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1 fter imaging (>1 day after administration of contrast material).
2 ine- [P > .12] or gadolinium-based [P > .13] contrast material).
3 e kidney injury in transgenic mice receiving contrast material.
4 me profiles reflecting the administration of contrast material.
5 ike or unknown-type reaction to iodine-based contrast material.
6 ffuse pattern after intravenous injection of contrast material.
7  fat suppression without oral or intravenous contrast material.
8 otocol performed without intravenous or oral contrast material.
9 nate dimeglumine, with 19 patients receiving contrast material.
10 opylene bottle filled with diluted iodinated contrast material.
11 predict enhancing lesions without the use of contrast material.
12 ) clinical-grade VEGFR2-targeted microbubble contrast material.
13 ment of post-CT AKI, regardless of iodinated contrast material.
14  image intervals by using a gadolinium-based contrast material.
15 ing without the need for intravenous or oral contrast material.
16 ons on MRI scans obtained without the use of contrast material.
17  performed without and with gadolinium-based contrast material.
18 in three automated phases after injection of contrast material.
19  of intravenous iodine- and gadolinium-based contrast material.
20 T MR imaging with or without intra-articular contrast material.
21 e fifth dimension represents the dynamics of contrast material.
22 5-T imaging, with or without intra-articular contrast material.
23 e reviewed, including alternative diagnostic contrast materials.
24 g them is to create a composite by combining contrasting materials.
25  seconds after administration of intravenous contrast material (100 mL of iohexol, Omnipaque 350; GE
26 T of the abdomen and pelvis with intravenous contrast material (100 mL Omnipaque 350; GE Healthcare,
27 T of the abdomen and pelvis with intravenous contrast material (100 mL Omnipaque 350; GE Healthcare,
28 on after administration of low-concentration contrast material (170 mg of iodine per milliliter), and
29  (MR) imaging was performed with and without contrast material 2 or 7 days after ablation.
30 nces were discussed i.e. 1. Gadolinium-based contrast materials, 2. hemoglobin degradation products 3
31 d for all patients who received a dose of CM contrast material 250 mL or greater while they underwent
32 odium) diluted in either saline or iodinated contrast material (50% and full-strength iohexol 300).
33         A total of 140 neonates who received contrast material (59 who underwent CT with iohexol or i
34 rves obtained after injection of microbubble contrast material 6 weeks after beginning pharmacologic
35                     The average volume of CM contrast material administered was 172 mL in the control
36 nhancing lesions on MRI scans obtained after contrast material administration are commonly thought to
37  bowel wall arterial phase enhancement after contrast material administration at baseline (rho = -0.5
38 ce breast MRI protocols without the need for contrast material administration in breast screening.Key
39                                  Intravenous contrast material administration was not associated with
40 ses, reconstruction kernels or timings after contrast material administration) in routine CT imaging
41 patient's renal status precluded intravenous contrast material administration.
42 -weighted imaging, before and 24 hours after contrast material administration.
43 time-varying concentration curves of various contrast material administrations in each organ for diff
44 -gated micro-CT by using both a conventional contrast material and a novel iodinated MMCM.
45 phic (CT) scan of the kidney with the use of contrast material and an iothalamate-based measurement o
46  function using existing MRI systems without contrast material and may assist in providing informatio
47 ence was not significantly different between contrast material and non-contrast material groups in an
48 injected at 2.5 mL/sec; phases 3-4, 40 mL of contrast material and saline injected at 2.5 mL/sec); bo
49 njected in four phases (phases 1-2, 60 mL of contrast material and saline injected at 2.5 mL/sec; pha
50 hantom was filled with nonionic iodine-based contrast material, and a gadolinium-filled capsule repre
51 T MR imaging with or without intra-articular contrast material appears to improve diagnostic accuracy
52 ntravenous and bismuth subsalicylate enteric contrast material at DE CT.
53  precise allocation of high refractive-index contrast materials at independently addressable radial a
54 ty by 10 minutes after the administration of contrast material before plateauing.
55 erformed after intravenous administration of contrast material before tumor resection.
56                              The duration of contrast material bolus (0.5 mL/kg of body weight) was 3
57                                  Duration of contrast material bolus injection does not influence CT
58 bstantial reductions in the use of iodinated contrast material can be achieved by using lower-energy
59 te that multivolume (1)H MR imaging, without contrast material, can be used as a biomarker for region
60                                     Adherent contrast material coating on these polyps aids in their
61 ermine maximal lesion width and height, oral contrast material coating, segmental location, and compu
62 3-T imaging, with or without intra-articular contrast material compared with 1.5-T imaging, with or w
63 uations, the solutions to which provided the contrast material concentration time curves for each com
64                 Quantitative measurements of contrast material concentrations in the colon and polyp
65 ful for salvaging CT studies with suboptimal contrast material delivery or providing additional infor
66                                        After contrast material delivery, relative percentage of enhan
67 the high-dose cohort, 36 (46%) received a CM contrast material dose between 250 and 299 mL, 29 (37%)
68 ine was seen in two of the four high-dose CM contrast material dose categories: 250-299 mL (decrease
69 ted of comparable patients who received a CM contrast material dose of 75-249 mL during the same peri
70 undergo neuroendovascular procedures with CM contrast material doses of 250 mL or greater.
71                         Passive diffusion of contrast material enables quantitative analysis of the f
72  intravenous administration of iodixanol for contrast material enhanced CT was not an independent ris
73 T2 weighted, diffusion weighted, and dynamic contrast-material enhanced) and nerve-sparing robot-assi
74                                  Intravenous contrast material-enhanced (100 mL of Omnipaque 350; GE
75 ght of these findings, the patient underwent contrast material-enhanced (120 mL of iopromide, Ultravi
76                                  Intravenous contrast material-enhanced (120 mL of Omnipaque 350; Nyc
77 and pelvis was performed and was followed by contrast material-enhanced (80 mL of iopamidol) computed
78                      Baseline arterial phase contrast material-enhanced (CE) MR imaging was used to m
79  background parenchymal enhancement (BPE) at contrast material-enhanced (CE) spectral mammography and
80                                              Contrast material-enhanced (CE) US is a recognized imagi
81                                          All contrast material-enhanced (contrast group) and unenhanc
82  To evaluate the association between dynamic contrast material-enhanced (DCE) and diffusion-weighted
83 ntiation of cancer from noncancer at dynamic contrast material-enhanced (DCE) breast MRI is improved
84  to moderate for features related to dynamic contrast material-enhanced (DCE) imaging (kappa = 0.266-
85 ast agent for their applicability in dynamic contrast material-enhanced (DCE) magnetic resonance (MR)
86 llular carcinoma (HCC) measured with dynamic contrast material-enhanced (DCE) magnetic resonance (MR)
87 The authors retrospectively analyzed dynamic contrast material-enhanced (DCE) magnetic resonance (MR)
88 e perfusion patterns at quantitative dynamic contrast material-enhanced (DCE) magnetic resonance (MR)
89 with DCIS who underwent preoperative dynamic contrast material-enhanced (DCE) MR imaging between 2004
90 tion (IRV) in parameters measured at dynamic contrast material-enhanced (DCE) MRI in patients with gl
91 R2)-targeted microbubbles and (b) 3D dynamic contrast material-enhanced (DCE) US by using nontargeted
92 d-attenuated inversion recovery [FLAIR]) and contrast material-enhanced (gadoterate meglumine, 0.1 mm
93 reoperative work-up included a water-soluble contrast material-enhanced (iodixanol, 320 mg of iodine
94 puted tomography (CT)-guided RF ablation and contrast material-enhanced 1-month follow-up CT and/or m
95 [ADC] maps [b < 1000 sec/mm(2)], and dynamic contrast material-enhanced [DCE] MR imaging).
96 es (T2-weighted, diffusion-weighted, dynamic contrast material-enhanced [DCE] pulse sequences) and sc
97 mography tumor volume and perfusion, dynamic contrast material-enhanced and diffusion-weighted magnet
98  of the IMA, the cross-sectional area of the contrast material-enhanced aortic lumen at the level of
99       The amount of necrotic tumor tissue on contrast material-enhanced arterial phase MR images and
100 ining iodine (2, 5, and 15 mg/mL), simulated contrast material-enhanced blood, and soft-tissue insert
101 with brain tumors who underwent nine or more contrast material-enhanced brain magnetic resonance (MR)
102 very, diffusion- and perfusion-weighted, and contrast material-enhanced brain magnetic resonance (MR)
103       All participants underwent equilibrium contrast material-enhanced cardiac MR imaging.
104                      Exclusion criteria were contrast material-enhanced chest CT performed for vascul
105 graphic (CT) examination across a library of contrast material-enhanced computational patient models.
106                                              Contrast material-enhanced computed tomographic (CT) ima
107 titutional review board waiver was obtained, contrast material-enhanced computed tomographic (CT) stu
108 ey from unilateral nephrectomy who underwent contrast material-enhanced computed tomography (CT) at t
109                               Unenhanced and contrast material-enhanced computed tomography (CT) imag
110 on tomography (PET) combined with diagnostic contrast material-enhanced computed tomography (CT) in d
111 roid prophylaxis administered 5 hours before contrast material-enhanced computed tomography (CT) is n
112 ars old) underwent unenhanced MR imaging and contrast material-enhanced computed tomography (CT) of t
113 -including chest radiography; bone scanning; contrast material-enhanced computed tomography (CT) of t
114                                        Thus, contrast material-enhanced computed tomography (CT) of t
115                                              Contrast material-enhanced computed tomography (CT) of t
116  10 patients undergoing either unenhanced or contrast material-enhanced computed tomography (CT) serv
117  Posttreatment evaluation was conducted with contrast material-enhanced computed tomography in the li
118 ation zone was identified with postprocedure contrast material-enhanced computed tomography.
119 h nonenhanced CT to assess calcium score and contrast material-enhanced coronary CT angiography were
120  corticosteroid premedication regimen before contrast material-enhanced CT (n = 1424) from 2008 to 20
121                                            A contrast material-enhanced CT angiography pulmonary embo
122                                            A contrast material-enhanced CT angiography pulmonary embo
123 ients with stable kidney function undergoing contrast material-enhanced CT by comparing with a propen
124                        Materials and Methods Contrast material-enhanced CT examinations of the chest
125   Results from 88 thoracic and 110 abdominal contrast material-enhanced CT examinations were analyzed
126  66 of 67 (98%) ablated lesions on the first contrast material-enhanced CT images at 4-8-week follow-
127      Texture was assessed for unenhanced and contrast material-enhanced CT images by using a software
128 oved study, gene expression profile data and contrast material-enhanced CT images from 70 patients wi
129  performed per tumor after identification on contrast material-enhanced CT images.
130 dding unenhanced computed tomography (CT) to contrast material-enhanced CT improves the diagnostic pe
131 d radiation dose (RD) and standard dose (SD) contrast material-enhanced CT of the abdomen and to qual
132 derwent molecular profiling and pretreatment contrast material-enhanced CT scans between 2004 and 201
133                                              Contrast material-enhanced CT was used to assess techniq
134            A total of 179 patients underwent contrast material-enhanced CT, and 66 patients underwent
135                                              Contrast material-enhanced dual-energy CT and convention
136    Purpose To determine whether single-phase contrast material-enhanced dual-energy material attenuat
137 cinoma at pathologic analysis, who underwent contrast material-enhanced dual-energy nephrographic pha
138                           Patients underwent contrast material-enhanced electrocardiography-gated car
139 rying iodinated contrast agent to create the contrast material-enhanced five-dimensional XCAT models,
140 , mass effect, or hydrocephalus (HMH) at non-contrast material-enhanced head computed tomographic (CT
141 the difference in R2* (DeltaR2*) between the contrast material-enhanced images and baseline images.
142                                 Endoleaks on contrast material-enhanced images were considered the re
143 lower in attenuation than the thyroid on non-contrast material-enhanced images, but patterns differed
144  33.3% for width measurements on T1-weighted contrast material-enhanced images.
145                   The neonates who underwent contrast material-enhanced imaging and the neonates who
146 T2-weighted, diffusion-weighted, and dynamic contrast material-enhanced imaging before prostatectomy
147                                     Advanced contrast material-enhanced imaging techniques are capabl
148                                              Contrast material-enhanced imaging was not available at
149                                              Contrast material-enhanced imaging was not available at
150 T2-weighted, diffusion-weighted, and dynamic contrast material-enhanced imaging) obtained before radi
151 T2-weighted, diffusion-weighted, and dynamic contrast material-enhanced imaging, and by using the sum
152 T2-weighted, diffusion-weighted, and dynamic contrast material-enhanced imaging, were included.
153 ighted, diffusion-weighted [DW], and dynamic contrast material-enhanced imaging.
154 t magnetic resonance (MR) imaging, including contrast material-enhanced LGE imaging and T1 mapping.
155 equence paradigm and limited role of dynamic contrast material-enhanced magnetic resonance (MR) imagi
156 e-matched control subjects underwent dynamic contrast material-enhanced magnetic resonance (MR) imagi
157 Post-PAE prostate ischemia was measured with contrast material-enhanced magnetic resonance (MR) imagi
158 east 10 mm were recruited to undergo dynamic contrast material-enhanced magnetic resonance (MR) imagi
159                                              Contrast material-enhanced magnetic resonance (MR) imagi
160 nts with GBM underwent baseline imaging with contrast material-enhanced magnetic resonance (MR) imagi
161 ured at baseline and after the first TACE on contrast material-enhanced magnetic resonance images.
162                        Materials and Methods Contrast material-enhanced MR angiography was performed
163 ctor.PurposeTo use 3-T MRI methods including contrast material-enhanced MR angiography, carotid plaqu
164 imensional ablation lengths were measured on contrast material-enhanced MR images, and bone remodelin
165                                      Delayed contrast material-enhanced MR imaging allowed simultaneo
166                   All participants underwent contrast material-enhanced MR imaging and ultrasonograph
167 ance (MR) imaging and dynamic susceptibility contrast material-enhanced MR imaging at baseline and at
168             Women underwent standard dynamic contrast material-enhanced MR imaging for further assess
169 3)Na and DWI sequences were performed before contrast material-enhanced MR imaging in patients with b
170                  T2- and T1-weighted dynamic contrast material-enhanced MR imaging was performed befo
171                         All studies in which contrast material-enhanced MR imaging was used for asses
172 T2-weighted; diffusion-weighted; and dynamic contrast material-enhanced MR imaging with a 3-T imager
173 ighted MR imaging, 0.42 and 0.28; at dynamic contrast material-enhanced MR imaging, 0.23 and 0.24, an
174 is: noncontrast MR cholangiopancreatography, contrast material-enhanced MR imaging/MR cholangiopancre
175                 All patients underwent a non-contrast material-enhanced MR protocol that included rou
176  qualitative and quantitative BPE at dynamic contrast material-enhanced MRI and breast cancer among p
177 cal reference standard and to compare DWI to contrast material-enhanced MRI for the detection of syno
178 wly diagnosed breast cancer by using dynamic contrast material-enhanced MRI is limited by access, hig
179                                              Contrast material-enhanced MRI of the brain was performe
180                                              Contrast material-enhanced MRI of the brain was performe
181 gnosed between 2008 and 2015, had a baseline contrast material-enhanced MRI study, had a pathologic g
182 18 and who underwent preoperative multiphase contrast material-enhanced MRI.
183 s were discovered incidentally at multiphase contrast material-enhanced multidetector computed tomogr
184                        The patient underwent contrast material-enhanced multidetector computed tomogr
185 tient underwent erect abdominal radiography, contrast material-enhanced multidetector row computed to
186 T2-weighted, diffusion-weighted, and dynamic contrast material-enhanced multiparametric MR imaging of
187                                              Contrast material-enhanced multiphase MR imaging was per
188                                              Contrast material-enhanced myocardial perfusion imaging
189  examine the subsequent quantitative dynamic contrast material-enhanced parameters in breast cancer w
190 ges were acquired in unenhanced and standard contrast material-enhanced phases, with observation diam
191 d a gadolinium-filled capsule representing a contrast material-enhanced polyp was positioned on the c
192 ging in comparison with full multiparametric contrast material-enhanced prostate MR imaging in men wi
193 d PET/MR imaging with diffusion-weighted and contrast material-enhanced sequences after unenhanced PE
194 se To compare the diagnostic performances of contrast material-enhanced spectral mammography and brea
195 cer screening: digital breast tomosynthesis, contrast material-enhanced spectral mammography, US (aut
196 rwent staging with single-energy dual-source contrast material-enhanced staging CT between September
197 d clinical prostate protocol, with a dynamic contrast material-enhanced study ( Figs 1 - 3 ).
198                Patients underwent diagnostic contrast material-enhanced study prior to the first dila
199 d clinical prostate protocol, with a dynamic contrast material-enhanced study.
200 dial iron quantification, and unenhanced and contrast material-enhanced T1 mapping.
201  texture features) from the multiparametric (contrast material-enhanced T1-weighted and fluid-attenua
202 using software at T2-weighted MR imaging and contrast material-enhanced T1-weighted MR imaging.
203 ension were examined at 1.5 T with a dynamic contrast material-enhanced three-dimensional fast low-an
204 als and Methods In this retrospective study, contrast material-enhanced three-dimensional T1-weighted
205                                Preoperative, contrast material-enhanced triphasic CT studies from 89
206    Purpose To demonstrate the feasibility of contrast material-enhanced ulrasonographic (US) nephrost
207                    Purpose To assess whether contrast material-enhanced ultrasonography (US) can be u
208 icle describes the successful integration of contrast material-enhanced US into a multimodality appro
209                                     Targeted contrast material-enhanced US signal was quantified 5 mi
210          Three-dimensional, high-frame-rate, contrast material-enhanced US was achieved by mechanical
211 eft anterior descending artery (LAD), and 20 contrast material-enhanced volume scans were acquired pe
212 -up head dual-energy CT scans obtained after contrast material-enhanced whole-body CT.
213 T2-weighted, diffusion-weighted, and dynamic contrast material-enhanced) and transrectal in-bore MRI-
214               On T1-weighted (unenhanced and contrast material-enhanced), T2-weighted, and DWI (b = 1
215 al oblique and sagittal T2-weighted, dynamic contrast material-enhanced, and diffusion-weighted imagi
216 iparametric MR imaging (T2-weighted, dynamic contrast material-enhanced, and diffusion-weighted seque
217 res of 658 brain metastases from T1-weighted contrast material-enhanced, T1-weighted nonenhanced, and
218                          Background MRI with contrast material enhancement is the imaging modality of
219                           Purpose To compare contrast material enhancement of glioblastoma multiforme
220 sis showed significant agreement in terms of contrast material enhancement, nonenhancement, necrosis,
221 olumes of interest were placed: regions with contrast material enhancement, regions with highest and
222  between the luminal B subtype and a dynamic contrast material-enhancement feature that quantifies th
223                                              Contrast material-enhancing vessel wall lesions were ass
224 used to evaluate the causal relation between contrast material exposure and AKI by evaluating patient
225                               The effects of contrast material exposure on the rate of acute kidney i
226                               The effects of contrast material exposure on the rate of AKI--defined a
227  had higher rates of dialysis and mortality, contrast material exposure was not an independent risk f
228   However, the risk of AKI is independent of contrast material exposure, even in patients with eGFR o
229 ID was defined as an intimal disruption with contrast material-filled outpouching from the aorta lume
230 edge of fluoroscopic anatomy and patterns of contrast material flow guide the planning and execution
231 ticle, provides an alternative to gadolinium contrast material for MR angiography for safe use in chr
232 ents received a bolus injection of 0.2 mL of contrast material for qualitative and quantitative evalu
233  that are assessable by using a noninvasive, contrast material-free, and radiation-free method.
234 ike or unknown-type reaction to iodine-based contrast material from June 1, 2008, to June 30, 2016, w
235 (contrast material group) or unenhanced (non-contrast material group) CT between 2000 and 2010 were i
236 ll patients who underwent contrast-enhanced (contrast material group) or unenhanced (non-contrast mat
237 ntrast material (radiopaque microsphere plus contrast material group), and 70-150-mum radiolucent mic
238 ast material (nonradiopaque microsphere plus contrast material group).
239  different between contrast material and non-contrast material groups in any eGFR subgroup; for the s
240 he suPAR-overexpressing mice that were given contrast material had greater functional and histologic
241    Purpose To investigate whether the use of contrast material has an effect on the detection of new
242  who underwent CT with intravenous iodinated contrast material (ICM) had a similar frequency of acute
243 ren undergoing CT with intravenous iodinated contrast material (ICM).
244 intravenous administration of low-osmolality contrast material in 112.
245 formed without intravenous administration of contrast material in 155 patients and with intravenous a
246 onds after the intravenous administration of contrast material in 27 patients with acute pancreatitis
247 n gadolinium-based and nonionic iodine-based contrast material in a colon phantom by using the charac
248 ureteral flow was defined by the presence of contrast material in the bladder.
249 cal injection protocols, the dynamics of the contrast material in the body were described according t
250  of 1 molar (containing 1 mol/mL gadobutrol) contrast material in the differentiation of malignant an
251 sion A technique to model the propagation of contrast material in XCAT human models was developed.
252 CT AKI by using traditional SCr criteria for contrast material-induced nephrotoxicity (CIN; SCr incre
253  as a single bolus; or protocol B, 100 mL of contrast material injected in four phases (phases 1-2, 6
254 , craniocaudal scan direction with 100 mL of contrast material injected intravenously as a single bol
255 olving along with the development of various contrast material injection protocols and multiphasic CB
256                     T1 time 12 minutes after contrast material injection was significantly associated
257                     T1 time 25 minutes after contrast material injection was significantly associated
258 p a method to incorporate the propagation of contrast material into computational anthropomorphic pha
259 ded intranodal injection of gadolinium-based contrast material into the inguinal lymph nodes, combine
260 ntravenous administration of the iso-osmolar contrast material (IOCM) iodixanol 320 and patients who
261 ith intranodal injection of gadolinium-based contrast material is feasible and can provide useful inf
262 s, the total cumulative dose of iodine-based contrast material is minimized and the risk of acute nep
263                                              Contrast material is often required to clearly visualize
264 kground Administration of a gadolinium-based contrast material is widely considered obligatory for fo
265                            We found that the contrast material maps clearly differentiated the distri
266                                              Contrast material maps clearly differentiated the distri
267 or cecal location, surface coating with oral contrast material, multiple CAD hits, advanced yet typic
268 , and 70-150-mum radiolucent microspheres in contrast material (nonradiopaque microsphere plus contra
269 the need to consider the effect of iodinated contrast material on the organ doses to patients undergo
270  repeated exposure to radiation, nephrotoxic contrast material, or gadolinium-based contrast agent.(C
271 eported allergy to iodine, iodine-containing contrast material, or shellfish were identified and thei
272                        The models with added contrast material propagation can be applied to simulate
273 lution of coexisting mesoscopic domains with contrasting material properties are critical in creating
274 f acquisition and reconstruction parameters, contrast material protocol injections, and radiation dos
275 roup), 70-150-mum radiopaque microspheres in contrast material (radiopaque microsphere plus contrast
276             Five radiologists blinded to the contrast material rated motion on a scale of 1 (no motio
277 he group with nonradiopaque microspheres and contrast material, retained tumoral contrast remained qu
278                                           In contrast, material shed almost continuously from contine
279 lectron detection can be used to obtain high-contrast, material-specific images of an organic photovo
280            Multivariate analysis showed that contrast material tagging markedly improved serrated pol
281 tologic findings; and presence or absence of contrast material tagging.
282                                           In contrast, materials that promote alphavbeta3 integrin bi
283              At the time of each reaction to contrast material, the patient's age and sex, whether pr
284 formed without intravenous administration of contrast material to evaluate the brain.
285 d nongated CT images obtained with iodinated contrast material to evaluate trauma 8 years prior showe
286 on in patients receiving low- or iso-osmolar contrast material to prevent recurrent radiocontrast med
287  ratio of 2.94 for the lack of rapid initial contrast material uptake and of 2.38 for the lack of was
288  ratio was 4.00 for not having rapid initial contrast material uptake in patients with a personal his
289                                   Additional contrast material volume administered was 23 mL +/- 12.9
290                              Mean and median contrast material volume at index imaging were 24 mL +/-
291 ime to transplantation, waiting list status, contrast material volume at index imaging, and additiona
292           Similar results were obtained when contrast material was added to radiopaque microspheres,
293   For the 80- and 100-kV protocols, 80 mL of contrast material was injected, versus 45 mL for the 70-
294                    Surface retention of oral contrast material was noted in all 18 cases.
295  of the sinuses without and with intravenous contrast material was performed.
296         A syringe filled with diluted iodine contrast material was placed into 30-, 35-, and 45-cm-wi
297 ept for micro-CT, which demonstrated soluble contrast material washout over time.
298 ns before and after intravenous injection of contrast material, we measured the evolution of lesional
299 eft ventricles and the severity of reflux of contrast material were assessed.
300 lification is generally tied to high optical contrast materials which limit the applicability of the

 
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