ライフサイエンスコーパス: controlled clinical trial

1 SIGN: Multicenter non-inferiority randomised controlled clinical trial.

2 Design: Randomized, controlled clinical trial.

3 a booster aP vaccine dose in this randomized controlled clinical trial.

4 nd, prospective, non-inferiority, randomised controlled clinical trial.

5 s syndrome deserving of a randomized placebo controlled clinical trial.

6 The DCCT was a large multicenter randomized controlled clinical trial.

7 ey have not been validated in a prospective, controlled clinical trial.

8 treatment, through a parallel-group, placebo-controlled clinical trial.

9 tage CHL in a multicenter phase 3 randomized controlled clinical trial.

10 study is a randomized, double-blind, placebo-controlled clinical trial.

11 cessions (REC), in a prospective randomized, controlled clinical trial.

12 ent has never been subjected to a randomized controlled clinical trial.

13 riodontal pockets, in a double-blind placebo-controlled clinical trial.

14 RTICIPANTS: Multicenter, randomized, placebo-controlled clinical trial.

15 Prospective, randomized, multicenter, controlled clinical trial.

16 Eighteen-month, multicenter, randomized, controlled clinical trial.

17 lticenter, randomized, double-blind, placebo-controlled clinical trial.

18 Randomized, double-blind, placebo-controlled clinical trial.

19 spective, 24-month, dose-ranging, paired-eye controlled clinical trial.

20 Prospective randomized controlled clinical trial.

21 be further explored in a randomised, placebo-controlled clinical trial.

22 Randomized, double-masked, placebo-controlled clinical trial.

23 currently being tested in randomized placebo-controlled clinical trials.

24 should be investigated in future randomized controlled clinical trials.

25 rigor analogous to multicenter, randomized, controlled clinical trials.

26 Proof of efficacy awaits randomized, placebo-controlled clinical trials.

27 PDT yielded comparable outcomes as those of controlled clinical trials.

28 38 Dutch volunteers enrolled in 2 randomized controlled clinical trials.

29 This represents the basis for forthcoming controlled clinical trials.

30 , body mass index, or waist circumference in controlled clinical trials.

31 nts, however, has to be further evaluated in controlled clinical trials.

32 nt of the impact of this intervention awaits controlled clinical trials.

33 was higher than previously reported in well-controlled clinical trials.

34 tifications are based on dedicated, strictly controlled clinical trials.

35 nalysis of the VISUAL-1 and VISUAL-2 placebo-controlled clinical trials.

36 6 randomized, double-masked, sham- and laser-controlled clinical trials.

37 are experimentally determined in randomised controlled clinical trials.

38 in depressed patients in randomised placebo-controlled clinical trials.

39 apple were included in an open, randomized, controlled clinical trial: 27 patients consumed daily de

40 In a randomized, placebo-controlled clinical trial, 40 participants received 1000

41 In a double-blinded randomized controlled clinical trial, 44 mothers with active caries

42 In a controlled clinical trial, 48 patients (mean age 50 +/-

43 There are few randomized, controlled clinical trials about the effect of non-surgi

44 Few prospective, randomized controlled clinical trials address the diagnosis and man

45 In a randomized double-blinded placebo-controlled clinical trial, adults with grass pollen-indu

46 studies, with six randomised, double-blind, controlled clinical trials, all of which investigated ve

47 onducted a randomized, double-blind, placebo-controlled clinical trial among pregnant women presentin

48 Here, we performed a randomized, sham-controlled clinical trial and measured electrophysiologi

49 lementation should be tested in a randomized controlled clinical trial and that the analysis should i

50 rognostic value of NT-proBNP thresholds in a controlled clinical trial and to evaluate the response t

51 mpliant, randomized, double-blinded, placebo-controlled clinical trial, and all patients provided inf

52 udies included randomised controlled trials, controlled clinical trials, and cohort studies; their ov

53 Finally, 11 studies (eight RCTs, two controlled clinical trials, and one retrospective study)

54 iteria: randomized controlled trials (RCTs), controlled clinical trials, and prospective clinical stu

55 , PsycINFO, the Cochrane Central Register of Controlled Clinical Trials, and the Cochrane Database of

56 not the high efficacy reported in randomised controlled clinical trials are materialising in real-wor

57 Moving forward, randomized controlled clinical trials are necessary to ensure that

58 cute liver failure, multicenter, randomized, controlled clinical trials are needed to confirm that hy

59 More well designed controlled clinical trials are needed which use phytoche

60 wever, long-term, multicentered, randomized, controlled clinical trials are required to know the clin

61 Controlled clinical trials are under way to assess the e

62 lable which require evaluation in randomized controlled clinical trials as adjunct therapies for shor

63 s compared to classical double-blind placebo-controlled clinical trials as the basis for precise pers

64 This double-blind, randomized, controlled clinical trial assessed the efficacy of multi

65 rallel-group, forced dose titration, placebo-controlled clinical trial at 30 sites from May 10, 2011,

66 , multicenter, randomized, active comparator-controlled, clinical trial at multiple locations of the

67 us study, a randomized double-blind, placebo-controlled clinical trial, between August 2003 and Novem

68 c reviews (SRs), randomized clinical trials, controlled clinical trials, case series, and case report

69 the PubMed and Cochrane Central Register of Controlled Clinical Trials (CENTRAL) search engines from

70 ed MEDLINE, the Cochrane Central Register of Controlled Clinical Trials, ClinicalTrials.gov, and rele

71 This prospective, randomized, controlled clinical trial compared changes in exercise p

72 This randomized placebo-controlled clinical trial compared the response to a gin

73 onducted a randomized, double-blind, placebo-controlled clinical trial comparing apixaban, at a dose

74 (PISTE) trial was a multicentre, randomised, controlled clinical trial comparing intravenous thrombol

75 We performed a prospective randomized controlled clinical trial comparing NPWT to standard dry

76 Randomized controlled clinical trials comparing a strategy of promp

77 y cases, do not have support from randomised controlled clinical trials comparing bariatric surgery w

78 e present study was a split-mouth randomized controlled clinical trial comprising 20 chronic periodon

79 Controlled clinical trials conduct the research that com

80 In a randomized, double-blind, placebo-controlled clinical trial conducted as a pilot study, 52

81 domized, double-blind, double-dummy, placebo-controlled clinical trial conducted at 10 university cli

82 ts (FISH) study, a randomized, double-blind, controlled clinical trial conducted at 15 North American

83 Multicenter prospective, double-masked, controlled clinical trial conducted at 80 clinical sites

84 : Phase 3, randomized, double-blind, placebo-controlled clinical trial conducted at 91 clinical sites

85 Randomized, double-blind, placebo-controlled clinical trial conducted from 2008 to 2013 in

86 YNDIET study is a 6-mo randomized, parallel, controlled clinical trial conducted in 122 overweight an

87 In this blinded, randomized, controlled clinical trial conducted over 6 months with a

88 reated with placebo in 12 randomized placebo-controlled clinical trials conducted mostly in outpatien

89 Phase 1-2, randomized, double-blind, placebo-controlled, clinical trial conducted from 2008 to 2012.

90 trials, quasi-randomized controlled trials, controlled clinical trials, controlled before-after stud

91 trials, quasi-randomized controlled trials, controlled clinical trials, controlled before-and-after

92 trials, quasi-randomized controlled trials, controlled clinical trials, controlled before-and-after

93 Our phase III randomized placebo-controlled clinical trial demonstrated that naproxen at

94 he mechanisms of action of novel agents, and controlled clinical trials documenting their efficacy an

95 This retrospective analysis of five placebo-controlled clinical trials does not support a decreased

96 er and neutropenia through observational and controlled clinical trials done by single institutions,

97 uble-masked, randomized, multicenter, active-controlled clinical trial enrolled 224 eyes of 224 patie

98 , participant- and surgeon-masked randomized controlled clinical trial (EudraCT No.

99 This randomized controlled clinical trial evaluated the effects of repea

100 xtension study of a multicenter, randomized, controlled clinical trial evaluating the effect and long

101 s performed to identify all blinded, placebo-controlled clinical trials evaluating acute selective NS

102 There is a major lack of randomized controlled clinical trials evaluating the efficacy of pr

103 Methods A systematic review of randomized controlled clinical trials evaluating weight loss interv

104 e, there is a paucity of randomised, placebo-controlled clinical trial evidence where the primary out

105 This study highlights the need for a controlled clinical trial examining the cause of the con

106 No randomized controlled clinical trials exist to definitively support

107 However, randomized, controlled, clinical trials failed to demonstrate benefi

108 mized, double-blind, 14- to 15-week, placebo-controlled clinical trial, followed by a 1-year open-lab

109 dence, from case reports to large randomized controlled clinical trials, for the possible adverse eff

110 -stratified multicentre, randomised, placebo-controlled clinical trial from Nov 16, 2010, to Sept 12,

111 lished when "at least two blinded randomized controlled clinical trials from two different groups of

112 Though no controlled clinical trial has been performed to provide

113 A number of controlled clinical trials have been performed to show i

114 Phase 3 randomised, placebo-controlled clinical trials have clarified aspects of dis

115 Numerous studies including controlled clinical trials have demonstrated that anti-T

116 Controlled clinical trials have identified a limited num

117 To date, randomized, controlled clinical trials have not reproduced the effic

118 Five studies, including 2 controlled clinical trials, have demonstrated significan

119 roup, multicenter, double-blind, randomized, controlled clinical trial in 150 adults after gastrointe

120 trial is a randomized, double-blind, placebo-controlled clinical trial in 160 patients with severe, n

121 pated in a randomized, double-blind, placebo-controlled clinical trial in 2011 and 2012 on the safety

122 We conducted a randomized, double-masked, controlled clinical trial in 225 10- to 18-y-old eligibl

123 ospective, double-blind, randomized, placebo-controlled clinical trial in an ambulatory care and home

124 dy was a pragmatic, single-centre randomised controlled clinical trial in community-dwelling individu

125 In this Phase I randomised controlled clinical trial in HIV-1 negative volunteers w

126 hase 1b, double-blinded, randomised, placebo-controlled clinical trial in Kampala, Uganda to examine

127 -center, randomized, double-blinded, placebo-controlled clinical trial in patients undergoing emergen

128 The first randomized controlled clinical trial in refractory adult and childh

129 ulticenter randomized, double-blind, placebo-controlled clinical trial in Tasmania and Victoria, Aust

130 r FMT in a randomized, single-blind, placebo-controlled clinical trial in Virginia.

131 a lack of long-term data and data outside of controlled clinical trials in carotid artery stenting.

132 9 disease will now be assessed in randomized controlled clinical trials in humans.

133 herapies have been shown to be of benefit in controlled clinical trials in humans.

134 We recommend controlled clinical trials in patients with ICUAW that c

135 Basic research, as well as controlled clinical trials, in this realm offers promisi

136 Sixteen controlled clinical trials, including more than 3000 chi

137 hrough population-based studies and in large controlled clinical trials; inflammatory marker levels a

138 Randomized, controlled trials; controlled clinical trials; interrupted time series; and

139 Randomized, double-blind, placebo-controlled clinical trials investigating the efficacy of

140 lticenter, double-blind, randomized, placebo-controlled clinical trial involving 114 North American e

141 A randomized, double-blind, sham-controlled clinical trial involving 239 participants who

142 d be required to mount a randomized, placebo-controlled clinical trial involving premanifest HD indiv

143 ruvada) has demonstrated efficacy in placebo-controlled clinical trials involving men who have sex wi

144 xtends beyond the skin and that a randomized controlled clinical trial is needed to confirm these fin

145 A randomized controlled clinical trial is the best way to minimize bi

146 The randomized controlled clinical trial is the gold standard scientifi

147 The aim of this randomized, controlled clinical trial is to determine whether ridge

148 Further evaluation in a randomized controlled clinical trial is warranted to test for effic

149 st evidence from population-level randomized controlled clinical trials is lacking.

150 Double-blind randomized placebo-controlled clinical trials lasting >=7 days were include

151 A controlled clinical trial may be warranted.

152 he largest randomized, double-blind, placebo controlled clinical trial, now underway, designed to eva

153 The trial was registered with Controlled Clinical Trials (number ISRCTN76894700).

154 Medline was searched to identify RCTs, controlled clinical trials, observational studies, case

155 We conducted a randomized, controlled clinical trial of a peer mentoring interventi

156 r herpesviruses in this disease is through a controlled clinical trial of an efficacious antiviral dr

157 However, a recent placebo-controlled clinical trial of AV-101 in depression found

158 d as neonates in a double-blind, randomized, controlled clinical trial of caffeine versus placebo und

159 This was a double-blind randomized placebo-controlled clinical trial of creatine monohydrate (10 g/

160 No double-blinded, placebo controlled clinical trial of curcumin has been successfu

161 cted a prospective, multicenter, randomized, controlled clinical trial of diabetic patients to invest

162 A randomized placebo-controlled clinical trial of dietary phosphatidylcholine

163 Population-based randomized controlled clinical trial of first graders from 44 schoo

164 lticenter, randomized, double-blind, placebo-controlled clinical trial of hydroxyurea in infants (beg

165 In 2013 we conducted a randomized, placebo-controlled clinical trial of live attenuated influenza v

166 st intermediate AMD enrolled in a randomized controlled clinical trial of lutein/zeaxanthin and/or om

167 igh-quality phenotype data from a randomized controlled clinical trial of nAMD.

168 In this randomized controlled clinical trial of patients with acute iliofem

169 were obtained from subjects during a placebo-controlled clinical trial of peanut OIT.

170 lticenter, randomized, double-blind, placebo-controlled clinical trial of peanut sublingual immunothe

171 -blinded, placebo-randomized, within-subject controlled clinical trial of single and multiple ascendi

172 ospective, double-blind, randomized, placebo-controlled clinical trial of the effects of 5 smoking ce

173 ples ascertained through the largest placebo-controlled clinical trial of the monoamine oxidase B inh

174 r, randomized, single-masked, sham-injection controlled clinical trial of the safety, tolerability, a

175 tudy was a randomized, double-blind, placebo-controlled clinical trial of vitamin D3 supplementation

176 Controlled clinical trials of anti-acid treatments are n

177 Several relatively small randomized controlled clinical trials of anticoagulation as cancer

178 Randomized controlled clinical trials of BT in severe asthma have n

179 Data from rigorously controlled clinical trials of convalescent plasma are al

180 Three randomized controlled clinical trials of fasting in humans were ide

181 We carried out two double-blind, placebo-controlled clinical trials of N-methyl-D-aspartate recep

182 a meta-analysis of English language placebo-controlled clinical trials of naloxone, naltrexone, nalm

183 int that should be used in future randomized controlled clinical trials of novel therapies in idiopat

184 6810), two phase 3, double-blind, randomised controlled clinical trials of the HPV-16/18 AS04-adjuvan

185 ase pathogenesis and knowledge provided from controlled clinical trials of these new therapeutic agen

186 oled analysis of weight gain in 8 randomized controlled clinical trials of treatment-naive people liv

187 oled analysis of weight gain in 8 randomized controlled clinical trials of treatment-naive people wit

188 Randomized controlled clinical trials offer the best evidence for c

189 blind, household-cluster-randomized, placebo-controlled clinical trial on Flores island, Indonesia, a

190 randomized, crossover, double-blind, placebo-controlled clinical trial on human immunodeficiency viru

191 o treat mast cell mediator-related symptoms, controlled clinical trials on how they improve quality o

192 d studies were randomized controlled trials, controlled clinical trials, or cohort studies with 10 or

193 IGN: In a multicenter prospective randomized controlled clinical trial, patients with GD were randomi

194 level of evidence of treatments based on the controlled clinical trials performed with each compound

195 This randomized, double-blind, prospective controlled clinical trial (phase 2B) was designed to inv

196 rechallenge, additional data are needed from controlled clinical trials, prospective registries, and

197 th blood pressure (BP) levels and randomized controlled clinical trials providing evidence of stroke

198 This randomized controlled clinical trial (RCT) called for 120 participa

199 stematically reviewed to identify randomized controlled clinical trials (RCTs) in chronic heart failu

200 ual patient data meta-analysis of randomized controlled clinical trials (RCTs) to evaluate whether ba

201 Randomized controlled clinical trials (RCTs), prospective cohort st

202 hest level of evidence comes from randomized controlled clinical trials (RCTs).

203 s phase 2, randomised, double-blind, placebo-controlled clinical trial recruited patients aged 18-65

204 Randomized controlled clinical trials remain the best method for mi

205 ICIPANTS: Multicenter, double-blind, placebo-controlled clinical trial (Renal Optimization Strategies

206 ncludes a review of split-mouth, randomized, controlled clinical trial results that specifically trac

207 polyneuropathy, according to recent placebo-controlled clinical trial results.

208 as efficacy can change when moving from the controlled clinical trial setting to clinical practice.

209 to these drugs in clinical care, outside of controlled clinical trial settings.

210 ants: 29 randomized controlled trials, seven controlled clinical trials, seven consecutive case serie

211 long-term follow-up of a randomized, placebo-controlled, clinical trial (SHEP) of patients aged 60 ye

212 monly used in cystic fibrosis based on short controlled clinical trials showing reductions in pulmona

213 Results of recent randomized controlled clinical trials suggest that most patients wi

214 A recent controlled clinical trial suggested a role for amantadin

215 However, there are controlled clinical trials suggesting its efficacy in ot

216 is a large body of evidence from randomized controlled clinical trials supporting the cardiovascular

217 as a prospective, single-blinded, randomized controlled clinical trial testing the hypothesis that he

218 k Trial), a randomized, double-blind, active-controlled clinical trial that enrolled hypertensive ind

219 I) 53 is a randomized, double-blind, placebo-controlled clinical trial that evaluated the safety of s

220 he ICTUS trial was a multicenter, randomized controlled clinical trial that included 1,200 patients w

221 Eight searches were performed seeking controlled clinical trials that addressed the ability of

222 review was conducted to identify randomised controlled clinical trials that assessed the use of poly

223 , prospective, retrospective, and randomized controlled clinical trials that evaluated implant stabil

224 ked, multicenter, randomized, sham injection-controlled clinical trials that evaluated intravitreal l

225 ive search strategies to identify randomized controlled clinical trials that evaluated the effects of

226 Randomized controlled clinical trials that evaluated the efficacy o

227 ed and inconsistent evidence from randomized controlled clinical trials that greater PAC involvement

228 tudies and post hoc analyses from randomized controlled clinical trials that provided data on the out

229 Prospective, randomized, controlled clinical trials that reported isoniazid acety

230 tudy was a randomized, double-blind, placebo-controlled, clinical trial that accrued subjects from fi

231 Here we show-in two independent randomized controlled clinical trials-that metformin increases circ

232 les from a randomized, double-blind, placebo-controlled clinical trial (the Vitamin D Antenatal Asthm

233 eing evaluated prospectively in a randomized controlled clinical trial, the AREDS2.

234 In this randomized, controlled clinical trial, the questionnaires Oral Impac

235 that we discuss need to be validated in well-controlled clinical trials, these new discoveries regard

236 We did a randomised controlled clinical trial to assess the efficacy and saf

237 We conducted a randomized, controlled clinical trial to assess the safety and effic

238 n the context of a randomized, double-blind, controlled clinical trial to assess whether cowpea or co

239 We conducted a randomized, double-blind, controlled clinical trial to determine whether hyperbari

240 METHODS AND We performed a randomized controlled clinical trial to evaluate the effect of high

241 STUS (Open-Label, 2x2 Factorial, Randomized, Controlled Clinical Trial to Evaluate the Safety of Apix

242 y (AREDS) is the only large-scale randomized controlled clinical trial to show a 25% beneficial effec

243 orm management of Legionnaires' disease, and controlled clinical trials to ascertain the optimum anti

244 The objective was to combine evidence from controlled clinical trials to assess the effect of n-3 L

245 sed of several histological types, rendering controlled clinical trials to establish the best treatme

246 nge will be to design prospective randomized controlled clinical trials to provide the evidence neces

247 f patients who would have been excluded from controlled clinical trials undergoes carotid artery sten

248 Data from a randomized double-blind placebo-controlled clinical trial undertaken in healthy young ad

249 le-center, randomized, double-blind, placebo-controlled clinical trial was conducted at Siriraj Hospi

250 A prospective, randomized, fellow-eye-controlled clinical trial was conducted at the Byers Eye

251 A randomized, double-blind, placebo-controlled clinical trial was conducted between May 7, 2

252 is 12-week double-blind, randomized, placebo-controlled clinical trial was conducted from February 1,

253 A 6-month randomized and placebo-controlled clinical trial was conducted in 171 postmenop

254 A 12-week, randomized, double-blind, placebo-controlled clinical trial was conducted in 50 unpaid tre

255 This randomized, double-blind, placebo-controlled clinical trial was conducted in 54 women with

256 A randomized, double-blind, placebo-controlled clinical trial was conducted in HV (n = 54) a

257 A single-blind randomized controlled clinical trial was conducted in southern Mala

258 lend.A prospective, double-blind, randomized controlled clinical trial was conducted in which childre

259 A randomized controlled clinical trial was conducted to compare the e

260 A controlled clinical trial was conducted to determine the

261 an 8-week randomized, double-blind, placebo-controlled clinical trial was conducted.

262 pective, randomized, placebo, and positively controlled clinical trial was designed to evaluate the c

263 A controlled clinical trial was done in young adult volunt

264 le neutralizing antibody response, a placebo-controlled clinical trial was performed in 48 healthy ad

265 A randomized, double-blind, placebo-controlled clinical trial was performed in 70 women with

266 A pilot randomized controlled clinical trial was performed to evaluate the

267 A randomized "two armed" controlled clinical trial was performed.

268 The hypothesis of this randomized controlled clinical trial was that local application of

269 ackground: The aim of the present randomized controlled clinical trial was to assess the bucco-lingua

270 The objective of this randomized controlled clinical trial was to assess the efficacy of

271 The goal of this 12-month randomized controlled clinical trial was to compare three-dimension

272 The purpose of this multicenter randomly controlled clinical trial was to compare two acellular d

273 The aim of this controlled clinical trial was to determine clinical appl

274 The primary aim of this randomized, controlled clinical trial was to determine the efficacy

275 e purpose of this single-masked, randomized, controlled clinical trial was to evaluate the effects of

276 KEEPS, a randomized, double-blinded, placebo-controlled clinical trial, was conducted at nine US acad

277 especified analysis of a randomized, placebo-controlled clinical trial, we compared the differences i

278 In a double-blind, randomized, controlled clinical trial, we compared the efficacy, tol

279 In this double-blind, placebo-controlled clinical trial, we enrolled a cohort of patie

280 In this randomised, double-blind, placebo-controlled clinical trial, we enrolled children and youn

281 In this double-blind, randomized, placebo-controlled clinical trial, we evaluated systemic and muc

282 hich was a randomized, double-blind, placebo-controlled clinical trial, we explored the effectiveness

283 In this randomised, double-blind, placebo-controlled clinical trial, we recruited patients from 78

284 For this phase 2, randomised, placebo-controlled, clinical trial, we enrolled patients with re

285 spective, randomized, double-masked, placebo-controlled clinical trials were conducted at 39 ophthalm

286 No controlled clinical trials were identified.

287 Prospective human controlled clinical trials were included that compared s

288 Two independent prospective randomized controlled clinical trials were performed for treatment

289 This was a controlled clinical trial where patients with an elevate

290 mplications data are derived from randomized controlled clinical trials, which report a high adverse

291 Future placebo-controlled clinical trials will be required to establish

292 However, long-term, multicenter randomized, controlled clinical trials will be required to know thei

293 of preliminary studies, ongoing randomized, controlled clinical trials will potentially provide defi

294 conducted a randomized double-blind placebo-controlled clinical trial with 208 opioid-dependent pati

295 Randomized controlled clinical trial with 4-week follow-up that inc

296 Randomized, blinded, placebo-controlled clinical trial with a 12-week treatment perio

297 Double-blind, randomized, placebo-controlled clinical trial with a 12-week treatment phase

298 In the present prospective randomized controlled clinical trial with three parallel arms (#NCT

299 Uncontrolled and controlled clinical trials with different compounds and

300 Prospective controlled clinical trials with immunomodulatory therapy