pD2 (-logEC50) for the contractile response to 5-HT was 7.19 +/- 0.15 and 6.62

143 A contractile response to a nonselective beta-AR agonist,

144 of alpha(1C) protein and mRNA as well as the contractile response to acetylcholine and KCl.

145 ppression of alpha1C, as well as that of the contractile response to acetylcholine, by 24 hours of tr

146 lonic circular smooth muscle cells and their contractile response to acetylcholine.

147 n mutants F31, F118 or F31/118 inhibited the contractile response to ACh stimulation but did not inhi

148 ed that PLCepsilon(-/-) mice had a decreased contractile response to acute isoproterenol administrati

149 s from HFD-fed mice also displayed a reduced contractile response to adrenergic stimulation when comp

150 al access to the myofilaments and to restore contractile response to adrenergic stimulation.

151 effects of ACE and chymase inhibitors on the contractile response to angiotensin I (Ang I) in human r

152 d with nontransgenic control mice, while the contractile response to angiotensin II receptor stimulat

153 xamethonium had no significant effect on the contractile response to any agonist, indicating that the

154 itive G(i) proteins in addition to G(s), the contractile response to beta(1)-AR stimulation by norepi

155 Although the contractile response to beta(2)-R* in TG4 cells was abol

156 led that in titin M-line-deficient mice, the contractile response to beta-adrenergic agonists and ext

157 The mechanisms underlying the blunted contractile response to beta-adrenergic receptor (beta-A

158 e an age-associated diminution in myocardial contractile response to beta-adrenergic receptor (beta-A

159 myocardium is characterized by an attenuated contractile response to beta-adrenergic receptor (betaAR

160 This blunts the local contractile response to beta-adrenergic stimulation and

161 LPS depresses cardiac contractility and the contractile response to beta-adrenergic stimulation by a

162 unction in LVH rats and markedly blunted the contractile response to beta-adrenergic stimulation.

163 ction), the force-frequency response and the contractile response to beta-adrenergic stimulation.

164 each residue plays a role in regulating the contractile response to beta-agonist stimulation.

165 Myocardial contractile response to beta1- and beta2-adrenergic rece

166 ; (2) as a special case, the lack of cardiac contractile response to beta2AR agonists in TG4 mice is

167 of GRK2 led to a G(i)-dependent decrease of contractile response to betaAR stimulation in cultured m

168 Furthermore, the in vivo left ventricular contractile response to betaAR stimulation was restored

169 A marked age-associated depression in contractile response to both beta-AR subtype stimulation

170 The contractile response to capsaicin was not affected by th

171 0.005-mg/kg dose of endotoxin decreased the contractile response to cholecystokinin octapeptide for

172 Endotoxin abolished the contractile response to cholecystokinin octapeptide in g

173 nitric oxide synthase reversed the decreased contractile response to cholecystokinin octapeptide.

174 p/dtmax in response to BK, indicating a poor contractile response to CSAR activation.

175 In a separate group of experiments, the contractile response to cumulative concentrations of the

176 cedure that removed the endothelium, and the contractile response to cumulative doses of endothelin-1

177 We studied the effect of allopurinol on the contractile response to dobutamine and exercise in 7 chr

178 Both radionuclide perfusion tracers and contractile response to dobutamine have been used to ide

179 ls treated with dichloroacetate had a larger contractile response to dobutamine stress than non-treat

180 tional tissue after MI demonstrates a larger contractile response to dobutamine than normal myocardiu

181 The quantitative myocardial contractile response to dobutamine was similar in patien

182 The contractile response to each agonist was suppressed sign

183 r endotoxin administration and decreased the contractile response to electrical field stimulation for

184 adder TLR4 and MyD88 expression and enhanced contractile response to electrical field stimulation.

185 onist dexmedetomidine completely blocked the contractile response to electrical stimulation in vas de

186 The contractile response to ET-1 is through activation of ET

187 In vitro contractile response to ET-1 was assessed by videomicros

188 ic GMP-dependent protein kinase (PKG) in the contractile response to exogenous NO in rat ventricular

189 nd inhibited C3a-induced potentiation of the contractile response to field stimulation of perfused ra

190 and prostaglandin E(2) abrogated the potent contractile response to hypoxia and restored the wild-ty

191 e, caused both the oxidation current and the contractile response to increase.

192 Lower ratios indicate an inadequate RV contractile response to increased afterload.

193 phorylation is the principal mediator of the contractile response to increased beta-agonist stimulati

194 elaxation in Gsalpha at baseline but not the contractile response to ISO in Gsalpha myocytes.

195 We studied the contractile response to isoprenaline (10 nm) in isolated

196 However, there were no differences in the contractile response to isoproterenol between myocytes f

197 In addition, the contractile response to isoproterenol was blunted in bot

198 LPS attenuation of the contractile response to isoproterenol was restored compl

199 etaARK1 (3 to 5-fold) have a blunted in vivo contractile response to isoproterenol when compared with

200 The contractile response to LPS required TLR4 signaling and

201 ethoctramine, and tropicamide to inhibit the contractile response to muscarine.

202 o test the hypothesis that modulation of the contractile response to muscarinic receptor activation c

203 Inflammation suppresses the phasic contractile response to muscarinic receptor activation i

204 sulin (50 mU/l) significantly attenuated the contractile response to NE in lean rats (14.7 +/- 3.3%;

205 nges in gene expression promoted an enhanced contractile response to oxytocin in pregnant human myome

206 al contractions (P < 0.05) and an attenuated contractile response to oxytocin.

207 Contractile response to phenylephrine (PE; 10(-10) to 10

208 to lipopolysaccharide in vitro decreased the contractile response to phenylephrine.

209 We found that the contractile response to pressure elevation was slower in

210 In vivo contractile response to the beta1AR agonist dobutamine,

211 r relaxation (acetylcholine) and an enhanced contractile response to vasoactive agents (phenylephrine

212 tion, these animals exhibit hypertrophic and contractile responses to 10-day infusion of angiotensin

213 WT and KO arteries exhibited similar contractile responses to 60 mM KCl and 0.3 uM cirazoline

214 orylation of RyR2 in both the heart rate and contractile responses to acute catecholaminergic stimula

215 gnaling molecule central to adaptive cardiac contractile responses to acute stress, which appears to

216 transgenic than TnIDD22,23 (P<0.02), whereas contractile responses to afterload were similar between

217 femoral, and mesenteric arteries had reduced contractile responses to agonists and depolarization in

218 Additionally, contractile responses to alpha-adrenergic agonists were

219 s in determining the airway inflammatory and contractile responses to antigen in a mouse model.

220 reatment fully rescued the ICa, [Ca2+]i, and contractile responses to beta2AR agonists in both WT and

221 In this study, the contractile responses to both beta1-AR and beta2-AR stim

222 d that TGF-beta pre-treatment enhanced acute contractile responses to bradykinin (BK) in isolated rat

223 anization leading to enhance cerebral artery contractile responses to Ca(V)1.2 agonists.

224 Explanted tissue was tested for contractile responses to carbachol and histamine.

225 ce) exhibited blunted heart rate and cardiac contractile responses to catecholamines (isoproterenol).

226 STZ in WT mice increased bladder weight and contractile responses to CCh and to electrical field sti

227 eased nerve-mediated contraction, heightened contractile responses to cholinergic and purinergic agon

228 We found increased contractile responses to EFS in infected animals compare

229 However, the age-associated diminutions in contractile responses to either beta1-AR or beta2-AR sti

230 of aging coronary arteries is their enhanced contractile responses to endothelial vasoconstricting fa

231 The contractile responses to exogenous noradrenaline (NA; 0.

232 VSM contractile responses to G-protein-coupled receptor stim

233 s in which Ser16 is phosphorylated, inhibits contractile responses to high extracellular KCl and to s

234 Contractile responses to high molar KCl and u46619 level

235 gallbladder stasis by decreasing gallbladder contractile responses to hormonal and neural stimuli.

236 croscopic measurement of afferent arteriolar contractile responses to increasing bath concentrations

237 protein in mediating vascular smooth muscle contractile responses to intraluminal pressure was exami

238 No difference in isolated vascular contractile responses to KCI (125 mM), phenylephrine, or

239 These findings indicate that contractile responses to NE in human LUT tissues are med

240 kade heightened arteriolar and large venular contractile responses to norepinephrine, a nonselective

241 However, phenylephrine infusion enhanced contractile responses to parasympathetic stimulation.

242 Cultured vessels also showed contractile responses to pharmacological agents and cont

243 ar reactivity, as demonstrated by diminished contractile responses to phenylephrine and enhanced rela

244 units results in severely impaired lymphatic contractile responses to pinacidil.

245 hiPSC-CMs, mattress hiPSC-CMs display robust contractile responses to positive inotropic agents, such

246 Beta diminished contractile responses to potassium and phenylephrine, bu

247 This model was compared with metabolic and contractile responses to repeated activation using value

248 ymphatic muscle would exhibit rate-sensitive contractile responses to stretch.

249 n altered Starling relationship, and blunted contractile responses to the beta-adrenergic agonist dob

250 ic left ventricular function, and attenuated contractile responses to the beta-adrenergic agonist, is

251 ly a 20% decrease in RLC phosphorylation and contractile responses to the muscarinic agonist carbacho

252 Contractile responses to these drugs were assessed in me

253 The integrated contractile responses to these regulatory mechanisms dep

254 ce and gp91(phox) knock-out mice had similar contractile responses to U46619 and hypoxia and similar

255 mg) doses of estradiol inhibited the maximal contractile responses to U46619 compared with arteries f

256 ion, both LNA and methylene blue potentiated contractile responses to U46619 of arteries from animals

257 elium, associated with significantly reduced contractile responses to UTP and enhanced endothelium-de

258 Contractile responses to vasopressin (100 mmol/L) were e

259 Ultrafast measurements of the contractile response using line-field phase-resolved opt

260 and carotid arteries, whereas a decrease in contractile response was found in mesenteric arteries.

261 beta-AR) agonist isoproterenol (ISO)-induced contractile response was measured in isolated hearts.

262 The enhanced contractile response was prevented by the CaCC blockers

263 h inducible SRF overexpression, the in vitro contractile response was significantly increased in all

264 the G(i) coupling negating the G(s)-mediated contractile response, we determined whether the heart fa

265 melittin-stimulated release of AA and their contractile response were attenuated in inflamed cells.

266 These enhanced contractile responses were also observed in MIP/Mtmr14(-

267 ed an increase in the IAS tone; these tissue contractile responses were confirmed by single-cell cont

268 In contrast, enhanced contractile responses were not observed in response to a

269 In contrast, Ca(2+) elevation and contractile responses were partially dependent on VDCC a

270 inhibition of RLC phosphorylation and aorta contractile responses, whereas a 90% decrease profoundly

271 e had no effect on RLC phosphorylation or on contractile responses, whereas an 80% decrease resulted

272 CR4 sustained normal vascular reactivity and contractile responses, whereas CXCR4 deficiency favored

273 a1 versus beta2) to the overall reduction in contractile response with aging is unknown.

274 "Diminished or absent contractile response with reduced esophageal opening (ie

275 onstrated a quantitatively normal myocardial contractile response without development of wall motion

276 m) markedly enhanced the beta(2)-AR-mediated contractile response, without altering base-line contrac