ライフサイエンスコーパス: contracture

1 ssure (LVEDP) by > or =20 mm Hg (ie, cardiac contracture).

2 es and followed a predictable course of scar contracture.

3 els to identify the elements responsible for contracture.

4 a pathological response by muscle - namely, contracture.

5 breast implants is associated with capsular contracture.

6 11 hearts treated with CP plus Ran developed contracture.

7 g that muscle is a key contributor to breast contracture.

8 er into rigor and developed greater ischemic contracture.

9 hat are critical in wound closure and tissue contracture.

10 ed ischemic contracture, and reduced maximum contracture.

11 orrelated with severity of internal rotation contracture.

12 seline and accelerated the onset of ischemic contracture.

13 ist of phasic contractions overlying a tonic contracture.

14 duced forskolin-induced relaxation of the NA contracture.

15 erwent attempted surgical repair of capsular contracture.

16 umber of preconditioning cycles and ischemic contracture.

17 components and initiating microenvironmental contracture.

18 echanosensor in sensory neurons causes joint contracture.

19 seline and reduced the time to peak ischemic contracture.

20 RPC3-NFkB axis, leading to intractable wound contracture.

21 resulted in growth delay, muscle atrophy and contracture.

22 act compares favorably with regard to breast contracture.

23 re, but have been implicated in pathological contractures.

24 ontent and fibrosis, and decreased hind limb contractures.

25 ore significantly reduced than rapid cooling contractures.

26 y eroded skin, rocker bottom feet, and joint contractures.

27 flexed digits, crumpled ears and mild joint contractures.

28 e force versus [Ca(2+)](i) relations for KCl contractures.

29 in the development of radiation-induced leg contractures.

30 number of readmissions for reconstruction of contractures.

31 rdle weakness with rigid spine and disabling contractures.

32 acterized by early childhood onset and joint contractures.

33 nown causes of inherited multiple congenital contractures.

34 stimulation, as assessed by caffeine-induced contractures.

35 s that are characterized by congenital joint contractures.

36 congenital facial and distal skeletal muscle contractures.

37 ing, defective eye movement and pectoral fin contractures.

38 ents with delayed motor milestones and ankle contractures.

39 atter is additionally characterized by joint contractures.

40 els to developmental malformations and joint contractures.

41 ents, the most common of which were scars or contractures (301/378 [80%]).

42 period for proteasome inhibition to prevent contractures 4 weeks post-NBPI by treating mice with sal

43 Twelve patients had capsular contracture (57%).

44 The patient who had knee joint contractures achieved increased knee extension with pass

45 plex congenita is defined by the presence of contractures across two or more major joints and results

46 lays an important role in scarring and wound contracture after GFS.

47 he main contributor of breast reconstruction contracture after radiation.

48 tive therapies that can prevent fibrosis and contracture after STSG.

49 S proteasome inhibitor, bortezomib, prevents contractures after NBPI.

50 tissues, metabolic changes in muscle during contracture, alterations in fatty acid metabolism during

51 l complications such as rupture and capsular contracture, although evidence increasingly points to a

52 for reasons other than significant capsular contracture, among which 1 (5%) had >or=20 CFU/10 ml son

53 ted were removed due to significant capsular contracture, among which 9 (33%) had >or=20 CFU bacteria

54 Complications include capsular contracture and calcification and possibly connective ti

55 h-mediated calcium overload, leading to cell contracture and death, and that application of the membr

56 ss and complications, including bladder neck contracture and deep venous thrombosis.

57 a specialized MH testing center using muscle contracture and genetic testing.

58 ventions such as cardioplegia delay ischemic contracture and improve postischemic contractile recover

59 myocardial A1ARs increased time-to-ischemic contracture and improved functional recovery during repe

60 legia (alone and in combination) on ischemic contracture and postischemic contractile recovery.

61 asty result in a high prevalence of capsular contracture and suboptimal cosmesis.

62 s a significant association between capsular contracture and the presence of bacteria on the implant.

63 arts increased to 89% when reperfused before contracture and to 56% when reperfused in the presence o

64 oms of ANM include muscle weakness, atrophy, contracture and tremors accompanied by clonus.

65 ing biomarkers suggestive of progressive ERM contracture and/or vitreoretinal traction as compared wi

66 zed by congenital muscle weakness with joint contractures and coexisting distal joint hyperlaxity.

67 defects on extremities including congenital contractures and hypertonia.

68 ostridium histolyticum significantly reduced contractures and improved the range of motion in joints

69 ildhood-onset disease characterized by joint contractures and in some cases by abnormalities of cardi

70 s an XLID syndrome with fingertip arches and contractures and mapped to proximal Xq.

71 heads at relaxation; this may contribute to contractures and muscle weakness.

72 These were: presence of scapular winging, contractures and normal respiratory function.

73 ess in a humero-peroneal distribution, early contractures and prominent cardiomyopathy with conductio

74 progressive muscle disease characterized by contractures and proximal weakness, which can be caused

75 erized by progressive muscle weakness, joint contractures and respiratory insufficiency, to Bethlem m

76 Additionally, structural soft tissue contractures and spinal deformities may develop from poo

77 d after 15 years old, with progressive joint contractures and spine deformities.

78 ion, resulting in shoulder capsular fibrotic contractures and the associated clinical stiffness.

79 twitch skeletal muscles, thus causing muscle contractures and the development of the observed limb de

80 leptic encephalopathies, cleft palate, joint contractures and/or omphalocele.

81 Eight patients had joint contractures and/or pes equinovarus.

82 cal complications, such as rupture, capsular contracture, and breast pain, are unavailable.

83 to the myocyte perfusate caused tachycardia, contracture, and fibrillation of the cultured myocytes.

84 ine in ATP during ischemia, delayed ischemic contracture, and reduced maximum contracture.

85 sic CCA phenotype with arachnodactyly, joint contractures, and abnormal pinnae, whereas her daughter

86 nging, mild facial weakness, Achilles tendon contractures, and diminished or absent deep tendon refle

87 apy, bracing, soft tissue releases for joint contractures, and early stabilization of the spine.

88 icrocornea, optic atrophy, progressive joint contractures, and growth failure.

89 icrocornea, optic atrophy, progressive joint contractures, and growth failure.

90 , prednisone use at study entry, large joint contractures, and heart enlargement.

91 r kidney disease, tendon friction rubs, hand contractures, and proximal muscle strength.

92 pigmentary retinal mottling; (4) congenital contractures; and (5) marked early hypertonia and sympto

93 ing body of evidence showing that congenital contractures are a shared outcome of prenatal defects in

94 postoperative complications and bladder neck contractures are excellent, and appear to be improved wh

95 ll muscle fails to induce twitches, however, contractures are induced by caffeine.

96 Contractures are reduced at low [Ca2+], unaffected by ad

97 The majority of bladder neck contractures are responsive to urethral dilation or cold

98 echanical stiffness, and therefore result in contracture, are unknown.

99 n hand function, inflammatory indices, joint contractures, arthritis signs, overall functional abilit

100 of the neck, elbows, and/or knees and joint contractures (arthrogryposis).

101 of the neck, elbows, and/or knees and joint contractures (arthrogryposis).

102 ese results question the utility of ischemic contracture as a predictor of the protective efficacy of

103 ocytosis and several syndromes with muscular contracture as a prominent feature.

104 ular resistance, and development of ischemic contracture as indicated by increases in left ventricula

105 ients affected by myopathy with early spinal contractures as a prominent feature.

106 asis of these syndromes redefines congenital contractures as unique defects of the sarcomere and prov

107 e, normal-glycogen hearts underwent ischemic contracture at 5 minutes, had an end-ischemic pH of 6.87

108 longer-term proteasome inhibition to prevent contractures at 8 and 12 weeks post-NBPI.

109 are short stature, a high incidence of joint contractures at birth and progressive scoliosis and frac

110 ed 1.5-fold and at the peak of acetylcholine contractures at the same lengths.

111 ity increased by about 80, 72 and 50% during contractures at the short, intermediate and long lengths

112 possible inclusion of early intervention for contracture avoidance and assistance with wound healing.

113 Grade 2 and 3 socket contractures, based on Tawfik's classification, were rep

114 nclude developmental delay, hypotonia, joint contractures, behavioral abnormalities, Marfanoid habitu

115 No differences were observed for KCl contractures between tissue types for either maximum for

116 ibition becomes less effective in preventing contractures beyond the neonatal period.

117 During contractures, birefringence increased by 25 and 18% at t

118 stic and treatment concerns for bladder neck contractures (BNCs) in the prostate cancer survivor.

119 vestigations confirmed sclerotic skin, joint contractures, bone abnormalities, alopecia, and growth i

120 pus callosum agenesis or hypoplasia, flexion contractures, brachydactyly of hands and feet with broad

121 Hypoxia also relaxed GTPgammaS contractures but importantly, arteries could not be rela

122 ity, including itching, pain, stiffness, and contracture, but best management practices remain unclea

123 7632 (1 microm) relaxed GTPgammaS and Ca(2+) contractures; but the latter required a higher concentra

124 ecticides, and these materials induce muscle contracture by irreversible activation of the calcium-re

125 d enhance treatment for patients with muscle contracture caused by other conditions than high heel we

126 -based, nonsurgical option, may reduce joint contractures caused by Dupuytren's disease.

127 r involving cleft palate, neonatal seizures, contractures, central nervous system (CNS) structural ma

128 hen subpectoral patients present with breast contracture, chemoparalysis of the muscle alone can reso

129 X-2(-/-) mice showed an increase in ischemic contracture compared with hearts from WT and COX-1(-/-)

130 agnosis between congenital Volkmann ischemic contracture (CVIC) and unilateral aplasia cutis congenit

131 was found between ECoG cycles and myometrial contracture cycles.

132 d into our rat model of post-traumatic elbow contracture decreased histological evidence of anterior

133 ese bacteria in the pathogenesis of capsular contracture deserves further study.

134 f neonatal development can prevent long-term contracture development.

135 the most common of the heritable congenital-contracture disorders, and ~50% of cases are caused by m

136 uscular dystrophy, traumatic laceration, and contracture due to upper motor neuron lesion as seen in

137 odotoxin (1 micromol/L) also reduced cardiac contracture during ischemia/reperfusion, compared to CP

138 elay in the time to full ATP-depletion rigor contracture during severe hypoxia and enhanced morpholog

139 nificantly reduced the magnitude of ischemic contracture during ventricular fibrillation and the acco

140 terised by delayed speech development, joint contractures, dysmorphic features and dysmotility of the

141 The histological hallmarks of contracture (e.g., fibrotic adhesions and reduced joint

142 t common known heritable cause of congenital contractures (e.g. clubfoot) and results from mutations

143 s cardioplegia has little effect on ischemic contracture, each affords similar protection of postisch

144 ry such as urinary incontinence, anastomotic contracture, erectile dysfunction and rectourethral fist

145 Case selection is critical because severe LR contracture, extensive scarring from prior strabismus su

146 ature with proximal shortening of the limbs, contractures, facial dysmorphism, congenital cataracts,

147 e compliance and are susceptible to terminal contracture following mild passive extensions.

148 A subset of anastomotic contractures following radical prostatectomy are recurre

149 by 4-chloro-m-cresol (4-CmC)-evoked maximal contracture force in single intact fibers from the mouse

150 erences in tetanic, but not in 4-CmC-evoked, contracture forces were recorded in fibers from aging mi

151 These findings provide evidence that contracture formation is not the result of stiffening at

152 e characterized by multiple congenital joint contractures, frequently is caused by lesions in the per

153 However, individuals with SHFYNG have joint contractures, greater cognitive impairment, and higher p

154 onset autosomal dominant myopathy with joint contractures, has recently been localized to 21q in a se

155 ine (2.5% vs. 0.5%, P < 0.001), and capsular contracture higher for silicone (5.0% vs. 2.8%, P < 0.00

156 Capsular contracture (III/IV) occurs in 7.2% of primary augmentat

157 lues for an increase in time to the onset of contracture in globally ischemic rat hearts.

158 neuromuscular junction, leading to a tetanic contracture in muscle fiber.

159 Ca(2+) release, suppresses caffeine-induced contracture in skeletal muscle, reduces sarcolemmal cati

160 Arthrogryposis, defined as congenital joint contractures in 2 or more body areas, is a clinical sign

161 EMG showed silent contractures in approximately half of the patients and n

162 ile activity responsible for skeletal muscle contractures in FSS patients.

163 for persons with DA2A and perhaps congenital contractures in general.

164 itis, with severe loss of motion and flexion contractures in multiple joints.

165 y improvement of skin changes and knee joint contractures in patients with stage 5 chronic kidney dis

166 histidine), at 0.1-10 mM, provokes sustained contractures in rabbit saphenous vein rings with greater

167 on in Ryr1 (Y524S, YS) display lethal muscle contractures in response to heat.

168 susceptibility to caffeine- and heat-induced contractures in vitro.

169 urethral strictures (excluding bladder neck contracture) in this setting, as well as risk factors an

170 The 5-HT maximum tension (% of 80 mM KCl contracture) increased from 17 +/- 2% in non-pregnant to

171 on-ischemic murine hearts, prolongs ischemic contracture, increases postischemic recovery of LVDP, an

172 mia by hastening the development of ischemic contracture, increasing coronary vascular resistance, an

173 Capsular contracture is a common adverse outcome following implan

174 Hypertrophic scar contracture is considered to be a pathologic and exagger

175 Acceleration of ischemic contracture is conventionally accepted as a predictor of

176 Capsular contracture is the most common and frustrating complicat

177 [Ca(2+)](i) decline during caffeine-induced contractures is attributable to Ca(2+) transport by NaCa

178 most conditions characterized by congenital contractures is largely unknown.

179 oss of MYLPF function can lead to congenital contractures, likely as a result of degeneration of skel

180 quired throughout skeletal growth to prevent contractures long term.

181 tion is not a viable strategy for preventing contractures long term.

182 ult in considerable morbidity owing to joint contracture, loss of flexibility, and disfigurement.

183 lts highlight how plantarflexor weakness and contracture may contribute to observed gait patterns.

184 overlap disorders with joint hypermobility, contractures, mild skeletal dysplasia and high myopia.

185 se (FAK) inhibitor promoted healing, reduced contracture, mitigated scar formation, restored collagen

186 Here, we show that myoblast progenitors from contractured muscle in children with CP are hyperprolife

187 ntly reported to cause "JMP" syndrome (joint contractures, muscle atrophy, microcytic anemia, and pan

188 inflammatory syndrome characterized by joint contractures, muscle atrophy, microcytic anemia, and pan

189 s, such as permanent dysaesthesia, ischaemic contractures, muscle dysfunction, loss of limb, and even

190 ng as early-onset joint hypermobility, joint contractures, muscle weakness and bone dysplasia as well

191 plantarflexor muscles, such as weakness and contracture, occur commonly in conditions such as cerebr

192 as supplied throughout ischemia, no ischemic contracture occurred, and postischemic recovery of contr

193 crements often represent the enlargement and contracture of channels rather than the opening and clos

194 Severe contracture of only SOL or both PF yielded similar resul

195 In addition to the recurrence, he had contracture of the conjunctiva in the socket of his prev

196 e the results of macular tissue shift due to contracture of the optic disc and neurovascular bundle.

197 We enrolled 308 patients with joint contractures of 20 degrees or more in this prospective,

198 oup of disorders characterized by congenital contractures of distal limbs without overt neurological

199 rden-Walker syndrome (MWKS), which encompass contractures of hands and feet, scoliosis, ophthalmopleg

200 tecollis, camptocormia and/or Pisa syndrome, contractures of hands or feet, inspiratory sighs, severe

201 ontrollable excitation of motoneurons causes contractures of innervated muscles and leads to local sp

202 e and myofiber histology and decreased fixed contractures of Lama2(-/-) mice.

203 of the palmar fascia, which leads to flexion contractures of the digits, and is associated with other

204 YH3 and characterized by multiple congenital contractures of the face and limbs and normal cognitive

205 1) is a disorder characterized by congenital contractures of the hands and feet for which few genes h

206 ned by us and is characterized by congenital contractures of the hands and feet, along with distincti

207 characterized by cleft palate and congenital contractures of the hands and feet.

208 is generally recommended for severe flexion contractures of the interphalangeal joints, other surgic

209 dular tumors, gingival fibromatosis, flexion contractures of the joints, and an accumulation of hyali

210 gical abnormalities" and for whom congenital contractures of the limbs and face, hypotonia, and globa

211 sorders characterized by multiple congenital contractures of the limbs.

212 multiple pterygia, scoliosis, and congenital contractures of the limbs.

213 infants have tremors with hypotonia and mild contractures of the shoulders and hips.

214 tory of the remaining cases is influenced by contractures of uninvolved muscle groups and subluxation

215 Contracture onset coincided with the decrease in glycoly

216 No patient had muscle contractures or Hirschsprung disease.

217 d/or toxicity of therapy; for example, joint contractures or joint damage may result in life-long dis

218 mily members with mutations had either joint contractures or skeletal myopathy.

219 injury (NBPI) causes disabling and incurable contractures, or limb stiffness, which result from prote

220 % of patients with skin involvement, flexion contractures, or oral manifestations achieved complete o

221 particularly if sclerodermatous skin, joint contractures, or oral manifestations are present.

222 utaneous tumors, gingival hypertrophy, joint contractures, osteolysis, and osteoporosis.

223 arly 4 times as likely to result in capsular contracture (p < 0.01).

224 ssociated with severity of internal rotation contracture (P <.001).

225 line (P = 0.0078) and changes in large joint contractures (P = 0.0072), tender joint counts (P = 0.01

226 In juveniles, scarring, contractures, persistent weakness, muscle dysfunction, a

227 ndons correlates with the bone fragility and contracture phenotype in humans.

228 outlet secondary to a recurrent bladder neck contracture postprostatectomy or cystectomy presents a r

229 erated whereas cardioplegia delayed ischemic contracture; preconditioning plus cardioplegia gave an i

230 Cariporide ameliorated ischemic contracture, prevented postresuscitation diastolic dysfu

231 MD) is an X-linked disorder characterized by contractures, progressive muscle weakness and cardiomyop

232 MD) is an X-linked disorder characterized by contractures, progressive weakness and cardiomyopathy.

233 ering from severe muscle weakness with joint contractures, pronounced growth retardation and kyphosis

234 Capsular contracture rate was greater in the subpectoral vs. prep

235 Finally, wound healing time and contracture rate were reported.

236 after variable rest intervals, rapid cooling contractures (RCCs) and fast application of caffeine.

237 of lactate were studied using rapid cooling contractures (RCCs) and fast application of caffeine.

238 owever, notable shortcomings including graft contracture, recurrence, and impotence have been reporte

239 nts, correcting abnormal posture, preventing contractures, reducing pain, and improving function and

240 ning surgery for hamstring and hip adduction contractures, respectively.

241 s and quality are abnormal and fractures and contractures result.

242 sterior urethral strictures and bladder neck contractures resulting from ablative therapies.

243 al condition characterized by multiple joint contractures resulting from reduced or absent fetal move

244 the ryanodine receptor (RyR1) display muscle contractures, rhabdomyolysis, and death in response to e

245 esia, shortening of all long bones, multiple contractures, rib anomalies, thoracic dysplasia, pulmona

246 r to repolarization-induced stop of caffeine contracture (RISC) in embryonic murine myoballs.

247 d for any of the following reasons: capsular contracture; rupture of the implant; hematoma or bleedin

248 istal arthrogryposis (DA) who had congenital contractures, scoliosis, and short stature.

249 pertrophy of calf muscles, progressive joint contractures, severe scoliosis, elevated serum creatine

250 ose that the definition of Volkmann ischemic contracture should be maintained only for the acquired f

251 address stone disease due to lower extremity contractures, spinal curvature, and pelvic tilt.

252 hanger and providing for the well-documented contracture-suppressant effect of the hormone on frog he

253 Lethal congenital contracture syndrome (LCCS) is a lethal autosomal recess

254 humans, GLE1 is mutated in lethal congenital contracture syndrome 1 (LCCS1) leading to prenatal death

255 Lethal congenital contracture syndrome 1 and lethal arthrogryposis with an

256 s causally linked to human lethal congenital contracture syndrome-1 (LCCS1); however, the resulting p

257 nition of a DST-associated lethal congenital contracture syndrome.

258 Freeman-Sheldon and Sheldon-Hall congenital contracture syndrome.

259 developmental pathway that causes congenital-contracture syndromes.

260 Freeman-Sheldon and Sheldon-Hall congenital contracture syndromes.

261 logy and pathogenesis of multiple-congenital-contracture syndromes.

262 ther with inherent drawbacks of the in-vitro contracture test confounded efforts to discover the unde

263 mbers by in vitro diagnostic pharmacological contracture testing of biopsied skeletal muscle.

264 and in mice mutant for fibrillin-2 is joint contractures that resolve over time.

265 , one of the most severe multiple congenital contracture (that is, arthrogryposis) syndromes, and nea

266 t disorder, characterized by twisting muscle contractures, that begins in childhood.

267 esses including disuse muscle atrophy, joint contractures, thromboembolic disease, and insulin resist

268 nteract to increase stiffness greatly of the contracture tissue in vivo.

269 The primary end point was a reduction in contracture to 0 to 5 degrees of full extension 30 days

270 ) reduces the force of a KCl (40 mM)-induced contracture to approximately 10% of the control value in

271 ate, and severe levels of muscle weakness or contracture to either the soleus (SOL) or gastrocnemius

272 rial activity from low amplitude, infrequent contractures to high amplitude, high frequency contracti

273 Given that contractures uniquely follow neonatal denervation, the c

274 sensitivity for activation, producing muscle contractures upon exposure to elevated temperatures.

275 The amplitude of caffeine-induced contractures, used to assess SR Ca(2+) load, was not sig

276 red to 54%, whereas in high-glycogen hearts, contracture was delayed to 13 minutes, the end-ischemic

277 hen cutaneous sclerosis, fasciitis, or joint contracture was first documented in the medical record.

278 Time to ischemic contracture was prolonged in the multipollutant-mixture

279 elationship for L-lactate showed that the NA contracture was relaxed by 50% at approximately 26 mM.

280 Revision for capsular contracture was similar between the 2 cohorts (11.4% vs

281 global ischemia, indexed by time-to-ischemic contracture, was accelerated by blocking adenosine recep

282 To elucidate the effects of weakness and contracture, we systematically introduced isolated defic

283 similar to familial dysautonomia as well as contractures, we identified a deleterious mutation in th

284 Progressive worsening of the proximal contractures, weakness, and a pectus carinatum deformity

285 Thus, times to 75% contracture were as follows: control, 14.3 +/- 0.4 minut

286 Signs of capsular contracture were assessed using clinic notes and indepen

287 ventricular developed pressure and ischemic contracture were assessed with an intraventricular ballo

288 ogen hearts, ischemic glycogen depletion and contracture were avoided, and the hearts were protected

289 Finally, faster wound healing and less contracture were observed in animals treated with EPO 50

290 ent trapezius muscles together with variable contractures were characteristic features.

291 Puffy fingers and finger joint contractures were detected significantly more often in I

292 ickness score (MRSS), and knee joint flexion contractures were measured with a goniometer.

293 ial dysmorphism, clubfeet and multiple joint contractures were observed already at birth.

294 of 11 hearts treated with CP alone developed contracture, whereas 6 out of 11 hearts treated with CP

295 novel variant phenotypes, such as congenital contractures, which are potentially associated with Carn

296 nd cromakalim increased the time to onset of contracture with a similar potency (EC25, 11.0 and 8.8 m

297 A combination of proximal contractures with distal joint hyperlaxity is a distinct

298 racterized by generalized autosomal dominant contractures with limited eye movements, restrictive lun

299 ouette on radiograph (P = 0.04), large joint contractures (wrist, elbow, knee) (P = 0.008), and predn

300 in relevant science fields is in a state of contracture, yet many universities continue to maintain